Korandil Iv 48mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Blurred vision or confusion
- Chest pain that worsens or does not improve
- Swelling of face, lips, or throat
- Difficulty breathing
- Rapid or irregular heartbeat
- Cold, clammy skin
If experiencing severe symptoms, call emergency services immediately.
What is nicoduce 48mg injection used for?
This medicine is an intravenous injection used in hospitals to treat unstable angina and acute coronary syndromes. It works by widening blood vessels to improve blood flow to the heart and reduce chest pain. It is given only by healthcare professionals under close monitoring.
- Generic Name: Nicorandil (48mg)
- Manufacturer: Abbott
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nicoduce 48mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा निकोरंडिल का इंजेक्शन रूप है, जिसे अस्पताल में डॉक्टर की देखरेख में दिया जाता है। इसका उपयोग अस्थिर एनजाइना और दिल से जुड़ी कुछ समस्याओं में सीने के दर्द को कम करने और दिल तक खून का प्रवाह बढ़ाने के लिए किया जाता है। यह दवा रक्त वाहिकाओं को फैलाकर दिल पर दबाव कम करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, चेहरे पर गर्मी लगना और जी मिचलाना शामिल हैं। कभी-कभी ब्लड प्रेशर अचानक कम हो सकता है, जिससे बेहोशी आ सकती है। अगर कोई भी दुष्प्रभाव गंभीर लगे तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा सिर्फ अस्पताल में डॉक्टर या नर्स द्वारा ही दी जानी चाहिए। इसे घर पर खुद न लगवाएं। इलाज के दौरान शराब न पिएं क्योंकि इससे चक्कर और ब्लड प्रेशर कम हो सकता है। अगर आपको सिरदर्द, धुंधला दिखना या बेहोशी महसूस हो तो तुरंत डॉक्टर को बताएं।
💊 nicoduce 48mg injection Uses & Benefits
[{"condition":"Unstable angina","description":"Used in hospital settings to relieve chest pain and improve blood flow in patients with unstable angina.","evidence":"Well-established"},{"condition":"Acute coronary syndrome","description":"Administered intravenously as part of the management of acute coronary syndromes to reduce cardiac workload and improve coronary blood flow.","evidence":"Well-established"},{"condition":"Stable angina (acute episodes)","description":"May be used intravenously for rapid relief of angina symptoms in a monitored setting.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prevention of contrast-induced nephropathy","description":"Sometimes studied for protecting kidney function during procedures using contrast dye, but evidence is limited.","evidence":"Limited"},{"condition":"Heart failure","description":"Occasionally used in research settings for heart failure management, but not standard practice.","evidence":"Limited"}]
Primary treatment for: Unstable angina
Also treats: Acute coronary syndrome, Stable angina
📋 Drug Information
| Generic Name(s) | Nicorandil (48mg) |
| Brand Name | nicoduce 48mg injection |
| Manufacturer | Abbott |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Potassium channel opener |
| Route of Administration | Parenteral (intravenous) |
| Storage | Store in a refrigerator (2-8°C). Do not freeze. Keep in the original container to protect from light. |
| Shelf Life | Not established from the available information. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by opening ATP-sensitive potassium channels in vascular smooth muscle cells, which leads to relaxation of blood vessels. It also has a nitrate-like effect that increases cyclic GMP levels, further promoting vasodilation. The combined effect reduces coronary artery resistance and improves blood flow to the heart muscle while decreasing the heart's workload.
Mechanism Steps
💡 How to Take nicoduce 48mg injection
Strength: Injection, 48 mg
Dosage Information
| Adult Dosage | The dose of this medicine is determined by a qualified clinician based on the patient's condition, response to treatment, and other factors. It is given intravenously, usually in a hospital setting. The typical adult dose may range from 2 mg to 48 mg per day, but the exact dose and rate of administration must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Dose should be individualized by a qualified clinician, and blood pressure should be monitored closely. |
| Renal Impairment | Dose adjustment may be needed in patients with severe kidney impairment. Consult a qualified clinician for individualized dosing. |
| Hepatic Impairment | Dose adjustment may be needed in patients with severe liver impairment. Consult a qualified clinician for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nicoduce 48mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Sildenafil | Major | |
| Tadalafil | Major | |
| Riociguat | Major | |
| Nitroglycerin | Moderate | |
| Isosorbide mononitrate | Moderate | |
| Metoprolol | Moderate | |
| Amlodipine | Moderate | |
| Alcohol | Moderate | |
| Ibuprofen | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil)
- Soluble guanylate cyclase stimulators (e.g., riociguat)
⚡ Moderate Interactions
- Other nitrates (e.g., nitroglycerin, isosorbide mononitrate)
- Antihypertensives (e.g., beta-blockers, calcium channel blockers)
- Alcohol
🍷 Alcohol Interaction
Alcohol can enhance the blood pressure-lowering effect of this medicine and increase the risk of dizziness, fainting, and falls. It is best to avoid alcohol while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to nicorandil or any component of the formulation","Severe hypotension (low blood pressure)","Cardiogenic shock","Concomitant use with phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil)","Concomitant use with riociguat","Acute myocardial infarction with low filling pressures","Severe dehydration"]
⚠️ Warnings & Precautions
["This medicine must be administered only by a healthcare professional in a monitored setting.","Blood pressure and heart rate should be monitored closely during administration.","Use with caution in patients with glaucoma or raised intracranial pressure.","Avoid use in patients with severe liver or kidney disease unless clearly necessary.","Patients should be warned about the risk of dizziness and advised not to drive or operate machinery until they know how this medicine affects them.","Alcohol should be avoided during treatment."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor before use if breastfeeding.
💊 Overdose Management
Overdose can cause severe hypotension, tachycardia, and fainting. Treatment is supportive and symptomatic. If overdose is suspected, seek immediate medical attention. There is no specific antidote.
⏰ Missed Dose
This medicine is given by a healthcare professional in a hospital or clinic setting. Missed doses are managed by the medical team. If you miss an appointment for your dose, contact your healthcare provider as soon as possible.
Additional Safety Advice
This medicine must only be given by a healthcare professional in a setting where blood pressure and heart rate can be monitored. Patients should inform their doctor about all other medicines they are taking, especially those for erectile dysfunction, as combining them can cause a dangerous drop in blood pressure. Alcohol should be avoided during treatment because it can worsen dizziness and low blood pressure. Anyone who develops severe headache, blurred vision, or fainting should receive immediate medical attention. This medicine is not for self-administration at home.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Close monitoring of blood pressure and heart rate is recommended. Dose adjustment may be necessary.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before receiving this medicine. The safety of this medicine in pregnancy is not well established. Alternative treatments may be considered.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your surgeon and anesthesiologist about this medicine. It may interact with other medications used during surgery and affect blood pressure.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it can cause dizziness and low blood pressure. Your dentist may take precautions during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise until your doctor says it is safe. Start with light activities and gradually increase as tolerated. Stop immediately if you experience chest pain, dizziness, or shortness of breath.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital, so it may require a short hospital stay. After discharge, you may feel dizzy or tired for a day or two. Avoid driving or operating heavy machinery until you feel normal. Discuss with your doctor when you can return to work.
🛑 When to Stop This Medicine
Do not stop this medicine without your doctor's advice. It is usually stopped by the healthcare team once your condition stabilizes or you are switched to oral medication. If you experience severe side effects, inform your doctor immediately.
📅 Long-Term Use Effects
This medicine is typically used for short-term treatment in a hospital setting. Long-term effects are not well established. Prolonged use may increase the risk of mouth ulcers and other side effects. Regular monitoring by a doctor is required if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Other nitrates like nitroglycerin can also relieve angina.
Evidence: Well-establishedUsed for long-term management of angina.
Evidence: Well-establishedCan help reduce angina episodes.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Discuss with your doctor about vaccinations, especially if you have heart disease.
📦 Storage Guide
✅ DO
Store in a refrigerator (2-8°C)
❌ DON'T
Do not freeze
✅ DO
Keep in the original container to protect from light
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store at room temperature for long periods
✈️ Traveling with This Medicine
This medicine is given in a hospital setting, so travel advice is not applicable. If you are prescribed this medicine for home use, which is unlikely, carry it in its original packaging with a copy of your prescription. Store it in a refrigerator (2-8°C) and do not freeze. Check with your airline and customs about carrying injectable medicines. Always carry a doctor's letter explaining your need for this medicine.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within minutes after intravenous administration.
A: No, you should not drive or operate machinery until you know how this medicine affects you, as it can cause dizziness.
A: No, alcohol can increase the blood pressure-lowering effect and cause dizziness or fainting.
A: The safety of this medicine in pregnancy is not well established. It should be used only if clearly needed and prescribed by your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for nicoduce 48mg injection
View AllAlternative brands with exact same active ingredient:
-
korandil iv 48mg injectionSun Pharmaceutical Industries Ltd ₹137.31 66.3% CHEAPER
-
niconova i.v. 48 injectionAstranova Biotech ₹225.00 44.7% CHEAPER
-
nicostar 48mg injectionLupin Ltd ₹365.91 10.1% CHEAPER
-
nikoran iv 48 injectionTorrent Pharmaceuticals Ltd ₹480.00 17.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be self-administered at home.
Fact: This medicine is given only by a healthcare professional in a hospital or clinic setting. - Myth: This medicine is a painkiller for all types of chest pain.
Fact: This medicine is specifically for angina and certain heart conditions, not for all chest pain. - Myth: You can take this medicine with alcohol without any issues.
Fact: Alcohol can increase the blood pressure-lowering effect and cause dizziness or fainting.
🔄 Alternative Options
Generic Alternatives
- Nicorandil injection
Brand Alternatives
- Korandil IV 48mg injection