Nilitis P 100 mg/500 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is nilitis p 100 mg/500 mg tablet used for?
This medicine is a combination of nabumetone and paracetamol used for short-term relief of acute pain and inflammation. It works by reducing prostaglandins. Take it with food and avoid alcohol.
- Generic Name: Nabumetone (100mg) + Paracetamol (500mg)
- Manufacturer: Ipca Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nilitis p 100 mg/500 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नबुमेटोन और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, पोस्ट-ऑपरेटिव दर्द और मासिक धर्म के दर्द में राहत देती है। इसे भोजन के साथ लें और शराब से बचें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, पेट दर्द, सिरदर्द, चक्कर आना और दस्त शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, गुर्दे की समस्या, यकृत की क्षति और त्वचा पर गंभीर प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला मल, उल्टी में खून, या पेट में तेज दर्द हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि पेट की जलन कम हो। शराब का सेवन न करें। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आपको गुर्दे या यकृत की बीमारी है, तो डॉक्टर को बताएं। गर्भावस्था के दौरान डॉक्टर की सलाह के बिना न लें।
💊 nilitis p 100 mg/500 mg tablet Uses & Benefits
[{"condition":"Musculoskeletal pain","description":"Relieves pain and inflammation associated with strains, sprains, and other musculoskeletal injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from mild to moderate dental pain, including toothache and post-extraction pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain following surgical procedures.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Helps relieve menstrual cramps and associated pain.","evidence":"Well-established"},{"condition":"Fever","description":"Paracetamol component helps reduce fever, though this combination is primarily used for pain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not a first-line treatment.","evidence":"Limited"},{"condition":"Osteoarthritis flare","description":"May be used short-term for osteoarthritis pain flares, but nabumetone alone is more common.","evidence":"Limited"}]
Primary treatment for: Musculoskeletal pain
Also treats: Dental pain, Post-operative pain, Dysmenorrhea, Fever
📋 Drug Information
| Generic Name(s) | Nabumetone (100mg) + Paracetamol (500mg) |
| Brand Name | nilitis p 100 mg/500 mg tablet |
| Manufacturer | Ipca Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nabumetone is a non-acidic prodrug that is metabolized in the liver to its active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA). 6-MNA inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, leading to analgesia and antipyresis. The combination provides both peripheral anti-inflammatory and central analgesic effects.
Mechanism Steps
💡 How to Take nilitis p 100 mg/500 mg tablet
Strength: Nabumetone 100 mg and Paracetamol 500 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once or twice daily, or as directed by your doctor. The dose must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not exceed the recommended dose. Take with food or milk to reduce stomach upset. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially gastrointestinal and kidney effects. Use with caution and at the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose adjustment may be necessary. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose adjustment may be necessary. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose should not exceed the equivalent of 2000 mg of paracetamol and 2000 mg of nabumetone, but the exact maximum for this combination must be determined by a qualified clinician based on individual patient factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nilitis p 100 mg/500 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Lithium | Moderate | |
| Methotrexate | Moderate | |
| SSRIs | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs
- Corticosteroids
- ACE inhibitors and ARBs
- Diuretics
⚡ Moderate Interactions
- Lithium
- Methotrexate
- SSRIs
- Anticoagulants (other than warfarin)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can potentiate liver damage, especially due to the paracetamol component.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nabumetone, paracetamol, or any component of the formulation","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs","Active peptic ulcer or gastrointestinal bleeding","Severe kidney impairment","Severe liver impairment","Third trimester of pregnancy","Coronary artery bypass graft (CABG) surgery"]
⚠️ Warnings & Precautions
["Cardiovascular risk: NSAIDs may increase the risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke.","Gastrointestinal risk: NSAIDs can cause serious gastrointestinal adverse events, including bleeding, ulceration, and perforation, which can be fatal.","Kidney risk: NSAIDs can cause kidney injury, especially in patients with pre-existing kidney disease, heart failure, or dehydration.","Liver risk: Paracetamol can cause liver damage in overdose. Do not exceed recommended dose.","Skin reactions: Serious skin reactions have been reported with NSAIDs and paracetamol. Discontinue at first sign of rash.","Use with caution in the elderly, who are at higher risk of adverse effects.","Do not use in patients with aspirin-sensitive asthma.","Avoid alcohol consumption while taking this medicine."]
🤱 Lactation Safety
Nabumetone and paracetamol are excreted in breast milk in small amounts. Consult your doctor before use during breastfeeding. Generally considered compatible with breastfeeding but monitor infant for any adverse effects.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to paracetamol and gastrointestinal bleeding due to nabumetone. Seek immediate medical attention. Treatment includes activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of gastrointestinal bleeding and liver damage. Do not take other NSAIDs or paracetamol-containing products simultaneously to prevent overdose. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, high blood pressure, or heart failure. Use with caution in the elderly. Do not use this medicine during the third trimester of pregnancy without medical advice. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for the next dose. Do not double the dose. Store at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use with caution and at the lowest effective dose for the shortest duration.
🤰 Pregnancy Planning (TTC)
Consult your doctor before planning pregnancy or if you become pregnant while taking this medicine. Avoid use during the third trimester.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain, but consult your surgeon before use, especially if you are on other medications or have bleeding risks.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise that may exacerbate pain or injury. Consult your doctor before starting any exercise program while on this medicine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It may affect your ability to perform tasks requiring alertness.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects, allergic reactions, or if your pain worsens. Do not stop abruptly without medical advice if you have been on long-term therapy.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney impairment, liver damage, and cardiovascular events. Regular monitoring of kidney and liver function is recommended. Use the lowest effective dose for the shortest duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help relieve localized pain and inflammation.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. Consult your doctor before vaccination if you are on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30 to 60 minutes after taking this medicine.
A: It is best taken with food or milk to reduce stomach upset.
A: Do not take other NSAIDs or paracetamol-containing products without consulting your doctor.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach upset. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol increases the risk of gastrointestinal bleeding and liver damage. - Myth: This medicine is safe for long-term use without monitoring.
Fact: Long-term use requires monitoring of kidney and liver function.
🔄 Alternative Options
Generic Alternatives
- Nabumetone 100 mg + Paracetamol 500 mg tablet