prostagard-d8 capsule - Silodosin (8mg) + Dutasteride (0.5mg) medicine

Prostagard-D8 Capsule: Comprehensive Guide to Uses, Side Effects, and Safety

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🏭 Aristo Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for BPH.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Sudden fainting or severe dizziness
  • Swelling of face, lips, or throat, or difficulty breathing
  • Chest pain or irregular heartbeat
  • Severe allergic reaction with rash and itching
  • Inability to urinate (acute urinary retention)
  • Blood in urine or painful urination
  • Breast lumps or nipple discharge
  • Yellowing of skin or eyes (jaundice)

If experiencing severe symptoms, call emergency services immediately.

What is prostagard-d8 capsule used for?

This medicine is a combination of Silodosin and Dutasteride used to treat benign prostatic hyperplasia (BPH) in men. It works by relaxing prostate muscles and shrinking the prostate gland, improving urinary symptoms.

  • Generic Name: Silodosin (8mg) + Dutasteride (0.5mg)
  • Manufacturer: Aristo Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 prostagard-d8 capsule के बारे में (Hindi Summary)

उपयोग: यह दवा सिलोडोसिन और ड्यूटास्टेराइड का संयोजन है, जिसका उपयोग पुरुषों में बेनाइन प्रोस्टेटिक हाइपरप्लासिया (बीपीएच) के इलाज के लिए किया जाता है। यह प्रोस्टेट ग्रंथि को आराम देकर और उसका आकार कम करके पेशाब की समस्याओं में सुधार करती है। यह दवा पेशाब की धारा को बेहतर बनाती है, बार-बार पेशाब आने की समस्या को कम करती है, और रात में पेशाब उठने की समस्या को कम करती है। यह दवा केवल पुरुषों के लिए है और डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।

साइड इफेक्ट्स: आम दुष्प्रभावों में रेट्रोग्रेड इजैकुलेशन (सूखा स्खलन), कम कामेच्छा, चक्कर आना, सिरदर्द, नाक बंद होना और थकान शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें अचानक रक्तचाप गिरना, बेहोशी, और एलर्जी प्रतिक्रियाएं जैसे चकत्ते, खुजली, और चेहरे या गले में सूजन शामिल हो सकती हैं। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। कैप्सूल को चबाएं या तोड़ें नहीं, पूरा निगल लें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या भारी मशीनरी चलाने से बचें। बैठने या लेटने से उठते समय धीरे-धीरे उठें ताकि चक्कर न आएं। यदि आपको लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। इस दवा को लेते समय और बंद करने के 6 महीने बाद तक रक्तदान न करें। गर्भवती महिलाओं को इस दवा को छूने से बचना चाहिए।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 prostagard-d8 capsule Uses & Benefits

  • [{"condition":"Benign Prostatic Hyperplasia (BPH)","description":"This medicine is used to treat symptomatic BPH in men with an enlarged prostate.
  • It improves urinary flow, reduces symptoms such as frequent urination, urgency, and weak stream, and lowers the risk of acute urinary retention and surgery.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Chronic prostatitis/chronic pelvic pain syndrome","description":"Sometimes alpha-blockers and 5-alpha-reductase inhibitors are used off-label to alleviate symptoms of chronic prostatitis, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Benign Prostatic Hyperplasia (BPH)

Also treats: Lower urinary tract symptoms (LUTS), Acute urinary retention (prevention), Prostate enlargement

📋 Drug Information

Generic Name(s)Silodosin (8mg) + Dutasteride (0.5mg)
Brand Nameprostagard-d8 capsule
ManufacturerAristo Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassUROLOGY
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and direct sunlight. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce the risk of dizziness and stomach upset.
2
Rise slowly from sitting or lying positions to prevent fainting.
3
Avoid driving or operating heavy machinery until you know how this medicine affects you.
4
Inform your doctor if you have liver or kidney disease before starting this medicine.
5
Do not donate blood while taking this medicine and for at least 6 months after stopping.
6
Use condoms if your partner is pregnant or could become pregnant.
7
Report any breast changes, such as lumps or tenderness, to your doctor.
8
Keep regular follow-up appointments to monitor your response and PSA levels.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Frequent urination
This medicine is commonly prescribed for urinary symptoms of BPH.
Likely Use
✅
Weak urine stream
This medicine helps improve urine flow.
Likely Use
✅
Nocturia (nighttime urination)
This medicine can reduce nighttime urination.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary
❌
Headache
This medicine is not a primary headache treatment.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionSilodosin is rapidly absorbed after oral administration, with peak plasma concentrations reached in about 1.5 to 2 hours. Food reduces peak concentration but does not significantly affect overall exposure. Dutasteride is well absorbed orally, with peak concentrations at 2 to 3 hours; food does not affect its bioavailability.
DistributionSilodosin is approximately 97% bound to plasma proteins and has a volume of distribution of about 0.8 L/kg. Dutasteride is highly lipophilic, has a large volume of distribution (about 300 to 500 L), and is extensively bound to plasma proteins (>99%).
Protein BindingSilodosin: ~97%; Dutasteride: >99%
MetabolismSilodosin is extensively metabolized in the liver, primarily by CYP3A4, UGT2B7, and UGT1A9 enzymes, to inactive metabolites. Dutasteride is metabolized by CYP3A4 and CYP3A5 to active metabolites, but the parent drug accounts for most of the activity.
Half-LifeSilodosin: approximately 13 hours; Dutasteride: approximately 5 weeks (terminal half-life)
ExcretionSilodosin is excreted mainly in feces (about 55%) and urine (about 34%) as metabolites. Dutasteride is excreted primarily in feces (about 40%) and urine (about 5%) as metabolites.
BioavailabilitySilodosin: approximately 32%; Dutasteride: approximately 60%
Onset of ActionSilodosin provides symptomatic relief within days, with maximum effect in 2 to 4 weeks. Dutasteride reduces prostate volume over 3 to 6 months, with maximum effect after 2 years.
Peak Plasma TimeSilodosin: 1.5 to 2 hours; Dutasteride: 2 to 3 hours
Duration of ActionSilodosin: 24 hours (once-daily dosing); Dutasteride: prolonged effect due to long half-life, with sustained reduction in DHT for weeks after discontinuation.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Silodosin is a selective alpha-1A adrenergic receptor antagonist that blocks receptors in the prostate, bladder neck, and urethra, leading to smooth muscle relaxation and improved urine flow. Dutasteride is a 5-alpha-reductase inhibitor that inhibits both type 1 and type 2 isoforms of the enzyme, preventing the conversion of testosterone to dihydrotestosterone (DHT). Reduced DHT levels cause the prostate epithelium to shrink, decreasing prostate volume and alleviating obstruction. The combination provides rapid symptom relief from silodosin and long-term prostate size reduction from dutasteride.

Mechanism Steps

1
Silodosin blocks alpha-1A receptors: Silodosin selectively binds to alpha-1A adrenergic receptors in the prostate, bladder neck, and urethra, preventing norepinephrine from causing smooth muscle contraction.
2
Smooth muscle relaxation: Blockade of alpha-1A receptors leads to relaxation of smooth muscles in the lower urinary tract, reducing resistance to urine flow.
3
Dutasteride inhibits 5-alpha-reductase: Dutasteride binds to and inhibits both type 1 and type 2 isoforms of the 5-alpha-reductase enzyme, blocking the conversion of testosterone to dihydrotestosterone (DHT).
4
Reduced DHT levels: Lower DHT levels cause the prostate gland to shrink by inducing apoptosis of prostate epithelial cells, leading to reduced prostate volume.
5
Combined effect: The combination provides immediate symptom relief from smooth muscle relaxation and long-term reduction in prostate size, improving urinary symptoms and reducing complications.

💡 How to Take prostagard-d8 capsule

Strength: Capsule containing Silodosin 8 mg and Dutasteride 0.5 mg.

1Take one capsule by mouth once daily.
2Swallow the capsule whole with a glass of water.
3Take it with food to reduce the risk of dizziness and stomach upset.
4Do not crush, chew, or open the capsule.
5Take it at the same time each day to maintain consistent levels.
6If you miss a dose, follow the missed dose instructions.
7Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe recommended dose for adults is one capsule (Silodosin 8 mg + Dutasteride 0.5 mg) taken orally once daily with food. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is required for elderly patients based on age alone. However, elderly patients may be more sensitive to the effects of this medicine, particularly dizziness and orthostatic hypotension. Use with caution and monitor blood pressure regularly.
Renal ImpairmentFor patients with moderate renal impairment (CrCl 30-50 mL/min), a reduced dose of silodosin (4 mg) may be considered. This medicine contains 8 mg silodosin, so it may not be suitable. Consult your doctor for dose adjustment. Dutasteride dose adjustment is not required for renal impairment.
Hepatic ImpairmentThis medicine is contraindicated in patients with severe hepatic impairment. For mild to moderate hepatic impairment, use with caution and monitor liver function. Dose adjustment may be necessary. Consult your doctor.
Maximum Daily DoseOne capsule (Silodosin 8 mg + Dutasteride 0.5 mg) per day.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces the risk of dizziness and stomach upset.
Grapefruit juice
Avoid
May increase silodosin levels by inhibiting CYP3A4.
Alcohol
Limit or avoid
May increase dizziness and low blood pressure.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with your regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of prostagard-d8 capsule

✅ Common Side Effects

Retrograde ejaculation (Common (10-28%))
This is usually harmless and reversible. Discuss with your doctor if it bothers you.
Dizziness (Common (3-5%))
Rise slowly from sitting or lying positions. Avoid driving if affected.
Headache (Common (2-4%))
Usually resolves on its own. Consult doctor if persistent.
Nasal congestion (Common (2-3%))
May subside with continued use. Use saline nasal spray if needed.
Decreased libido (Common (2-5%))
Discuss with your doctor if it becomes bothersome.

🚨 Serious Side Effects

Orthostatic hypotension (Uncommon (0.1-1%))
Rise slowly. If you feel faint, sit or lie down immediately and inform your doctor.
Syncope (fainting) (Rare (<0.1%))
Seek immediate medical attention if you faint.
Allergic reactions (rash, itching, swelling) (Rare (<0.1%))
Stop the medicine and seek emergency care if you experience swelling of face, lips, or throat, or difficulty breathing.
Breast tenderness or enlargement (Uncommon (0.1-1%))
Report to your doctor; may require evaluation.
High-grade prostate cancer (Rare)
Regular PSA monitoring and prostate exams are recommended. Discuss risks and benefits with your doctor.

⚠️ Rare Side Effects

Angioedema
Seek emergency medical help immediately.
Priapism (prolonged erection)
Seek immediate medical attention to prevent permanent damage.
Liver enzyme elevation
Monitor liver function tests if symptoms occur.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Clarithromycin Major
Ritonavir Major
Prazosin Major
Terazosin Major
Sildenafil Major
Tadalafil Major
Verapamil Moderate
Diltiazem Moderate
Warfarin Moderate

🚨 Major Interactions

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
  • Alpha-blockers (e.g., prazosin, terazosin)
  • PDE5 inhibitors (e.g., sildenafil, tadalafil)

⚡ Moderate Interactions

  • Moderate CYP3A4 inhibitors (e.g., verapamil, diltiazem)
  • Antihypertensives
  • Warfarin

🍷 Alcohol Interaction

Alcohol may increase the risk of dizziness, drowsiness, and low blood pressure when taken with this medicine. It is advisable to limit or avoid alcohol consumption while on this medication.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to silodosin, dutasteride, or any component of the formulation","Women who are pregnant or may become pregnant","Children and adolescents","Severe hepatic impairment","History of orthostatic hypotension","Concomitant use with strong CYP3A4 inhibitors"]

⚠️ Warnings & Precautions

["This medicine is for male use only. Women should not handle broken capsules.","May cause dizziness and fainting; avoid driving or operating machinery until you know how it affects you.","Rise slowly from sitting or lying positions to prevent falls.","Inform your doctor if you have liver or kidney disease.","Do not donate blood while taking this medicine and for 6 months after stopping.","Use condoms if your partner is pregnant or could become pregnant.","Dutasteride reduces PSA levels; inform your doctor about this medicine before PSA testing.","Report any breast changes, such as lumps or tenderness.","Seek immediate medical help for signs of allergic reaction."]

🤱 Lactation Safety

This medicine is not indicated for use in women. It is not known if silodosin or dutasteride are excreted in human breast milk. Breastfeeding is not recommended while taking this medicine.

💊 Overdose Management

Overdose with this medicine may cause severe hypotension, dizziness, and fainting. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or open the capsule; swallow it whole. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause dizziness. Rise slowly from sitting or lying positions to prevent dizziness or fainting. Inform your doctor if you have liver disease, kidney disease, or low blood pressure. Do not donate blood while taking this medicine and for at least 6 months after stopping, as it can affect a recipient's prostate-specific antigen (PSA) levels. Women who are pregnant or may become pregnant should not handle this medicine, especially if the capsule is broken, because dutasteride can be absorbed through the skin and may harm a male fetus. Use a condom during sexual intercourse if your partner is pregnant or could become pregnant. Regular follow-up with your doctor is important to monitor your response and check for any complications.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and orthostatic hypotension. Use with caution and monitor blood pressure regularly. Falls are a risk; take precautions to prevent them.

🤰 Pregnancy Planning (TTC)

This medicine is not for use in women. Men taking this medicine who are planning to father a child should be aware that dutasteride may affect semen quality. Consult your doctor for advice.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and affect blood pressure. Your doctor may advise you to stop the medicine temporarily before surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure. It may cause dizziness or affect blood pressure during the procedure. Take precautions to prevent falls.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce pressure on the prostate.
🥗
Stay well hydrated, but limit fluids before bedtime to reduce nighttime urination.
😴
Avoid caffeine and alcohol, which can irritate the bladder.
💧
Practice pelvic floor exercises to strengthen bladder muscles.
🧘
Eat a balanced diet rich in fruits, vegetables, and whole grains.
🌞
Get regular exercise, such as walking or swimming, to improve overall health.
🚭
Avoid smoking, as it can worsen urinary symptoms.

🏋️ Exercise Considerations

This medicine may cause dizziness and orthostatic hypotension. Avoid strenuous exercise or sudden changes in position until you know how the medicine affects you. If you feel dizzy during exercise, stop immediately and sit or lie down.

🥗 Diet Recommendations

Include foods rich in lycopene, such as tomatoes and watermelon.
Eat plenty of fiber to prevent constipation, which can worsen urinary symptoms.
Limit spicy and acidic foods that may irritate the bladder.
Reduce sodium intake to help manage blood pressure.
Include omega-3 fatty acids from fish or flaxseed for prostate health.

💼 Impact on Daily Work & Life

This medicine may cause dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause retrograde ejaculation, which can affect sexual function but is not harmful. Discuss any concerns with your doctor.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe dizziness, fainting, or allergic reactions, seek immediate medical attention. Your doctor may adjust the dose or switch to another medicine. Stopping suddenly may cause symptoms to return.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to sustained reduction in prostate size and improved urinary symptoms. Dutasteride reduces PSA levels by about 50%, which must be considered during prostate cancer screening. There is a potential increased risk of high-grade prostate cancer associated with dutasteride, so regular monitoring is essential. Silodosin may cause retrograde ejaculation, which is usually reversible. Regular follow-up with your doctor is recommended to monitor for any complications.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Weight loss, dietary changes, and pelvic floor exercises can help manage BPH symptoms.

Evidence: Well-established
Minimally invasive procedures

Procedures like TURP or laser therapy may be considered if medicines are ineffective.

Evidence: Well-established
Herbal supplements

Saw palmetto and other herbs are sometimes used, but evidence is limited and they may interact with medicines.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no specific vaccine interactions with this medicine. However, inform your doctor about all medicines before receiving any vaccine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Keep out of reach of children

❌ DON'T

Do not use after expiry date

✈️ Traveling with This Medicine

When traveling, carry your medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue taking your dose at the same local time each day. Check customs regulations for carrying prescription medicines. Carry enough supply for your entire trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 65-year-old man with frequent urination and weak stream
Rajesh, a 65-year-old retired teacher, was diagnosed with BPH. He started this medicine as prescribed. Within a week, he noticed improved urinary flow and fewer nighttime bathroom trips. He experienced mild dizziness initially but it subsided after a few days. He emphasizes taking the medicine with breakfast and rising slowly from bed.
💡 Lesson: Consistent daily use and taking the medicine with food can improve tolerability and symptom relief.
👤 A 58-year-old man with enlarged prostate and elevated PSA
Suresh, a 58-year-old businessman, had an enlarged prostate and elevated PSA. His doctor prescribed this medicine. After 6 months, his prostate size reduced significantly, and his PSA levels dropped by about 50%, which his doctor explained was expected due to dutasteride. He advises regular follow-ups and not panicking about PSA changes.
💡 Lesson: Dutasteride reduces PSA levels, so regular monitoring and communication with your doctor are essential.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Silodosin provides symptom relief within days, but dutasteride takes 3 to 6 months to shrink the prostate. Full benefits may take up to 6 months to 2 years.

Q: Can I take this medicine with other medications?

A: Inform your doctor about all medications you take, especially blood pressure medicines, alpha-blockers, and CYP3A4 inhibitors. Some interactions can be serious.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Q: Is this medicine safe for long-term use?

A: Yes, it is generally safe for long-term use under medical supervision. Regular follow-ups are needed to monitor PSA levels and prostate health.

Q: Can women take this medicine?

A: No, this medicine is not for women. It is contraindicated in pregnancy and women of childbearing potential.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Will it affect my sex life?
  • Does it cause hair loss?

🔄 Substitutes for prostagard-d8 capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken by women for hair loss.
    Fact: This medicine is not approved for use in women and is contraindicated in pregnancy. It can cause harm to a male fetus.
  • Myth: This medicine works immediately.
    Fact: Silodosin provides symptom relief within days, but dutasteride takes months to shrink the prostate. Full benefits may take up to 6 months.
  • Myth: You can stop taking this medicine once symptoms improve.
    Fact: BPH is a chronic condition. Stopping the medicine may cause symptoms to return. Consult your doctor before stopping.

🔄 Alternative Options

Generic Alternatives

  • Silodosin + Dutasteride combination capsules from other manufacturers

Brand Alternatives

  • Urimax-D
  • Silodal-D
  • Dutasil
  • Prostam-D

📊 Comparison with Similar Medicines

[{"medicine":"This medicine (Silodosin + Dutasteride)","composition":"Silodosin 8 mg + Dutasteride 0.5 mg","onset":"Rapid (days) for silodosin; slow (months) for dutasteride","prostate_size_reduction":"Yes, significant","side_effects":"Retrograde ejaculation, dizziness, decreased libido"},{"medicine":"Tamsulosin + Dutasteride","composition":"Tamsulosin 0.4 mg + Dutasteride 0.5 mg","onset":"Rapid for tamsulosin; slow for dutasteride","prostate_size_reduction":"Yes, significant","side_effects":"Dizziness, retrograde ejaculation, decreased libido"},{"medicine":"Silodosin alone","composition":"Silodosin 8 mg","onset":"Rapid (days)","prostate_size_reduction":"No","side_effects":"Retrograde ejaculation, dizziness"}]

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