Atnemol MF 250mg/325mg Tablet: Complete Information
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is polmef 250mg/325mg tablet used for?
This medicine is a combination of Mefenamic Acid 250 mg and Paracetamol 325 mg used for short-term relief of mild to moderate pain, including menstrual cramps, dental pain, and musculoskeletal pain. It works by reducing inflammation and pain signals. Take it with food to avoid stomach upset and do not exceed the recommended dose.
- Generic Name: Mefenamic Acid (250mg) + Paracetamol (325mg)
- Manufacturer: Humbing Ethicals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 polmef 250mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेफेनामिक एसिड और पैरासिटामोल का संयोजन है, जिसका उपयोग हल्के से मध्यम दर्द और सूजन के इलाज के लिए किया जाता है। यह मासिक धर्म के दर्द, दांत दर्द, मांसपेशियों और जोड़ों के दर्द, और बुखार में राहत देती है। इसे भोजन के साथ लेना चाहिए ताकि पेट में जलन न हो।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, कब्ज, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, अल्सर, गुर्दे की समस्या, यकृत की क्षति, और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकते हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खाली पेट न लें, भोजन के साथ लें। शराब का सेवन न करें। 7 दिनों से अधिक बिना डॉक्टर की सलाह के न लें। यदि आपको पेट में अल्सर, गुर्दे या यकृत की बीमारी है, तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से परामर्श करें।
💊 polmef 250mg/325mg tablet Uses & Benefits
[{"condition":"Musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and bones, such as in back pain, sprains, and strains.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Menstrual cramps (dysmenorrhea)","description":"Reduces pain and cramping associated with menstruation.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate pain after minor surgeries.","evidence":"Well-established"},{"condition":"Fever","description":"Paracetamol component helps reduce fever, though mefenamic acid also has antipyretic properties.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Osteoarthritis","description":"May be used for short-term pain relief in osteoarthritis, but not for long-term management due to GI risks.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation
Also treats: Dysmenorrhea, Dental pain, Musculoskeletal pain, Post-operative pain, Fever
📋 Drug Information
| Generic Name(s) | Mefenamic Acid (250mg) + Paracetamol (325mg) |
| Brand Name | polmef 250mg/325mg tablet |
| Manufacturer | Humbing Ethicals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that reversibly inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, leading to decreased synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol (acetaminophen) acts primarily in the central nervous system by inhibiting prostaglandin synthesis, and it may also modulate the endogenous cannabinoid system and descending serotonergic pathways, producing analgesic and antipyretic effects with minimal anti-inflammatory action.
Mechanism Steps
💡 How to Take polmef 250mg/325mg tablet
Strength: Each tablet contains Mefenamic Acid 250 mg and Paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times a day, preferably with food. The maximum daily dose should not exceed 3 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not take for more than 7 days without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose adjustment may be necessary. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with liver disease. Dose adjustment may be necessary. Consult your doctor. |
| Maximum Daily Dose | Maximum 3 tablets (750 mg mefenamic acid + 975 mg paracetamol) in 24 hours. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of polmef 250mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| SSRIs | Moderate | |
| Alcohol | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
- Methotrexate
- Lithium
⚡ Moderate Interactions
- ACE inhibitors (e.g., enalapril, lisinopril)
- Diuretics (e.g., furosemide, hydrochlorothiazide)
- SSRIs (e.g., fluoxetine, sertraline)
- Alcohol
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulcers, and liver damage, especially when combined with paracetamol and NSAIDs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to mefenamic acid, paracetamol, or any component of the formulation","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs","Active or history of peptic ulcer or gastrointestinal bleeding","Severe kidney disease","Severe liver disease","Third trimester of pregnancy","Children under 14 years of age (unless directed by a doctor)","Concurrent use with other NSAIDs"]
⚠️ Warnings & Precautions
["Take with food or milk to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose or duration of treatment.","Use with caution in elderly patients due to increased risk of side effects.","Use with caution in patients with kidney or liver disease.","May cause drowsiness or dizziness; avoid driving or operating machinery until you know how it affects you.","Do not use for more than 7 days without consulting a doctor.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Stop use and consult a doctor if you experience signs of gastrointestinal bleeding, allergic reaction, or liver problems."]
🤱 Lactation Safety
Mefenamic acid is excreted in breast milk in small amounts. Paracetamol is also excreted in breast milk but is considered safe. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose can cause severe nausea, vomiting, abdominal pain, drowsiness, and potentially liver damage (from paracetamol) and kidney damage (from mefenamic acid). Seek immediate medical attention. Treatment is supportive and may include activated charcoal, gastric lavage, and administration of acetylcysteine for paracetamol toxicity. Monitor liver and kidney function.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it increases the risk of stomach bleeding. Do not use this medicine for more than 7 days without consulting your doctor. If you have a history of stomach ulcers, kidney disease, liver disease, or asthma, inform your doctor before taking this medicine. Do not take other pain relievers or fever reducers without consulting your doctor. If you are pregnant or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs like mefenamic acid may affect ovulation and are generally avoided during pregnancy, especially in the third trimester. Paracetamol is considered safer but should be used only when necessary.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain relief, but it should be used with caution after surgery due to the risk of bleeding and kidney problems. Follow your surgeon's instructions carefully.
🦷 Dental Procedures
This medicine can be used for dental pain, but inform your dentist if you are taking it before any dental procedure. It may increase bleeding risk during dental surgery.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you have musculoskeletal pain. Gentle stretching and low-impact activities are generally safe. Listen to your body and stop if pain worsens.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your pain persists beyond 7 days, if you experience severe side effects, or if you develop signs of gastrointestinal bleeding, allergic reaction, or liver problems. Do not stop abruptly if you are on a prescribed regimen without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney damage, liver damage, and cardiovascular events. Regular monitoring of kidney and liver function, as well as blood counts, may be required. It is not recommended for long-term use without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay help relieve localized pain and inflammation.
Evidence: LimitedSome evidence for pain relief in certain conditions.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust dosing times gradually to avoid missing doses. Check customs regulations for carrying prescription medicines. Always carry enough supply for your trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it orally.
A: No, it should be taken with food or milk to reduce the risk of stomach upset and bleeding.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: No, alcohol increases the risk of stomach bleeding and liver damage. Avoid alcohol while taking this medicine.
A: It should only be used short-term (up to 7 days) unless directed by your doctor. Long-term use increases the risk of kidney, liver, and gastrointestinal problems.
🤔 Common Patient Concerns
🔄 Substitutes for polmef 250mg/325mg tablet
View AllAlternative brands with exact same active ingredient:
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mefevin-p tabletVintek Pharmaceuticals ₹18.75 58.3% CHEAPER
-
gr mol mf 250mg/325mg tabletGracia Life Science India Pvt Ltd ₹30.00 33.3% CHEAPER
-
mefril mf 250mg/325mg tabletMerril Pharma Pvt Ltd ₹30.00 33.3% CHEAPER
-
mefcon p 250mg/325mg tabletCatholicon Pharmaceuticals Pvt Ltd ₹33.00 26.7% CHEAPER
-
aedimef p 250mg/325mg tabletAadi Health Care ₹34.00 24.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe to take on an empty stomach.
Fact: It should be taken with food or milk to reduce the risk of stomach upset and gastrointestinal bleeding. - Myth: This medicine can be taken for long periods without any risk.
Fact: Long-term use increases the risk of kidney, liver, and gastrointestinal problems. It should only be used short-term unless directed by a doctor. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol increases the risk of stomach bleeding and liver damage when taken with this medicine. - Myth: This medicine is safe for children.
Fact: It is not recommended for children under 14 years unless specifically prescribed by a doctor.
🔄 Alternative Options
Generic Alternatives
- Mefenamic Acid + Paracetamol 250mg/325mg tablet
Brand Alternatives
- Atnemol MF 250mg/325mg tablet