Adplatin 100mg Injection (Oxaliplatin): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing, swelling of face or throat, or severe rash during or after infusion
- Fever of 100.4°F (38°C) or higher, chills, or sore throat
- Unusual bleeding, bruising, or blood in stool or urine
- New or worsening numbness, weakness, or difficulty walking
- Chest pain, sudden leg swelling, or shortness of breath
- Severe diarrhea or vomiting leading to dehydration
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is oxitan 100mg infusion used for?
This medicine is a platinum-based chemotherapy drug given by intravenous infusion to treat colorectal cancer and some other cancers. It works by damaging cancer cell DNA and is always administered by a healthcare professional.
- Generic Name: Oxaliplatin (100mg)
- Manufacturer: Fresenius Kabi India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 oxitan 100mg infusion के बारे में (Hindi Summary)
उपयोग: यह दवा ऑक्सालिप्लाटिन 100 मिलीग्राम इंजेक्शन के रूप में उपलब्ध है और यह कीमोथेरेपी की एक दवा है। इसका उपयोग मुख्य रूप से कोलोरेक्टल कैंसर (आंत और मलाशय का कैंसर) के इलाज के लिए किया जाता है, खासकर जब कैंसर शरीर के अन्य हिस्सों में फैल चुका हो। यह दवा कैंसर कोशिकाओं के डीएनए को नुकसान पहुंचाकर उन्हें नष्ट करती है। यह दवा केवल डॉक्टर या प्रशिक्षित स्वास्थ्यकर्मी द्वारा नस के माध्यम से दी जाती है, इसे घर पर स्वयं नहीं लगाया जा सकता। इस दवा का उपयोग पेट के कैंसर और अग्नाशय के कैंसर में भी कुछ विशेष परिस्थितियों में किया जा सकता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में हाथ-पैरों में झनझनाहट या सुन्नपन, ठंडी चीजों को छूने पर असहजता, मतली, उल्टी, दस्त, थकान, मुंह के छाले और रक्त कोशिकाओं की संख्या में कमी शामिल हैं। कुछ रोगियों में ठंडा पानी पीने या ठंडी वस्तु छूने पर गले में असहजता हो सकती है। गंभीर दुष्प्रभावों में तेज एलर्जी, लगातार बढ़ती नसों की समस्या, बुखार के साथ संक्रमण, खून बहना, और सांस लेने में कठिनाई शामिल हो सकते हैं। कोई भी नया या बिगड़ता लक्षण दिखने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या कैंसर डे-केयर सेंटर में प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इसे घर पर स्वयं न लगाएं। हर खुराक से पहले डॉक्टर आपके रक्त की जांच, गुर्दे और लीवर की कार्यप्रणाली और नसों की स्थिति की जांच करेंगे। अगर आपको पहले कभी प्लैटिनम वाली दवाओं से एलर्जी हुई है, गुर्दे की बीमारी है, या आप गर्भवती हैं या गर्भधारण की योजना बना रही हैं, तो डॉक्टर को बताएं। इंजेक्शन के कुछ दिनों बाद तक ठंडी चीजें न खाएं-पिएं। इलाज के दौरान और उसके बाद डॉक्टर की सलाह अनुसार गर्भनिरोधक उपाय अपनाएं। इस दवा के दौरान लाइव वैक्सीन न लगवाएं।
💊 oxitan 100mg infusion Uses & Benefits
[{"condition":"Metastatic colorectal cancer","description":"This medicine is used in combination with other chemotherapy drugs as first-line or subsequent treatment for colorectal cancer that has spread to other organs.","evidence":"Well-established"},{"condition":"Adjuvant treatment of stage III colon cancer","description":"After surgical removal of stage III colon cancer, this medicine is used in combination regimens to reduce the risk of cancer returning.","evidence":"Well-established"},{"condition":"Advanced gastric or gastroesophageal junction cancer","description":"This medicine may be used in some chemotherapy combinations for advanced stomach or food pipe cancers.","evidence":"Moderate"},{"condition":"Pancreatic cancer","description":"This medicine is sometimes included in combination chemotherapy for advanced pancreatic cancer.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Ovarian cancer","description":"This medicine has been used off-label in some platinum-sensitive ovarian cancer regimens, but it is not a standard first choice.","evidence":"Limited"},{"condition":"Lymphoma","description":"Rarely, this medicine has been used off-label in certain relapsed lymphomas, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Colorectal cancer
Also treats: Gastric cancer, Pancreatic cancer, Gastroesophageal junction cancer
📋 Drug Information
| Generic Name(s) | Oxaliplatin (100mg) |
| Brand Name | oxitan 100mg infusion |
| Manufacturer | Fresenius Kabi India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Platinum compounds-Anticancer |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store this medicine in its original packaging in a refrigerator at 2°C to 8°C. Do not freeze. Protect from light. Keep out of reach of children. Once prepared for infusion, use as directed by the healthcare professional. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture when stored under recommended conditions. Check the expiry date on the packaging before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by entering cancer cells and undergoing chemical changes to form reactive platinum compounds. These reactive compounds bind to DNA and create cross-links between strands, which prevents DNA from being copied and read. This damage triggers programmed cell death, called apoptosis, in cancer cells. Because cancer cells divide rapidly, they are more sensitive to this DNA damage than most normal cells.
Mechanism Steps
💡 How to Take oxitan 100mg infusion
Strength: This medicine is available as a 100 mg injection (lyophilized powder or concentrate for solution for infusion) containing oxaliplatin 100 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 85 mg/m² given as an intravenous infusion over 2 hours, typically every 2 weeks as part of a combination chemotherapy regimen. The exact dose and schedule depend on the specific cancer being treated, the combination of drugs used, and the patient's overall health. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and blood counts. Dose reductions may be needed for nerve damage or low blood counts. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially nerve damage and bone marrow suppression. Dose selection should be cautious, and kidney function should be monitored closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Patients with mild to moderate kidney impairment may not need a dose adjustment, but those with severe kidney impairment should be monitored closely. Dose reduction may be considered based on kidney function. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | Patients with mild to moderate liver impairment may not need a dose adjustment. Severe liver impairment may require dose reduction or closer monitoring. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended dose of this medicine is 85 mg/m² per cycle when given every 2 weeks. Higher doses are not recommended due to increased risk of nerve damage and other side effects. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of oxitan 100mg infusion
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Warfarin | Major | |
| Nephrotoxic drugs | Major | |
| Clozapine | Major | |
| Phenytoin | Moderate | |
| Other myelosuppressive chemotherapy | Moderate | |
| Vancomycin | Moderate | |
| Aminoglycosides | Moderate | |
| Amphotericin B | Moderate | |
| Cisplatin | Moderate |
🚨 Major Interactions
- Live vaccines
- Nephrotoxic drugs (e.g., aminoglycosides, amphotericin B, cisplatin)
- Warfarin and other anticoagulants
- Clozapine
⚡ Moderate Interactions
- Phenytoin
- Other myelosuppressive chemotherapy drugs
- Nephrotoxic antibiotics (e.g., vancomycin)
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. Alcohol can worsen nausea, vomiting, dehydration, and fatigue, and it may add to liver stress. It can also increase the risk of nerve damage. Discuss any alcohol use with your oncology team.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergic reaction to oxaliplatin or other platinum-containing drugs","Severe bone marrow suppression","Severe kidney impairment","Pregnancy","Breastfeeding","Live vaccine administration during treatment"]
⚠️ Warnings & Precautions
["This medicine must be administered only by a qualified healthcare professional in a setting equipped to manage emergencies.","Peripheral neuropathy may worsen with repeated doses and can become permanent. Report symptoms early.","Cold sensitivity can occur during or shortly after infusion. Avoid cold drinks and cold objects.","Severe allergic reactions can occur, sometimes during the first few minutes of infusion. Emergency equipment should be available.","Low blood counts can increase the risk of infection and bleeding. Report fever, chills, or unusual bruising immediately.","This medicine can cause kidney damage. Adequate hydration and monitoring are important.","Avoid live vaccines during treatment.","Use effective contraception during treatment and for a period after the last dose.","Inform your doctor if you have heart disease, lung disease, or a history of blood clots.","Do not drive or operate machinery if you feel dizzy, tired, or have nerve symptoms."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because of the potential for serious side effects in a breastfed baby, breastfeeding is not recommended during treatment and for a period after the last dose as advised by your doctor.
💊 Overdose Management
Overdose of this medicine is a medical emergency. Symptoms may include severe nerve damage, bone marrow suppression, and kidney failure. There is no specific antidote. Treatment is supportive and may include blood transfusions, growth factors, and dialysis if needed. If an overdose is suspected, contact emergency medical services immediately.
⏰ Missed Dose
This medicine is given by a healthcare professional in a clinic or hospital. If you miss a scheduled appointment for your infusion, contact your cancer care team as soon as possible to reschedule. Do not attempt to self-administer this medicine at home.
Additional Safety Advice
This medicine must be given only by a qualified healthcare professional in a setting equipped to manage allergic reactions and other emergencies. Do not attempt to administer it at home. Before each dose, your doctor will check your blood counts, kidney function, liver function, and neurological symptoms. Tell your doctor if you have ever had an allergic reaction to platinum-based drugs, if you have kidney disease, or if you are pregnant or planning pregnancy. Avoid cold drinks and cold objects for a few days after each infusion if you notice cold sensitivity. Use effective contraception during treatment and for a period after the last dose as advised by your doctor. Do not receive live vaccines while on this medicine. Inform any other doctor or dentist treating you that you are receiving this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially nerve damage and bone marrow suppression. Kidney function should be monitored closely, and doses may need to be adjusted. Discuss any concerns with your doctor.
🤰 Pregnancy Planning (TTC)
This medicine can harm the developing baby. Both men and women should use effective contraception during treatment and for a period after the last dose as advised by their doctor. If you are planning pregnancy, discuss with your oncologist before starting treatment.
🏥 Post-Surgery Considerations
If you have recently had surgery, your doctor will decide when it is safe to start this medicine. It is often started after you have recovered from surgery and any wound healing is complete. Inform your surgeon and oncologist about all medicines you are taking.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine before any dental procedure. This medicine can increase the risk of bleeding and infection. Your dentist may recommend delaying procedures until your blood counts are normal. Good oral hygiene is important during treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Gentle exercise such as walking or light stretching can help manage fatigue and improve mood, but avoid strenuous activities if you feel weak or dizzy. If you have peripheral neuropathy, avoid activities that require fine balance or coordination, such as cycling or using gym equipment, until you feel safe. Always consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may need to take time off work for infusions and recovery. Fatigue and nerve symptoms can affect your ability to work, especially if your job requires fine motor skills or driving. Discuss your work schedule with your employer and doctor. Many patients are able to continue working with adjustments.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your oncologist. Treatment schedules are carefully planned. Your doctor may reduce the dose, delay a cycle, or stop treatment if you develop severe side effects such as persistent neuropathy, severe allergic reactions, or very low blood counts. Always follow your doctor's advice.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to persistent peripheral neuropathy, which may not fully resolve after treatment ends. Kidney function may be affected, especially with repeated cycles. Regular monitoring of blood counts, kidney function, and neurological symptoms is important. Some patients may experience ongoing fatigue. Your doctor will assess the benefits and risks of continuing treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the cancer type and stage, other chemotherapy combinations may be used.
Evidence: Well-establishedFor some colorectal cancers, targeted drugs may be used alone or with chemotherapy.
Evidence: Well-establishedFor certain types of colorectal cancer with specific genetic markers, immunotherapy may be an option.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine because it suppresses the immune system. Inactivated vaccines may be given, but their effectiveness may be reduced. Discuss vaccination with your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original packaging and protect from light
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
If you need to travel while receiving this medicine, carry it in its original packaging with the prescription and a letter from your oncologist. This medicine is usually stored in a refrigerator, so use a cool pack during travel and avoid freezing. Check airline and customs regulations for carrying injectable medicines. Plan your travel around your treatment schedule to avoid missing doses. Inform your doctor before traveling, especially if you will be away for an extended period.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working after the first infusion, but measurable tumor response usually takes several weeks and multiple cycles. Your doctor will monitor your progress with scans and blood tests.
A: This medicine is given as an intravenous infusion over 2 hours by a healthcare professional in a clinic or hospital setting.
A: The most common side effects are tingling or numbness in the hands and feet, cold sensitivity, nausea, vomiting, diarrhea, fatigue, and low blood cell counts.
A: You should avoid driving if you feel dizzy, tired, or have nerve symptoms. Ask your doctor when it is safe to drive.
A: No, this medicine can harm the developing baby and is not recommended during pregnancy. Use effective contraception during treatment.
🤔 Common Patient Concerns
🔄 Substitutes for oxitan 100mg infusion
View AllAlternative brands with exact same active ingredient:
-
oxyrea 100 injectionNeon Laboratories Ltd ₹1,510.50 70.2% CHEAPER
-
kinaplat 100mg infusionCadila Pharmaceuticals Ltd ₹1,577.38 68.9% CHEAPER
-
oxichemo 100mg infusionLupin Ltd ₹1,875.00 63% CHEAPER
-
oxaltor 100mg infusionTorrent Pharmaceuticals Ltd ₹2,566.96 49.4% CHEAPER
-
oxpla 100mg injectionZydus Cadila ₹3,271.88 35.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken at home as an injection.
Fact: This medicine must be given only by a healthcare professional in a clinic or hospital setting. - Myth: This medicine causes hair loss in everyone.
Fact: Hair loss is not a common side effect of this medicine, unlike some other chemotherapy drugs. - Myth: You can stop this medicine whenever you feel better.
Fact: Treatment schedules are carefully planned by your oncologist. Do not stop or change the schedule without consulting your doctor. - Myth: This medicine is safe to take during pregnancy.
Fact: This medicine can harm the developing baby and is not recommended during pregnancy.
🔄 Alternative Options
Generic Alternatives
- Oxaliplatin 100 mg injection
Brand Alternatives
- Adplatin 100mg injection