Prostagard-D8 Capsule: Comprehensive Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Sudden fainting or severe dizziness
- Swelling of face, lips, or throat, or difficulty breathing
- Chest pain or irregular heartbeat
- Severe allergic reaction with rash and itching
- Inability to urinate (acute urinary retention)
- Blood in urine or painful urination
- Breast lumps or nipple discharge
- Yellowing of skin or eyes (jaundice)
If experiencing severe symptoms, call emergency services immediately.
What is prostagard-d8 capsule used for?
This medicine is a combination of Silodosin and Dutasteride used to treat benign prostatic hyperplasia (BPH) in men. It works by relaxing prostate muscles and shrinking the prostate gland, improving urinary symptoms.
- Generic Name: Silodosin (8mg) + Dutasteride (0.5mg)
- Manufacturer: Aristo Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 prostagard-d8 capsule के बारे में (Hindi Summary)
उपयोग: यह दवा सिलोडोसिन और ड्यूटास्टेराइड का संयोजन है, जिसका उपयोग पुरुषों में बेनाइन प्रोस्टेटिक हाइपरप्लासिया (बीपीएच) के इलाज के लिए किया जाता है। यह प्रोस्टेट ग्रंथि को आराम देकर और उसका आकार कम करके पेशाब की समस्याओं में सुधार करती है। यह दवा पेशाब की धारा को बेहतर बनाती है, बार-बार पेशाब आने की समस्या को कम करती है, और रात में पेशाब उठने की समस्या को कम करती है। यह दवा केवल पुरुषों के लिए है और डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में रेट्रोग्रेड इजैकुलेशन (सूखा स्खलन), कम कामेच्छा, चक्कर आना, सिरदर्द, नाक बंद होना और थकान शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें अचानक रक्तचाप गिरना, बेहोशी, और एलर्जी प्रतिक्रियाएं जैसे चकत्ते, खुजली, और चेहरे या गले में सूजन शामिल हो सकती हैं। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। कैप्सूल को चबाएं या तोड़ें नहीं, पूरा निगल लें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या भारी मशीनरी चलाने से बचें। बैठने या लेटने से उठते समय धीरे-धीरे उठें ताकि चक्कर न आएं। यदि आपको लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। इस दवा को लेते समय और बंद करने के 6 महीने बाद तक रक्तदान न करें। गर्भवती महिलाओं को इस दवा को छूने से बचना चाहिए।
💊 prostagard-d8 capsule Uses & Benefits
- [{"condition":"Benign Prostatic Hyperplasia (BPH)","description":"This medicine is used to treat symptomatic BPH in men with an enlarged prostate.
- It improves urinary flow, reduces symptoms such as frequent urination, urgency, and weak stream, and lowers the risk of acute urinary retention and surgery.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Chronic prostatitis/chronic pelvic pain syndrome","description":"Sometimes alpha-blockers and 5-alpha-reductase inhibitors are used off-label to alleviate symptoms of chronic prostatitis, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Benign Prostatic Hyperplasia (BPH)
Also treats: Lower urinary tract symptoms (LUTS), Acute urinary retention (prevention), Prostate enlargement
📋 Drug Information
| Generic Name(s) | Silodosin (8mg) + Dutasteride (0.5mg) |
| Brand Name | prostagard-d8 capsule |
| Manufacturer | Aristo Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | UROLOGY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and direct sunlight. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Silodosin is a selective alpha-1A adrenergic receptor antagonist that blocks receptors in the prostate, bladder neck, and urethra, leading to smooth muscle relaxation and improved urine flow. Dutasteride is a 5-alpha-reductase inhibitor that inhibits both type 1 and type 2 isoforms of the enzyme, preventing the conversion of testosterone to dihydrotestosterone (DHT). Reduced DHT levels cause the prostate epithelium to shrink, decreasing prostate volume and alleviating obstruction. The combination provides rapid symptom relief from silodosin and long-term prostate size reduction from dutasteride.
Mechanism Steps
💡 How to Take prostagard-d8 capsule
Strength: Capsule containing Silodosin 8 mg and Dutasteride 0.5 mg.
Dosage Information
| Adult Dosage | The recommended dose for adults is one capsule (Silodosin 8 mg + Dutasteride 0.5 mg) taken orally once daily with food. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients based on age alone. However, elderly patients may be more sensitive to the effects of this medicine, particularly dizziness and orthostatic hypotension. Use with caution and monitor blood pressure regularly. |
| Renal Impairment | For patients with moderate renal impairment (CrCl 30-50 mL/min), a reduced dose of silodosin (4 mg) may be considered. This medicine contains 8 mg silodosin, so it may not be suitable. Consult your doctor for dose adjustment. Dutasteride dose adjustment is not required for renal impairment. |
| Hepatic Impairment | This medicine is contraindicated in patients with severe hepatic impairment. For mild to moderate hepatic impairment, use with caution and monitor liver function. Dose adjustment may be necessary. Consult your doctor. |
| Maximum Daily Dose | One capsule (Silodosin 8 mg + Dutasteride 0.5 mg) per day. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of prostagard-d8 capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Clarithromycin | Major | |
| Ritonavir | Major | |
| Prazosin | Major | |
| Terazosin | Major | |
| Sildenafil | Major | |
| Tadalafil | Major | |
| Verapamil | Moderate | |
| Diltiazem | Moderate | |
| Warfarin | Moderate |
🚨 Major Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- Alpha-blockers (e.g., prazosin, terazosin)
- PDE5 inhibitors (e.g., sildenafil, tadalafil)
⚡ Moderate Interactions
- Moderate CYP3A4 inhibitors (e.g., verapamil, diltiazem)
- Antihypertensives
- Warfarin
🍷 Alcohol Interaction
Alcohol may increase the risk of dizziness, drowsiness, and low blood pressure when taken with this medicine. It is advisable to limit or avoid alcohol consumption while on this medication.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to silodosin, dutasteride, or any component of the formulation","Women who are pregnant or may become pregnant","Children and adolescents","Severe hepatic impairment","History of orthostatic hypotension","Concomitant use with strong CYP3A4 inhibitors"]
⚠️ Warnings & Precautions
["This medicine is for male use only. Women should not handle broken capsules.","May cause dizziness and fainting; avoid driving or operating machinery until you know how it affects you.","Rise slowly from sitting or lying positions to prevent falls.","Inform your doctor if you have liver or kidney disease.","Do not donate blood while taking this medicine and for 6 months after stopping.","Use condoms if your partner is pregnant or could become pregnant.","Dutasteride reduces PSA levels; inform your doctor about this medicine before PSA testing.","Report any breast changes, such as lumps or tenderness.","Seek immediate medical help for signs of allergic reaction."]
🤱 Lactation Safety
This medicine is not indicated for use in women. It is not known if silodosin or dutasteride are excreted in human breast milk. Breastfeeding is not recommended while taking this medicine.
💊 Overdose Management
Overdose with this medicine may cause severe hypotension, dizziness, and fainting. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or open the capsule; swallow it whole. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause dizziness. Rise slowly from sitting or lying positions to prevent dizziness or fainting. Inform your doctor if you have liver disease, kidney disease, or low blood pressure. Do not donate blood while taking this medicine and for at least 6 months after stopping, as it can affect a recipient's prostate-specific antigen (PSA) levels. Women who are pregnant or may become pregnant should not handle this medicine, especially if the capsule is broken, because dutasteride can be absorbed through the skin and may harm a male fetus. Use a condom during sexual intercourse if your partner is pregnant or could become pregnant. Regular follow-up with your doctor is important to monitor your response and check for any complications.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and orthostatic hypotension. Use with caution and monitor blood pressure regularly. Falls are a risk; take precautions to prevent them.
🤰 Pregnancy Planning (TTC)
This medicine is not for use in women. Men taking this medicine who are planning to father a child should be aware that dutasteride may affect semen quality. Consult your doctor for advice.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and affect blood pressure. Your doctor may advise you to stop the medicine temporarily before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may cause dizziness or affect blood pressure during the procedure. Take precautions to prevent falls.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness and orthostatic hypotension. Avoid strenuous exercise or sudden changes in position until you know how the medicine affects you. If you feel dizzy during exercise, stop immediately and sit or lie down.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause retrograde ejaculation, which can affect sexual function but is not harmful. Discuss any concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe dizziness, fainting, or allergic reactions, seek immediate medical attention. Your doctor may adjust the dose or switch to another medicine. Stopping suddenly may cause symptoms to return.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to sustained reduction in prostate size and improved urinary symptoms. Dutasteride reduces PSA levels by about 50%, which must be considered during prostate cancer screening. There is a potential increased risk of high-grade prostate cancer associated with dutasteride, so regular monitoring is essential. Silodosin may cause retrograde ejaculation, which is usually reversible. Regular follow-up with your doctor is recommended to monitor for any complications.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Weight loss, dietary changes, and pelvic floor exercises can help manage BPH symptoms.
Evidence: Well-establishedProcedures like TURP or laser therapy may be considered if medicines are ineffective.
Evidence: Well-establishedSaw palmetto and other herbs are sometimes used, but evidence is limited and they may interact with medicines.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, inform your doctor about all medicines before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry your medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue taking your dose at the same local time each day. Check customs regulations for carrying prescription medicines. Carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Silodosin provides symptom relief within days, but dutasteride takes 3 to 6 months to shrink the prostate. Full benefits may take up to 6 months to 2 years.
A: Inform your doctor about all medications you take, especially blood pressure medicines, alpha-blockers, and CYP3A4 inhibitors. Some interactions can be serious.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Yes, it is generally safe for long-term use under medical supervision. Regular follow-ups are needed to monitor PSA levels and prostate health.
A: No, this medicine is not for women. It is contraindicated in pregnancy and women of childbearing potential.
🤔 Common Patient Concerns
🔄 Substitutes for prostagard-d8 capsule
View AllAlternative brands with exact same active ingredient:
-
silozem capsuleZeelab Pharmacy Pvt Ltd ₹90.00 64.7% CHEAPER
-
davaindia silodosin+dutasteride 8mg/0.5mg tabletDavaindia Generic Pharmacy ₹140.00 45.1% CHEAPER
-
sildum-d tabletAdjener Pharmaceuticals Pvt Ltd ₹164.06 35.7% CHEAPER
-
sosin-d capsuleADZO Lifesciences Pvt Ltd ₹206.25 19.1% CHEAPER
-
silodyx d 8mg/0.5mg tabletEdinburgh Pharmaceuticals ₹225.00 11.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken by women for hair loss.
Fact: This medicine is not approved for use in women and is contraindicated in pregnancy. It can cause harm to a male fetus. - Myth: This medicine works immediately.
Fact: Silodosin provides symptom relief within days, but dutasteride takes months to shrink the prostate. Full benefits may take up to 6 months. - Myth: You can stop taking this medicine once symptoms improve.
Fact: BPH is a chronic condition. Stopping the medicine may cause symptoms to return. Consult your doctor before stopping.
🔄 Alternative Options
Generic Alternatives
- Silodosin + Dutasteride combination capsules from other manufacturers
Brand Alternatives
- Urimax-D
- Silodal-D
- Dutasil
- Prostam-D