Diof 200 mg/600 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Seizures or confusion
- Sudden joint pain or swelling
- Severe skin rash with blisters
If experiencing severe symptoms, call emergency services immediately.
What is ofm 200mg/600mg tablet used for?
This medicine is a combination antibiotic containing Ofloxacin 200 mg and Metronidazole 600 mg. It is used to treat bacterial and protozoal infections, especially infectious diarrhoea and dysentery. It works by killing bacteria and protozoa. It is a prescription-only medicine and must be taken exactly as directed.
- Generic Name: Ofloxacin (200mg) + Metronidazole (600mg)
- Manufacturer: Lekar Pharma Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ofm 200mg/600mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ओफ्लोक्सासिन 200 मिलीग्राम और मेट्रोनिडाजोल 600 मिलीग्राम का संयोजन है। इसका उपयोग बैक्टीरियल और प्रोटोज़ोअल संक्रमणों, विशेष रूप से संक्रामक दस्त और पेचिश के इलाज के लिए किया जाता है। यह पेट और आंतों के संक्रमण में भी प्रभावी है। यह दवा केवल डॉक्टर के पर्चे पर ही मिलती है और इसे डॉक्टर के निर्देशानुसार ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में असहजता, मुँह में धातु जैसा स्वाद, सिरदर्द और चक्कर आना शामिल हैं। कुछ रोगियों में भूख न लगना, दस्त या कब्ज भी हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें टेंडन टूटना, तंत्रिका क्षति, दौरे और त्वचा पर गंभीर प्रतिक्रियाएँ शामिल हो सकती हैं। शराब के साथ इस दवा का सेवन करने पर गंभीर प्रतिक्रिया हो सकती है।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। दवा को पानी के साथ निगलें। इलाज के दौरान और आखिरी खुराक के 48 घंटे बाद तक शराब बिल्कुल न लें। अगर आपको चक्कर आते हैं तो वाहन न चलाएँ। धूप में बाहर निकलते समय सनस्क्रीन और सुरक्षात्मक कपड़े पहनें। गुर्दे या जिगर की समस्या, हृदय रोग या टेंडन की समस्या हो तो डॉक्टर को बताएं।
💊 ofm 200mg/600mg tablet Uses & Benefits
[{"condition":"Infectious diarrhoea and dysentery","description":"This medicine is used to treat diarrhoea caused by susceptible bacteria and protozoa, including Shigella, Salmonella, and Entamoeba histolytica.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"It is prescribed for mixed aerobic-anaerobic infections such as intra-abdominal abscesses and peritonitis, often as part of a broader treatment plan.","evidence":"Well-established"},{"condition":"Pelvic inflammatory disease","description":"This combination may be used in certain regimens for pelvic inflammatory disease, though other antibiotics are often preferred.","evidence":"Moderate"},{"condition":"Bacterial vaginosis","description":"Metronidazole component is effective against Gardnerella vaginalis, and ofloxacin may cover other associated bacteria.","evidence":"Moderate"},{"condition":"Giardiasis","description":"The metronidazole component is effective against Giardia lamblia, and ofloxacin may help with concurrent bacterial infections.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Helicobacter pylori eradication","description":"Sometimes used as part of combination regimens, though not a first-line choice.","evidence":"Limited"},{"condition":"Diverticulitis","description":"May be used in mild cases, but other regimens are more standard.","evidence":"Limited"}]
Primary treatment for: Infectious diarrhoea and dysentery
Also treats: Intra-abdominal infections, Pelvic inflammatory disease, Bacterial vaginosis, Giardiasis
📋 Drug Information
| Generic Name(s) | Ofloxacin (200mg) + Metronidazole (600mg) |
| Brand Name | ofm 200mg/600mg tablet |
| Manufacturer | Lekar Pharma Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimicrobial agents with distinct mechanisms. Ofloxacin is a fluoroquinolone that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination. This leads to bacterial cell death. Metronidazole is a nitroimidazole prodrug that enters anaerobic organisms and is reduced by ferredoxin-like electron transport proteins to form reactive nitro radical anions. These reactive metabolites cause DNA strand breakage and inhibit nucleic acid synthesis, leading to cell death. The combination provides broad-spectrum coverage against aerobic Gram-negative bacteria and anaerobic bacteria and protozoa.
Mechanism Steps
💡 How to Take ofm 200mg/600mg tablet
Strength: Each tablet contains Ofloxacin 200 mg and Metronidazole 600 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally twice daily, or as prescribed by your doctor. The exact dose and duration depend on the type and severity of the infection, your kidney and liver function, and other medications you are taking. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Complete the full course even if you feel better. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially tendon rupture, central nervous system effects, and QT prolongation. Dose adjustment may be necessary based on renal function. Use with caution and monitor closely. |
| Renal Impairment | Ofloxacin requires dose adjustment in patients with renal impairment. For creatinine clearance below 50 mL/min, the dose may need to be reduced or the dosing interval extended. Metronidazole generally does not require adjustment, but caution is advised. Consult your doctor for specific guidance. |
| Hepatic Impairment | Metronidazole is metabolized in the liver, and dose reduction may be necessary in severe hepatic impairment. Ofloxacin undergoes limited hepatic metabolism. Use with caution in patients with liver disease and monitor liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet twice daily (Ofloxacin 400 mg + Metronidazole 1200 mg). Do not exceed this unless specifically directed by a specialist. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ofm 200mg/600mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Amiodarone | Major | |
| Antacids (Al/Mg) | Moderate | |
| Theophylline | Moderate | |
| Caffeine | Moderate | |
| Lithium | Moderate | |
| Phenytoin | Moderate | |
| Sucralfate | Minor | |
| Iron supplements | Minor |
🚨 Major Interactions
- Warfarin
- Alcohol
- QT-prolonging drugs (e.g., amiodarone, sotalol)
- Antacids containing aluminum or magnesium
- Theophylline
⚡ Moderate Interactions
- Caffeine
- Cimetidine
- Lithium
- Phenytoin
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Metronidazole can cause a disulfiram-like reaction characterized by severe nausea, vomiting, flushing, headache, and palpitations. This reaction can be dangerous and requires immediate medical attention if it occurs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ofloxacin, metronidazole, or other quinolones or nitroimidazoles","Pregnancy and breastfeeding","Children and adolescents under 18 years (unless specifically directed by a specialist)","History of tendon disorders related to fluoroquinolone use","Myasthenia gravis","Severe hepatic impairment","Alcohol consumption during treatment and for 48 hours after"]
⚠️ Warnings & Precautions
["Fluoroquinolones, including ofloxacin, can cause disabling and potentially irreversible serious adverse reactions, including tendinitis, tendon rupture, peripheral neuropathy, and central nervous system effects. Reserve for patients with no alternative treatment options.","Avoid alcohol completely during treatment and for 48 hours after the last dose due to disulfiram-like reaction.","May cause dizziness and confusion; avoid driving or operating machinery until you know how it affects you.","Can cause photosensitivity; use sunscreen and protective clothing.","May prolong QT interval; use with caution in patients with cardiac disease or electrolyte abnormalities.","May cause blood sugar disturbances; monitor glucose in diabetic patients.","Not for use in viral infections.","Complete the full course as prescribed to prevent resistance."]
🤱 Lactation Safety
Both ofloxacin and metronidazole are excreted in breast milk. This medicine is generally not recommended during breastfeeding. If treatment is essential, breastfeeding may need to be interrupted during therapy and for 48 hours after the last dose. Consult your doctor for guidance.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, dizziness, and potentially seizures. There is no specific antidote. Treatment is supportive and symptomatic. Gastric lavage may be considered if ingestion is recent. Monitor vital signs, ECG, and renal function. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop treatment early, even if you feel better, because incomplete treatment can lead to resistance. Swallow the tablet whole with a full glass of water. Avoid alcohol completely during treatment and for at least 48 hours after the last dose, as it can cause a severe reaction. Do not drive or operate heavy machinery if you feel dizzy or confused. Use sunscreen and protective clothing when outdoors because this medicine can make your skin more sensitive to sunlight. Inform your doctor if you have kidney or liver problems, heart rhythm disorders, or a history of tendon problems. Do not share this medicine with others. Keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, central nervous system effects, and QT prolongation. Dose adjustment may be needed based on kidney function. Monitor closely for side effects.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. If you are trying to conceive, consult your doctor for alternative treatments. Use effective contraception during treatment.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent infections after surgery. Inform your surgeon and anesthesiologist about all medicines you are taking. It may interact with other medications used during surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with other medications and can increase the risk of bleeding. Your dentist may recommend postponing elective procedures until you complete the course.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, as it can increase the risk of tendon rupture. Light activities like walking are generally safe. If you experience joint pain or swelling, stop exercising and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause dizziness, confusion, and fatigue, which may affect your ability to drive or operate machinery. Avoid driving or operating heavy machinery until you know how the medicine affects you. Take sick leave if needed to rest and recover.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance. If you experience serious side effects, contact your doctor immediately for guidance.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of antibiotic resistance, tendon problems, peripheral neuropathy, and liver or kidney issues. It should only be used for the prescribed duration. Regular monitoring of kidney and liver function may be required if prolonged therapy is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for managing dehydration caused by diarrhoea.
Evidence: Well-establishedMay help restore gut flora and reduce antibiotic-associated diarrhoea.
Evidence: ModerateCan reduce duration and severity of diarrhoea in children.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines such as typhoid vaccine. Avoid taking live vaccines during treatment and for several days after. Consult your doctor for specific timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust dosing times gradually to maintain even intervals. Check customs regulations for carrying prescription medicines. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but you must complete the full course as prescribed.
A: Yes, take it with food to reduce stomach upset.
A: Avoid alcohol, antacids, iron, and zinc supplements within 2 hours of this medicine.
A: This medicine is generally not recommended for children under 18 unless specifically directed by a specialist.
🤔 Common Patient Concerns
🔄 Substitutes for ofm 200mg/600mg tablet
View AllAlternative brands with exact same active ingredient:
-
diof 200 mg/600 mg tabletZuventus Healthcare Ltd ₹47.35 12.2% COSTLIER
-
noragyl o tabletMankind Pharma Ltd ₹64.88 53.8% COSTLIER
-
largyl o tabletLark Laboratories Ltd ₹66.00 56.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhoea.
Fact: This medicine only works for specific bacterial and protozoal infections. It is not effective for viral diarrhoea or diarrhoea caused by non-infectious conditions. - Myth: I can stop taking this medicine once I feel better.
Fact: You must complete the full course as prescribed, even if symptoms improve, to prevent recurrence and antibiotic resistance. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a severe disulfiram-like reaction with metronidazole. Avoid alcohol completely during treatment and for 48 hours after. - Myth: This medicine is safe for children.
Fact: This medicine is generally not recommended for children under 18 unless specifically directed by a specialist.
🔄 Alternative Options
Generic Alternatives
- Ofloxacin 200 mg + Metronidazole 600 mg tablet (various manufacturers)
Brand Alternatives
- Diof 200 mg/600 mg tablet