Dinor M Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden severe pain, swelling, or inability to move a joint or tendon
- Numbness, tingling, or burning in hands or feet
- Severe or bloody diarrhea that worsens during treatment
- Signs of a severe allergic reaction such as facial swelling, difficulty breathing, or widespread rash
- Irregular heartbeat, palpitations, or fainting
- Seizures, confusion, or hallucinations
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is normogyl suspension used for?
This medicine is a prescription oral syrup containing metronidazole and norfloxacin, two antibiotics used together to treat certain mixed bacterial and protozoal infections of the gastrointestinal tract. It is not for viral infections and must be taken exactly as prescribed.
- Generic Name: Metronidazole (100mg/5ml) + Norfloxacin (100mg/5ml)
- Manufacturer: Pharmasynth Formulations Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 normogyl suspension के बारे में (Hindi Summary)
उपयोग: यह दवा मेट्रोनिडाजोल और नोरफ्लोक्सासिन का संयोजन है, जिसका उपयोग डॉक्टर द्वारा निर्धारित कुछ विशिष्ट जीवाणु और परजीवी संक्रमणों के इलाज के लिए किया जाता है। यह आमतौर पर दस्त, पेचिश और आंतों के संक्रमण में दी जाती है जब दोनों प्रकार के रोगजनकों की संभावना हो। यह दवा वायरल संक्रमण जैसे सर्दी-जुकाम के लिए प्रभावी नहीं है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए और पूरा कोर्स पूरा करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में असहजता, मुंह में धातु जैसा स्वाद, सिरदर्द, चक्कर आना और दस्त शामिल हैं। ये आमतौर पर हल्के होते हैं और उपचार जारी रखने पर कम हो जाते हैं। गंभीर दुष्प्रभावों में टेंडन में दर्द या टूटना, तंत्रिका संबंधी समस्याएं, त्वचा पर गंभीर प्रतिक्रियाएं और दिल की धड़कन में अनियमितता शामिल हो सकती हैं। शराब के साथ लेने पर गंभीर प्रतिक्रिया हो सकती है। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन बिल्कुल न करें, क्योंकि इससे गंभीर प्रतिक्रिया हो सकती है। दवा लेते समय चक्कर आ सकते हैं, इसलिए वाहन चलाने या मशीन चलाने से बचें। धूप में बाहर जाते समय सनस्क्रीन और सुरक्षात्मक कपड़े पहनें। एंटासिड, आयरन की गोलियां या डेयरी उत्पादों के साथ इस दवा को 2 घंटे के अंतराल पर लें। पूरा कोर्स पूरा करें, बीच में न छोड़ें।
💊 normogyl suspension Uses & Benefits
[{"condition":"Infectious diarrhea with suspected mixed bacterial and protozoal involvement","description":"This medicine is used to treat acute infectious diarrhea when a clinician suspects both anaerobic bacteria or protozoa and susceptible aerobic bacteria are contributing to the illness.","evidence":"Moderate"},{"condition":"Bacillary dysentery","description":"It may be prescribed for dysentery caused by susceptible Shigella or other invasive bacteria when dual coverage is considered necessary.","evidence":"Moderate"},{"condition":"Amebic dysentery","description":"The metronidazole component targets Entamoeba histolytica, while norfloxacin covers secondary bacterial infection.","evidence":"Moderate"},{"condition":"Giardiasis with bacterial co-infection","description":"Used when giardiasis is accompanied by a susceptible bacterial infection requiring fluoroquinolone coverage.","evidence":"Limited"}]
Off-label uses: [{"condition":"Small intestinal bacterial overgrowth","description":"Occasionally prescribed off-label when a clinician suspects mixed anaerobic and aerobic bacterial overgrowth.","evidence":"Limited"},{"condition":"Diverticulitis with mixed flora","description":"Rarely used off-label in outpatient settings when oral combination therapy is deemed appropriate.","evidence":"Limited"}]
Primary treatment for: Infectious diarrhea with mixed bacterial and protozoal involvement
Also treats: Bacillary dysentery, Amebic dysentery, Giardiasis with bacterial co-infection
📋 Drug Information
| Generic Name(s) | Metronidazole (100mg/5ml) + Norfloxacin (100mg/5ml) |
| Brand Name | normogyl suspension |
| Manufacturer | Pharmasynth Formulations Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the bottle tightly closed. Do not freeze. |
| Shelf Life | Not established from the available information. Refer to the expiry date printed on the package. |
| WHO Guideline | Not established from the available information. The World Health Organization does not specifically recommend this fixed-dose combination for routine use. Clinicians should follow local guidelines and culture sensitivity results. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research has not issued specific recommendations for this fixed-dose combination. Use should be guided by clinical judgment and local resistance patterns. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two complementary mechanisms. Metronidazole enters susceptible anaerobic microorganisms and protozoa, where its nitro group is reduced to reactive intermediates that damage DNA and inhibit nucleic acid synthesis, leading to cell death. Norfloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair, thereby stopping bacterial growth and causing bacterial death. The combination provides coverage against certain anaerobic bacteria, protozoa, and susceptible aerobic gram-negative bacteria.
Mechanism Steps
💡 How to Take normogyl suspension
Strength: Each 5 ml of syrup contains metronidazole 100 mg and norfloxacin 100 mg.
Dosage Information
| Adult Dosage | The adult dose of this medicine is determined by the prescribing clinician based on the specific infection, its severity, and the patient's renal and hepatic function. A typical course may involve taking the syrup orally every 8 to 12 hours for 5 to 7 days, but this varies. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Fluoroquinolones are generally avoided in children and adolescents due to potential effects on cartilage development. |
| Elderly Dosage | Elderly patients may require dose adjustment based on renal function, as norfloxacin is primarily excreted by the kidneys. Monitor renal function and watch for central nervous system effects. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. Norfloxacin accumulation can increase the risk of toxicity. Consult a clinician for specific dosing based on creatinine clearance. Metronidazole may also require adjustment in severe renal impairment. |
| Hepatic Impairment | Metronidazole is metabolized in the liver, so dose reduction may be necessary in patients with severe hepatic impairment. Monitor liver function closely. Norfloxacin undergoes limited hepatic metabolism. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | Not established from the available information. The maximum daily dose must be determined by the prescribing clinician based on the specific clinical situation. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of normogyl suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Antacids | Major | |
| Iron supplements | Major | |
| QT-prolonging drugs | Major | |
| Cimetidine | Moderate | |
| Phenytoin | Moderate | |
| Lithium | Moderate | |
| Sulfonylureas | Moderate | |
| Theophylline | Moderate |
🚨 Major Interactions
- Warfarin
- Alcohol
- QT-prolonging drugs
- Antacids containing aluminum or magnesium
- Iron supplements
⚡ Moderate Interactions
- Cimetidine
- Phenytoin
- Lithium
- Sulfonylureas
- Theophylline
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. The metronidazole component can cause a disulfiram-like reaction characterized by flushing, severe nausea, vomiting, headache, rapid heartbeat, and low blood pressure. This reaction can be dangerous and requires immediate medical attention if it occurs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to metronidazole, norfloxacin, or other fluoroquinolones","History of tendon disorders associated with fluoroquinolone use","Myasthenia gravis","Severe renal impairment without dose adjustment","Pregnancy and breastfeeding unless clearly needed","Children and adolescents under 18 years (fluoroquinolones generally avoided)"]
⚠️ Warnings & Precautions
["Fluoroquinolones, including norfloxacin, can cause disabling and potentially irreversible serious adverse reactions involving tendons, muscles, joints, nerves, and the central nervous system.","Avoid alcohol during treatment and for at least 48 hours after the last dose due to disulfiram-like reaction.","May cause dizziness and lightheadedness; avoid driving or operating machinery until you know how it affects you.","Photosensitivity can occur; use sunscreen and protective clothing when outdoors.","May cause blood sugar disturbances; monitor glucose closely if diabetic.","Use with caution in patients with epilepsy or other seizure disorders.","Do not use for viral infections; it is ineffective against viruses.","Complete the full prescribed course even if symptoms improve early."]
🤱 Lactation Safety
Metronidazole is excreted in breast milk and norfloxacin may also pass into breast milk. Breastfeeding is generally not recommended while taking this medicine. If treatment is essential, discuss with your doctor about temporarily interrupting breastfeeding or alternative options.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, dizziness, and potentially seizures or cardiac arrhythmias. There is no specific antidote. Treatment is supportive and symptomatic. Seek immediate medical attention or contact a poison control center if overdose is suspected. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you miss multiple doses, consult your doctor.
Additional Safety Advice
Take this medicine exactly as prescribed by your clinician, with a full glass of water, and preferably with food to reduce stomach upset. Do not skip doses or stop early, even if you feel better, because incomplete treatment can lead to resistance and relapse. Avoid all alcohol-containing products during treatment and for at least 48 hours after the last dose, as this can trigger a severe reaction. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Use sunscreen and protective clothing when outdoors because norfloxacin can make your skin more sensitive to sunlight. Inform your clinician about all other medicines, especially blood thinners, antacids, and diabetes medicines. Keep this medicine out of reach of children and store it as directed on the label.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney impairment, tendon disorders, and central nervous system effects from this medicine. Dose adjustment based on renal function is often necessary. Monitor closely for dizziness, confusion, and falls. Ensure adequate hydration.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before taking this medicine. Fluoroquinolones are generally avoided during pregnancy due to potential effects on fetal cartilage development. Metronidazole should be used only if clearly needed. Effective contraception is advised during treatment.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist if you are taking this medicine before surgery. It may interact with other medications used during surgery. Your doctor may advise stopping it before elective procedures, depending on the infection being treated.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with antibiotics or other medicines used during dental work. Do not stop the medicine without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you experience dizziness, fatigue, or joint pain. Fluoroquinolones can increase the risk of tendon injury, so stop exercising and consult your doctor if you notice tendon pain or swelling.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, headache, or fatigue, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Take sick leave if you have severe diarrhea or feel unwell. Inform your employer if you need to take time off to recover.
🛑 When to Stop This Medicine
Stop taking this medicine only if your doctor advises you to, or if you experience a serious side effect such as tendon pain, severe allergic reaction, or neurological symptoms. Do not stop early just because you feel better, as this can lead to relapse. If you need to stop for any reason, consult your doctor for alternative treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended and can lead to antibiotic resistance, gut flora imbalance, and rare but serious effects such as peripheral neuropathy, tendon damage, and liver or kidney problems. If prolonged therapy is necessary, regular monitoring of blood counts, liver and kidney function, and neurological status is advised. Always discuss the risks and benefits with your clinician before extending treatment beyond the recommended duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for managing dehydration from diarrhea, regardless of cause.
Evidence: Well-establishedMay help restore gut flora and reduce diarrhea duration, but should be taken after the antibiotic course.
Evidence: ModerateRecommended in children with diarrhea to reduce severity and duration.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines such as the typhoid vaccine. Avoid receiving live vaccines during treatment and for several days after. Consult your doctor for specific timing recommendations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container with cap tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case customs or security asks for documentation. Store it at room temperature and protect it from extreme heat or direct sunlight. If crossing time zones, continue your dosing schedule as close to the original times as possible, but do not double doses. Keep it in your carry-on luggage to avoid temperature extremes in checked baggage. Check local regulations about carrying prescription antibiotics before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but you must complete the full prescribed course to ensure the infection is fully treated.
A: No, stopping early can cause the infection to return and may lead to antibiotic resistance. Complete the full course as prescribed.
A: Avoid alcohol completely, and separate the dose from antacids, iron supplements, and dairy products by at least 2 hours.
A: Some medicines can interact with this product. Always inform your doctor about all medicines you are taking, especially blood thinners, diabetes medicines, and antacids.
🤔 Common Patient Concerns
🔄 Substitutes for normogyl suspension
View AllAlternative brands with exact same active ingredient:
-
gastogym m suspensionBiological E Ltd ₹22.47 2.1% COSTLIER
-
dinor m syrupGodetia Healthcare ₹23.44 6.5% COSTLIER
-
Nitiflox M SuspensionWood Rock Healthcare Pvt Ltd ₹23.44 6.5% COSTLIER
-
Tronidom M SuspensionRemedies Pharmaceuticals (India) Ltd ₹24.38 10.8% COSTLIER
-
lotinor syrupQuest Pharmaceuticals ₹26.25 19.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhea.
Fact: This medicine only works for specific bacterial and protozoal infections. It is not effective for viral diarrhea or diarrhea caused by non-infectious conditions. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full prescribed course to prevent relapse and antibiotic resistance. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a serious disulfiram-like reaction with metronidazole. Avoid alcohol completely during treatment and for 48 hours after. - Myth: This medicine is safe for children.
Fact: Fluoroquinolones are generally avoided in children due to potential joint and cartilage effects. Consult a pediatrician.
🔄 Alternative Options
Generic Alternatives
- Metronidazole and norfloxacin oral suspension (generic)