Metafolate Tablet: Complete Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Muscle pain or difficulty breathing
- Severe stomach pain with nausea or vomiting
- Extreme tiredness or weakness
- Blood in stool or vomit
- Yellowing of skin or eyes
- Decreased urine output
- Sudden swelling of face, lips, or throat
- Severe hypoglycemia symptoms (shakiness, sweating, confusion)
If experiencing severe symptoms, call emergency services immediately.
What is oosure-m tablet used for?
This medicine is a combination of Metformin 500 mg and L-Methyl Folate 0.5 mg used to treat type 2 diabetes and support folate levels. It is taken orally with meals, usually once or twice daily, as prescribed by a doctor. It helps lower blood sugar and may reduce homocysteine levels.
- Generic Name: Metformin (500mg) + L-Methyl Folate (0.5mg)
- Manufacturer: Akumentis Healthcare Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 oosure-m tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेटफॉर्मिन 500 मिलीग्राम और एल-मिथाइल फोलेट 0.5 मिलीग्राम का संयोजन है। इसका उपयोग टाइप 2 डायबिटीज (मधुमेह) के इलाज में किया जाता है, खासकर उन लोगों में जिनमें फोलेट की कमी या हाइपरहोमोसिस्टीनemia की समस्या होती है। यह दवा रक्त शर्करा को नियंत्रित करने में मदद करती है और शरीर में फोलेट के स्तर को बनाए रखती है। इसे डॉक्टर के निर्देशानुसार भोजन के साथ लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट में असुविधा, भूख न लगना और मुँह में धातु जैसा स्वाद शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ हफ्तों में ठीक हो जाते हैं। कभी-कभी सिरदर्द, चक्कर आना या थकान हो सकती है। दुर्लभ मामलों में लैक्टिक एसिडोसिस हो सकता है, जो एक गंभीर स्थिति है। अगर आपको मांसपेशियों में दर्द, सांस लेने में कठिनाई, पेट में दर्द या अत्यधिक थकान महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार भोजन के साथ लें। दिनभर पर्याप्त पानी पिएं। शराब का सेवन न करें या सीमित करें, क्योंकि इससे लैक्टिक एसिडोसिस और लो ब्लड शुगर का खतरा बढ़ सकता है। अगर आपको किडनी, लिवर या हृदय की समस्या है, तो डॉक्टर को बताएं। नियमित रूप से ब्लड शुगर, किडनी फंक्शन और विटामिन बी12 की जांच कराएं। डॉक्टर की सलाह के बिना दवा बंद न करें।
💊 oosure-m tablet Uses & Benefits
[{"condition":"Type 2 diabetes mellitus","description":"This medicine helps lower blood glucose levels in adults with type 2 diabetes when used along with diet and exercise.","evidence":"Well-established"},{"condition":"Folate deficiency","description":"The L-Methyl Folate component helps correct low folate levels and supports red blood cell production.","evidence":"Well-established"},{"condition":"Hyperhomocysteinemia","description":"L-Methyl Folate helps lower elevated homocysteine levels, which may be associated with cardiovascular risk.","evidence":"Moderate"},{"condition":"Prediabetes","description":"Metformin may be prescribed in some cases to delay progression to type 2 diabetes in high-risk individuals.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Polycystic ovary syndrome (PCOS)","description":"Metformin is sometimes used off-label to improve insulin sensitivity and menstrual regularity in PCOS.","evidence":"Moderate"},{"condition":"Weight management","description":"Metformin may cause modest weight loss in some individuals, but it is not approved as a weight-loss medicine.","evidence":"Limited"},{"condition":"Gestational diabetes","description":"Metformin is occasionally used in gestational diabetes under specialist supervision, but it is not first-line therapy.","evidence":"Limited"}]
Primary treatment for: Type 2 diabetes mellitus
Also treats: Folate deficiency, Hyperhomocysteinemia, Prediabetes, Polycystic ovary syndrome (off-label)
📋 Drug Information
| Generic Name(s) | Metformin (500mg) + L-Methyl Folate (0.5mg) |
| Brand Name | oosure-m tablet |
| Manufacturer | Akumentis Healthcare Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from direct sunlight, moisture, and heat. Do not refrigerate unless specified. Keep in the original container tightly closed. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. |
| WHO Guideline | The World Health Organization includes metformin in its Essential Medicines List for the treatment of type 2 diabetes. Specific recommendations for this combination product are not established from the available information. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines for the management of type 2 diabetes recommend metformin as a first-line oral antidiabetic agent. The addition of L-Methyl Folate may be considered in patients with folate deficiency or elevated homocysteine. Specific recommendations for this fixed-dose combination are not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Metformin works mainly by reducing glucose production in the liver, decreasing glucose absorption from the intestines, and improving the body's sensitivity to insulin. It does not directly stimulate insulin release from the pancreas, so it rarely causes hypoglycemia when used alone. L-Methyl Folate is the active form of folate that participates in one-carbon metabolism, supporting DNA synthesis, red blood cell formation, and the conversion of homocysteine to methionine. Together, these ingredients help manage blood sugar while supporting nutritional folate status.
Mechanism Steps
💡 How to Take oosure-m tablet
Strength: Metformin 500 mg + L-Methyl Folate 0.5 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily with meals, or as prescribed by your doctor. The dose depends on your blood sugar levels, kidney function, and overall health. Your doctor may start with a lower dose and gradually increase it. Do not change the dose without consulting your doctor. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially if kidney function is reduced. Your doctor will adjust the dose based on kidney function and overall health. Regular monitoring of blood sugar and kidney function is important. |
| Renal Impairment | This medicine is contraindicated in severe kidney impairment (eGFR <30 mL/min/1.73 m²). In mild to moderate kidney impairment, the dose may need to be reduced. Your doctor will check your kidney function before and during treatment. Do not take this medicine if you have severe kidney disease. |
| Hepatic Impairment | This medicine should be used with caution in people with liver disease because of the increased risk of lactic acidosis. Your doctor may reduce the dose or recommend alternative treatment. Regular liver function tests may be advised. |
| Maximum Daily Dose | The maximum recommended daily dose of metformin is 2000-2550 mg, depending on the formulation. The maximum daily dose of L-Methyl Folate in this combination is 0.5 mg. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of oosure-m tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Iodinated contrast media | Major | |
| Alcohol | Major | |
| Diuretics | Moderate | |
| Cimetidine | Moderate | |
| Sulfonylureas | Moderate | |
| Insulin | Moderate | |
| Phenytoin | Moderate | |
| Antacids | Minor | |
| Vitamin B12 supplements | Minor | |
| Corticosteroids | Moderate |
🚨 Major Interactions
- Iodinated contrast media
- Alcohol
- Diuretics (e.g., furosemide)
- Cationic drugs (e.g., cimetidine)
⚡ Moderate Interactions
- Sulfonylureas (e.g., glibenclamide)
- Insulin
- Phenytoin
🍷 Alcohol Interaction
Alcohol should be avoided or limited while taking this medicine. Alcohol increases the risk of lactic acidosis, a rare but serious complication of metformin. It can also cause hypoglycemia, especially if you skip meals. If you drink alcohol, do so in moderation and always with food. Discuss safe limits with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["Lactic acidosis is a rare but serious complication. Seek immediate medical help if you experience muscle pain, difficulty breathing, stomach pain, or extreme tiredness.","Your doctor may temporarily stop this medicine before surgery or imaging tests with contrast dye.","Avoid excessive alcohol consumption while taking this medicine.","Monitor blood sugar regularly as advised by your doctor.","Inform your doctor if you have kidney, liver, or heart problems.","Long-term use may cause vitamin B12 deficiency. Periodic monitoring is recommended.","Do not use this medicine for weight loss without medical supervision.","Keep all appointments for blood tests and check-ups."]
🤱 Lactation Safety
Metformin is excreted in small amounts in breast milk. It is generally considered compatible with breastfeeding, but monitoring of the infant's blood sugar is advised. L-Methyl Folate is also present in breast milk and is considered safe. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause lactic acidosis, which is a medical emergency. Symptoms include severe nausea, vomiting, diarrhea, stomach pain, muscle pain, difficulty breathing, and extreme tiredness. If you suspect an overdose, seek immediate medical attention. Treatment may include supportive care, intravenous fluids, and hemodialysis to remove metformin from the blood. Do not try to induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure what to do, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually with meals to reduce stomach upset. Do not crush, chew, or break the tablet unless your doctor advises otherwise. Drink plenty of water throughout the day to help your kidneys clear the medicine and reduce the risk of lactic acidosis. Avoid excessive alcohol consumption while taking this medicine, as alcohol increases the risk of lactic acidosis and low blood sugar. Inform your doctor if you have kidney, liver, or heart problems before starting this medicine. Your doctor may check your kidney function, vitamin B12 levels, and blood sugar regularly. Do not stop taking this medicine suddenly without consulting your doctor. If you are scheduled for a surgery or imaging test with contrast dye, tell your doctor that you are taking this medicine. Keep this medicine out of reach of children and store it in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially if kidney function is reduced. Your doctor will adjust the dose based on kidney function and overall health. Regular monitoring of blood sugar, kidney function, and vitamin B12 levels is important. Falls and dizziness should be reported to your doctor.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Metformin may be continued during pregnancy under medical supervision, but your doctor will weigh the benefits and risks. L-Methyl Folate is beneficial for preventing neural tube defects. Do not start or stop any medicine without consulting your doctor.
🏥 Post-Surgery Considerations
This medicine may need to be temporarily stopped before surgery or imaging tests with contrast dye because of the risk of lactic acidosis and kidney injury. Your doctor will advise you when to stop and when to restart. Follow your doctor's instructions carefully.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. There is no significant interaction with dental anesthetics, but maintaining good blood sugar control is important for healing. If you are scheduled for a procedure that requires fasting, consult your doctor about dose adjustments.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe and beneficial while taking this medicine. However, if you experience symptoms of hypoglycemia (shakiness, sweating, confusion) during exercise, stop and eat or drink something sugary. Stay hydrated, especially during intense workouts. If you have heart or kidney problems, consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people, especially when starting treatment. Avoid driving or operating heavy machinery if you feel dizzy or unwell. Most people can continue their normal work routine while taking this medicine. Inform your employer if you have diabetes and need regular breaks for meals or blood sugar monitoring.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects like lactic acidosis, severe allergic reaction, or persistent hypoglycemia, seek immediate medical attention. Your doctor may adjust the dose or switch to a different medicine if needed. Always follow your doctor's advice regarding when to stop.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to vitamin B12 deficiency, which can cause anemia and nerve problems. Regular monitoring of vitamin B12 levels is recommended. Metformin may also cause mild gastrointestinal symptoms that usually improve over time. L-Methyl Folate is generally safe for long-term use. Your doctor will monitor your kidney function, blood sugar, and overall health regularly. Do not stop this medicine without consulting your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are essential for managing type 2 diabetes and can complement medicine.
Evidence: Well-establishedSulfonylureas, DPP-4 inhibitors, or SGLT2 inhibitors may be used as alternatives or in combination.
Evidence: Well-establishedEating foods high in folate can help maintain normal folate levels.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you have diabetes, you may be at higher risk of infections. Discuss with your doctor about recommended vaccines such as influenza, pneumococcal, and hepatitis B vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. Store it at room temperature and away from direct sunlight. If you are crossing time zones, continue taking your doses at the usual times relative to meals. Check customs regulations for carrying prescription medicines. Carry enough supply for your entire trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within a few days, but the full effect may take 1-2 weeks. L-Methyl Folate begins to raise folate levels within hours, but clinical effects on homocysteine may take several weeks.
A: It is best to take this medicine with meals to reduce stomach upset. Taking it on an empty stomach may increase the risk of nausea and diarrhea.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is not safe for people with severe kidney disease. Your doctor will check your kidney function before and during treatment. In mild to moderate kidney impairment, the dose may need to be adjusted.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps manage blood sugar levels but does not cure diabetes. Lifestyle changes and regular monitoring are essential. - Myth: This medicine causes weight gain.
Fact: Metformin typically does not cause weight gain and may even cause modest weight loss in some people. - Myth: You can stop taking this medicine once your sugar levels are normal.
Fact: Do not stop this medicine without consulting your doctor. Stopping suddenly can cause blood sugar levels to rise again. - Myth: This medicine is safe for everyone.
Fact: This medicine is not safe for people with severe kidney disease, metabolic acidosis, or known allergies to its ingredients.
🔄 Alternative Options
Generic Alternatives
- Metformin 500 mg + L-Methyl Folate 0.5 mg tablet (generic)
Brand Alternatives
- Metafolate Tablet