biramet 500mg tablet - Abiraterone Acetate (500mg) medicine

Biramet 500mg Tablet - Uses, Price, Side Effects

4.6 (12 reviews)

Abiraterone Acetate (500mg)

🏭 Metta Life Sciences Private Limited 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is biramet 500mg tablet used for?

Biramet 500mg Tablet contains Abiraterone Acetate, a CYP17 inhibitor used in combination with prednisone for the treatment of metastatic castration-resistant prostate cancer. It works by blocking androgen production in the adrenal glands, testes, and prostate tumor itself, thereby slowing cancer growth.

Generic Name: Abiraterone Acetate
Manufacturer: Metta Life Sciences Private Limited
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 biramet 500mg tablet Uses & Benefits

Metastatic castration-resistant prostate cancer (mCRPC) in combination with prednisone; metastatic high-risk castration-sensitive prostate cancer (mCSPC).

Off-label uses: Breast cancer, Ovarian cancer

📋 Drug Information

Generic Name(s)	Abiraterone Acetate
Brand Name	Abirapro 250mg Tablet
Manufacturer	Metta Life Sciences Private Limited
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Anticancer-others
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from moisture and light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAbsorbed orally; food increases absorption significantly (up to 10-fold).

DistributionHighly protein bound; distributes extensively into tissues.

Protein Binding>99% bound to plasma proteins (albumin and alpha-1 acid glycoprotein).

MetabolismMetabolized primarily by CYP3A4 and SULT2A1 to active metabolite abiraterone.

Half-LifeApproximately 12 hours (abiraterone).

ExcretionFecal (88%) and renal (5%) as metabolites.

BioavailabilityUnknown; food increases AUC by 10-fold.

Onset of ActionWithin 2-4 weeks for PSA decline.

Peak Plasma Time2 hours (fasted); 4-6 hours (fed).

Duration of ActionContinuous with daily dosing.

How It Works

Selectively inhibits CYP17A1 (17α-hydroxylase/C17,20-lyase) in the adrenal glands and prostate cancer cells, blocking androgen synthesis.

Mechanism Steps

1Abiraterone acetate is hydrolyzed to abiraterone in the body.

2Abiraterone selectively and irreversibly inhibits CYP17A1 (17α-hydroxylase/C17,20-lyase).

3Inhibition of 17α-hydroxylase blocks conversion of pregnenolone to 17α-hydroxypregnenolone.

💡 How to Take biramet 500mg tablet

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of biramet 500mg tablet

✅ Common Side Effects

Fatigue
Joint swelling/discomfort
Hot flush
Diarrhea
Hypertension
Hypokalemia
Edema

🚨 Serious Side Effects

Hepatotoxicity
Adrenal insufficiency
Cardiovascular events (MI, stroke)
QT prolongation
Hypoglycemia

⚠️ Rare Side Effects

Interstitial lung disease
Rhabdomyolysis
Anaphylaxis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Spironolactone	Moderate	Reduced efficacy of abiraterone
CYP3A4 Inducers (e.g., Rifampin)	Major	Decreased abiraterone exposure

🚨 Major Interactions

CYP3A4 Inducers
CYP3A4 Inhibitors
QT-prolonging agents

⚡ Moderate Interactions

Warfarin
Dextromethorphan
Theophylline

ℹ️ Minor Interactions

Grapefruit juice
St. John's Wort

🍽️ Food Interactions

High-fat meals increase absorption; take on an empty stomach at least 1 hour before or 2 hours after a meal.

🍷 Alcohol Interaction

No specific interaction; avoid excessive alcohol due to hepatotoxicity risk.

🛡️ Safety & Warnings

Liver

Moderate

Kidney

Low

Heart

Low

Pregnancy

Category A

🚫 Contraindications

Pregnancy, severe hepatic impairment (Child-Pugh C), hypersensitivity to abiraterone.

📊 Monitoring Parameters

Serum PSA, LFTs (ALT, AST, bilirubin), serum potassium, blood pressure, serum cortisol (if symptoms of adrenal insufficiency).

🤱 Lactation Safety

Not recommended; discontinue breastfeeding during treatment.

💊 Overdose Management

No specific antidote; supportive care including monitoring of electrolytes, liver function, and cardiac status.

⏰ Missed Dose

If missed, take as soon as remembered; do not double dose. If >12 hours, skip dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

🔗 View Profile

🔄 Substitutes for biramet 500mg tablet

View All

Alternative brands with exact same active ingredient (Abiraterone Acetate (500mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Certified Buyer Jul 10, 2026

Effective and reliable. Worked as expected.

Regular Customer Jul 10, 2026

Found this to be a helpful product. Good results.

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.