Nobimef-d Tablet: Comprehensive Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is nobimef-d tablet used for?
This medicine is a combination of Aceclofenac and Paracetamol used for short-term relief of pain and inflammation. It is taken orally with food, usually two to three times daily, and should not be used for more than 7 days without medical advice.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nobimef-d tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिफेनाक और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है। यह मुख्य रूप से जोड़ों के दर्द, मांसपेशियों के दर्द, दांतों के दर्द, और ऑपरेशन के बाद के दर्द में राहत के लिए दी जाती है। इसे भोजन के साथ लेना चाहिए और डॉक्टर की सलाह के बिना 7 दिनों से अधिक नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, एलर्जी, गुर्दे या यकृत की समस्या हो सकती है। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को भोजन या दूध के साथ लें। शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव और यकृत की क्षति का खतरा बढ़ सकता है। डॉक्टर की सलाह के बिना अन्य दर्द निवारक दवाएं न लें। यदि आपको पेट अल्सर, गुर्दे या यकृत की बीमारी, हृदय की समस्या या अस्थमा है तो अपने डॉक्टर को बताएं। 7 दिनों से अधिक इस दवा का उपयोग न करें।
💊 nobimef-d tablet Uses & Benefits
[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces joint pain and inflammation" class="semantic-link" title="Medicines for swelling">swelling in rheumatoid arthritis as an adjunct to disease-modifying therapy.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides effective relief from acute dental pain, including post-extraction pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate post-operative pain.","evidence":"Well-established"},{"condition":"Musculoskeletal pain","description":"Relieves pain from sprains, strains, and other soft tissue injuries.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but evidence is limited.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain, but not a first-line choice.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation associated with musculoskeletal conditions, dental pain, and post-operative pain.
Also treats: Osteoarthritis, Rheumatoid arthritis, Dental pain, Post-operative pain, Musculoskeletal pain
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nobimef-d tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), and Paracetamol, a centrally acting analgesic and antipyretic. Aceclofenac selectively inhibits cyclooxygenase-2 (COX-2) and to a lesser extent COX-1, reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, producing analgesia and antipyresis. The combination provides additive pain relief through complementary mechanisms.
Mechanism Steps
💡 How to Take nobimef-d tablet
Strength: Aceclofenac 100 mg + Paracetamol 325 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally two to three times daily, preferably after meals. The maximum daily dose should not exceed three tablets in 24 hours. The exact dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not self-medicate or exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose adjustment may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver disease. Dose adjustment may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is three tablets in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nobimef-d tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Antihypertensives | Moderate | |
| Zidovudine | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs
- Corticosteroids
- Methotrexate
- ACE inhibitors and ARBs
- Diuretics
⚡ Moderate Interactions
- Lithium
- SSRIs
- Antihypertensives
- Zidovudine
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulceration, and liver damage, especially with Paracetamol. It may also enhance drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to Aceclofenac, Paracetamol, or any component of the formulation","Active peptic ulcer or history of recurrent peptic ulcer","Severe heart failure","Severe kidney disease","Severe liver disease","Third trimester of pregnancy","Children under 12 years of age (unless specifically prescribed)","Asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs"]
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose or duration.","Use with caution in elderly patients.","Use with caution in patients with kidney or liver disease.","Use with caution in patients with cardiovascular risk factors.","Do not use for more than 7 days without medical advice.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Do not drive or operate machinery if you feel dizzy or drowsy.","Keep out of reach of children."]
🤱 Lactation Safety
Aceclofenac and Paracetamol are excreted in breast milk in small amounts. Paracetamol is generally considered safe during breastfeeding. Aceclofenac is not recommended during breastfeeding due to lack of sufficient data. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, especially due to Paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and jaundice. Seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine for Paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine with food or milk to reduce stomach upset. Do not exceed the recommended dose or duration of treatment. Avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding and liver damage. Do not take other pain relievers or NSAIDs without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly.
🤰 Pregnancy Planning (TTC)
Consult your doctor before taking this medicine if you are planning pregnancy. NSAIDs may affect ovulation and are generally avoided during pregnancy, especially in the third trimester.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain as prescribed by your doctor. Inform your surgeon about all medicines you are taking. Avoid alcohol and follow your doctor's instructions for pain management.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may increase bleeding risk during dental surgery. Your dentist may advise temporary discontinuation.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase pain or risk of injury while taking this medicine. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as stomach bleeding, allergic reactions, or if your pain does not improve within 7 days. Do not stop abruptly if you have been taking it for a long time without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney problems, liver damage, and cardiovascular events. Regular monitoring of liver and kidney function is recommended if prolonged use is necessary. Do not use for more than 7 days without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help relieve localized pain and inflammation.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccination timing while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing times gradually. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30 to 60 minutes after taking this medicine.
A: It is best taken with food or milk to reduce stomach upset.
A: It should only be taken for short periods as prescribed by your doctor. Long-term use requires medical supervision.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach upset. - Myth: It is safe to take this medicine for long periods without doctor supervision.
Fact: Prolonged use can cause serious side effects and should be monitored by a doctor. - Myth: This medicine is safe during pregnancy.
Fact: It is generally avoided during pregnancy, especially in the third trimester, unless prescribed by a doctor.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac + Paracetamol generic tablets