Aci Deject 50mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing, wheezing, or swelling of the face, lips, or throat.
- Severe dizziness, fainting, or a sudden drop in blood pressure.
- Chest pain, palpitations, or slow heartbeat.
- Confusion, hallucinations, or extreme drowsiness.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- Unusual bleeding or bruising, or blood in vomit or stool.
- Decreased urine output or swelling in the legs or feet.
If experiencing severe symptoms, call emergency services immediately.
What is peploc 50mg injection used for?
This medicine is a ranitidine injection used to reduce stomach acid in hospital settings when oral medicines cannot be taken. It treats conditions like bleeding ulcers, severe GERD, and prevents acid aspiration during surgery. It is given by a healthcare professional and requires dose adjustment in kidney disease.
- Generic Name: Ranitidine (50mg)
- Manufacturer: Zydus Healthcare Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 peploc 50mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा रैनिटिडीन का इंजेक्शन है, जिसका उपयोग अस्पताल में उन स्थितियों में किया जाता है जब मरीज मुँह से दवा नहीं ले सकता या तेजी से पेट के एसिड को कम करने की आवश्यकता होती है। इसका उपयोग पेट के अल्सर से रक्तस्राव, गंभीर एसिड रिफ्लक्स, और सर्जरी से पहले एसिड एस्पिरेशन को रोकने के लिए किया जाता है। यह दवा केवल डॉक्टर या नर्स द्वारा ही दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, नींद आना, कब्ज, दस्त, मतली, पेट में असहजता और इंजेक्शन लगाने की जगह पर दर्द या लालिमा शामिल हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, सांस लेने में कठिनाई, या मानसिक भ्रम जैसी समस्याएं हो सकती हैं। कोई भी गंभीर लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल स्वास्थ्य कर्मियों द्वारा दी जानी चाहिए। इसे स्वयं न लगाएं। अपने डॉक्टर को अपनी सभी दवाओं, एलर्जी, गुर्दे या लीवर की बीमारी के बारे में बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। इलाज के दौरान शराब न पिएं और वाहन चलाने से बचें।
💊 peploc 50mg injection Uses & Benefits
[{"condition":"Active peptic ulcer bleeding","description":"Used in hospital settings to reduce gastric acid secretion and help stabilize clot formation in patients with bleeding ulcers.","evidence":"Well-established"},{"condition":"Gastroesophageal reflux disease (GERD) with severe symptoms","description":"Provides rapid acid suppression when oral therapy is not possible or when symptoms are severe.","evidence":"Well-established"},{"condition":"Aspiration prophylaxis before surgery","description":"Given before certain surgical procedures to reduce stomach acid volume and acidity, lowering the risk of lung injury if aspiration occurs.","evidence":"Established"},{"condition":"Zollinger-Ellison syndrome","description":"Used to control excessive gastric acid production in this rare condition when oral therapy is not feasible.","evidence":"Established"},{"condition":"Stress ulcer prophylaxis in critically ill patients","description":"May be used in intensive care settings to prevent stress-related mucosal bleeding in high-risk patients.","evidence":"Established"}]
Off-label uses: [{"condition":"Prevention of acid aspiration during labor","description":"Sometimes used off-label in obstetric settings to reduce gastric acid before anesthesia.","evidence":"Limited"},{"condition":"Treatment of urticaria (hives)","description":"H2 blockers like ranitidine have been used off-label as add-on therapy for chronic urticaria not controlled by antihistamines alone.","evidence":"Limited"}]
Primary treatment for: Peptic ulcer disease
Also treats: Gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, Stress ulcer prophylaxis, Aspiration prophylaxis
📋 Drug Information
| Generic Name(s) | Ranitidine (50mg) |
| Brand Name | peploc 50mg injection |
| Manufacturer | Zydus Healthcare Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | H2 Receptor Blocker |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store this medicine at room temperature, between 15°C and 30°C (59°F to 86°F). Protect from light and excessive heat. Do not freeze. Keep the vial or ampoule in its original carton until use. Once opened, use immediately or as directed by the manufacturer. Discard any unused portion properly. |
| Shelf Life | The shelf life is typically 24 to 36 months from the date of manufacture, depending on the specific product. Always check the expiry date on the packaging before use. Do not use if the expiry date has passed. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by competitively blocking histamine H2 receptors located on the parietal cells of the stomach. When histamine binds to these receptors, it normally stimulates the production of gastric acid. By occupying the receptor site, ranitidine prevents histamine from triggering acid secretion, leading to reduced both basal and stimulated acid output. This effect lowers the volume and acidity of stomach contents, which helps protect the stomach lining and allows ulcers to heal. The action is reversible and dose-dependent.
Mechanism Steps
💡 How to Take peploc 50mg injection
Strength: Injection: 50 mg per vial or ampoule (2 mL). Each mL contains 25 mg of ranitidine.
Dosage Information
| Adult Dosage | The adult dose of this medicine is individualized by a qualified clinician based on the indication, patient's age, weight, kidney and liver function, and other medicines being taken. For active peptic ulcer bleeding or severe GERD, a common intravenous dose is 50 mg every 6 to 8 hours, but this may vary. For aspiration prophylaxis before surgery, a single 50 mg intravenous or intramuscular dose may be given 45 to 60 minutes before induction of anesthesia. In patients with kidney impairment, the dose or frequency must be reduced. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Never self-administer this medicine. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. In some clinical settings, ranitidine injection may be used in children under specialist supervision, but the dose must be calculated based on weight and kidney function. Do not use in children without explicit medical advice. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the central nervous system effects of this medicine, such as confusion, hallucinations, and drowsiness. Kidney function often declines with age, so the dose may need to be reduced. The dose must be individualized by a qualified clinician based on kidney function and overall health. Close monitoring is recommended. |
| Renal Impairment | In patients with kidney impairment, the dose of this medicine must be reduced. For adults with a creatinine clearance less than 50 mL/min, the usual recommendation is to give 50 mg intravenously every 12 to 24 hours, depending on the degree of impairment. In severe kidney disease, the dose may be further reduced. Dose must be individualized by a qualified clinician based on renal function. Monitor for side effects such as confusion and adjust accordingly. |
| Hepatic Impairment | No specific dose adjustment is usually required for patients with liver disease alone, because ranitidine is primarily eliminated by the kidneys. However, in patients with both liver and kidney impairment, caution is advised, and the dose should be individualized by a qualified clinician. Monitor liver enzymes if symptoms occur. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine for adults with normal kidney function is typically 200 mg to 300 mg per day, given in divided doses. However, the exact maximum dose depends on the indication and patient's condition. In patients with kidney impairment, the maximum daily dose is lower. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of peploc 50mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Atazanavir | Major | |
| Ketoconazole | Major | |
| Procainamide | Major | |
| Metformin | Moderate | |
| Glipizide | Moderate | |
| Midazolam | Moderate | |
| Triazolam | Moderate | |
| Antacids | Minor | |
| Food | Minor |
🚨 Major Interactions
- Warfarin
- Atazanavir
- Ketoconazole
- Procainamide
⚡ Moderate Interactions
- Metformin
- Glipizide
- Midazolam
- Triazolam
🍷 Alcohol Interaction
Alcohol may increase the risk of stomach irritation, dizziness, and drowsiness while receiving this medicine. It is advisable to avoid alcohol during treatment, especially if you have a history of ulcers or liver disease. Alcohol can also worsen the underlying condition being treated, such as gastritis or reflux.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to ranitidine or any component of the formulation.","Known allergy to other H2 receptor antagonists (cross-reactivity may occur).","Use in patients with a history of acute porphyria, as ranitidine may precipitate attacks."]
⚠️ Warnings & Precautions
["This medicine should be administered only by a qualified healthcare professional.","Dose reduction is required in patients with kidney impairment to prevent accumulation and central nervous system side effects.","Elderly patients are more sensitive to the central nervous system effects such as confusion and hallucinations.","Rapid intravenous injection may cause bradycardia and hypotension; administer slowly over at least 5 minutes.","Use with caution in patients with liver disease; monitor liver enzymes if symptoms occur.","Avoid use in patients with a history of porphyria.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Do not use if the solution is discolored or contains particles.","Keep out of reach of children.","Do not mix with other medicines in the same syringe unless directed."]
🤱 Lactation Safety
Ranitidine passes into breast milk in small amounts. It is generally considered compatible with breastfeeding, but monitoring for infant side effects such as drowsiness or poor feeding is advised. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose with this medicine is unlikely in a hospital setting because it is administered by healthcare professionals. If an overdose is suspected, it may cause severe drowsiness, confusion, low blood pressure, or slow heart rate. Treatment is supportive and symptomatic. There is no specific antidote. The patient should be monitored closely, and vital signs should be supported. In cases of recent ingestion (not applicable for injection), activated charcoal may be considered. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
This medicine is given by a healthcare professional in a controlled setting, so missed doses are managed by the clinical team. If you are receiving this medicine at home through a home care program, contact your nurse or doctor immediately if you miss a dose. Do not attempt to double the dose or self-administer an extra dose. Follow the schedule provided by your healthcare team.
Additional Safety Advice
This medicine must be given only by a healthcare professional. Do not attempt to self-administer it. Inform your doctor if you are allergic to ranitidine or any other medicine. Tell your doctor about all prescription, over-the-counter, and herbal products you are taking, especially blood thinners, seizure medicines, and drugs that affect heart rhythm. Your kidney and liver function may need to be checked before and during treatment. Use with caution if you are elderly, pregnant, or breastfeeding. Avoid alcohol while receiving this medicine because it may worsen stomach irritation and dizziness. Do not drive or operate heavy machinery until you know how this medicine affects you. If you miss a scheduled dose in a hospital setting, the nursing staff will manage the timing according to your treatment plan. Keep all follow-up appointments and report any new or unusual symptoms promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to experience central nervous system side effects such as confusion, hallucinations, and drowsiness. Kidney function often declines with age, so the dose may need to be reduced. Close monitoring is recommended. Falls and fractures are a concern in elderly patients, so caution should be taken to prevent dizziness-related accidents.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before using this medicine. Ranitidine is generally considered safe during pregnancy, but the need for the medicine should be evaluated. If you become pregnant while on this medicine, inform your doctor immediately. Do not start or stop any medicine without medical advice.
🏥 Post-Surgery Considerations
This medicine may be used before, during, or after surgery to reduce the risk of acid aspiration or to treat stress ulcers. After surgery, your doctor will determine if you need to continue it. Follow all postoperative instructions carefully. Report any unusual symptoms such as severe abdominal pain, bleeding, or difficulty breathing.
🦷 Dental Procedures
If you are scheduled for a dental procedure, inform your dentist that you are receiving this medicine. It is generally safe, but your dentist may take precautions if you have a history of allergies or are taking other medicines. No specific dose adjustment is usually needed for dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may experience dizziness or drowsiness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. Light walking is generally safe, but consult your doctor before starting any new exercise routine, especially if you have been hospitalized for a serious condition.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is usually given in a hospital or clinic, so it may temporarily affect your ability to work or drive. You may feel dizzy or drowsy after administration. Do not drive or operate heavy machinery until you feel fully alert. If you are receiving this medicine as an outpatient, arrange for someone to drive you home. Discuss with your doctor when you can safely resume work and normal activities.
🛑 When to Stop This Medicine
This medicine is stopped when your doctor determines that it is no longer needed, or when you are switched to oral therapy. Do not stop this medicine on your own, especially if you are being treated for a serious condition like bleeding ulcers. If you experience severe side effects, your doctor may stop the medicine and choose an alternative. Always consult your healthcare provider before stopping any treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is uncommon because it is typically used for short periods in hospital settings. Prolonged use of ranitidine, especially at high doses, has been associated with rare side effects such as vitamin B12 deficiency, bone fractures, and increased risk of certain infections. However, these risks are mainly seen with long-term oral therapy. If long-term use is necessary, regular monitoring of kidney function, blood counts, and vitamin B12 levels may be advised. Always consult your doctor before stopping or continuing this medicine.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
These medicines provide stronger and longer-lasting acid suppression and may be used as alternatives.
Evidence: Well-establishedAnother H2 blocker with a longer duration of action and fewer drug interactions.
Evidence: Well-establishedAvoiding trigger foods, losing weight, and elevating the head of the bed can help manage acid reflux.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking. In general, vaccinations can be given while on this medicine, but the decision should be made by your doctor based on your overall health.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C).
❌ DON'T
Do not freeze.
✅ DO
Keep in original container until use.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Protect from light and excessive heat.
❌ DON'T
Do not store in bathroom or near heat sources.
✅ DO
Check for discoloration or particles before use.
❌ DON'T
Do not use if the solution is cloudy or contains particles.
✅ DO
Discard unused portion properly.
❌ DON'T
Do not save opened vials for later use.
✈️ Traveling with This Medicine
This medicine is usually given in a hospital or clinic and is not typically self-administered during travel. If you are prescribed this medicine for home care, carry it in its original packaging with the prescription label. Keep a copy of your prescription and a letter from your doctor explaining the medical need. Store it at room temperature, away from direct sunlight and extreme heat. If traveling by air, carry it in your hand luggage with proper documentation. Check the laws of your destination country regarding injectable medicines. Do not pack it in checked baggage. If you need to travel with this medicine, consult your healthcare provider for specific instructions.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: After intravenous administration, this medicine starts reducing stomach acid within 5 to 10 minutes. After intramuscular injection, it takes about 15 to 30 minutes.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting. It is not for self-administration.
A: Common side effects include headache, dizziness, drowsiness, constipation, diarrhea, nausea, and injection site pain. These are usually mild and temporary.
A: Ranitidine is generally considered safe during pregnancy when clearly needed, but you should consult your obstetrician before use.
A: It is advisable to avoid alcohol as it may worsen stomach irritation and increase dizziness or drowsiness.
A: In a hospital setting, inform your nurse or doctor. They will manage the schedule. Do not attempt to self-administer an extra dose.
🤔 Common Patient Concerns
🔄 Substitutes for peploc 50mg injection
View AllAlternative brands with exact same active ingredient:
-
gertac 50mg injectionZydus Cadila ₹2.50 20.9% CHEAPER
-
Ritin 50mg InjectionV.S. Healthcare Ltd ₹2.58 18.4% CHEAPER
-
ranitidine 50mg injectionAbbott ₹2.81 11.1% CHEAPER
-
aci deject 50mg injectionIndus Pharma Pvt Ltd ₹3.00 5.1% CHEAPER
-
ranalix 50mg injectionElixir Life Care Pvt Ltd ₹3.04 3.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Ranitidine injection can be self-administered at home.
Fact: This medicine must be given by a trained healthcare professional. Self-administration can be dangerous. - Myth: Ranitidine injection works instantly for any stomach pain.
Fact: It reduces acid secretion but does not treat all types of abdominal pain. It is specific for acid-related conditions. - Myth: Ranitidine injection is safe for everyone.
Fact: It is not safe for people with allergies to ranitidine or those with acute porphyria. Dose adjustment is needed in kidney disease. - Myth: Ranitidine injection can be used to treat food poisoning.
Fact: It is not an antibiotic or antidote for food poisoning. It only reduces stomach acid.
🔄 Alternative Options
Generic Alternatives
- Ranitidine injection
Brand Alternatives
- Aci Deject 50mg Injection