O2 M Oral Suspension: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Seizures or confusion
- Numbness or tingling in hands or feet
- Sudden joint pain or swelling
If experiencing severe symptoms, call emergency services immediately.
What is ofdia suspension used for?
This medicine is a combination antibiotic containing ofloxacin and metronidazole. It is used to treat bacterial and protozoal infections, especially infectious diarrhea and dysentery. It works by killing the microorganisms causing the infection. Take it exactly as prescribed, and avoid alcohol during treatment.
- Generic Name: Ofloxacin (100mg/5ml) + Metronidazole (200mg/5ml)
- Manufacturer: United Formulations Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ofdia suspension के बारे में (Hindi Summary)
उपयोग: यह दवा ओफ्लोक्सासिन और मेट्रोनिडाजोल का संयोजन है, जिसका उपयोग बैक्टीरियल और प्रोटोज़ोअल संक्रमणों के इलाज के लिए किया जाता है। यह मुख्य रूप से दस्त, पेचिश, और आंतों के संक्रमण में प्रभावी है। यह दवा संक्रमण पैदा करने वाले सूक्ष्मजीवों को मारती है। इसे डॉक्टर के निर्देशानुसार ही लें और कोर्स पूरा करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द, चक्कर आना और मुँह में धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभावों में टेंडन टूटना, तंत्रिका क्षति, दौरे और एलर्जी प्रतिक्रियाएँ हो सकती हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक न छोड़ें और कोर्स पूरा करें। उपयोग से पहले बोतल को अच्छी तरह हिलाएँ। दवा के साथ शराब न लें और कोर्स खत्म होने के 48 घंटे बाद तक भी न लें। पर्याप्त पानी पिएँ। धूप से बचें और सनस्क्रीन का उपयोग करें। गुर्दे या यकृत की समस्या हो तो डॉक्टर को बताएं।
💊 ofdia suspension Uses & Benefits
[{"condition":"Infectious diarrhea","description":"Used to treat diarrhea caused by susceptible bacteria and protozoa, including Shigella, Salmonella, and Entamoeba histolytica.","evidence":"Well-established"},{"condition":"Amebic dysentery","description":"Effective against Entamoeba histolytica, which causes bloody diarrhea and abdominal pain.","evidence":"Well-established"},{"condition":"Giardiasis","description":"Treats infection with Giardia lamblia, a common cause of watery diarrhea and malabsorption.","evidence":"Well-established"},{"condition":"Bacterial vaginosis","description":"Metronidazole component is effective against anaerobic bacteria associated with bacterial vaginosis.","evidence":"Well-established"},{"condition":"Pelvic inflammatory disease","description":"Combination covers a broad range of pathogens causing pelvic inflammatory disease.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Diverticulitis","description":"Sometimes used off-label for mild diverticulitis to cover anaerobic and aerobic bacteria.","evidence":"Limited"},{"condition":"Perianal abscess","description":"May be used as adjunctive therapy after drainage.","evidence":"Limited"}]
Primary treatment for: Infectious diarrhea
Also treats: Amebic dysentery, Giardiasis, Bacterial vaginosis, Pelvic inflammatory disease
📋 Drug Information
| Generic Name(s) | Ofloxacin (100mg/5ml) + Metronidazole (200mg/5ml) |
| Brand Name | ofdia suspension |
| Manufacturer | United Formulations Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C). Protect from light and moisture. Do not freeze. Shake well before use. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antibiotics with different mechanisms. Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication, transcription, repair, and recombination. This leads to inhibition of bacterial cell division and death. Metronidazole enters anaerobic organisms and is reduced by ferredoxin-like electron transport proteins, forming reactive intermediates that damage DNA and cause cell death. The combination provides synergistic or additive effects against mixed aerobic-anaerobic infections.
Mechanism Steps
💡 How to Take ofdia suspension
Strength: Each 5 ml of oral suspension contains Ofloxacin 100 mg and Metronidazole 200 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 ml (providing 200 mg ofloxacin and 400 mg metronidazole) twice daily, or as prescribed by your doctor. The dose and duration depend on the type and severity of infection, your kidney and liver function, and your response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Ofloxacin is not generally recommended for children due to the risk of joint and tendon problems. Metronidazole may be used in children for certain infections, but the combination should be used only under specialist supervision. |
| Elderly Dosage | Elderly patients may have reduced renal function and are more susceptible to side effects, especially tendon rupture and CNS effects. Dose adjustment may be necessary based on renal function. Use with caution and monitor closely. |
| Renal Impairment | In patients with renal impairment, the dose of ofloxacin should be adjusted. For creatinine clearance 20-50 ml/min, the usual dose may be given once daily. For creatinine clearance less than 20 ml/min, the dose may need further reduction. Metronidazole dose generally does not require adjustment in renal impairment, but metabolites may accumulate. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In patients with severe hepatic impairment, metronidazole dose should be reduced, and liver function should be monitored. Ofloxacin dose may not require adjustment, but caution is advised. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose should not exceed 20 ml (400 mg ofloxacin and 800 mg metronidazole) unless directed by a specialist. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ofdia suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Antacids | Major | |
| Theophylline | Major | |
| NSAIDs | Major | |
| Cimetidine | Moderate | |
| Lithium | Moderate | |
| Phenytoin | Moderate | |
| Cyclosporine | Moderate | |
| Caffeine | Minor |
🚨 Major Interactions
- Warfarin
- Alcohol
- Antacids containing aluminum or magnesium
- Theophylline
- NSAIDs
⚡ Moderate Interactions
- Cimetidine
- Lithium
- Phenytoin
- Cyclosporine
🍷 Alcohol Interaction
Avoid alcohol completely while taking this medicine and for at least 48 hours after the last dose. Alcohol can cause a disulfiram-like reaction with metronidazole, leading to severe nausea, vomiting, flushing, headache, and rapid heartbeat. It may also increase the risk of liver toxicity.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to ofloxacin, metronidazole, or any component of the formulation","History of tendon disorders associated with fluoroquinolone use","Myasthenia gravis (may exacerbate muscle weakness)","Use of disulfiram within the past two weeks","Alcohol consumption during treatment and for 48 hours after","Pregnancy (especially first trimester) unless clearly needed","Breastfeeding (unless benefits outweigh risks)"]
⚠️ Warnings & Precautions
["Fluoroquinolones, including ofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions, including tendinitis, tendon rupture, peripheral neuropathy, and CNS effects. Reserve for infections with no alternative treatment options.","Metronidazole may cause a disulfiram-like reaction with alcohol. Avoid alcohol.","May cause dizziness and confusion. Avoid driving or operating machinery until you know how it affects you.","May cause photosensitivity. Avoid excessive sun exposure and use sunscreen.","Use with caution in patients with renal impairment. Dose adjustment may be needed.","Use with caution in patients with hepatic impairment. Monitor liver function.","May exacerbate myasthenia gravis. Avoid in these patients.","May cause seizures, especially in patients with CNS disorders or those taking NSAIDs.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.","Do not use for viral infections."]
🤱 Lactation Safety
Ofloxacin and metronidazole are excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Consult your doctor.
💊 Overdose Management
In case of overdose, seek immediate medical attention. Symptoms may include nausea, vomiting, dizziness, and seizures. Treatment is symptomatic and supportive. Hemodialysis may be considered for ofloxacin overdose, but not for metronidazole. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better. Shake the bottle well before each use to ensure the medicine is mixed properly. Measure the dose with the provided measuring cup or spoon, not a kitchen spoon. Avoid alcohol while taking this medicine and for at least 48 hours after finishing, as it can cause severe nausea and vomiting. Drink plenty of fluids to stay hydrated. Avoid excessive sunlight and use sunscreen, as this medicine can make your skin more sensitive to sun. Inform your doctor if you have kidney or liver problems, as dose adjustments may be needed. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, peripheral neuropathy, and CNS effects. Renal function should be assessed before prescribing, and dose adjusted accordingly. Monitor closely for any adverse effects.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Ofloxacin and metronidazole are not recommended during pregnancy unless clearly needed. Use effective contraception during treatment and for at least 48 hours after the last dose.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery to prevent or treat infection. Inform your surgeon if you are taking this medicine, as it may interact with other medications used during surgery. It may also affect wound healing if not used appropriately.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with other medications and can increase the risk of bleeding if you are on anticoagulants. Your dentist may advise temporary discontinuation or dose adjustment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while you are recovering from an infection. If you experience joint pain, swelling, or tendon discomfort, stop exercising and consult your doctor immediately, as this medicine can rarely cause tendon rupture.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, confusion, or seizures in rare cases. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take rest during the initial days of treatment, especially if you have fever or diarrhea.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance. If you experience serious side effects like tendon pain, severe allergic reaction, or seizures, stop the medicine and seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to overgrowth of non-susceptible organisms, including fungi, and may increase the risk of tendon rupture, peripheral neuropathy, and liver toxicity. Prolonged use should be avoided unless absolutely necessary. Regular monitoring of liver and kidney function is advised for extended therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for managing dehydration from diarrhea, used alongside antibiotics.
Evidence: Well-establishedMay help restore gut flora and reduce antibiotic-associated diarrhea.
Evidence: ModerateRecommended for children with diarrhea to reduce duration and severity.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the efficacy of live bacterial vaccines like typhoid vaccine. Avoid taking live vaccines during treatment and for several days after. Consult your doctor for specific timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Shake well before each use
❌ DON'T
Do not use if the suspension has changed color or consistency
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. If traveling across time zones, adjust dosing times gradually to maintain even intervals. Store at room temperature and protect from light. Check customs regulations for carrying prescription medicines. Always carry enough for your entire trip plus extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it is important to complete the full course as prescribed.
A: Yes, you can take it with or without food. If it upsets your stomach, take it with a meal.
A: Avoid alcohol completely, as it can cause a severe reaction. Also avoid excessive sun exposure and use sunscreen.
A: It is not recommended during pregnancy unless clearly needed. Consult your doctor.
A: No, you must complete the full course to prevent recurrence and resistance.
🤔 Common Patient Concerns
🔄 Substitutes for ofdia suspension
View AllAlternative brands with exact same active ingredient:
-
oflo m suspensionLeo Pharmaceuticals ₹21.78 41.9% CHEAPER
-
oflaquin m suspensionNodysis Pharma Pvt Ltd ₹27.06 27.8% CHEAPER
-
vox m 100mg/200mg suspensionAllentis Pharmaceuticals Pvt Ltd ₹30.94 17.5% CHEAPER
-
oflaquin m syrupNodysis Pharma Pvt Ltd ₹38.44 2.5% COSTLIER
-
kidogyl ds syrupAstrum Healthcare Pvt Ltd ₹46.41 23.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any diarrhea.
Fact: It only works for specific bacterial or protozoal infections. It is not effective for viral diarrhea or diarrhea caused by other conditions. - Myth: You can stop taking it once you feel better.
Fact: You must complete the full course to prevent recurrence and resistance, even if symptoms improve. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a severe reaction with metronidazole. Avoid alcohol completely during and for 48 hours after treatment.
🔄 Alternative Options
Generic Alternatives
- Ofloxacin + Metronidazole oral suspension (generic)