nymtoss cold tablet - Nimesulide (100mg) + Phenylephrine (10mg) medicine

Elfast N Tablet: Comprehensive Guide To Uses, Side Effects, And Safety

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🏭 Scotwin Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 29, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for short-term use in acute pain and congestion.
Reviewed by
SaathiMed Expert Panel | Oct 29, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is nymtoss cold tablet used for?

This medicine is a combination of Nimesulide (100 mg) and Phenylephrine (10 mg) used for short-term relief of acute pain, inflammation, and nasal congestion. It works by reducing prostaglandins and constricting nasal blood vessels. It is not recommended for children under 12, pregnant women, or those with severe liver, kidney, or heart disease.

  • Generic Name: Nimesulide (100mg) + Phenylephrine (10mg)
  • Manufacturer: Scotwin Healthcare
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 nymtoss cold tablet के बारे में (Hindi Summary)

उपयोग: यह दवा नाइमेसुलाइड और फेनाइलेफ्रिन का संयोजन है, जिसका उपयोग तीव्र दर्द, सूजन और नाक की भीड़ के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, और सर्दी-जुकाम से जुड़ी नाक की भीड़ में राहत देती है। यह दवा केवल डॉक्टर की सलाह पर ही लेनी चाहिए और लंबे समय तक नहीं लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में असुविधा, सिरदर्द, चक्कर आना और रक्तचाप में वृद्धि शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, यकृत विषाक्तता, गुर्दे की क्षति, और त्वचा पर गंभीर प्रतिक्रियाएं हो सकती हैं। यदि आपको काला मल, उल्टी में खून, या पेट में तेज दर्द हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब न लें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें। यकृत, गुर्दे, या हृदय रोग वाले मरीज सावधानी बरतें। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से मिलें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 nymtoss cold tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides short-term relief from pain following dental procedures or due to dental infections.","evidence":"Well-established"},{"condition":"Upper respiratory tract infections with nasal congestion","description":"Reduces pain, fever, and nasal congestion associated with common cold and sinusitis.","evidence":"Moderate"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate post-operative pain.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks due to its anti-inflammatory and analgesic properties.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain relief.","evidence":"Limited"}]

Primary treatment for: Acute musculoskeletal pain with nasal congestion

Also treats: Dental pain, Upper respiratory tract infections, Post-operative pain

📋 Drug Information

Generic Name(s)Nimesulide (100mg) + Phenylephrine (10mg)
Brand Namenymtoss cold tablet
ManufacturerScotwin Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Stay well hydrated throughout the day.
3
Avoid alcohol while taking this medicine.
4
Do not take more than the prescribed dose.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual bleeding or bruising immediately.
7
Monitor your blood pressure regularly if you have hypertension.
8
Do not use this medicine for hangovers or minor aches without medical advice.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Acute musculoskeletal pain
This medicine is commonly prescribed for this.
Likely Use
✅
Nasal congestion
Phenylephrine provides decongestion.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Chronic pain
Not recommended for long-term use.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNimesulide is rapidly absorbed from the gastrointestinal tract after oral administration. Phenylephrine is also absorbed orally but undergoes extensive first-pass metabolism. Not established from the available information for specific absorption rates of this combination.
DistributionNimesulide is highly protein-bound and distributes widely into body tissues. Phenylephrine distribution is not well characterized. Not established from the available information for specific volume of distribution of this combination.
Protein BindingNimesulide is approximately 99% bound to plasma proteins. Phenylephrine protein binding is not established from the available information.
MetabolismNimesulide is extensively metabolized in the liver, primarily by CYP2C9, to several metabolites. Phenylephrine is metabolized by monoamine oxidase (MAO) in the liver and gut. Not established from the available information for specific metabolic pathways of this combination.
Half-LifeThe elimination half-life of nimesulide is approximately 2-5 hours. The half-life of phenylephrine is approximately 2.5-3 hours. Not established from the available information for the combination product.
ExcretionNimesulide metabolites are excreted primarily in urine and feces. Phenylephrine is excreted in urine as unchanged drug and metabolites. Not established from the available information for specific excretion ratios of this combination.
BioavailabilityThe oral bioavailability of nimesulide is approximately 50-70%. The oral bioavailability of phenylephrine is low (approximately 38%) due to first-pass metabolism. Not established from the available information for the combination product.
Onset of ActionNimesulide onset of action is typically within 30 minutes to 1 hour. Phenylephrine onset of action is within 15-30 minutes. Not established from the available information for the combination product.
Peak Plasma TimeNimesulide peak plasma concentration is reached in 1.5-3 hours. Phenylephrine peak plasma concentration is reached in 1-2 hours. Not established from the available information for the combination product.
Duration of ActionNimesulide duration of action is approximately 6-8 hours. Phenylephrine duration of action is approximately 4-6 hours. Not established from the available information for the combination product.

How It Works

This medicine combines two active ingredients with distinct mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Phenylephrine is a sympathomimetic amine that acts primarily on alpha-1 adrenergic receptors, causing vasoconstriction of blood vessels in the nasal mucosa, thereby reducing swelling and congestion. The combination provides both analgesic/anti-inflammatory and decongestant effects.

Mechanism Steps

1
COX-2 inhibition by Nimesulide: Nimesulide selectively binds to and inhibits the COX-2 enzyme, blocking the conversion of arachidonic acid to prostaglandin H2, a precursor of various prostaglandins.
2
Reduced prostaglandin synthesis: The inhibition of COX-2 leads to decreased production of prostaglandins, which are responsible for pain, inflammation, and fever.
3
Alpha-1 adrenergic receptor activation by Phenylephrine: Phenylephrine binds to alpha-1 adrenergic receptors on vascular smooth muscle cells in the nasal mucosa.
4
Vasoconstriction and decongestion: Activation of alpha-1 receptors causes vasoconstriction, reducing blood flow and swelling in the nasal passages, thereby relieving congestion.

💡 How to Take nymtoss cold tablet

Strength: Tablet containing Nimesulide 100 mg and Phenylephrine 10 mg.

1Take the tablet orally with a full glass of water.
2Take with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take at the same time each day to maintain consistent levels.
5Do not lie down immediately after taking the tablet.
6Follow the prescribed dose and duration exactly.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally once or twice daily, as prescribed by your doctor. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. The maximum duration of treatment is typically 5-7 days. Take with food to reduce stomach upset.
Pediatric DosagePediatric dosing is not established from available information. This medicine is not recommended for children below 12 years of age. Consult a pediatrician for alternative treatments.
Elderly DosageElderly patients (above 65 years) may be more sensitive to the effects of this medicine. Use with caution and at the lowest effective dose for the shortest duration. Monitor renal and hepatic function closely.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing. Avoid in severe renal impairment.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Avoid in severe hepatic impairment.
Maximum Daily DoseThe maximum recommended daily dose is 200 mg of nimesulide and 20 mg of phenylephrine (two tablets). Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of nymtoss cold tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. Consult doctor if persistent.
Abdominal discomfort (Common (5-10%))
Take with food or milk. If severe, consult doctor.
Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if severe or persistent.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Increased blood pressure (Common (5-10%))
Monitor blood pressure regularly. Consult doctor if elevated.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black stool, vomiting blood, or severe abdominal pain.
Liver toxicity (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe fatigue to your doctor immediately.
Kidney impairment (Rare (<0.1%))
Report decreased urine output or swelling to your doctor immediately.
Severe skin reactions (Stevens-Johnson syndrome) (Very rare (<0.01%))
Seek immediate medical attention if you develop rash, blisters, or peeling skin.
Cardiovascular events (stroke, heart attack) (Rare (<0.1%))
Seek emergency care if you experience chest pain, shortness of breath, or sudden weakness.

⚠️ Rare Side Effects

Agranulocytosis
Report fever, sore throat, or unusual tiredness to your doctor immediately.
Thrombocytopenia
Report unusual bleeding or bruising to your doctor immediately.
Anaphylaxis
Seek emergency care if you experience swelling of face, lips, throat, or difficulty breathing.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
ACE inhibitors Major
MAOIs Major
Diuretics Moderate
Beta-blockers Moderate
Tricyclic antidepressants Moderate
Antacids Minor
Corticosteroids Minor
Grapefruit juice Moderate

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs
  • ACE inhibitors
  • Monoamine oxidase inhibitors (MAOIs)

⚡ Moderate Interactions

  • Diuretics
  • Beta-blockers
  • Tricyclic antidepressants

🍷 Alcohol Interaction

Alcohol may increase the risk of gastrointestinal bleeding and liver toxicity when taken with this medicine. Avoid alcohol consumption while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to nimesulide, phenylephrine, or any component of the formulation","Active peptic ulcer disease or history of recurrent ulcers","Severe liver impairment","Severe kidney impairment","Uncontrolled hypertension","Severe cardiovascular disease","Children below 12 years of age","Pregnancy (especially third trimester)","Breastfeeding","Concurrent use with MAOIs"]

⚠️ Warnings & Precautions

["Use with caution in elderly patients due to increased risk of adverse effects.","Avoid in patients with dehydration or hypovolemia.","Monitor blood pressure closely in patients with hypertension.","Do not use for prolonged periods without medical supervision.","May impair ability to drive or operate machinery.","Avoid alcohol consumption.","Consult doctor before use in patients with asthma, especially if aspirin-sensitive.","Use with caution in patients with diabetes, thyroid disorders, or prostatic hypertrophy."]

🤱 Lactation Safety

Not established from the available information. This medicine may pass into breast milk and could affect the nursing infant. Consult your doctor before use if breastfeeding.

💊 Overdose Management

Overdose may cause severe nausea, vomiting, abdominal pain, drowsiness, and increased blood pressure. Seek immediate medical attention. Treatment is symptomatic and supportive. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and provide supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it may increase the risk of gastrointestinal bleeding. Do not use this medicine if you are pregnant, especially in the third trimester, or if you are breastfeeding without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, high blood pressure, or heart disease. Do not take other NSAIDs or blood thinners concurrently without medical advice. If you experience symptoms like black stools, vomiting blood, severe abdominal pain, yellowing of eyes or skin, or decreased urine output, seek immediate medical attention. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration and monitor closely.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor for safe alternatives for pain relief.

🏥 Post-Surgery Considerations

Use with caution after surgery due to increased risk of bleeding and kidney impairment. Consult your surgeon before taking this medicine.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase the risk of bleeding.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.
🌞
Stay hydrated.
🚭
Avoid smoking and excessive alcohol.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that may increase the risk of bleeding or injury while taking this medicine. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated
Avoid grapefruit juice
Limit alcohol consumption

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also increase blood pressure, so monitor if you have hypertension.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if you experience severe side effects such as black stools, vomiting blood, severe abdominal pain, yellowing of eyes or skin, decreased urine output, or signs of an allergic reaction. Do not stop abruptly if you are on a prescribed regimen without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine can increase the risk of gastrointestinal bleeding, liver toxicity, kidney impairment, and cardiovascular events. Regular monitoring of liver and kidney function, blood pressure, and complete blood count is recommended. It should not be used for more than 7 days without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Hot/cold compresses

May help relieve localized pain and inflammation.

Evidence: Moderate
Acupuncture

May provide pain relief for some individuals.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information. Consult your doctor regarding vaccination timing if you are on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines. Do not leave in hot cars or checked luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with acute back pain and nasal congestion
Started this medicine as prescribed for acute back pain and cold symptoms. Within 2 days noticed significant improvement in pain and nasal congestion. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old retiree with dental pain and hypertension
Was prescribed this medicine for dental pain. After taking it, experienced a rise in blood pressure. Doctor advised to monitor blood pressure and use the medicine for a shorter duration. Switched to an alternative pain reliever.
💡 Lesson: Patients with hypertension should use this medicine with caution and monitor blood pressure regularly.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine typically starts relieving pain within 30 minutes to 1 hour, and nasal congestion within 15-30 minutes.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce the risk of stomach upset.

Q: Is it safe to take with other painkillers?

A: Do not take with other NSAIDs or blood thinners without consulting your doctor, as it may increase the risk of bleeding.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for nymtoss cold tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any type of pain.
    Fact: This medicine is specifically for acute pain with inflammation and nasal congestion. It is not suitable for all types of pain and should be used only as prescribed.
  • Myth: It is safe to take this medicine for long periods.
    Fact: Prolonged use can increase the risk of liver, kidney, and gastrointestinal problems. It should be used for the shortest duration possible.
  • Myth: This medicine is safe for children.
    Fact: This medicine is not recommended for children below 12 years of age due to safety concerns.

🔄 Alternative Options

Generic Alternatives

  • Nimesulide + Phenylephrine combination generics may be available.

Brand Alternatives

  • Elfast N Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Elfast N Tablet","composition":"Nimesulide 100 mg + Phenylephrine 10 mg","uses":"Acute pain with nasal congestion","notes":"Short-term use only"},{"medicine":"Nimesulide + Paracetamol","composition":"Nimesulide 100 mg + Paracetamol 325 mg","uses":"Pain and fever","notes":"No decongestant effect"},{"medicine":"Ibuprofen + Phenylephrine","composition":"Ibuprofen 200 mg + Phenylephrine 10 mg","uses":"Pain and nasal congestion","notes":"Different NSAID"}]

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