Avoprost D 8mg/0.5mg Capsule: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fainting or severe dizziness
- Swelling of the face, lips, tongue, or throat
- Difficulty breathing or swallowing
- Prolonged, painful erection lasting more than 4 hours
- Severe abdominal pain or blood in urine
- Yellowing of the skin or eyes (jaundice)
- Chest pain or irregular heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is davaindia silodosin+dutasteride 8mg/0.5mg tablet used for?
This medicine is a combination of Silodosin 8 mg and Dutasteride 0.5 mg used to treat benign prostatic hyperplasia (BPH) in men. It works by relaxing prostate muscles (silodosin) and shrinking the prostate (dutasteride). It is taken once daily by mouth.
- Generic Name: Silodosin + Dutasteride
- Manufacturer: Davaindia Generic Pharmacy
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 davaindia silodosin+dutasteride 8mg/0.5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सिलोडोसिन 8 मिलीग्राम और ड्यूटास्टेराइड 0.5 मिलीग्राम का संयोजन है, जिसका उपयोग पुरुषों में बेनाइन प्रोस्टेटिक हाइपरप्लासिया (बीपीएच) के इलाज के लिए किया जाता है। बीपीएच प्रोस्टेट ग्रंथि का एक गैर-कैंसरयुक्त बढ़ाव है जिससे पेशाब करने में कठिनाई, बार-बार पेशाब आना, और रात में पेशाब आना जैसी समस्याएं होती हैं। यह दवा प्रोस्टेट की मांसपेशियों को आराम देकर और प्रोस्टेट के आकार को कम करके लक्षणों से राहत दिलाती है। यह दवा केवल पुरुषों के लिए है और इसे डॉक्टर के परामर्श के बिना नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सूखा स्खलन (रेट्रोग्रेड इजैकुलेशन), कामेच्छा में कमी, नपुंसकता, चक्कर आना, खड़े होने पर चक्कर आना, सिरदर्द और नाक बंद होना शामिल हैं। ये आमतौर पर हल्के होते हैं और समय के साथ कम हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें बेहोशी, गंभीर निम्न रक्तचाप, एलर्जी प्रतिक्रिया (चेहरे, होंठ, जीभ या गले में सूजन), और प्रियापिज्म (लंबे समय तक दर्दनाक इरेक्शन) शामिल हो सकते हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक को न बदलें और डॉक्टर से पूछे बिना दवा लेना बंद न करें। कैप्सूल को पूरा निगलें, चबाएं या तोड़ें नहीं। इसे हर दिन एक ही समय पर, भोजन के साथ लें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या भारी मशीनरी चलाने से बचें। बैठने या लेटने की स्थिति से धीरे-धीरे उठें ताकि चक्कर न आएं। यदि आपको लीवर या किडनी की समस्या है, कम रक्तचाप है, या मोतियाबिंद की सर्जरी करानी है तो अपने डॉक्टर को बताएं। गर्भवती महिलाओं को इस दवा को छूने से बचना चाहिए, खासकर अगर कैप्सूल टूटा हुआ हो।
💊 davaindia silodosin+dutasteride 8mg/0.5mg tablet Uses & Benefits
- [{"condition":"Benign prostatic hyperplasia (BPH)","description":"This medicine is used to treat symptomatic BPH in men with an enlarged prostate.
- It provides rapid relief of lower urinary tract symptoms (LUTS) such as weak urine stream, hesitancy, frequency, and urgency, while also reducing prostate size over time.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Benign prostatic hyperplasia (BPH)
Also treats: Lower urinary tract symptoms (LUTS), Nocturia, Urinary retention (mild to moderate)
📋 Drug Information
| Generic Name(s) | Silodosin + Dutasteride |
| Brand Name | Avoprost D 8mg/0.5mg Capsule |
| Manufacturer | Davaindia Generic Pharmacy |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | UROLOGY |
| Action Class | Alpha-1 adrenergic blocker + 5-alpha-reductase inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed. Protect from light and moisture. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Silodosin is a selective antagonist of alpha-1A adrenergic receptors, which are predominantly found in the prostate, bladder neck, and urethra. By blocking these receptors, silodosin relaxes the smooth muscle in these areas, leading to improved urine flow and reduced BPH symptoms. Dutasteride is a dual inhibitor of type 1 and type 2 5-alpha-reductase enzymes, which convert testosterone to dihydrotestosterone (DHT). By lowering DHT levels, dutasteride shrinks the prostate gland and slows the progression of BPH. The combination provides both immediate symptomatic relief and long-term reduction in prostate volume.
Mechanism Steps
💡 How to Take davaindia silodosin+dutasteride 8mg/0.5mg tablet
Strength: Capsule containing Silodosin 8 mg and Dutasteride 0.5 mg.
Dosage Information
| Adult Dosage | The recommended dose of this medicine is one capsule (Silodosin 8 mg + Dutasteride 0.5 mg) taken orally once daily with a meal. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. This medicine is for use in adult men only. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients based on age alone. However, elderly patients may be more sensitive to the effects of this medicine, particularly orthostatic hypotension. Use with caution and monitor blood pressure regularly. |
| Renal Impairment | For patients with moderate renal impairment (creatinine clearance 30-50 mL/min), a lower dose of silodosin (4 mg) may be considered. This medicine contains 8 mg silodosin, so it may not be suitable for patients with moderate renal impairment. For severe renal impairment (creatinine clearance <30 mL/min), silodosin is not recommended. Dutasteride has not been studied in severe renal impairment. Consult your doctor for dose adjustments. |
| Hepatic Impairment | Silodosin has not been studied in patients with severe hepatic impairment and is contraindicated in such patients. Dutasteride should be used with caution in patients with hepatic impairment. No dose adjustment is recommended for mild to moderate hepatic impairment, but monitoring is advised. |
| Maximum Daily Dose | One capsule (Silodosin 8 mg + Dutasteride 0.5 mg) per day. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of davaindia silodosin+dutasteride 8mg/0.5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Clarithromycin | Major | |
| Ritonavir | Major | |
| Prazosin | Major | |
| Terazosin | Major | |
| Sildenafil | Major | |
| Tadalafil | Major | |
| Diltiazem | Moderate | |
| Verapamil | Moderate | |
| Warfarin | Moderate |
🚨 Major Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- Alpha-blockers (e.g., prazosin, terazosin)
- PDE5 inhibitors (e.g., sildenafil, tadalafil)
⚡ Moderate Interactions
- Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil)
- Antihypertensives
- Warfarin
🍷 Alcohol Interaction
Alcohol may increase the risk of dizziness, drowsiness, and low blood pressure when taken with this medicine. It is advisable to limit or avoid alcohol consumption while on this medication.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to silodosin, dutasteride, or any component of the formulation","Women who are pregnant or may become pregnant","Children and adolescents","Severe hepatic impairment","Concomitant use with strong CYP3A4 inhibitors","History of orthostatic hypotension"]
⚠️ Warnings & Precautions
["This medicine may cause orthostatic hypotension and syncope. Advise patients to sit or lie down if they feel dizzy and to rise slowly.","Patients should be cautioned about driving or operating machinery until they know how the medicine affects them.","Dutasteride reduces PSA levels by approximately 50%. This should be considered when interpreting PSA test results for prostate cancer screening.","Women who are pregnant or may become pregnant should not handle this medicine, especially if the capsule is broken, as dutasteride can be absorbed through the skin and may cause harm to a male fetus.","Men taking this medicine should use condoms during sexual intercourse if their partner is pregnant or could become pregnant.","Patients should not donate blood while taking this medicine and for at least 6 months after stopping to prevent exposure to a pregnant transfusion recipient.","This medicine may increase the risk of high-grade prostate cancer. Patients should discuss the risks and benefits with their doctor.","Use with caution in patients with hepatic or renal impairment.","This medicine may interact with other medications; inform your doctor about all medicines you are taking."]
🤱 Lactation Safety
Not applicable. This medicine is not indicated for use in women.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of suspected overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. Monitor vital signs, especially blood pressure, and manage hypotension if it occurs. Gastric lavage may be considered if ingestion is recent. Contact a poison control center for guidance.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor. Swallow the capsule whole with a glass of water; do not crush, chew, or open it. Take it at the same time each day, preferably with a meal. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause dizziness. Rise slowly from sitting or lying positions to prevent dizziness or fainting. Inform your doctor if you have liver or kidney problems, low blood pressure, or are planning to undergo cataract surgery. This medicine can affect the results of a prostate-specific antigen (PSA) test; inform your doctor that you are taking it before any PSA testing. Women who are pregnant or may become pregnant should not handle this medicine, especially if the capsule is broken, as dutasteride can be absorbed through the skin and may harm a male fetus. Use a condom during sexual intercourse if your partner is pregnant or could become pregnant. Do not donate blood while taking this medicine and for at least 6 months after stopping, to prevent exposure to a pregnant transfusion recipient.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine, particularly orthostatic hypotension. Use with caution and monitor blood pressure regularly. Dose adjustment may be necessary based on renal and hepatic function.
🤰 Pregnancy Planning (TTC)
This medicine is not for use in women. Men taking this medicine who are planning to father a child should discuss with their doctor, as dutasteride may affect fertility and can harm a male fetus if their partner becomes pregnant. Use condoms during sexual intercourse if your partner is pregnant or could become pregnant.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery, especially cataract surgery, as it may increase the risk of intraoperative floppy iris syndrome (IFIS). Your doctor may advise you to stop the medicine temporarily before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. This medicine may cause dizziness or low blood pressure, which can be exacerbated by sitting in a dental chair for long periods. Take precautions when getting up from the dental chair.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or orthostatic hypotension. Avoid strenuous exercises that require sudden changes in position. Stay hydrated during exercise. If you feel dizzy, stop and sit down. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Take precautions when rising from a seated position. Inform your employer if your job involves operating machinery or working at heights. Most people can continue their normal activities with caution.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe dizziness, fainting, allergic reactions, or priapism, seek immediate medical attention. Your doctor may adjust the dose or switch to an alternative medicine. Stopping suddenly may cause your BPH symptoms to return.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well-tolerated. Dutasteride may reduce PSA levels by approximately 50%, which should be considered when interpreting PSA tests. There is a potential increased risk of high-grade prostate cancer associated with dutasteride. Regular monitoring of prostate health, liver function, and renal function is advised. Do not stop the medicine without consulting your doctor, as symptoms may return.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Weight loss, dietary changes, and pelvic floor exercises can help manage BPH symptoms.
Evidence: Well-establishedTamsulosin, alfuzosin, or doxazosin may be used alone or in combination with 5-alpha-reductase inhibitors.
Evidence: Well-establishedTransurethral resection of the prostate (TURP) or laser therapy may be considered for severe BPH.
Evidence: Well-establishedProstatic urethral lift (UroLift) or water vapor thermal therapy (Rezum) are options for some patients.
Evidence: Growing evidence💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children and pets
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue taking your dose at the same local time as usual. For international travel, check customs regulations regarding prescription medicines. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Silodosin provides symptom relief within a few days, while dutasteride takes 3-6 months to shrink the prostate. Full benefits may take several months.
A: This medicine can interact with other drugs, especially those for blood pressure, erectile dysfunction, and certain antifungals. Always inform your doctor about all medicines you are taking.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Yes, this medicine is generally safe for long-term use under medical supervision. Regular follow-up and monitoring are recommended.
A: This medicine can cause retrograde ejaculation and decreased libido, which may affect fertility. Discuss with your doctor if you are planning to father a child.
🤔 Common Patient Concerns
🔄 Substitutes for davaindia silodosin+dutasteride 8mg/0.5mg tablet
View AllAlternative brands with exact same active ingredient:
-
silozem capsuleZeelab Pharmacy Pvt Ltd ₹90.00 35.7% CHEAPER
-
sildum-d tabletAdjener Pharmaceuticals Pvt Ltd ₹164.06 17.2% COSTLIER
-
sosin-d capsuleADZO Lifesciences Pvt Ltd ₹206.25 47.3% COSTLIER
-
silodyx d 8mg/0.5mg tabletEdinburgh Pharmaceuticals ₹225.00 60.7% COSTLIER
-
siliostru d 8mg/0.5mg capsuleAvighna Medicare Pvt. Ltd. ₹241.99 72.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Avoprost D can be taken by women for hair loss.
Fact: This medicine is not approved for use in women. Dutasteride can cause serious harm to a male fetus and should not be handled by pregnant women. - Myth: Avoprost D works immediately.
Fact: Silodosin provides symptom relief within days, but dutasteride takes 3-6 months to shrink the prostate. Full benefits may take several months. - Myth: You can stop taking Avoprost D once symptoms improve.
Fact: BPH is a chronic condition. Stopping the medicine may cause symptoms to return. Always consult your doctor before stopping. - Myth: Avoprost D is a cure for BPH.
Fact: This medicine manages symptoms and reduces prostate size but does not cure BPH. Long-term treatment is often necessary.
🔄 Alternative Options
Generic Alternatives
- Silodosin + Dutasteride combination capsules from other manufacturers
Brand Alternatives
- Avoprost D 8mg/0.5mg capsule