davaindia silodosin+dutasteride 8mg/0.5mg tablet - Uses, Price, Side Effects & Substitutes
What is davaindia silodosin+dutasteride 8mg/0.5mg tablet used for?
Avoprost D 8mg/0.5mg Capsule (Silodosin + Dutasteride) is used to treat UROLOGY. It contains Silodosin (8mg) + Dutasteride (0.5mg), which Silodosin selectively blocks alpha-1A adrenergic receptors in prostate, relaxing. Always consult your doctor before use. Take as prescribed.
- Generic Name: Silodosin + Dutasteride
- Manufacturer: Davaindia Generic Pharmacy
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ davaindia silodosin+dutasteride 8mg/0.5mg tablet Uses & Benefits
Benign prostatic hyperplasia (BPH) with moderate to severe symptoms
Off-label uses: None well-established
๐ Drug Information
| Generic Name(s) | Silodosin + Dutasteride |
| Brand Name | Avoprost D 8mg/0.5mg Capsule |
| Manufacturer | Davaindia Generic Pharmacy |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | UROLOGY |
| Action Class | Alpha-1 adrenergic blocker + 5-alpha-reductase inhibitor |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Silodosin selectively blocks alpha-1A adrenergic receptors in prostate, relaxing smooth muscle; Dutasteride inhibits 5-alpha-reductase types 1 and 2, reducing dihydrotestosterone (DHT) levels
Mechanism Steps
๐ก How to Take davaindia silodosin+dutasteride 8mg/0.5mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of davaindia silodosin+dutasteride 8mg/0.5mg tablet
โ Common Side Effects
- Dizziness
- Orthostatic hypotension
- Nasal congestion
- Decreased libido
- Ejaculation disorders
- Gynecomastia
๐จ Serious Side Effects
- Syncope
- Intraoperative floppy iris syndrome (IFIS)
- Severe hypotension
- Allergic reactions
โ ๏ธ Rare Side Effects
- QT prolongation
- Hepatotoxicity
- Depression
- Breast cancer (dutasteride)
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | Increased silodosin and dutasteride levels |
| Rifampin | Major | Decreased dutasteride levels |
| Tamsulosin | Major | Additive alpha-blocker effects, hypotension |
| Sildenafil | Moderate | Increased risk of hypotension |
| Warfarin | Moderate | Possible increased INR |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- CYP3A4 inducers (e.g., rifampin)
- Alpha-blockers (e.g., tamsulosin)
- Antihypertensives
โก Moderate Interactions
- Phosphodiesterase-5 inhibitors (e.g., sildenafil)
- Moderate CYP3A4 inhibitors (e.g., erythromycin)
- Anticoagulants (e.g., warfarin)
โน๏ธ Minor Interactions
- Grapefruit juice
- Cimetidine
๐ฝ๏ธ Food Interactions
Avoid high-fat meals with Silodosin; Dutasteride absorption unaffected by food
๐ท Alcohol Interaction
May increase risk of orthostatic hypotension
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, women of childbearing potential, severe hepatic impairment, concurrent use with other alpha-blockers
๐ Monitoring Parameters
Blood pressure, prostate-specific antigen (PSA), liver function tests, urinary symptoms
๐คฑ Lactation Safety
Not recommended; excreted in breast milk (dutasteride)
๐ Overdose Management
Supportive care; monitor blood pressure; may require vasopressors for hypotension
โฐ Missed Dose
Take as soon as remembered; if close to next dose, skip missed dose. Do not double.