axyclo tablet sr - Aceclofenac (100mg) + Serratiopeptidase (15mg) medicine

Acimol-SP Tablet: Complete Medicine Guide

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🏭 Axyzen Life Sciences 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 18, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Use only if clearly needed and prescribed by a doctor. Avoid in the third trimester. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for approved indications.
Reviewed by
SaathiMed Expert Panel | Oct 18, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is axyclo tablet sr used for?

This medicine is a combination of aceclofenac and serratiopeptidase used to relieve pain and inflammation in conditions like arthritis and post-operative swelling. It works by reducing prostaglandins and breaking down fibrin.

  • Generic Name: Aceclofenac + Serratiopeptidase
  • Manufacturer: Axyzen Life Sciences
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 axyclo tablet sr के बारे में (Hindi Summary)

उपयोग: यह दवा एसिटोक्लोफेनैक और सेरेशियोपेप्टिडेज़ का संयोजन है, जिसका उपयोग गठिया, जोड़ों के दर्द, सूजन, और ऑपरेशन के बाद होने वाली सूजन को कम करने के लिए किया जाता है। यह दर्द और सूजन को कम करने में मदद करती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, पेट दर्द, अपच, सिरदर्द, चक्कर आना और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन पेट में रक्तस्राव, अल्सर, गुर्दे की समस्या, और एलर्जी प्रतिक्रिया हो सकती है। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन न करें। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको गुर्दे या लीवर की बीमारी है, तो डॉक्टर से परामर्श लें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 axyclo tablet sr Uses & Benefits

[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces joint pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness associated with rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Helps alleviate pain and inflammation in the spine and sacroiliac joints.","evidence":"Well-established"},{"condition":"Post-operative inflammation","description":"Reduces swelling and pain after surgical procedures.","evidence":"Moderate"},{"condition":"Dental pain and swelling","description":"Used for pain and inflammation following dental extractions or oral surgery.","evidence":"Moderate"},{"condition":"Soft tissue injuries","description":"Helps reduce pain and swelling in sprains, strains, and sports injuries.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label for preventing migraines, but evidence is limited.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain, though not a first-line treatment.","evidence":"Limited"}]

Primary treatment for: Inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and post-operative swelling.

Also treats: Ankylosing spondylitis, Dental pain, Soft tissue injuries, Dysmenorrhea

📋 Drug Information

Generic Name(s)Aceclofenac + Serratiopeptidase
Brand NameAcimol-SP Tablet
ManufacturerAxyzen Life Sciences
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNSAID + Proteolytic Enzyme
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place away from direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Stay well hydrated throughout the day.
3
Avoid alcohol while taking this medicine.
4
Do not take more than the prescribed dose.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual bleeding or bruising immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Post-operative swelling
This medicine helps reduce swelling after surgery.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAceclofenac is rapidly absorbed after oral administration. Serratiopeptidase is absorbed through the intestinal mucosa, though its systemic bioavailability is debated.
DistributionAceclofenac is highly protein-bound and distributes into synovial fluid, liver, and other tissues. Serratiopeptidase distribution is not well characterized.
Protein BindingAceclofenac is approximately 99% bound to plasma proteins. Serratiopeptidase binding is not established from the available information.
MetabolismAceclofenac is metabolized in the liver primarily by CYP2C9 to inactive metabolites. Serratiopeptidase is likely degraded by proteases in the gastrointestinal tract and plasma.
Half-LifeThe elimination half-life of aceclofenac is approximately 3-4 hours. The half-life of serratiopeptidase is not established from the available information.
ExcretionAceclofenac metabolites are excreted mainly in urine and feces. Serratiopeptidase excretion is not established from the available information.
BioavailabilityThe oral bioavailability of aceclofenac is approximately 80-100%. The bioavailability of serratiopeptidase is not established from the available information.
Onset of ActionPain relief typically begins within 30-60 minutes after oral administration of aceclofenac. The anti-edema effect of serratiopeptidase may take several hours to days.
Peak Plasma TimePeak plasma concentration of aceclofenac is reached in about 1.5-3 hours. Peak time for serratiopeptidase is not established from the available information.
Duration of ActionThe analgesic and anti-inflammatory effects of aceclofenac last approximately 12-24 hours. The duration of serratiopeptidase action is not established from the available information.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Aceclofenac is a non-steroidal anti-inflammatory drug that inhibits the cyclooxygenase enzymes COX-1 and COX-2, leading to decreased synthesis of prostaglandins, prostacyclin, and thromboxane. This results in analgesic, anti-inflammatory, and antipyretic effects. Serratiopeptidase is a proteolytic enzyme that hydrolyzes fibrin and other proteins, reducing edema and promoting tissue repair. Together, they provide symptomatic relief in inflammatory conditions.

Mechanism Steps

1
COX enzyme inhibition: Aceclofenac binds to and inhibits cyclooxygenase enzymes, blocking the conversion of arachidonic acid to prostaglandins.
2
Reduced prostaglandin synthesis: Decreased prostaglandin levels lead to reduced pain, inflammation, and fever.
3
Proteolytic action: Serratiopeptidase hydrolyzes fibrin and other proteins, breaking down dead tissue and reducing edema.
4
Enhanced tissue repair: By clearing fibrin deposits, serratiopeptidase improves blood flow and promotes healing.

💡 How to Take axyclo tablet sr

Strength: Tablet containing Aceclofenac 100 mg and Serratiopeptidase 15 mg.

1Take the tablet orally with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Follow your doctor's prescribed dose and duration.
5Do not take more than the recommended dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally once or twice daily, preferably after meals. The exact dose and duration depend on the condition being treated, its severity, and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and renal impairment. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with renal impairment. Dose reduction may be necessary. Consult your doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction may be necessary. Consult your doctor for individualized dosing.
Maximum Daily DoseThe maximum recommended daily dose is 200 mg of aceclofenac (two tablets) and 30 mg of serratiopeptidase. Do not exceed this without medical advice.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of axyclo tablet sr

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food. If persistent, consult your doctor.
Stomach pain (Common (5-10%))
Take with food or milk. Avoid alcohol. Consult doctor if severe.
Indigestion (Common (5-10%))
Take with meals. Avoid spicy foods. Consult doctor if persistent.
Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if severe or persistent.
Dizziness (Uncommon (1-5%))
Avoid driving or operating machinery until you feel normal.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black stool, vomiting blood, or severe abdominal pain.
Peptic ulcer (Rare (<0.1%))
Report persistent stomach pain or indigestion to your doctor immediately.
Kidney impairment (Rare (<0.1%))
Seek medical attention if you notice decreased urine output or swelling.
Liver toxicity (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe fatigue immediately.
Severe allergic reaction (Rare (<0.1%))
Seek emergency care if you experience swelling of face, lips, throat, or difficulty breathing.

⚠️ Rare Side Effects

Anaphylaxis
Call emergency services immediately.
Stevens-Johnson syndrome
Seek immediate medical attention if you develop rash, blisters, or peeling skin.
Aplastic anemia
Report unusual fatigue, bruising, or infections to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Corticosteroids Major
Methotrexate Major
Antihypertensives Moderate
Diuretics Moderate
Lithium Moderate
Antacids Minor
Aspirin Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs
  • Corticosteroids
  • Methotrexate

⚡ Moderate Interactions

  • Antihypertensives
  • Diuretics
  • Lithium

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and may worsen stomach irritation.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to aceclofenac, serratiopeptidase, or any component","History of gastrointestinal bleeding or peptic ulcer","Severe heart failure","Severe renal impairment","Severe hepatic impairment","Third trimester of pregnancy","Active bleeding disorders","Use in children below 18 years (unless prescribed)"]

⚠️ Warnings & Precautions

["Take with food to minimize stomach upset.","Avoid alcohol during treatment.","Do not use for prolonged periods without medical supervision.","Use with caution in the elderly.","Inform your doctor if you have asthma, as NSAIDs may trigger bronchospasm.","Do not drive if you experience dizziness.","Stop use and consult doctor if you notice signs of bleeding."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before use while breastfeeding.

💊 Overdose Management

Overdose may cause nausea, vomiting, stomach pain, dizziness, and in severe cases, gastrointestinal bleeding, kidney failure, or liver damage. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Always take it with food or milk to reduce stomach irritation. Avoid alcohol while taking this medicine as it increases the risk of stomach bleeding. Do not take other NSAIDs or pain relievers without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Do not drive or operate heavy machinery if you feel dizzy. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration and monitor closely.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy if you are taking this medicine. Avoid use during the third trimester.

🏥 Post-Surgery Considerations

This medicine may be prescribed after surgery to reduce pain and swelling. Follow your surgeon's instructions carefully and report any unusual bleeding.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that may increase pain and swelling. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. Take breaks and avoid prolonged standing if you have joint pain.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if you experience severe side effects such as stomach bleeding, allergic reactions, or if your symptoms do not improve within the prescribed duration. Do not stop abruptly without consulting your doctor if you have been on long-term therapy.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney impairment, liver toxicity, and cardiovascular events. Regular monitoring of liver and kidney function is advised. Use the lowest effective dose for the shortest duration.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Hot and cold compresses

Helps reduce swelling and pain.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information. Consult your doctor regarding vaccination timing while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and avoid exposure to extreme heat or moisture. If traveling across time zones, adjust dosing times as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old woman with post-operative swelling after knee replacement
Was prescribed this medicine for 5 days after surgery. Swelling reduced significantly, and pain was well controlled. She was advised to avoid alcohol and monitor for any signs of bleeding.
💡 Lesson: Short-term use under medical supervision is effective and safe for post-operative inflammation.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Pain relief typically begins within 30-60 minutes after taking this medicine. The anti-swelling effect may take a few hours to days.

Q: Can I take this medicine on an empty stomach?

A: No, it should be taken with food or milk to reduce stomach irritation.

Q: Is it safe to take this medicine with other painkillers?

A: Do not take other NSAIDs or painkillers without consulting your doctor, as it may increase the risk of side effects.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for axyclo tablet sr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken on an empty stomach.
    Fact: It should be taken with food to reduce stomach irritation.
  • Myth: It is safe to take this medicine for long periods without monitoring.
    Fact: Long-term use requires medical supervision and monitoring of liver and kidney function.
  • Myth: This medicine is a antibiotic.
    Fact: It is not an antibiotic; it is a combination of an NSAID and an enzyme.

🔄 Alternative Options

Generic Alternatives

  • Aceclofenac + Serratiopeptidase generic tablets

Brand Alternatives

  • Aceclo-SP
  • Zerodol-SP
  • Hifenac-SP
  • Acenac-SP

📊 Comparison with Similar Medicines

[{"medicine":"Aceclofenac + Serratiopeptidase","composition":"Aceclofenac 100mg + Serratiopeptidase 15mg","uses":"Pain and inflammation","notes":"This medicine"},{"medicine":"Aceclofenac + Paracetamol","composition":"Aceclofenac 100mg + Paracetamol 325mg","uses":"Pain and fever","notes":"No enzyme component"},{"medicine":"Diclofenac + Serratiopeptidase","composition":"Diclofenac 50mg + Serratiopeptidase 10mg","uses":"Pain and inflammation","notes":"Different NSAID"}]

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