Abraxane 100mg Injection: Comprehensive Guide
When to Call Your Doctor IMMEDIATELY
- Fever, chills, or sore throat (signs of infection)
- Severe allergic reaction (rash, swelling, difficulty breathing)
- Chest pain or irregular heartbeat
- Severe numbness or weakness in hands or feet
- Unusual bleeding or bruising
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is pac-nab suspension for injection used for?
This medicine is an albumin-bound form of paclitaxel used to treat metastatic breast cancer, non-small cell lung cancer, and pancreatic cancer. It is given as an intravenous infusion by a healthcare professional.
- Generic Name: Paclitaxel (100mg)
- Manufacturer: Metta Life Sciences Private Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 pac-nab suspension for injection के बारे में (Hindi Summary)
उपयोग: यह दवा पैक्लिटैक्सेल का एक विशेष इंजेक्शन रूप है, जिसका उपयोग कैंसर के इलाज में किया जाता है। यह मुख्य रूप से मेटास्टेटिक स्तन कैंसर, नॉन-स्मॉल सेल लंग कैंसर और अग्नाशय के कैंसर के लिए दी जाती है। यह दवा कैंसर कोशिकाओं के विभाजन को रोककर उन्हें नष्ट करती है। इसे डॉक्टर या नर्स द्वारा नस के माध्यम से दिया जाता है।
साइड इफेक्ट्स: आम दुष्प्रभावों में बालों का झड़ना, हाथ-पैरों में झुनझुनी या सुन्नपन, थकान, मतली, उल्टी, दस्त और मुंह के छाले शामिल हैं। गंभीर दुष्प्रभावों में रक्त कोशिकाओं की कमी, गंभीर एलर्जी, हृदय संबंधी समस्याएं और तंत्रिका क्षति हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य डॉक्टर की देखरेख में ही दी जानी चाहिए। इलाज के दौरान नियमित रूप से रक्त परीक्षण कराना आवश्यक है। संक्रमण से बचने के लिए सावधानी बरतें। गर्भवती महिलाओं और स्तनपान कराने वाली महिलाओं को यह दवा नहीं लेनी चाहिए। अन्य दवाओं के साथ परस्पर क्रिया के बारे में डॉक्टर को बताएं।
💊 pac-nab suspension for injection Uses & Benefits
[{"condition":"Metastatic breast cancer","description":"Used as first-line or subsequent therapy for metastatic breast cancer, often after failure of anthracycline-based regimens.","evidence":"Well-established"},{"condition":"Non-small cell lung cancer","description":"Indicated in combination with carboplatin for first-line treatment of locally advanced or metastatic non-small cell lung cancer.","evidence":"Well-established"},{"condition":"Pancreatic cancer","description":"Used in combination with gemcitabine for first-line treatment of metastatic pancreatic adenocarcinoma.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Ovarian cancer","description":"Sometimes used off-label for recurrent or refractory ovarian cancer, though other taxanes may be preferred.","evidence":"Limited"},{"condition":"Gastric cancer","description":"Occasionally used off-label in combination regimens for advanced gastric cancer.","evidence":"Limited"}]
Primary treatment for: Metastatic breast cancer
Also treats: Non-small cell lung cancer, Pancreatic cancer
📋 Drug Information
| Generic Name(s) | Paclitaxel (100mg) |
| Brand Name | pac-nab suspension for injection |
| Manufacturer | Metta Life Sciences Private Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimicrotubule agents- Taxanes |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store vials refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light. Do not freeze. Once reconstituted, use immediately or store as directed by the pharmacy. |
| Shelf Life | Refer to the manufacturer's expiration date on the vial. Do not use beyond the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to the beta-tubulin subunit of microtubules, stabilizing them and preventing their normal disassembly. This disruption of microtubule dynamics leads to cell cycle arrest at the G2/M phase and subsequent apoptosis of cancer cells. The albumin-bound formulation facilitates transport across endothelial cells via albumin receptor-mediated pathways, potentially enhancing drug delivery to tumor tissues.
Mechanism Steps
💡 How to Take pac-nab suspension for injection
Strength: 100 mg per vial, lyophilized powder for reconstitution for intravenous infusion.
Dosage Information
| Adult Dosage | The dose of this medicine varies by indication and is individualized by a qualified clinician. For metastatic breast cancer, a common dose is 260 mg/m² intravenously over 30 minutes every 3 weeks. For non-small cell lung cancer, it is often given at 100 mg/m² on days 1, 8, and 15 of a 21-day cycle in combination with carboplatin. For pancreatic cancer, a typical dose is 125 mg/m² on days 1, 8, and 15 of a 28-day cycle with gemcitabine. Dose adjustments are required for hepatic impairment, severe neutropenia, or neuropathy. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects such as neuropathy and bone marrow suppression. Dose selection should be cautious, and monitoring should be more frequent. |
| Renal Impairment | No specific dose adjustment is recommended for renal impairment, but caution is advised in severe renal impairment. |
| Hepatic Impairment | For patients with moderate to severe hepatic impairment, dose reduction is recommended. For mild impairment, no adjustment may be needed. Consult prescribing information for specific guidelines. |
| Maximum Daily Dose | The maximum tolerated dose varies by regimen and patient factors. Do not exceed the dose prescribed by your oncologist. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of pac-nab suspension for injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Gemfibrozil | Major | |
| Warfarin | Moderate | |
| Live vaccines | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP2C8 inhibitors (e.g., gemfibrozil)
⚡ Moderate Interactions
- Warfarin
- Live vaccines
🍷 Alcohol Interaction
Alcohol may increase the risk of liver toxicity and worsen side effects such as nausea and fatigue. It is advisable to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe hypersensitivity to paclitaxel or albumin","Baseline neutrophil count < 1,500 cells/mm³","Severe hepatic impairment","Pregnancy (unless potential benefit justifies risk)","Breastfeeding"]
⚠️ Warnings & Precautions
["Administer only under supervision of qualified oncologist.","Premedication may not be required but hypersensitivity reactions can occur.","Bone marrow suppression is common; monitor blood counts regularly.","Peripheral neuropathy may be dose-limiting; report symptoms promptly.","Avoid live vaccines during therapy.","Use effective contraception during and after treatment."]
🤱 Lactation Safety
It is not known whether paclitaxel is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment and for at least 2 weeks after the last dose.
💊 Overdose Management
Overdose of this medicine may cause severe bone marrow suppression, peripheral neuropathy, and mucositis. There is no specific antidote. Treatment is supportive and symptomatic, with close monitoring of blood counts and organ function. In case of suspected overdose, contact emergency medical services immediately.
⏰ Missed Dose
This medicine is administered by a healthcare professional in a clinical setting. If a scheduled dose is missed, contact your oncology team immediately to reschedule. Do not attempt to self-administer.
Additional Safety Advice
This medicine must only be administered by a qualified healthcare professional in a clinical setting equipped to manage chemotherapy side effects. Regular blood tests are required to monitor blood cell counts, liver function, and kidney function. Patients should avoid contact with people who have active infections and practice good hygiene to reduce infection risk. Effective contraception is advised for both men and women during treatment and for several months afterward, as this medicine can harm a developing fetus. Avoid live vaccines during treatment. Inform your doctor of all other medications, including over-the-counter drugs and herbal supplements, as interactions can occur. Do not breastfeed while receiving this medicine. Report any signs of infection, unusual bleeding, or severe allergic reactions immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects such as neuropathy, bone marrow suppression, and cardiac toxicity. Dose selection should be cautious, and monitoring should be more frequent.
🤰 Pregnancy Planning (TTC)
This medicine can harm a developing fetus. Women should use effective contraception during treatment and for at least 6 months after the last dose. Men should also use contraception for at least 3 months after treatment. Discuss pregnancy planning with your doctor before starting treatment.
🏥 Post-Surgery Considerations
This medicine may impair wound healing due to its effects on cell division. Inform your surgeon if you are receiving this medicine. Timing of surgery should be discussed with your oncologist.
🦷 Dental Procedures
This medicine can increase the risk of bleeding and infection. Inform your dentist that you are receiving this medicine. Dental procedures may need to be postponed until blood counts recover.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise may need to be modified based on fatigue and neuropathy. Gentle activities like walking or swimming are encouraged, but avoid activities that could cause injury if you have numbness or balance issues.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
Fatigue and neuropathy may affect your ability to work or drive. Adjust your schedule as needed and discuss with your employer about accommodations. Avoid operating heavy machinery if you feel dizzy or fatigued.
🛑 When to Stop This Medicine
Do not stop treatment without consulting your oncologist. Treatment may be stopped or adjusted based on disease progression, severe side effects, or other medical reasons. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term effects may include persistent peripheral neuropathy, cardiac toxicity, and secondary cancers. Regular follow-up with your oncologist is essential to monitor for late effects. Report any new or worsening symptoms promptly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Docetaxel or conventional paclitaxel may be alternatives.
Evidence: Well-establishedFor certain breast cancers, targeted therapies may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment due to the risk of infection. Inactivated vaccines may be given, but response may be reduced. Consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store refrigerated at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Use immediately after reconstitution
❌ DON'T
Do not store reconstituted solution for long periods
✈️ Traveling with This Medicine
This medicine is administered in a clinical setting, so travel should be planned around treatment schedules. If you need to travel, carry a copy of your prescription and medical records. Store vials refrigerated at 2°C to 8°C; use a cooler bag with ice packs during travel. Inform airport security about your medication and carry it in original packaging. Check customs regulations for controlled substances.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Clinical response may take several weeks to become evident. Your doctor will monitor your progress with regular scans and tests.
A: Many patients can continue working, but fatigue and other side effects may require adjustments. Discuss with your doctor.
A: Hair loss is usually temporary and regrows after treatment ends.
🤔 Common Patient Concerns
🔄 Substitutes for pac-nab suspension for injection
View AllAlternative brands with exact same active ingredient:
-
dutaxel 100mg injectionSamarth Life Sciences Pvt Ltd ₹592.20 93.4% CHEAPER
-
taxeleon 100mg injectionNeon Laboratories Ltd ₹750.00 91.7% CHEAPER
-
glantax p 100mg injectionGland Pharma Limited ₹854.00 90.5% CHEAPER
-
Relipac 100mg InjectionReliance Life Sciences ₹1,330.71 85.2% CHEAPER
-
paclistar 100mg injectionLupin Ltd ₹1,716.12 80.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a targeted therapy with no side effects.
Fact: This medicine is a chemotherapy agent and can cause significant side effects, including bone marrow suppression and neuropathy. - Myth: This medicine can be taken at home.
Fact: This medicine must be administered by a healthcare professional in a clinical setting.
🔄 Alternative Options
Generic Alternatives
- Paclitaxel (conventional)
Brand Alternatives
- Abraxane