ovalink sr tablet - Dehydroepiandrosterone (Micronized) (75mg) + Folic Acid (4.5mg) medicine

Evaserve Tablet: Complete Guide To Uses, Dosage, And Safety

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🏭 Lincoln Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 27, 2026
⚠️ Hepatotoxicity Risk 🤰 Pregnancy Category Not established from the available information. DHEA is not recommended during pregnancy unless specifically prescribed by a fertility specialist. Folic acid is recommended in pregnancy to prevent neural tube defects, but the DHEA component requires careful medical supervision. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Limited to moderate for DHEA in fertility; well-established for folic acid supplementation.
Reviewed by
SaathiMed Expert Panel | Oct 27, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe allergic reaction with swelling of face, lips, or throat
  • Yellowing of skin or eyes (jaundice)
  • Severe abdominal pain or vomiting blood
  • Sudden severe headache or vision changes
  • Irregular heartbeat or chest pain
  • Unusual vaginal bleeding
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is ovalink sr tablet used for?

This medicine is a prescription oral tablet combining micronized dehydroepiandrosterone (DHEA) 75 mg and folic acid 4.5 mg. It is used in fertility treatment to support ovarian function and prevent neural tube defects. It must be taken under medical supervision.

  • Generic Name: Dehydroepiandrosterone (Micronized) (75mg) + Folic Acid (4.5mg)
  • Manufacturer: Lincoln Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ovalink sr tablet के बारे में (Hindi Summary)

उपयोग: यह दवा मुख्य रूप से महिलाओं में प्रजनन क्षमता बढ़ाने और डिम्बग्रंथि के कार्य को सहारा देने के लिए इस्तेमाल की जाती है। इसमें डीएचईए और फोलिक एसिड होता है, जो अंडों की गुणवत्ता सुधारने और गर्भावस्था के दौरान न्यूरल ट्यूब दोष को रोकने में मदद करता है। यह दवा डॉक्टर की सलाह के बिना नहीं लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँहासे, तैलीय त्वचा, चेहरे पर बाल बढ़ना, मासिक धर्म में अनियमितता और पेट में हल्की गड़बड़ी शामिल हैं। कुछ महिलाओं को स्तनों में कोमलता या मूड में बदलाव भी महसूस हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको सांस लेने में कठिनाई, पीलिया या गंभीर पेट दर्द हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लेने से पेट की परेशानी कम होती है। अपने डॉक्टर को अपनी सभी दवाओं और स्वास्थ्य समस्याओं के बारे में बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं बिना डॉक्टर की सलाह के इसका सेवन न करें। नियमित रूप से हार्मोन और लीवर की जांच कराते रहें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 ovalink sr tablet Uses & Benefits

[{"condition":"Diminished ovarian reserve in women undergoing fertility treatment","description":"This medicine is used as an adjunct to support ovarian response and improve egg quality in women with low ovarian reserve, often before in vitro fertilization cycles.","evidence":"Limited to moderate; used in specialist fertility practice"},{"condition":"Folic acid supplementation in women of childbearing age","description":"The folic acid component helps prevent neural tube defects in babies and supports normal cell division, especially important before conception and in early pregnancy.","evidence":"Well-established for folic acid"},{"condition":"Age-related decline in endogenous DHEA levels","description":"Some clinicians prescribe DHEA for adults with documented low DHEA levels, although this use remains controversial and requires careful monitoring.","evidence":"Limited"}]

Off-label uses: [{"condition":"Poor ovarian responders in assisted reproduction","description":"Sometimes prescribed off-label to women who respond poorly to standard ovarian stimulation protocols.","evidence":"Limited"},{"condition":"Lupus and autoimmune conditions","description":"DHEA has been studied off-label for fatigue and disease activity in some autoimmune conditions, but evidence is not strong enough for routine use.","evidence":"Limited"}]

Primary treatment for: Diminished ovarian reserve

Also treats: Folic acid deficiency, Age-related DHEA decline

📋 Drug Information

Generic Name(s)Dehydroepiandrosterone (Micronized) (75mg) + Folic Acid (4.5mg)
Brand Nameovalink sr tablet
ManufacturerLincoln Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGYNAECOLOGICAL
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C in a cool, dry place away from direct sunlight and moisture. Keep the tablets in their original container tightly closed.
Shelf Life24 months from the date of manufacture, or as printed on the packaging.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset and improve absorption.
2
Do not exceed the prescribed dose, as DHEA can cause hormonal imbalance.
3
Inform your doctor immediately if you experience acne, hair growth, or voice changes.
4
Regular monitoring of hormone levels and liver function is important during treatment.
5
Avoid alcohol while taking this medicine to reduce liver stress.
6
Consult your doctor before starting any new medicine or supplement.
7
If you are pregnant or planning pregnancy, discuss the risks and benefits with your doctor.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Diminished ovarian reserve
This medicine is commonly prescribed for this condition.
Likely Use
✅
Folic acid deficiency
This medicine provides folic acid supplementation.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMicronized dehydroepiandrosterone is absorbed from the gastrointestinal tract after oral administration, and the micronized form is designed to improve dissolution and absorption compared to non-micronized DHEA. Folic acid is rapidly absorbed from the small intestine, with peak serum levels occurring within one to two hours. Food may enhance the absorption of DHEA and reduce gastrointestinal upset.
DistributionDehydroepiandrosterone and its metabolites are distributed widely throughout body tissues, including the ovaries, adrenal glands, skin, and adipose tissue. Folic acid is distributed to all body tissues and is concentrated in the liver, where it is stored and converted to active forms. Both components can cross the placenta, and folic acid is also excreted in breast milk.
Protein BindingDehydroepiandrosterone is highly bound to albumin and sex hormone-binding globulin in the bloodstream. Folic acid is approximately 50% bound to plasma proteins. These binding characteristics influence the availability of free active hormone and vitamin for tissue uptake.
MetabolismDehydroepiandrosterone undergoes extensive metabolism in the liver and peripheral tissues, primarily through conversion to androstenedione, testosterone, and estrogens, as well as sulfation to DHEA sulfate. Folic acid is metabolized in the liver to tetrahydrofolate and other reduced folate forms, which are essential for one-carbon metabolism.
Half-LifeThe elimination half-life of dehydroepiandrosterone is approximately 15 to 30 minutes for the free hormone, while its sulfate metabolite has a much longer half-life of 10 to 20 hours. The half-life of folic acid is approximately 15 to 30 minutes for the parent vitamin, but its active metabolites have longer tissue retention.
ExcretionMetabolites of dehydroepiandrosterone are excreted primarily in the urine as sulfate and glucuronide conjugates, with a small amount in feces. Folic acid and its metabolites are excreted in urine and feces, and some are secreted in breast milk.
BioavailabilityThe oral bioavailability of micronized dehydroepiandrosterone is variable but generally higher than non-micronized forms, with estimates ranging from 10% to 50% depending on individual factors. Folic acid has a bioavailability of approximately 50% to 85% from oral supplements when taken on an empty stomach, and food can slightly reduce its absorption.
Onset of ActionThe onset of action for DHEA effects on ovarian function is not immediate and may take several weeks to months of consistent use. Folic acid begins to raise serum folate levels within hours, but red blood cell folate levels take several weeks to reach steady state.
Peak Plasma TimePeak plasma levels of dehydroepiandrosterone and its sulfate metabolite occur approximately 1 to 3 hours after oral administration. Folic acid reaches peak serum concentrations within 1 to 2 hours after ingestion.
Duration of ActionThe duration of action of DHEA is related to its conversion to longer-acting hormones and its sulfate metabolite, which can persist for many hours. Folic acid effects on cellular metabolism are continuous as long as adequate levels are maintained through daily supplementation.

How It Works

This medicine works through two distinct components. Micronized dehydroepiandrosterone is a natural steroid hormone precursor that the body converts into androgens and estrogens in peripheral tissues. In women with diminished ovarian reserve, this conversion may increase intrafollicular androgen levels, which are thought to improve follicle development and egg quality. Folic acid is a water-soluble B vitamin that serves as a coenzyme in one-carbon transfer reactions essential for DNA synthesis, repair, and methylation. By supporting rapid cell division, folic acid helps prevent neural tube defects and supports normal blood cell formation.

Mechanism Steps

1
Absorption of DHEA and folic acid: After oral intake, micronized dehydroepiandrosterone is absorbed through the gastrointestinal tract, and folic acid is absorbed primarily in the proximal small intestine.
2
Conversion of DHEA to active hormones: In peripheral tissues such as the ovary, adipose tissue, and skin, DHEA is converted to androstenedione and then to testosterone or estrone, which can act on local receptors.
3
Folic acid activation: Folic acid is reduced to dihydrofolate and then to tetrahydrofolate, which enters one-carbon metabolism pathways.
4
Cellular effects: Androgens and estrogens modulate gene expression in target tissues, while tetrahydrofolate supports DNA synthesis and methylation, promoting normal cell division and development.

💡 How to Take ovalink sr tablet

Strength: Immediate-release oral tablet containing 75 mg micronized dehydroepiandrosterone and 4.5 mg folic acid.

1Take one tablet by mouth with a full glass of water.
2Take it with food to reduce stomach upset and improve absorption.
3Swallow the tablet whole; do not crush or chew.
4Take it at the same time each day to maintain consistent levels.
5Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally once daily, preferably with food, or as directed by your physician. The exact dose and duration depend on the indication, your hormone levels, and your response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients should use this medicine with caution and only under medical supervision. Lower doses may be appropriate, and regular monitoring of hormone levels and liver function is recommended.
Renal ImpairmentDose adjustment may be necessary in patients with kidney impairment. Consult your doctor for individualized dosing.
Hepatic ImpairmentDose adjustment may be necessary in patients with liver impairment. Consult your doctor for individualized dosing and monitoring.
Maximum Daily DoseThe maximum daily dose should not exceed one tablet (75 mg DHEA + 4.5 mg folic acid) unless specifically prescribed by your doctor. Do not exceed the recommended dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and improves absorption.
Grapefruit
Avoid excessive intake
May affect liver enzymes and hormone metabolism.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of ovalink sr tablet

✅ Common Side Effects

Acne or oily skin (Common (5-10%))
Use gentle skin care and consult your doctor if it becomes bothersome.
Facial hair growth (Common (5-10%))
Report to your doctor if excessive or distressing.
Menstrual irregularities (Common (5-10%))
Track your cycles and inform your gynecologist.
Nausea or stomach upset (Common (5-10%))
Take with food to reduce symptoms.

🚨 Serious Side Effects

Severe allergic reaction (Rare (<0.1%))
Seek emergency medical help if you experience rash, swelling, or difficulty breathing.
Liver enzyme elevation (Rare (<0.1%))
Report jaundice, dark urine, or abdominal pain to your doctor immediately.
Hormone-sensitive tumor growth (Rare (<0.1%))
Avoid this medicine if you have a history of hormone-sensitive cancer unless cleared by your oncologist.

⚠️ Rare Side Effects

Deepening of voice
Stop the medicine and consult your doctor if voice changes occur.
Severe mood changes
Seek psychiatric or medical advice if you experience depression or anxiety.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Hormone replacement therapy Major
Insulin Moderate
Methotrexate Moderate
Antacids Minor
Sulfasalazine Minor

🚨 Major Interactions

  • Warfarin
  • Hormone replacement therapy

⚡ Moderate Interactions

  • Insulin and oral hypoglycemics
  • Methotrexate

🍷 Alcohol Interaction

Alcohol may increase the risk of liver enzyme abnormalities and can worsen hormonal side effects such as acne and mood changes. It is advisable to limit or avoid alcohol while taking this medicine, especially if you have any liver concerns.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to dehydroepiandrosterone or folic acid","Hormone-sensitive cancers such as breast, uterine, or ovarian cancer","Pregnancy without specialist supervision","Untreated liver disease","Undiagnosed vaginal bleeding"]

⚠️ Warnings & Precautions

["Use only under the supervision of a qualified healthcare professional.","Do not use if you are pregnant or planning pregnancy without medical advice.","Inform your doctor about all medicines and supplements you are taking.","Avoid in patients with a history of hormone-sensitive tumors.","Monitor liver function during long-term therapy.","Keep out of reach of children."]

🤱 Lactation Safety

It is not known whether dehydroepiandrosterone passes into breast milk in significant amounts, but it is generally advised to avoid this medicine during breastfeeding unless clearly needed and prescribed by a doctor. Folic acid is safe in breast milk and is often recommended for nursing mothers.

💊 Overdose Management

Overdose with this medicine may cause severe hormonal side effects such as acne, mood changes, or menstrual irregularities. If you suspect an overdose, contact your doctor or a poison control center immediately. Treatment is supportive and symptomatic, with monitoring of vital signs and hormone levels. Do not induce vomiting unless instructed by a medical professional.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember if it is less than half the dosing interval away. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor, usually once daily with food to improve absorption and reduce stomach upset. Do not increase or decrease the dose on your own, because DHEA is a hormone precursor and inappropriate dosing can disturb your natural hormone balance. Inform your doctor about all other medicines, supplements, and herbal products you are taking, especially hormone therapies, blood thinners, and diabetes medicines. Women who are pregnant, planning pregnancy, or breastfeeding must consult their doctor before using this medicine. Regular monitoring of hormone levels, liver function, and blood counts may be required during treatment. Keep this medicine out of reach of children and store it in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients should use this medicine with caution due to potential hormonal effects and drug interactions. Regular monitoring is advised.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before using this medicine. Folic acid is recommended, but DHEA should only be used under specialist supervision.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be stopped temporarily.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. No specific precautions are usually needed, but maintain good oral hygiene.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to support hormonal balance.
🥗
Eat a balanced diet rich in folate, such as leafy greens and legumes.
😴
Exercise regularly to improve overall well-being.
💧
Get adequate sleep to support hormone regulation.
🧘
Manage stress through yoga or meditation.
🌞
Avoid smoking and excessive alcohol.

🏋️ Exercise Considerations

Moderate exercise is generally safe while taking this medicine. However, if you experience dizziness, fatigue, or unusual muscle pain, consult your doctor before continuing strenuous activities.

🥗 Diet Recommendations

Include folate-rich foods like spinach, lentils, and citrus fruits.
Reduce processed and high-sugar foods.
Stay well hydrated.
Limit caffeine and alcohol.

💼 Impact on Daily Work & Life

This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or mood changes, avoid these activities until you feel normal.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects or become pregnant, contact your doctor immediately for guidance.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to persistent hormonal side effects such as acne, hair changes, and menstrual irregularities. Regular monitoring of liver function, hormone levels, and blood counts is recommended. The need for continued use should be reassessed periodically by your doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Folic acid supplementation alone

If DHEA is not needed, folic acid alone can be taken for neural tube defect prevention.

Evidence: Well-established
Lifestyle and dietary changes

A healthy diet and lifestyle can support fertility and overall health.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. Continue with routine vaccinations as advised by your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture during travel. If crossing time zones, continue taking your dose at the same local time each day. Check customs regulations for carrying prescription medicines in your destination country.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 34-year-old woman with diminished ovarian reserve undergoing IVF
She was prescribed this medicine by her fertility specialist. After three months of consistent use, her doctor noted improved ovarian response during stimulation. She experienced mild acne but managed it with gentle skin care.
💡 Lesson: Consistent use and regular follow-up with your fertility specialist are key to achieving the best outcomes.
👤 A 42-year-old woman with low DHEA levels and fatigue
She started this medicine after blood tests showed low DHEA. Within six weeks, she reported improved energy and mood. Her doctor monitored her hormone levels every three months.
💡 Lesson: Regular monitoring helps ensure safety and effectiveness of hormone supplementation.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: The effects on ovarian function may take several weeks to months. Folic acid levels rise within hours, but red blood cell folate takes weeks to reach steady state.

Q: Can I take this medicine without food?

A: It is best taken with food to reduce stomach upset and improve absorption.

Q: Is it safe during pregnancy?

A: Consult your doctor. Folic acid is beneficial, but DHEA should only be used if specifically prescribed by a specialist.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my liver function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for ovalink sr tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Evaserve Tablet is a general energy booster.
    Fact: It is a prescription hormone and vitamin supplement, not a general tonic.
  • Myth: It can be taken without doctor's advice.
    Fact: It requires medical supervision due to hormonal effects.

🔄 Alternative Options

Generic Alternatives

  • Micronized DHEA 75 mg + Folic Acid 4.5 mg tablet

Brand Alternatives

  • Evaserve Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Evaserve Tablet","composition":"DHEA 75 mg + Folic Acid 4.5 mg","use":"Fertility support"},{"medicine":"DHEA 25 mg","composition":"DHEA 25 mg","use":"Hormone supplementation"}]

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