Fillif Peg 6mg Injection: Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Sudden severe pain in the upper left abdomen or left shoulder (possible splenic rupture).
- Difficulty breathing, rapid breathing, or bluish skin color (possible ARDS).
- Swelling of the face, lips, tongue, or throat (possible severe allergic reaction).
- Rapid swelling of the arms, legs, or abdomen, or sudden weight gain (possible capillary leak syndrome).
- Fever, chills, or sore throat (possible infection).
- Unusual bleeding or bruising.
- Decreased urine output or blood in urine.
If experiencing severe symptoms, call emergency services immediately.
What is peg-religrast injection used for?
This medicine is a long-acting injectable form of pegfilgrastim used to prevent infections during chemotherapy by stimulating white blood cell production. It is given as a single 6 mg subcutaneous injection once per chemotherapy cycle.
- Generic Name: Pegfilgrastim (6mg)
- Manufacturer: Reliance Life Sciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 peg-religrast injection के बारे में (Hindi Summary)
उपयोग: यह दवा पेगफिलग्रास्टिम का एक दीर्घ-अवधि वाला इंजेक्शन है, जिसका उपयोग कीमोथेरेपी के दौरान होने वाले न्यूट्रोपेनिया (श्वेत रक्त कोशिकाओं की कमी) को रोकने के लिए किया जाता है। यह हड्डी के मज्जा को अधिक न्यूट्रोफिल बनाने के लिए उत्तेजित करती है, जिससे संक्रमण का खतरा कम होता है। यह दवा कीमोथेरेपी के बाद एक बार चमड़े के नीचे इंजेक्शन के रूप में दी जाती है। यह कैंसर का इलाज नहीं है, बल्कि कीमोथेरेपी के दौरान संक्रमण से बचाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में हड्डियों में दर्द, सिरदर्द, थकान, मतली और इंजेक्शन स्थल पर लालिमा या सूजन शामिल हैं। गंभीर दुष्प्रभावों में प्लीहा का टूटना, सांस लेने में कठिनाई, गंभीर एलर्जी प्रतिक्रिया और केशिका रिसाव सिंड्रोम शामिल हैं। यदि आपको पेट के ऊपरी बाएं हिस्से में अचानक तेज दर्द, सांस लेने में तकलीफ, या चेहरे पर सूजन हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को 2°C से 8°C के बीच रेफ्रिजरेटर में स्टोर करें और जमने न दें। उपयोग से पहले सिरिंज को कमरे के तापमान पर 30 मिनट के लिए रखें। यदि घोल धुंधला हो या उसमें कण दिखाई दें तो उपयोग न करें। यह दवा केवल एक बार उपयोग के लिए है। बिना प्रशिक्षण के स्वयं इंजेक्शन न लगाएं। कीमोथेरेपी के 14 दिन पहले और 24 घंटे बाद तक यह दवा न दें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर को बताएं।
💊 peg-religrast injection Uses & Benefits
[{"condition":"Chemotherapy-induced neutropenia","description":"This medicine is used to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs.","evidence":"Well-established"},{"condition":"Febrile neutropenia prophylaxis","description":"It reduces the duration of severe neutropenia and the risk of febrile neutropenia in patients undergoing chemotherapy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Stem cell mobilization","description":"Sometimes used off-label to mobilize peripheral blood stem cells for collection prior to autologous transplantation.","evidence":"Limited"},{"condition":"Severe chronic neutropenia","description":"Rarely used off-label in some congenital or cyclic neutropenia syndromes, though other G-CSF agents are more common.","evidence":"Limited"}]
Primary treatment for: Chemotherapy-induced neutropenia
Also treats: Febrile neutropenia, Bone marrow suppression
📋 Drug Information
| Generic Name(s) | Pegfilgrastim (6mg) |
| Brand Name | peg-religrast injection |
| Manufacturer | Reliance Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Granulocyte-colony stimulating factor (G-CSF) |
| Route of Administration | Parenteral (subcutaneous injection) |
| Storage | Store in a refrigerator at 2°C to 8°C. Do not freeze. Keep the prefilled syringe in its original carton to protect from light. Do not shake. Before use, allow the syringe to reach room temperature for about 30 minutes. Do not use if the solution is cloudy or contains particles. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture when stored under recommended conditions. Refer to the product label for the exact expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine binds to the granulocyte colony-stimulating factor (G-CSF) receptor on hematopoietic cells, thereby stimulating the proliferation, differentiation, and activation of neutrophil precursors. The pegylation of the molecule extends its half-life, allowing for once-per-chemotherapy-cycle dosing. This leads to an increased production of neutrophils and enhanced phagocytic activity, which helps the body combat infections during periods of chemotherapy-induced myelosuppression.
Mechanism Steps
💡 How to Take peg-religrast injection
Strength: 6 mg/0.6 mL single-dose prefilled syringe for subcutaneous injection.
Dosage Information
| Adult Dosage | The recommended adult dose of this medicine is 6 mg administered subcutaneously once per chemotherapy cycle. It should not be given within 14 days before and 24 hours after chemotherapy. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. For patients with severe renal impairment, no dose adjustment is required, but monitoring is advised. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No overall differences in safety or effectiveness have been observed between elderly and younger patients. However, dose selection should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy. |
| Renal Impairment | No dose adjustment is required for renal impairment. However, caution is advised in patients with severe renal impairment due to reduced clearance. |
| Hepatic Impairment | No dose adjustment is required for hepatic impairment. However, monitor liver function in patients with pre-existing liver disease. |
| Maximum Daily Dose | The maximum recommended dose is 6 mg per chemotherapy cycle. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of peg-religrast injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Chemotherapy agents | Major | |
| Lithium | Moderate | |
| Topotecan | Moderate | |
| Bleomycin | Moderate | |
| Corticosteroids | Minor |
🚨 Major Interactions
- Chemotherapy agents (e.g., cyclophosphamide, doxorubicin)
- Lithium
⚡ Moderate Interactions
- Topotecan
- Bleomycin
🍷 Alcohol Interaction
There is no known direct interaction between this medicine and alcohol. However, alcohol can suppress bone marrow function and may worsen neutropenia. It is advisable to avoid alcohol during chemotherapy and while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to pegfilgrastim, filgrastim, or any component of the formulation","Concurrent use with chemotherapy within 14 days before and 24 hours after administration","Patients with sickle cell disease (may precipitate severe sickle cell crisis)"]
⚠️ Warnings & Precautions
["Splenic rupture: Monitor for left upper abdominal or shoulder pain.","Acute respiratory distress syndrome: Monitor for respiratory symptoms.","Severe allergic reactions: Discontinue immediately if anaphylaxis occurs.","Capillary leak syndrome: Monitor for edema, hypotension, and hemoconcentration.","Sickle cell crisis: Use with caution in patients with sickle cell disease.","Glomerulonephritis: Monitor urine output and renal function.","Myelodysplastic syndrome/AML: Monitor long-term in patients with congenital neutropenia.","Aortitis: Report fever, abdominal pain, or malaise.","Injection site reactions: Rotate injection sites.","Do not administer within 14 days before or 24 hours after chemotherapy."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
Overdose of this medicine may result in excessive leukocytosis and bone pain. There is no specific antidote. Treatment should be symptomatic and supportive. Monitor complete blood counts and provide appropriate care. In case of accidental overdose, contact your doctor immediately.
⏰ Missed Dose
This medicine is usually given as a single dose per chemotherapy cycle. If you miss a scheduled dose, contact your doctor or nurse as soon as possible to reschedule. Do not self-administer an extra dose. If you miss a dose, do not double the next dose.
Additional Safety Advice
This medicine must be stored in the refrigerator at 2°C to 8°C and should not be frozen. Do not shake the prefilled syringe. Before injection, allow the syringe to reach room temperature for about 30 minutes. Do not use if the solution is cloudy or contains particles. This medicine is for single use only; discard any unused portion. Do not self-administer unless you have been trained by a healthcare professional. Inform your doctor if you have a history of sickle cell disease, kidney problems, or are pregnant or breastfeeding. Avoid close contact with people who have infections while your white blood cell count is low. Do not receive this medicine within 14 days before or 24 hours after chemotherapy. Always follow your doctor's instructions regarding the timing of the injection.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects such as fatigue and bone pain. Monitor closely and adjust supportive care as needed. No specific dose adjustment is required based on age alone.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before receiving this medicine. It should be used during pregnancy only if clearly needed. Effective contraception is recommended during treatment.
🏥 Post-Surgery Considerations
This medicine is not typically used in the post-surgical setting unless the patient is undergoing chemotherapy. Consult your doctor for specific guidance.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine. Dental procedures may need to be postponed if your white blood cell count is low. Consult your doctor before any dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild to moderate exercise is generally safe, but avoid strenuous activities if you have bone pain or fatigue. Consult your doctor before starting any exercise program during chemotherapy.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue or dizziness, which can affect your ability to drive or operate machinery. Avoid driving if you feel unwell. Most patients can continue light work, but consult your doctor based on your condition.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. It is usually given as a single dose per chemotherapy cycle. If you experience severe side effects, your doctor may adjust or discontinue treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is generally limited to the duration of chemotherapy. Potential long-term effects include an increased risk of myelodysplastic syndrome or acute myeloid leukemia in patients with congenital neutropenia. Regular monitoring of blood counts and clinical assessment is recommended. Report any unusual symptoms to your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Short-acting G-CSF requiring daily injections.
Evidence: Well-establishedUsed in some patients to prevent infections during neutropenia.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during chemotherapy and while receiving this medicine due to the risk of infection. Inactivated vaccines may be given, but consult your doctor for timing.
📦 Storage Guide
✅ DO
Store in refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not shake the prefilled syringe
✅ DO
Allow to reach room temperature before injection
❌ DON'T
Do not use if solution is cloudy or contains particles
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label. Keep it in a cool, insulated bag with ice packs to maintain the temperature between 2°C and 8°C. Do not freeze. Carry a copy of your prescription and a letter from your doctor explaining the medical need. Check airline regulations for carrying injectable medications. If crossing time zones, consult your doctor about timing adjustments. Store securely and keep away from direct sunlight.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts increasing white blood cell counts within 24 hours, with peak effects in 24 to 72 hours.
A: It is given as a subcutaneous injection, usually in the abdomen, thigh, or upper arm, by a healthcare professional.
A: Common side effects include bone pain, headache, fatigue, nausea, and injection site reactions.
A: Only if you have been trained by a healthcare professional. Otherwise, it should be administered in a clinic.
A: It should be used during pregnancy only if clearly needed. Consult your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for peg-religrast injection
View AllAlternative brands with exact same active ingredient:
-
pegheal 6mg injectionBiochem Pharmaceutical Industries ₹3,206.57 33.8% CHEAPER
-
peggrafeel 6mg injectionDr Reddy's Laboratories Ltd ₹3,414.00 29.6% CHEAPER
-
lupifil p 6mg injectionLupin Ltd ₹3,911.00 19.3% CHEAPER
-
pegg trust 6mg injectionPanacea Biotec Ltd ₹4,992.10 3% COSTLIER
-
pegstim injectionZydus Cadila ₹5,398.00 11.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure cancer.
Fact: This medicine does not treat cancer itself; it helps prevent infections by boosting white blood cell counts during chemotherapy. - Myth: This medicine can be taken at home without medical supervision.
Fact: This medicine should be administered by a healthcare professional, although some patients may be trained for self-injection. - Myth: This medicine can be given at any time during chemotherapy.
Fact: It must be given at least 24 hours after chemotherapy and not within 14 days before the next cycle.
🔄 Alternative Options
Generic Alternatives
- Pegfilgrastim
Brand Alternatives
- Neulasta
- Fulphila
- Udenyca
- Ziextenzo