Nexflo Oz 200mg/200mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Sudden tendon pain or swelling
- Numbness or tingling in hands or feet
- Seizures or confusion
If experiencing severe symptoms, call emergency services immediately.
What is nexflo oz 200mg/200mg tablet used for?
This medicine is a combination antibiotic and antiprotozoal tablet containing Ofloxacin 200 mg and Ornidazole 200 mg. It is used to treat various bacterial and protozoal infections, including diarrhoea, dysentery, and intra-abdominal infections. It works by killing bacteria and protozoa. It must be taken exactly as prescribed, and alcohol must be avoided.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nexflo oz 200mg/200mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ओफ्लोक्सासिन और ओर्निडाजोल का संयोजन है, जिसका उपयोग विभिन्न जीवाणु और प्रोटोज़ोआ संक्रमणों के इलाज के लिए किया जाता है। यह दस्त, पेचिश, पेट के अंदर के संक्रमण, स्त्री रोग संबंधी संक्रमण, और कुछ यौन संचारित संक्रमणों के इलाज में प्रभावी है। यह दवा कीटाणुओं को मारकर काम करती है। इसे डॉक्टर के निर्देशानुसार ही लें और कोर्स पूरा करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द, चक्कर आना और मुँह में धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, टेंडन टूटना, तंत्रिका समस्याएँ, दौरे और गंभीर दस्त हो सकते हैं। कोई भी गंभीर लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। कोर्स बीच में न छोड़ें, भले ही आप बेहतर महसूस करें। दवा लेते समय और आखिरी खुराक के 48 घंटे बाद तक शराब न लें, क्योंकि इससे गंभीर प्रतिक्रिया हो सकती है। चक्कर आने पर वाहन न चलाएँ। पर्याप्त पानी पिएँ। धूप से बचें। गुर्दे या यकृत की समस्या हो तो डॉक्टर को बताएँ।
💊 nexflo oz 200mg/200mg tablet Uses & Benefits
[{"condition":"Bacterial and protozoal diarrhoea","description":"Used to treat infectious diarrhoea caused by susceptible bacteria and protozoa like Giardia and Entamoeba.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Effective against mixed aerobic and anaerobic infections in the abdomen, such as peritonitis and abscesses.","evidence":"Well-established"},{"condition":"Pelvic inflammatory disease","description":"Used as part of combination therapy for pelvic inflammatory disease caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Bacterial vaginosis","description":"Treats bacterial vaginosis by eliminating causative anaerobic bacteria.","evidence":"Well-established"},{"condition":"Amoebic liver abscess","description":"Used in the treatment of amoebic liver abscess caused by Entamoeba histolytica.","evidence":"Well-established"},{"condition":"Giardiasis","description":"Effective against Giardia lamblia infection in the intestines.","evidence":"Well-established"},{"condition":"Trichomoniasis","description":"Used to treat trichomoniasis, a sexually transmitted protozoal infection.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prophylaxis in colorectal surgery","description":"Sometimes used off-label to prevent postoperative infections in colorectal surgery.","evidence":"Limited"},{"condition":"Chronic prostatitis","description":"Occasionally prescribed off-label for chronic bacterial prostatitis.","evidence":"Limited"}]
Primary treatment for: Bacterial and protozoal infections
Also treats: Diarrhoea, Dysentery, Intra-abdominal infections, Pelvic inflammatory disease, Bacterial vaginosis, Amoebiasis, Giardiasis, Trichomoniasis
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nexflo oz 200mg/200mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimicrobial agents with different mechanisms. Ofloxacin is a fluoroquinolone that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination. This leads to inhibition of bacterial DNA synthesis and cell death. Ornidazole is a nitroimidazole that enters microbial cells and is reduced by ferredoxin-like electron transport proteins in anaerobic organisms. The reduced nitro radical intermediates cause DNA strand breakage and inhibit DNA synthesis, leading to cell death. The combination provides broad-spectrum coverage against aerobic and anaerobic bacteria as well as protozoa.
Mechanism Steps
💡 How to Take nexflo oz 200mg/200mg tablet
Strength: Each tablet contains Ofloxacin 200 mg and Ornidazole 200 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet twice daily (every 12 hours) or as prescribed by your doctor. The exact dose and duration depend on the type and severity of the infection, your age, weight, kidney and liver function, and other medications you are taking. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Complete the full course even if you feel better. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially tendon rupture, kidney problems, and central nervous system effects. Dose adjustment may be required based on renal function. Consult your doctor. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For Ofloxacin, the dose may need to be reduced or the interval increased. Ornidazole may also require adjustment. Consult your doctor for personalized dosing. |
| Hepatic Impairment | Dose adjustment may be required in patients with severe hepatic impairment. Monitor liver function. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is generally 400 mg of Ofloxacin and 400 mg of Ornidazole (two tablets per day), but this may vary based on the indication and patient factors. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nexflo oz 200mg/200mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Antacids | Major | |
| Theophylline | Major | |
| NSAIDs | Major | |
| Alcohol | Major | |
| Cyclosporine | Moderate | |
| Oral hypoglycemics | Moderate | |
| Phenytoin | Moderate | |
| Caffeine | Minor | |
| Corticosteroids | Minor |
🚨 Major Interactions
- Antacids, sucralfate, iron, zinc
- Warfarin
- Theophylline
- NSAIDs
- Alcohol
⚡ Moderate Interactions
- Caffeine
- Cyclosporine
- Oral hypoglycemics
- Phenytoin
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Concurrent use can cause a disulfiram-like reaction characterized by severe nausea, vomiting, flushing, headache, and rapid heartbeat. Alcohol may also worsen central nervous system side effects such as dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Ofloxacin, Ornidazole, or other fluoroquinolones/nitroimidazoles","History of tendon disorders related to fluoroquinolone use","Myasthenia gravis","Severe renal impairment (dose adjustment required)","Epilepsy or other seizure disorders (use with caution)","Pregnancy and breastfeeding (unless clearly needed)","Children under 18 years (fluoroquinolones generally not recommended)"]
⚠️ Warnings & Precautions
["May cause dizziness and drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid excessive sunlight and use sunscreen due to photosensitivity risk.","May worsen muscle weakness in patients with myasthenia gravis.","Can cause tendon inflammation or rupture; stop and consult doctor if tendon pain occurs.","May cause peripheral neuropathy; report numbness or tingling.","Can cause severe diarrhoea; do not treat without medical advice.","May interact with alcohol causing disulfiram-like reaction.","Use with caution in elderly patients and those with renal or hepatic impairment.","May prolong QT interval; use caution with other QT-prolonging drugs.","Complete the full course as prescribed to prevent resistance."]
🤱 Lactation Safety
Ofloxacin and Ornidazole are excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor.
💊 Overdose Management
Overdose may cause nausea, vomiting, dizziness, and seizures. There is no specific antidote. Treatment is supportive and symptomatic. Maintain adequate hydration. In case of overdose, seek immediate medical attention or contact a poison control center.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop the course early, even if you feel better, as this can lead to treatment failure and antibiotic resistance. Take the tablet with a full glass of water, with or without food, but taking it with food may reduce stomach upset. Avoid alcohol completely while taking this medicine and for at least 48 hours after the last dose, as it can cause severe nausea, vomiting, flushing, and rapid heartbeat. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have kidney or liver problems, epilepsy, or myasthenia gravis. Avoid excessive sun exposure as this medicine can make your skin more sensitive to sunlight. Do not share this medicine with others. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, kidney problems, and central nervous system effects. Dose adjustment may be needed based on renal function. Monitor closely for side effects.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It should be used during pregnancy only if clearly needed. Discuss alternative treatments if possible.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery to prevent or treat infections. Follow your surgeon's instructions carefully. Inform your surgeon if you are taking this medicine before any surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with other medications used during dental work. Maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, as it can increase the risk of tendon rupture. If you experience joint or tendon pain, stop exercising and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or confusion, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is advisable to take rest and stay hydrated. Inform your employer if you need to take time off.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to treatment failure and antibiotic resistance. If you experience serious side effects, contact your doctor immediately; they may advise you to stop.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of antibiotic resistance, tendon problems, peripheral neuropathy, and liver or kidney issues. It should only be used for the prescribed duration. Regular monitoring of liver and kidney function may be required if used for prolonged periods. Consult your doctor if you have any concerns.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help restore gut flora and reduce antibiotic-associated diarrhoea.
Evidence: ModerateEssential for managing dehydration from diarrhoea.
Evidence: Well-establishedAvoiding spicy and fatty foods can reduce stomach upset.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines like typhoid vaccine. Avoid taking live vaccines during treatment and for several days after. Consult your doctor for specific advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust dosing times gradually to maintain even intervals. Check customs regulations for carrying prescription medicines. Always carry enough supply for the entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it is important to complete the full course as prescribed.
A: Yes, you can take it with or without food, but taking it with food reduces stomach upset.
A: Avoid alcohol, antacids, iron, and zinc supplements within 2 hours before or 6 hours after taking this medicine. Also avoid excessive sun exposure.
A: Fluoroquinolones are generally not recommended for children under 18 years. Consult a pediatrician.
A: No, you must complete the full course to prevent recurrence and antibiotic resistance.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhoea.
Fact: It only works for specific bacterial or protozoal infections. Viral diarrhoea does not respond to antibiotics. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course to prevent recurrence and resistance. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a severe disulfiram-like reaction and must be avoided. - Myth: This medicine is safe for children.
Fact: Fluoroquinolones are generally not recommended for children under 18 years.
🔄 Alternative Options
Generic Alternatives
- Ofloxacin 200 mg + Ornidazole 200 mg tablet
Brand Alternatives
- Oflox OZ
- O2
- Zanocin OZ
- Normet
- Ofloxacin Ornidazole