polmef 250mg/325mg tablet - Mefenamic Acid (250mg) + Paracetamol (325mg) medicine

Atnemol MF 250mg/325mg Tablet: Complete Information

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🏭 Humbing Ethicals 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. However, NSAIDs like mefenamic acid are generally avoided in the third trimester due to risk of premature closure of ductus arteriosus and other complications. Paracetamol is generally considered safe in pregnancy when used as directed. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for short-term pain relief.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bruising or bleeding

If experiencing severe symptoms, call emergency services immediately.

What is polmef 250mg/325mg tablet used for?

This medicine is a combination of Mefenamic Acid 250 mg and Paracetamol 325 mg used for short-term relief of mild to moderate pain, including menstrual cramps, dental pain, and musculoskeletal pain. It works by reducing inflammation and pain signals. Take it with food to avoid stomach upset and do not exceed the recommended dose.

  • Generic Name: Mefenamic Acid (250mg) + Paracetamol (325mg)
  • Manufacturer: Humbing Ethicals
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 polmef 250mg/325mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा मेफेनामिक एसिड और पैरासिटामोल का संयोजन है, जिसका उपयोग हल्के से मध्यम दर्द और सूजन के इलाज के लिए किया जाता है। यह मासिक धर्म के दर्द, दांत दर्द, मांसपेशियों और जोड़ों के दर्द, और बुखार में राहत देती है। इसे भोजन के साथ लेना चाहिए ताकि पेट में जलन न हो।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, कब्ज, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, अल्सर, गुर्दे की समस्या, यकृत की क्षति, और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकते हैं।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खाली पेट न लें, भोजन के साथ लें। शराब का सेवन न करें। 7 दिनों से अधिक बिना डॉक्टर की सलाह के न लें। यदि आपको पेट में अल्सर, गुर्दे या यकृत की बीमारी है, तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से परामर्श करें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 polmef 250mg/325mg tablet Uses & Benefits

[{"condition":"Musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and bones, such as in back pain, sprains, and strains.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Menstrual cramps (dysmenorrhea)","description":"Reduces pain and cramping associated with menstruation.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate pain after minor surgeries.","evidence":"Well-established"},{"condition":"Fever","description":"Paracetamol component helps reduce fever, though mefenamic acid also has antipyretic properties.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Osteoarthritis","description":"May be used for short-term pain relief in osteoarthritis, but not for long-term management due to GI risks.","evidence":"Limited"}]

Primary treatment for: Pain and inflammation

Also treats: Dysmenorrhea, Dental pain, Musculoskeletal pain, Post-operative pain, Fever

📋 Drug Information

Generic Name(s)Mefenamic Acid (250mg) + Paracetamol (325mg)
Brand Namepolmef 250mg/325mg tablet
ManufacturerHumbing Ethicals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food or milk to reduce the risk of stomach upset and bleeding.
2
Do not exceed the recommended dose of 3 tablets in 24 hours.
3
Avoid alcohol completely while taking this medicine.
4
Do not use this medicine for more than 7 days without consulting your doctor.
5
If you have a history of stomach ulcers, kidney disease, or liver disease, inform your doctor before taking this medicine.
6
Report any unusual bleeding, bruising, or dark stools immediately.
7
Stay well hydrated throughout the day to help protect your kidneys.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Menstrual cramps
This medicine is commonly prescribed for this.
Likely Use
Dental pain
This medicine is commonly prescribed for this.
Likely Use
Muscle pain
This medicine is commonly prescribed for this.
Likely Use
Fever
This medicine contains paracetamol which reduces fever.
Likely Use
Chest pain
This medicine is not for chest pain; seek immediate medical attention.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMefenamic acid is rapidly absorbed from the gastrointestinal tract after oral administration. Paracetamol is also rapidly and completely absorbed from the gastrointestinal tract. Food may delay the absorption of both drugs but does not significantly reduce the extent of absorption.
DistributionMefenamic acid is highly bound to plasma proteins and has a volume of distribution of approximately 0.2 L/kg. Paracetamol distributes widely into most body tissues, with a volume of distribution of about 0.9 L/kg.
Protein BindingMefenamic acid is approximately 90% bound to plasma proteins. Paracetamol is only about 10-25% bound to plasma proteins.
MetabolismMefenamic acid is metabolized in the liver primarily by CYP2C9 to inactive metabolites. Paracetamol is metabolized in the liver via glucuronidation and sulfation, and a small fraction via CYP2E1 to a toxic intermediate (NAPQI) that is normally detoxified by glutathione.
Half-LifeThe elimination half-life of mefenamic acid is approximately 2 hours. The elimination half-life of paracetamol is about 2-3 hours.
ExcretionMefenamic acid is excreted mainly in the urine as metabolites and unchanged drug. Paracetamol is excreted in the urine as glucuronide and sulfate conjugates.
BioavailabilityThe oral bioavailability of mefenamic acid is approximately 80-90%. Paracetamol has an oral bioavailability of about 80-100%.
Onset of ActionPain relief typically begins within 30 to 60 minutes after oral administration.
Peak Plasma TimePeak plasma concentrations of mefenamic acid are reached in about 2-4 hours. Paracetamol peaks in about 0.5-2 hours.
Duration of ActionThe analgesic effect lasts approximately 4 to 6 hours, so dosing is usually every 6 to 8 hours as needed.

How It Works

Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that reversibly inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, leading to decreased synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol (acetaminophen) acts primarily in the central nervous system by inhibiting prostaglandin synthesis, and it may also modulate the endogenous cannabinoid system and descending serotonergic pathways, producing analgesic and antipyretic effects with minimal anti-inflammatory action.

Mechanism Steps

1
Inhibition of cyclooxygenase: Mefenamic acid binds to and reversibly inhibits COX-1 and COX-2 enzymes, blocking the conversion of arachidonic acid to prostaglandin H2.
2
Reduced prostaglandin synthesis: This leads to decreased production of prostaglandins, prostacyclin, and thromboxane, which are key mediators of pain, inflammation, and fever.
3
Central analgesic action of paracetamol: Paracetamol acts mainly in the brain and spinal cord by inhibiting prostaglandin synthesis and activating descending inhibitory pathways, reducing pain perception.
4
Antipyretic effect: Both drugs act on the hypothalamus to reduce fever by promoting heat loss and inhibiting prostaglandin-mediated temperature elevation.

💡 How to Take polmef 250mg/325mg tablet

Strength: Each tablet contains Mefenamic Acid 250 mg and Paracetamol 325 mg.

1Take the tablet orally with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Follow your doctor's prescribed dose and frequency.
5Do not take more than the recommended dose.
6If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally two to three times a day, preferably with food. The maximum daily dose should not exceed 3 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not take for more than 7 days without medical advice.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with kidney disease. Dose adjustment may be necessary. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with liver disease. Dose adjustment may be necessary. Consult your doctor.
Maximum Daily DoseMaximum 3 tablets (750 mg mefenamic acid + 975 mg paracetamol) in 24 hours.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and gastrointestinal irritation.
Alcohol
Avoid
Increases risk of stomach bleeding and liver damage.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of polmef 250mg/325mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk to reduce nausea. If it persists, consult your doctor.
Vomiting (Common (5-10%))
Stay hydrated with small sips of water. If vomiting is severe or persistent, contact your doctor.
Stomach pain (Common (5-10%))
Take with food. Avoid alcohol. If pain is severe or persists, seek medical advice.
Heartburn (Common (5-10%))
Take with food. Avoid lying down immediately after taking. If it continues, consult your doctor.
Diarrhea (Common (5-10%))
Drink plenty of fluids. If diarrhea is severe or lasts more than 2 days, consult your doctor.
Constipation (Common (5-10%))
Increase fiber and fluid intake. If it persists, consult your doctor.
Headache (Common (5-10%))
Usually resolves on its own. If severe or persistent, consult your doctor.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how this medicine affects you.
Drowsiness (Common (5-10%))
Avoid driving or operating machinery. If drowsiness is excessive, consult your doctor.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black, tarry stools, vomiting blood, or severe abdominal pain.
Peptic ulcer (Rare (<0.1%))
Report persistent stomach pain, especially if it worsens after eating. Seek medical help if you suspect an ulcer.
Kidney problems (Rare (<0.1%))
Contact your doctor if you notice decreased urine output, swelling in legs, or fatigue.
Liver damage (Rare (<0.1%))
Seek medical attention if you develop yellowing of skin or eyes, dark urine, or severe fatigue.
Severe allergic reaction (Rare (<0.1%))
Call emergency services if you experience swelling of face, lips, tongue, or throat, difficulty breathing, or a severe rash.
Blood disorders (Rare (<0.1%))
Report unusual bruising, bleeding, or signs of infection. Your doctor may monitor your blood counts.

⚠️ Rare Side Effects

Visual disturbances
Consult your doctor if you experience blurred vision or other visual changes.
Mood changes
Report any unusual mood swings, depression, or anxiety to your doctor.
Skin rash
Stop the medicine and consult your doctor if a rash appears.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Ibuprofen Major
Corticosteroids Major
Methotrexate Major
Lithium Major
ACE inhibitors Moderate
Diuretics Moderate
SSRIs Moderate
Alcohol Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, naproxen)
  • Corticosteroids
  • Methotrexate
  • Lithium

⚡ Moderate Interactions

  • ACE inhibitors (e.g., enalapril, lisinopril)
  • Diuretics (e.g., furosemide, hydrochlorothiazide)
  • SSRIs (e.g., fluoxetine, sertraline)
  • Alcohol

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulcers, and liver damage, especially when combined with paracetamol and NSAIDs.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to mefenamic acid, paracetamol, or any component of the formulation","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs","Active or history of peptic ulcer or gastrointestinal bleeding","Severe kidney disease","Severe liver disease","Third trimester of pregnancy","Children under 14 years of age (unless directed by a doctor)","Concurrent use with other NSAIDs"]

⚠️ Warnings & Precautions

["Take with food or milk to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose or duration of treatment.","Use with caution in elderly patients due to increased risk of side effects.","Use with caution in patients with kidney or liver disease.","May cause drowsiness or dizziness; avoid driving or operating machinery until you know how it affects you.","Do not use for more than 7 days without consulting a doctor.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Stop use and consult a doctor if you experience signs of gastrointestinal bleeding, allergic reaction, or liver problems."]

🤱 Lactation Safety

Mefenamic acid is excreted in breast milk in small amounts. Paracetamol is also excreted in breast milk but is considered safe. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose can cause severe nausea, vomiting, abdominal pain, drowsiness, and potentially liver damage (from paracetamol) and kidney damage (from mefenamic acid). Seek immediate medical attention. Treatment is supportive and may include activated charcoal, gastric lavage, and administration of acetylcysteine for paracetamol toxicity. Monitor liver and kidney function.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it increases the risk of stomach bleeding. Do not use this medicine for more than 7 days without consulting your doctor. If you have a history of stomach ulcers, kidney disease, liver disease, or asthma, inform your doctor before taking this medicine. Do not take other pain relievers or fever reducers without consulting your doctor. If you are pregnant or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs like mefenamic acid may affect ovulation and are generally avoided during pregnancy, especially in the third trimester. Paracetamol is considered safer but should be used only when necessary.

🏥 Post-Surgery Considerations

This medicine may be used for post-operative pain relief, but it should be used with caution after surgery due to the risk of bleeding and kidney problems. Follow your surgeon's instructions carefully.

🦷 Dental Procedures

This medicine can be used for dental pain, but inform your dentist if you are taking it before any dental procedure. It may increase bleeding risk during dental surgery.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints and muscles.
🥗
Engage in regular low-impact exercise like walking or swimming.
😴
Practice good posture to prevent musculoskeletal pain.
💧
Include anti-inflammatory foods like fruits, vegetables, and omega-3 rich fish in your diet.
🧘
Get adequate sleep to help your body recover.
🌞
Stay well hydrated to support kidney function.

🏋️ Exercise Considerations

Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you have musculoskeletal pain. Gentle stretching and low-impact activities are generally safe. Listen to your body and stop if pain worsens.

🥗 Diet Recommendations

Include omega-3 rich foods like salmon, flaxseeds, and walnuts.
Reduce intake of processed and fried foods.
Stay well hydrated by drinking plenty of water.
Eat a balanced diet rich in fruits and vegetables.
Avoid alcohol and caffeine in excess.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your pain persists beyond 7 days, if you experience severe side effects, or if you develop signs of gastrointestinal bleeding, allergic reaction, or liver problems. Do not stop abruptly if you are on a prescribed regimen without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney damage, liver damage, and cardiovascular events. Regular monitoring of kidney and liver function, as well as blood counts, may be required. It is not recommended for long-term use without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve mobility.

Evidence: Well-established
Hot and cold compresses

May help relieve localized pain and inflammation.

Evidence: Limited
Acupuncture

Some evidence for pain relief in certain conditions.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust dosing times gradually to avoid missing doses. Check customs regulations for carrying prescription medicines. Always carry enough supply for your trip and a few extra days in case of delays.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 28-year-old woman with severe menstrual cramps
She was prescribed this medicine for dysmenorrhea. She took one tablet with breakfast and another with dinner during her periods. She experienced significant relief from cramps within an hour. She was advised to take it with food to avoid stomach upset, which she followed diligently.
💡 Lesson: Taking this medicine with food improves tolerability and ensures better pain relief during menstrual cramps.
👤 A 45-year-old man with acute back pain after lifting heavy objects
He was prescribed this medicine for musculoskeletal pain. He took it three times a day with meals for 5 days. His pain improved significantly, and he was able to return to work. He was cautioned not to exceed the dose and to avoid alcohol.
💡 Lesson: Short-term use of this medicine with food is effective for acute musculoskeletal pain, but it should not be used long-term without medical supervision.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it orally.

Q: Can I take it on an empty stomach?

A: No, it should be taken with food or milk to reduce the risk of stomach upset and bleeding.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Q: Is it safe to take with alcohol?

A: No, alcohol increases the risk of stomach bleeding and liver damage. Avoid alcohol while taking this medicine.

Q: Can I take it for a long time?

A: It should only be used short-term (up to 7 days) unless directed by your doctor. Long-term use increases the risk of kidney, liver, and gastrointestinal problems.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe during pregnancy?
  • Can I take it with other painkillers?

🔄 Substitutes for polmef 250mg/325mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is safe to take on an empty stomach.
    Fact: It should be taken with food or milk to reduce the risk of stomach upset and gastrointestinal bleeding.
  • Myth: This medicine can be taken for long periods without any risk.
    Fact: Long-term use increases the risk of kidney, liver, and gastrointestinal problems. It should only be used short-term unless directed by a doctor.
  • Myth: This medicine is safe to take with alcohol.
    Fact: Alcohol increases the risk of stomach bleeding and liver damage when taken with this medicine.
  • Myth: This medicine is safe for children.
    Fact: It is not recommended for children under 14 years unless specifically prescribed by a doctor.

🔄 Alternative Options

Generic Alternatives

  • Mefenamic Acid + Paracetamol 250mg/325mg tablet

Brand Alternatives

  • Atnemol MF 250mg/325mg tablet

📊 Comparison with Similar Medicines

[{"medicine":"Atnemol MF 250mg/325mg tablet","composition":"Mefenamic Acid 250mg + Paracetamol 325mg","onset":"30-60 minutes","duration":"4-6 hours","common_side_effects":"Nausea, stomach pain, dizziness"},{"medicine":"Ibuprofen + Paracetamol","composition":"Ibuprofen 400mg + Paracetamol 325mg","onset":"30-60 minutes","duration":"4-6 hours","common_side_effects":"Nausea, stomach pain, headache"},{"medicine":"Diclofenac + Paracetamol","composition":"Diclofenac 50mg + Paracetamol 325mg","onset":"30-60 minutes","duration":"4-6 hours","common_side_effects":"Nausea, stomach pain, dizziness"}]

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