orcinac-s 100mg/15mg tablet - Aceclofenac (100mg) + Serratiopeptidase (15mg) medicine

Acelo S 100mg/15mg Tablet: Complete Medicine Guide

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🏭 Iva Healthcare Pvt. Ltd. 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Use only if clearly needed and prescribed by a doctor. Avoid in the third trimester. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is orcinac-s 100mg/15mg tablet used for?

This medicine is a combination of Aceclofenac and Serratiopeptidase used to relieve pain and inflammation in conditions like arthritis, post-surgical swelling, and dental pain. It works by reducing prostaglandin synthesis and breaking down inflammatory proteins.

  • Generic Name: Aceclofenac (100mg) + Serratiopeptidase (15mg)
  • Manufacturer: Iva Healthcare Pvt. Ltd.
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 orcinac-s 100mg/15mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एसिटोक्लोफेनाक और सेराटियोपेप्टिडेज़ का संयोजन है, जिसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है। यह गठिया, सर्जरी के बाद की सूजन, दांत दर्द और मासिक धर्म के दर्द में राहत देती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, पेट दर्द, अपच, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, गुर्दे की समस्या और एलर्जी प्रतिक्रिया शामिल हो सकती है।

सुरक्षा सलाह: इस दवा को भोजन के साथ लें। शराब से बचें। अन्य दर्द निवारक दवाओं के साथ न लें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 orcinac-s 100mg/15mg tablet Uses & Benefits

[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces joint pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness associated with rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Helps alleviate pain and inflammation in the spine and sacroiliac joints.","evidence":"Well-established"},{"condition":"Post-surgical swelling","description":"Reduces inflammation and edema following surgical procedures.","evidence":"Moderate"},{"condition":"Dental pain","description":"Provides relief from dental pain and inflammation after dental procedures.","evidence":"Moderate"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label for preventing migraines, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Pain and inflammation

Also treats: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Post-surgical swelling, Dental pain, Dysmenorrhea

📋 Drug Information

Generic Name(s)Aceclofenac (100mg) + Serratiopeptidase (15mg)
Brand Nameorcinac-s 100mg/15mg tablet
ManufacturerIva Healthcare Pvt. Ltd.
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food or milk to minimize stomach upset.
2
Do not exceed the prescribed dose or duration without consulting your doctor.
3
Avoid alcohol and other NSAIDs while taking this medicine.
4
Report any signs of gastrointestinal bleeding, such as black stools or vomiting blood, immediately.
5
If you have kidney or liver disease, your doctor may need to adjust the dose or monitor you closely.
6
Do not use this medicine during the third trimester of pregnancy.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAceclofenac is rapidly absorbed from the gastrointestinal tract after oral administration. Serratiopeptidase is also absorbed orally, though its bioavailability may be influenced by food and gastrointestinal enzymes. Not established from the available information for specific absorption rates.
DistributionAceclofenac is highly protein-bound and distributes well into synovial fluid and inflamed tissues. Serratiopeptidase distributes to sites of inflammation. Not established from the available information for specific volume of distribution.
Protein BindingAceclofenac is approximately 99% bound to plasma proteins. Serratiopeptidase binding is not well established.
MetabolismAceclofenac is metabolized in the liver primarily by cytochrome P450 enzymes, mainly CYP2C9, to inactive metabolites. Serratiopeptidase is metabolized by proteolytic degradation in the gastrointestinal tract and liver.
Half-LifeThe elimination half-life of aceclofenac is approximately 3-4 hours. The half-life of serratiopeptidase is not well established.
ExcretionAceclofenac and its metabolites are excreted primarily via the kidneys (urine) and to a lesser extent in feces. Serratiopeptidase is excreted as degraded peptides.
BioavailabilityThe oral bioavailability of aceclofenac is approximately 80-90%. Bioavailability of serratiopeptidase is not well established.
Onset of ActionAceclofenac typically begins to relieve pain within 30-60 minutes after oral administration. Serratiopeptidase may take longer to exert its anti-edematous effects, often within a few hours to days.
Peak Plasma TimePeak plasma concentration of aceclofenac is reached approximately 1.5-3 hours after oral administration. Peak time for serratiopeptidase is not well established.
Duration of ActionThe analgesic and anti-inflammatory effects of aceclofenac last approximately 12-24 hours, allowing for twice-daily dosing. The duration of serratiopeptidase action is not well established.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Aceclofenac is a non-steroidal anti-inflammatory drug that inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, thereby reducing the synthesis of prostaglandins which are mediators of pain and inflammation. Serratiopeptidase is a proteolytic enzyme that breaks down fibrin and other proteins involved in inflammation, thereby reducing swelling and promoting tissue repair. Together, they provide analgesic, anti-inflammatory, and anti-edema effects.

Mechanism Steps

1
COX enzyme inhibition: Aceclofenac inhibits the cyclooxygenase enzymes, primarily COX-2, which are responsible for converting arachidonic acid into prostaglandins.
2
Reduced prostaglandin synthesis: By inhibiting COX enzymes, aceclofenac decreases the production of prostaglandins, which are key mediators of pain, inflammation, and fever.
3
Proteolytic action: Serratiopeptidase hydrolyzes proteins such as fibrin, bradykinin, and other inflammatory peptides, reducing edema and promoting tissue repair.
4
Enhanced anti-inflammatory effect: The combined actions of aceclofenac and serratiopeptidase result in a synergistic anti-inflammatory and anti-edematous effect.

💡 How to Take orcinac-s 100mg/15mg tablet

Strength: Tablet containing Aceclofenac 100 mg and Serratiopeptidase 15 mg.

1Take the tablet with a full glass of water.
2Swallow it whole; do not crush or chew.
3Take it with food or milk to reduce stomach upset.
4Follow the prescribed schedule exactly.
5Do not take more than the recommended dose.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally twice daily, preferably with food. However, the dose must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine. Use with caution and monitor renal and hepatic function. Dose adjustment may be required.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose is one tablet twice daily (200 mg aceclofenac and 30 mg serratiopeptidase). Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of orcinac-s 100mg/15mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. If it persists, consult your doctor.
Stomach pain (Common (5-10%))
Take with food or milk. Avoid alcohol. Consult doctor if severe.
Indigestion (Common (5-10%))
Take with meals. Avoid spicy foods. Consult doctor if persistent.
Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if severe or persistent.
Dizziness (Uncommon (1-5%))
Avoid driving or operating machinery until you know how it affects you.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black stool, vomiting blood, or severe abdominal pain.
Peptic ulcer (Rare (<0.1%))
Report persistent stomach pain or indigestion to your doctor immediately.
Kidney impairment (Rare (<0.1%))
Seek medical attention if you experience decreased urine output, swelling, or fatigue.
Liver toxicity (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe fatigue to your doctor.
Severe allergic reaction (Very rare (<0.01%))
Seek emergency help if you experience swelling of face, lips, throat, or difficulty breathing.

⚠️ Rare Side Effects

Anaphylaxis
Call emergency services immediately.
Stevens-Johnson syndrome
Seek immediate medical attention if you develop rash, blisters, or peeling skin.
Aplastic anemia
Report unusual tiredness, infections, or bleeding to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Corticosteroids Major
Methotrexate Major
Lithium Major
Antihypertensives Moderate
Diuretics Moderate
SSRIs Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs
  • Corticosteroids
  • Methotrexate
  • Lithium

⚡ Moderate Interactions

  • Antihypertensives
  • Diuretics
  • SSRIs

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding and ulcers.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Active peptic ulcer or gastrointestinal bleeding","Severe heart failure","Severe kidney disease","Severe liver disease","History of asthma triggered by NSAIDs","Third trimester of pregnancy","Known allergy to aceclofenac or serratiopeptidase"]

⚠️ Warnings & Precautions

["Take with food to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not take other NSAIDs without consulting your doctor.","Use with caution in elderly patients.","Monitor kidney and liver function during long-term use.","Inform your doctor if you have a history of stomach ulcers or bleeding.","Do not use during the third trimester of pregnancy."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before use while breastfeeding.

💊 Overdose Management

Seek immediate medical attention. Symptoms of overdose may include severe stomach pain, vomiting, drowsiness, and difficulty breathing. Treatment is supportive and symptomatic.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine with food or milk to reduce stomach upset. Do not take it on an empty stomach. Avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding. Do not take other NSAIDs or pain relievers without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma. Do not use this medicine for more than the recommended duration without medical advice. If you are pregnant or breastfeeding, consult your doctor before taking this medicine. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use with caution and monitor closely.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy. This medicine is generally avoided during the third trimester and may affect fertility.

🏥 Post-Surgery Considerations

This medicine is often used to reduce post-surgical swelling and pain. Follow your surgeon's instructions regarding dosing and duration.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that may increase pain and swelling. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if you experience severe side effects such as stomach bleeding, allergic reactions, or kidney problems. Do not stop abruptly without consulting your doctor if you have been on long-term therapy.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney impairment, liver toxicity, and cardiovascular events. Regular monitoring of kidney and liver function is advised. Use the lowest effective dose for the shortest duration.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Hot/cold compresses

May help reduce localized swelling and pain.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are established. Consult your doctor for personalized advice.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old man with post-surgical swelling
After knee surgery, he was prescribed this medicine. Swelling reduced noticeably within a few days, and pain was well controlled. He was advised to avoid alcohol and monitor for any stomach discomfort.
💡 Lesson: This medicine effectively reduces post-surgical edema and pain when taken as directed.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Aceclofenac typically begins to relieve pain within 30-60 minutes, while serratiopeptidase may take a few hours to days to reduce swelling.

Q: Can I take it on an empty stomach?

A: No, it should be taken with food or milk to reduce stomach upset.

Q: Is it safe during pregnancy?

A: Consult your doctor. It is generally avoided in the third trimester.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for orcinac-s 100mg/15mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure arthritis.
    Fact: It only relieves symptoms; it does not cure the underlying condition.
  • Myth: It is safe to take indefinitely.
    Fact: Long-term use can cause serious side effects; use only as prescribed.

🔄 Alternative Options

Generic Alternatives

  • Aceclofenac + Serratiopeptidase generic tablets

Brand Alternatives

  • Acelo S
  • Aceclo S
  • Aceclofenac Serratiopeptidase

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Aceclofenac 100 mg + Serratiopeptidase 15 mg","uses":"Pain and inflammation","notes":"Combination provides anti-inflammatory and anti-edema effects."},{"medicine":"Aceclofenac alone","composition":"Aceclofenac 100 mg","uses":"Pain and inflammation","notes":"Lacks anti-edema effect of serratiopeptidase."}]

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