Fibnib 150mg Soft Gelatin Capsule (Nintedanib): Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe or persistent diarrhea leading to dehydration
- Yellowing of skin or eyes (jaundice)
- Severe abdominal pain with fever
- Blood in vomit or black, tarry stools
- Chest pain, shortness of breath, or sudden weakness
- Swelling of face, lips, or throat
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is nintena 150mg soft gelatin capsule used for?
This medicine is a prescription oral antifibrotic used to slow lung function decline in idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and chronic fibrosing interstitial lung diseases with a progressive phenotype. It is taken as a 150 mg capsule twice daily with food.
- Generic Name: Nintedanib (150mg)
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nintena 150mg soft gelatin capsule के बारे में (Hindi Summary)
उपयोग: यह दवा निन्टेडैनिब 150 मिलीग्राम सॉफ्ट जिलेटिन कैप्सूल के रूप में उपलब्ध है। यह मुख्य रूप से इडियोपैथिक पल्मोनरी फाइब्रोसिस (आईपीएफ), सिस्टमिक स्क्लेरोसिस से जुड़े इंटरस्टिशियल लंग डिजीज (एसएससी-आईएलडी), और प्रगतिशील क्रोनिक फाइब्रोसिंग इंटरस्टिशियल लंग डिजीज के इलाज के लिए दी जाती है। यह फेफड़ों में निशान (फाइब्रोसिस) बनने की प्रक्रिया को धीमा करती है, जिससे फेफड़ों की कार्यक्षमता को बनाए रखने में मदद मिलती है। यह दवा बीमारी को पूरी तरह ठीक नहीं करती, लेकिन इसके बढ़ने की गति को कम करती है। इसे डॉक्टर की सलाह के बिना शुरू या बंद नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सबसे आम दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, पेट दर्द, भूख न लगना, और वजन कम होना शामिल हैं। कुछ मरीजों को सिरदर्द, थकान, या त्वचा पर दाने भी हो सकते हैं। गंभीर दुष्प्रभावों में लिवर की क्षति, आंतों में छेद, गंभीर रक्तस्राव, और दिल का दौरा या स्ट्रोक शामिल हैं। अगर आपको गंभीर दस्त, आंखों या त्वचा का पीला पड़ना, असामान्य रक्तस्राव, या सीने में दर्द हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। कैप्सूल को पानी के साथ पूरा निगलें, चबाएं या तोड़ें नहीं। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। डॉक्टर की सलाह के बिना दवा बंद न करें। इस दवा के साथ शराब न पिएं क्योंकि इससे लिवर को नुकसान का खतरा बढ़ सकता है। अगर आपको लिवर की बीमारी, रक्तस्राव विकार, या दिल की समस्या है तो डॉक्टर को बताएं। गर्भवती महिलाओं को यह दवा नहीं लेनी चाहिए। इलाज के दौरान और आखिरी खुराक के कम से कम 3 महीने बाद तक प्रभावी गर्भनिरोधक का इस्तेमाल करें। स्तनपान कराने वाली महिलाएं यह दवा न लें। नियमित रूप से लिवर फंक्शन टेस्ट कराते रहें।
💊 nintena 150mg soft gelatin capsule Uses & Benefits
[{"condition":"Idiopathic pulmonary fibrosis (IPF)","description":"This medicine slows the decline in lung function in adults with IPF.","evidence":"Well-established"},{"condition":"Systemic sclerosis-associated interstitial lung disease (SSc-ILD)","description":"It reduces the rate of lung function decline in patients with SSc-ILD.","evidence":"Well-established"},{"condition":"Chronic fibrosing interstitial lung diseases with a progressive phenotype","description":"This medicine is used to slow disease progression in adults with progressive chronic fibrosing ILDs.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Progressive fibrosing interstitial lung disease other than IPF or SSc-ILD","description":"Sometimes prescribed off-label for other progressive fibrotic lung diseases based on clinician judgment.","evidence":"Limited"},{"condition":"Advanced non-small cell lung cancer","description":"Nintedanib has been studied in combination with chemotherapy for NSCLC, but this is not a standard use for this formulation.","evidence":"Limited"}]
Primary treatment for: Idiopathic pulmonary fibrosis (IPF)
Also treats: Systemic sclerosis-associated interstitial lung disease (SSc-ILD), Chronic fibrosing interstitial lung diseases with a progressive phenotype
📋 Drug Information
| Generic Name(s) | Nintedanib (150mg) |
| Brand Name | nintena 150mg soft gelatin capsule |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep the capsules in their original blister pack or bottle to protect from moisture and light. Do not refrigerate or freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting a group of enzymes called tyrosine kinases, specifically the receptor tyrosine kinases FGFR, PDGFR, and VEGFR. These enzymes are involved in signaling pathways that promote the growth of fibroblasts and the deposition of scar tissue in the lungs. By blocking these pathways, this medicine reduces the proliferation and migration of fibroblasts and slows the progression of fibrosis. It also has anti-inflammatory effects by inhibiting certain kinases involved in immune cell activation.
Mechanism Steps
💡 How to Take nintena 150mg soft gelatin capsule
Strength: Soft gelatin capsule containing 150 mg of nintedanib.
Dosage Information
| Adult Dosage | The recommended dose of this medicine is 150 mg taken orally twice daily, approximately 12 hours apart, with food. For patients with mild hepatic impairment (Child-Pugh A), the dose may be reduced to 100 mg twice daily. Dose adjustments may be necessary based on tolerability and side effects. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients based on age alone. However, elderly patients may be more sensitive to side effects and should be monitored closely. |
| Renal Impairment | No dose adjustment is required for patients with mild to moderate renal impairment. This medicine has not been studied in patients with severe renal impairment or end-stage renal disease. |
| Hepatic Impairment | For patients with mild hepatic impairment (Child-Pugh A), the recommended dose is 100 mg twice daily. This medicine is contraindicated in patients with moderate or severe hepatic impairment (Child-Pugh B or C). |
| Maximum Daily Dose | 300 mg per day (150 mg twice daily). In mild hepatic impairment, the maximum daily dose is 200 mg (100 mg twice daily). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nintena 150mg soft gelatin capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Warfarin | Major | |
| Aspirin | Moderate | |
| Clopidogrel | Moderate | |
| Verapamil | Moderate | |
| Quinidine | Moderate | |
| Antacids | Minor | |
| Carbamazepine | Major | |
| Phenytoin | Major |
🚨 Major Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin)
- Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin)
- Anticoagulants (e.g., warfarin, heparin)
- Antiplatelet agents (e.g., aspirin, clopidogrel)
⚡ Moderate Interactions
- P-glycoprotein inhibitors (e.g., verapamil, quinidine)
- Grapefruit juice
🍷 Alcohol Interaction
Alcohol may increase the risk of liver damage and should be avoided while taking this medicine. It can also worsen gastrointestinal side effects such as nausea and diarrhea.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy","Moderate or severe hepatic impairment (Child-Pugh B or C)","Known hypersensitivity to nintedanib or any component of the capsule","Concomitant use with strong CYP3A4 inhibitors (relative contraindication)"]
⚠️ Warnings & Precautions
["Diarrhea: May be severe; monitor and treat promptly to prevent dehydration.","Liver injury: Monitor liver enzymes regularly; discontinue if severe.","Gastrointestinal perforation: Report severe abdominal pain immediately.","Bleeding: Use with caution in patients with bleeding disorders or on anticoagulants.","Arterial thromboembolic events: Monitor for signs of heart attack or stroke.","Embryo-fetal toxicity: Use effective contraception; avoid pregnancy.","Nephrotic range proteinuria: Monitor urine protein in patients with renal disease."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because of the potential for serious adverse reactions in breastfed infants, breastfeeding is not recommended during treatment and for at least 3 months after the last dose.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of suspected overdose, discontinue the medicine and seek immediate medical attention. Supportive care and symptomatic treatment should be provided. Monitor vital signs and liver function.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the capsule whole with water; do not chew or crush it. Take it with food to reduce stomach upset. Do not stop taking this medicine without consulting your doctor, as sudden discontinuation may worsen your condition. Avoid alcohol while on this medicine because it increases the risk of liver damage. Inform your doctor if you have a history of liver disease, bleeding disorders, or heart problems. Use effective contraception during treatment and for at least three months after the last dose if you are a woman of childbearing potential. Do not breastfeed while taking this medicine. Keep all follow-up appointments for liver function tests and other monitoring. Store the capsules at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects such as diarrhea, fatigue, and liver enzyme elevations. Close monitoring is recommended. No specific dose adjustment is required based on age alone, but individual tolerability should guide treatment.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated in pregnancy. Women of childbearing potential should use effective contraception during treatment and for at least 3 months after the last dose. If you are planning to become pregnant, consult your doctor to discuss alternative treatments and timing.
🏥 Post-Surgery Considerations
This medicine may increase the risk of bleeding and impair wound healing. Inform your surgeon that you are taking this medicine. Your doctor may recommend temporarily stopping the medicine before surgery. Do not restart without medical advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it may increase the risk of bleeding during dental procedures. Your dentist may take extra precautions. Do not stop the medicine without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally encouraged, but you should avoid strenuous activities if you feel fatigued or short of breath. Consult your doctor before starting any new exercise program. Stop exercising and seek medical attention if you experience chest pain, severe shortness of breath, or dizziness.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or diarrhea, which can affect your ability to drive or operate machinery. Use caution until you know how this medicine affects you. Most patients can continue their daily activities with some adjustments. Inform your employer about your condition and any necessary accommodations.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects such as liver injury, gastrointestinal perforation, or major bleeding, your doctor may advise you to stop. In case of planned surgery, inform your surgeon and doctor, as temporary discontinuation may be needed.
📅 Long-Term Use Effects
Long-term use of this medicine may be associated with persistent gastrointestinal side effects, liver enzyme abnormalities, and increased risk of bleeding. Regular monitoring of liver function, renal function, and blood counts is necessary. The benefits of slowing lung function decline generally outweigh the risks in appropriate patients. Your doctor will periodically assess whether continued treatment is beneficial.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another antifibrotic medicine approved for IPF.
Evidence: Well-establishedExercise and education program to improve lung function and quality of life.
Evidence: Well-establishedFor patients with low blood oxygen levels.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Patients with interstitial lung disease should receive appropriate vaccinations, including influenza and pneumococcal vaccines, to prevent respiratory infections. Live vaccines should be avoided if you are on immunosuppressive therapy. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from moisture. If crossing time zones, adjust dosing times gradually to maintain approximately 12-hour intervals. Check local regulations regarding carrying prescription medicines. Carry enough supply for your entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working gradually. It may take several weeks to months to see a noticeable slowing in lung function decline. Regular follow-up with your doctor is important.
A: No, you should not stop taking this medicine without consulting your doctor. Stopping suddenly may lead to worsening of your condition.
A: Stay hydrated and inform your doctor. Your doctor may recommend antidiarrheal medication or adjust your dose. Seek immediate care if diarrhea is severe or persistent.
🤔 Common Patient Concerns
🔄 Substitutes for nintena 150mg soft gelatin capsule
View AllAlternative brands with exact same active ingredient:
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mantedanib capsule 150mgMankind Pharma Ltd ₹843.74 455.5% COSTLIER
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nintenib 150 soft gelatin capsuleBDR Pharmaceuticals Internationals Pvt ₹843.75 455.5% COSTLIER
-
fibronib 150 capsuleChemo Healthcare Pvt Ltd ₹900.00 492.6% COSTLIER
-
nintabid 150mg capsuleJ B Chemicals and Pharmaceuticals Ltd ₹900.00 492.6% COSTLIER
-
nintib 150 soft gelatin capsuleCipla Ltd ₹1,060.64 598.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure pulmonary fibrosis.
Fact: This medicine slows the progression of fibrosis but does not cure the disease. - Myth: You can stop taking this medicine once you feel better.
Fact: This medicine must be taken continuously as prescribed; stopping may lead to worsening of the disease. - Myth: This medicine is safe to take during pregnancy.
Fact: This medicine is contraindicated in pregnancy and can harm the fetus.