Nupara Suspension: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain or persistent vomiting
- Black, tarry stools or blood in vomit
- Decreased urine output or swelling in legs
- Difficulty breathing or swelling of face, lips, or throat
- Severe headache with stiff neck and fever
- Unusual bruising or bleeding
- Chest pain or palpitations
- Confusion or extreme fatigue
If experiencing severe symptoms, call emergency services immediately.
What is Nupara Suspension used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of pain and fever. It works by reducing inflammation and blocking pain signals. It should be taken with food and not used for more than 5 days without medical advice.
- Generic Name: Nimesulide (500mg) + Paracetamol (125mg)
- Manufacturer: Scala Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Nupara Suspension के बारे में (Hindi Summary)
उपयोग: यह दवा निमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द और बुखार से राहत के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सिरदर्द और सर्जरी के बाद के दर्द में प्रभावी है। यह सूजन को कम करने और शरीर के तापमान को नियंत्रित करने में मदद करती है। इसका उपयोग केवल अल्पकालिक (5 दिनों तक) के लिए किया जाना चाहिए और डॉक्टर की सलाह के बिना लंबे समय तक नहीं लेना चाहिए। बच्चों को 12 वर्ष से कम उम्र में यह दवा नहीं दी जानी चाहिए। गर्भवती और स्तनपान कराने वाली महिलाओं को इसका उपयोग नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में लिवर की क्षति, पेट या आंतों में रक्तस्राव, गुर्दे की समस्या और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको पीलिया, गहरे रंग का मूत्र, काला मल, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक या अवधि से अधिक न लें। इसे भोजन या दूध के साथ लें ताकि पेट की जलन कम हो। इस दवा के साथ शराब का सेवन न करें। पैरासिटामोल या अन्य दर्द निवारक दवाओं के साथ इसका सेवन डॉक्टर की सलाह के बिना न करें। यदि आपको लिवर या गुर्दे की बीमारी, पेट के अल्सर या रक्तस्राव की समस्या है, तो डॉक्टर को बताएं। 5 दिनों से अधिक इसका उपयोग न करें। बच्चों की पहुंच से दूर रखें।
💊 Nupara Suspension Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Headache","description":"Helps alleviate tension headaches and mild migraine attacks.","evidence":"Moderate"},{"condition":"Fever","description":"Reduces fever associated with infections or other causes.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate post-surgical pain.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Osteoarthritis flare-up","description":"Sometimes used for short-term relief of osteoarthritis pain, but not recommended for long-term use due to safety concerns.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual cramps, but other NSAIDs are preferred.","evidence":"Limited"}]
Primary treatment for: Pain and fever
Also treats: Musculoskeletal pain, Dental pain, Headache, Post-operative pain
📋 Drug Information
| Generic Name(s) | Nimesulide (500mg) + Paracetamol (125mg) |
| Brand Name | Nupara Suspension |
| Manufacturer | Scala Pharmaceuticals |
| Packaging / Form | bottle of 60 ml Suspension (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place, away from direct sunlight. Do not refrigerate. Keep the bottle tightly closed. Shake well before use. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins that cause pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system, where it inhibits prostaglandin synthesis and modulates pain perception, and also acts on the hypothalamus to reduce fever. Together, they provide analgesic and antipyretic effects, with nimesulide adding anti-inflammatory action.
Mechanism Steps
💡 How to Take Nupara Suspension
Strength: Each 5 mL of suspension contains nimesulide 500 mg and paracetamol 125 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5-10 mL (providing 500 mg nimesulide and 125 mg paracetamol per 5 mL) taken orally every 8 hours as needed for pain and fever. The maximum recommended daily dose should not exceed 15 mL in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not use for more than 5 days without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is contraindicated in children below 12 years of age. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding, kidney impairment, and liver toxicity. Use with caution and at the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. This medicine is contraindicated in severe kidney impairment (creatinine clearance <30 mL/min). Consult a doctor for dose adjustment. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose reduction and close monitoring of liver function are recommended. This medicine is contraindicated in severe liver impairment or active liver disease. |
| Maximum Daily Dose | The maximum recommended daily dose is 15 mL (providing 1500 mg nimesulide and 375 mg paracetamol) in divided doses. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Nupara Suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, aspirin)
- Corticosteroids
- Methotrexate
- ACE inhibitors and ARBs
⚡ Moderate Interactions
- Diuretics (e.g., furosemide)
- Lithium
- SSRIs
- Antihypertensives
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially with paracetamol, and can worsen gastrointestinal irritation and bleeding caused by nimesulide.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nimesulide, paracetamol, or any component of the formulation","Active peptic ulcer or history of recurrent peptic ulcer","History of gastrointestinal bleeding or perforation related to NSAID use","Severe liver impairment or active liver disease","Severe kidney impairment (e.g., creatinine clearance
⚠️ Warnings & Precautions
["Use the lowest effective dose for the shortest possible duration.","Avoid alcohol and other hepatotoxic drugs.","Take with food to reduce gastrointestinal irritation.","Monitor for signs of liver injury (jaundice, dark urine, fatigue).","Monitor for signs of gastrointestinal bleeding (black stools, vomiting blood).","Use with caution in elderly patients and those with kidney or liver disease.","Do not use in children under 12 years without medical advice.","Inform your doctor if you have asthma, especially aspirin-sensitive asthma.","Do not exceed the recommended dose of paracetamol from all sources.","Discontinue and consult a doctor if symptoms persist or worsen."]
🤱 Lactation Safety
Nimesulide is not recommended during breastfeeding as it may pass into breast milk and cause harm to the infant. Paracetamol is considered safe during breastfeeding when used at recommended doses. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, especially due to paracetamol and nimesulide. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and jaundice. If you suspect an overdose, seek emergency medical attention immediately. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and gastrointestinal bleeding. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor. If you have a history of liver or kidney disease, stomach ulcers, or bleeding disorders, inform your doctor before taking this medicine. Do not use this medicine for more than 5 days without medical advice. Keep out of reach of children. Store in a cool, dry place, away from direct sunlight. Do not use if the seal is broken or the suspension appears discolored.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and liver toxicity from this medicine. Use with caution, at the lowest effective dose, and for the shortest duration. Monitor renal and hepatic function regularly.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy and in women planning to become pregnant. If you are trying to conceive, consult your doctor for safe alternatives for pain and fever management.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain management, but it should be prescribed with caution due to the risk of bleeding and kidney impairment. Follow your surgeon's instructions and do not self-medicate.
🦷 Dental Procedures
This medicine can be used for dental pain, but inform your dentist if you are taking it before any dental procedure, as it may increase the risk of bleeding. Your dentist may recommend an alternative painkiller.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or fatigue. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you have pain, gentle stretching and low-impact exercises are generally safe, but consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated. If your job involves physical labor, consult your doctor about modifications.
🛑 When to Stop This Medicine
Stop taking this medicine if your pain or fever resolves, or after 5 days, whichever is earlier, unless your doctor advises otherwise. If you experience any serious side effects like jaundice, dark urine, severe abdominal pain, or signs of an allergic reaction, stop immediately and seek medical attention. Do not stop abruptly if you are on a prescribed regimen without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious side effects, including liver damage, kidney impairment, gastrointestinal bleeding, and cardiovascular events. If long-term use is unavoidable, regular monitoring of liver and kidney function is essential. Discontinue use and consult a doctor if any unusual symptoms occur.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A safer alternative for pain and fever, especially for short-term use.
Evidence: Well-establishedAnother NSAID that can be used for pain and inflammation, but also has gastrointestinal risks.
Evidence: Well-establishedCan complement medicine for chronic pain management.
Evidence: Well-establishedMay help relieve localized pain and inflammation.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination, as some vaccines may be postponed during acute illness.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Shake well before use
❌ DON'T
Do not use if the suspension appears discolored or has particles
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription to avoid issues at customs. Store it in a cool, dry place away from direct sunlight. If traveling across time zones, adjust dosing times gradually to maintain intervals. Do not leave it in a hot car or checked luggage. Check local regulations regarding carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain and reducing fever within 30 to 60 minutes after taking it.
A: This medicine should not be used for more than 5 days without medical advice. Prolonged use can cause serious liver and kidney damage.
A: No, you should not take this medicine with other NSAIDs or paracetamol-containing products without consulting your doctor, as it can increase the risk of side effects.
A: This medicine is contraindicated in children below 12 years of age. Consult a pediatrician for appropriate pain and fever management in children.
A: This medicine is contraindicated during pregnancy, especially in the third trimester. Consult your doctor for safe alternatives.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Nupara Suspension is safe for long-term use.
Fact: This medicine is intended for short-term use only. Prolonged use can cause serious liver and kidney damage. - Myth: Nupara Suspension can be given to children without a doctor's advice.
Fact: This medicine is contraindicated in children below 12 years of age. Always consult a pediatrician before giving any medicine to a child. - Myth: It is safe to take Nupara Suspension with other painkillers.
Fact: Taking this medicine with other NSAIDs or paracetamol-containing products can increase the risk of side effects. Always consult your doctor before combining medicines.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol suspension (generic)
Brand Alternatives
- Nise
- Nimulid
- Nimsaid
- Nimucet