Axonrich Gold Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Severe dizziness or fainting
- Chest pain or palpitations
- Severe skin rash or hives
- High fever with chills
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is Neurozine Injection used for?
This medicine is an injectable combination of methylcobalamin (vitamin B12) and thiamine (vitamin B1) used to treat deficiencies of these vitamins, which can cause anemia, nerve damage, and other symptoms. It is given by a healthcare professional.
- Generic Name: Methylcobalamin (1000mg) + Thiamine(Vitamin B1) (100mg)
- Manufacturer: Trimak Lifesciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Neurozine Injection के बारे में (Hindi Summary)
उपयोग: यह दवा मेथिलकोबालामिन (विटामिन बी12) और थायमिन (विटामिन बी1) का इंजेक्शन है। इसका उपयोग इन विटामिनों की कमी के इलाज के लिए किया जाता है, जिससे एनीमिया, नसों की समस्या, और थकान जैसी समस्याएं हो सकती हैं। यह इंजेक्शन डॉक्टर या नर्स द्वारा दिया जाता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन की जगह पर दर्द, लालिमा, या सूजन शामिल हैं। कभी-कभी मतली, दस्त, या चक्कर आ सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी की प्रतिक्रिया हो सकती है, जिसमें सांस लेने में कठिनाई, चेहरे या गले में सूजन, और ब्लड प्रेशर में गिरावट शामिल है। अगर ऐसा हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा दी जानी चाहिए। खुद से इंजेक्शन न लगाएं। इंजेक्शन लेने से पहले अपने डॉक्टर को अपनी सभी बीमारियों और दवाओं के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। शराब का सेवन न करें। इंजेक्शन के बाद चक्कर आने पर वाहन न चलाएं। डॉक्टर के बताए अनुसार नियमित जांच कराएं।
💊 Neurozine Injection Uses & Benefits
[{"condition":"Vitamin B12 deficiency","description":"This medicine provides methylcobalamin to correct vitamin B12 deficiency, which can cause anemia, fatigue, and neurological symptoms.","evidence":"Well-established"},{"condition":"Thiamine (vitamin B1) deficiency","description":"It supplies thiamine to treat or prevent vitamin B1 deficiency, which can lead to beriberi or Wernicke's encephalopathy.","evidence":"Well-established"},{"condition":"Peripheral neuropathy","description":"This medicine is used to support nerve health and reduce symptoms such as tingling, numbness, and burning in the hands and feet, especially when caused by vitamin deficiencies.","evidence":"Moderate"},{"condition":"Megaloblastic anemia","description":"Methylcobalamin is essential for red blood cell production and is used to treat certain types of anemia caused by vitamin B12 deficiency.","evidence":"Well-established"},{"condition":"Wernicke-Korsakoff syndrome","description":"Thiamine is a critical treatment for this serious neurological condition, often seen in people with chronic alcohol use disorder.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Diabetic neuropathy","description":"Sometimes prescribed to help manage nerve pain in diabetes, although evidence for benefit is mixed.","evidence":"Limited"},{"condition":"Age-related cognitive decline","description":"Occasionally used with the hope of improving memory or cognitive function, but robust evidence is lacking.","evidence":"Insufficient"},{"condition":"Chronic fatigue syndrome","description":"May be given to address potential vitamin deficiencies, but it is not a proven treatment for this condition.","evidence":"Limited"}]
Primary treatment for: Vitamin B12 and thiamine deficiency
Also treats: Peripheral neuropathy, Megaloblastic anemia, Wernicke-Korsakoff syndrome, Beriberi
📋 Drug Information
| Generic Name(s) | Methylcobalamin (1000mg) + Thiamine(Vitamin B1) (100mg) |
| Brand Name | Neurozine Injection |
| Manufacturer | Trimak Lifesciences |
| Packaging / Form | ampoule of 1 Injection (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Parenteral (intramuscular or intravenous injection) |
| Storage | Store in a refrigerator at 2°C to 8°C. Do not freeze. Protect from light. Keep the vial in the outer carton until use. Do not use if the solution is discolored or contains particles. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise stated on the label. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by supplying two essential vitamins that act as coenzymes in critical biochemical reactions. Methylcobalamin is the active form of vitamin B12 and serves as a cofactor for two key enzymes: methionine synthase and methylmalonyl-CoA mutase. Methionine synthase converts homocysteine to methionine, which is necessary for DNA synthesis and methylation reactions. Methylmalonyl-CoA mutase converts methylmalonyl-CoA to succinyl-CoA, which is used in the citric acid cycle for energy production. In the nervous system, methylcobalamin supports the maintenance of the myelin sheath that insulates nerve fibers, and it helps in the synthesis of neurotransmitters. Thiamine, after being converted to its active form thiamine pyrophosphate, acts as a coenzyme for several enzymes involved in carbohydrate metabolism, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase. These enzymes are crucial for generating energy and for the synthesis of nucleic acids and neurotransmitters. Thiamine also plays a role in nerve conduction and muscle function. Together, these vitamins support normal nerve function, red blood cell formation, and energy metabolism.
Mechanism Steps
💡 How to Take Neurozine Injection
Strength: Injection: Methylcobalamin 1000 mg + Thiamine (Vitamin B1) 100 mg.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the specific indication, severity of deficiency, age, weight, renal and hepatic function, and clinical response. For vitamin B12 deficiency, typical adult doses range from 1000 mcg intramuscularly daily for one week, then weekly for one month, and then monthly. For thiamine deficiency, typical adult doses range from 10 to 100 mg intramuscularly or intravenously daily, depending on the severity. In severe cases such as Wernicke's encephalopathy, higher doses may be used. This information is for educational purposes only and does not replace professional medical advice. Always follow your doctor's prescription. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing. |
| Elderly Dosage | Elderly patients may have reduced renal function and may require lower doses. Dose adjustment should be based on clinical response and renal function. Consult a doctor for individualized dosing. |
| Renal Impairment | Patients with renal impairment may require dose adjustment. Monitor renal function and adjust dose as needed. Consult a doctor for specific guidance. |
| Hepatic Impairment | Patients with hepatic impairment may require dose adjustment. Monitor liver function and adjust dose as needed. Consult a doctor for specific guidance. |
| Maximum Daily Dose | The maximum daily dose should not exceed the recommended dose prescribed by your doctor. For methylcobalamin, doses up to 1000 mcg per day are commonly used. For thiamine, doses up to 100 mg per day are typical, but higher doses may be used in severe deficiency under medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Neurozine Injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Chloramphenicol | Major | |
| Omeprazole | Major | |
| Metformin | Major | |
| Alcohol | Moderate | |
| Colchicine | Moderate | |
| Aminoglycosides | Moderate | |
| Vitamin C | Minor | |
| Potassium supplements | Minor |
🚨 Major Interactions
- Chloramphenicol
- Omeprazole and other proton pump inhibitors
- Metformin
⚡ Moderate Interactions
- Alcohol
- Colchicine
- Aminoglycosides
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. Chronic alcohol consumption can lead to thiamine deficiency and worsen neurological symptoms. Alcohol can also impair the absorption of vitamin B12 from the gut, although this is less relevant for injectable forms. Additionally, alcohol may increase the risk of liver problems and can interact with other medications. It is best to discuss alcohol use with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to methylcobalamin, thiamine, or any component of the formulation.","Leber's disease (hereditary optic nerve atrophy) because vitamin B12 can accelerate vision loss.","Severe hypokalemia (low potassium) should be corrected before starting therapy, as vitamin B12 can cause potassium to shift into cells."]
⚠️ Warnings & Precautions
["This medicine should only be administered by a healthcare professional.","Emergency equipment for treating anaphylaxis should be immediately available.","Use with caution in patients with kidney or liver disease.","Do not use if the solution is discolored or contains particulate matter.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Avoid alcohol while on this medicine.","Do not drive or operate machinery if you feel dizzy after the injection.","Keep all follow-up appointments and laboratory tests."]
🤱 Lactation Safety
Methylcobalamin and thiamine are excreted in breast milk and are considered safe for nursing infants when used at recommended doses. However, consult your doctor before receiving this injection while breastfeeding.
💊 Overdose Management
Overdose with this medicine is unlikely to cause serious harm because it contains water-soluble vitamins. However, if a large dose is accidentally given, treatment should be symptomatic and supportive. In case of suspected overdose, contact a poison control center or seek emergency medical attention. There is no specific antidote. Monitor vital signs and provide supportive care as needed.
⏰ Missed Dose
If you miss a scheduled dose, contact your healthcare provider to reschedule. Do not try to self-administer an extra dose. Your doctor will determine the best time for the next injection based on your treatment plan.
Additional Safety Advice
This medicine must only be given by a healthcare professional. Do not attempt to self-inject. Before receiving this injection, tell your doctor about all your medical conditions, especially allergies, kidney problems, liver problems, or any blood disorders. Also inform your doctor about all other medicines, supplements, and herbal products you are taking, as some may interact with this medicine. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits with your doctor before receiving this injection. Avoid alcohol while being treated with this medicine, as alcohol can worsen vitamin deficiencies and reduce the effectiveness of treatment. Do not drive or operate heavy machinery immediately after receiving the injection if you feel dizzy or unwell. Keep all follow-up appointments and laboratory tests as advised by your doctor. If you miss a scheduled dose, contact your healthcare provider to reschedule; do not try to catch up on your own. Store this medicine as directed on the label, and keep it out of reach of children. Do not use the injection if the solution is discolored or contains particles. Always check the expiry date before use.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal function and may require lower doses. They should be monitored closely for side effects and response to treatment.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, ensure your vitamin B12 and thiamine levels are adequate. Consult your doctor for appropriate supplementation.
🏥 Post-Surgery Considerations
After surgery, your doctor may prescribe this medicine if you are at risk of vitamin deficiency. Follow your doctor's instructions for dosing and monitoring.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. No specific precautions are typically needed for dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If you experience dizziness or weakness after the injection, avoid strenuous exercise until you feel better. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people. If affected, avoid driving or operating heavy machinery until you feel normal. Otherwise, it should not interfere with your daily activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will determine the duration of treatment based on your condition and response. If you experience serious side effects, seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when used as prescribed. However, regular monitoring of vitamin levels and clinical response is important. In rare cases, high doses of vitamin B12 may cause acne-like skin eruptions. Prolonged thiamine use is not associated with significant long-term effects. Follow your doctor's advice for periodic check-ups.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Oral methylcobalamin and thiamine can be used for mild deficiency or maintenance.
Evidence: Well-establishedIncreasing intake of foods rich in these vitamins can help prevent deficiency.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C.
❌ DON'T
Do not freeze.
✅ DO
Keep the vial in the outer carton to protect from light.
❌ DON'T
Do not use if the solution is discolored or contains particles.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not store at room temperature for prolonged periods.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label. Keep it in a cool, dry place, and use a cooler bag if necessary. Carry a copy of your prescription to show at customs if needed. If you need to adjust the timing of your injections due to time zone changes, consult your doctor for guidance. Do not expose the medicine to extreme temperatures.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action varies. For acute neurological symptoms, improvement may be seen within hours to days. For anemia, reticulocyte count may increase within 2-5 days, with hemoglobin improvement over weeks.
A: This medicine is formulated as an injection and must be given by a healthcare professional. Oral forms of these vitamins are available but may not be suitable for severe deficiency.
A: Vitamin B12 and thiamine are essential during pregnancy. However, consult your doctor before receiving this injection to ensure it is appropriate for you.
A: Common side effects include injection site pain, nausea, and dizziness. Serious allergic reactions are rare but require immediate medical attention.
🤔 Common Patient Concerns
🔄 Substitutes for Neurozine Injection
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This injection is a general tonic for weakness.
Fact: This medicine is only for treating specific vitamin deficiencies and should not be used as a general tonic. - Myth: It can be self-administered at home.
Fact: This injection must be given by a healthcare professional due to the risk of allergic reactions. - Myth: It is safe to take without any blood tests.
Fact: Vitamin levels should be checked to confirm deficiency before starting treatment.
🔄 Alternative Options
Generic Alternatives
- Methylcobalamin injection
- Thiamine injection
- Methylcobalamin and thiamine injection
Brand Alternatives
- Neurobion Forte Injection
- Nurokind Injection
- Methylcobalamin Injection
- Thiamine Injection