Esamlovin N 5mg/2.5mg Tablet: Complete Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Very slow heartbeat (below 50 beats per minute)
- Chest pain or difficulty breathing
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Severe abdominal pain or vomiting
If experiencing severe symptoms, call emergency services immediately.
What is nebrol plus tablet used for?
This medicine is a combination of Nebivolol 5 mg and S-Amlodipine 2.5 mg used to treat high blood pressure. It works by relaxing blood vessels and slowing the heart rate. It is taken once daily orally, usually in the morning, with or without food. Do not stop it suddenly without consulting your doctor.
- Generic Name: Nebivolol (5mg) + S-Amlodipine (2.5mg)
- Manufacturer: Brilliant Lifesciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nebrol plus tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाइपरटेंशन) के इलाज के लिए इस्तेमाल की जाती है। इसमें नेबिवोलोल और एस-एम्लोडिपिन दो सक्रिय तत्व हैं जो मिलकर रक्त वाहिकाओं को आराम देते हैं और हृदय की गति को धीमा करते हैं, जिससे रक्तचाप कम होता है। यह दवा दिल के दौरे और स्ट्रोक के खतरे को कम करने में मदद करती है। इसे डॉक्टर के निर्देशानुसार ही लें, अपने आप बंद न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, थकान और टखनों में सूजन शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें बहुत धीमी हृदय गति, बेहोशी, सांस लेने में कठिनाई और चेहरे या गले में सूजन शामिल हो सकते हैं। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को रोज एक ही समय पर लें, आमतौर पर सुबह। इसे चबाएं नहीं, पूरा निगल लें। शराब न पिएं क्योंकि इससे चक्कर और बेहोशी बढ़ सकती है। अचानक दवा बंद न करें, इससे दिल की समस्या बढ़ सकती है। बैठने या लेटने से उठते समय धीरे-धीरे उठें। नियमित रूप से रक्तचाप और हृदय गति की जांच कराएं।
💊 nebrol plus tablet Uses & Benefits
- [{"condition":"Essential hypertension","description":"This medicine is used to lower high blood pressure in adults when a single agent is insufficient.
- It reduces both systolic and diastolic blood pressure, helping to prevent stroke, heart attack, and kidney damage.","evidence":"Well-established"},{"condition":"Hypertension with angina","description":"The combination may be beneficial in patients who have both high blood pressure and angina because nebivolol reduces cardiac workload and S-amlodipine improves coronary blood flow.","evidence":"Moderate"},{"condition":"Hypertension with heart failure","description":"Nebivolol has been studied in heart failure, and this combination may be used in selected patients with stable heart failure and high blood pressure under specialist care.","evidence":"Limited"}]
Off-label uses: [{"condition":"Performance anxiety","description":"Beta blockers like nebivolol are sometimes used off-label to reduce symptoms of performance anxiety, such as tremor and rapid heartbeat, but this combination is not approved for that purpose.","evidence":"Limited"},{"condition":"Migraine prophylaxis","description":"Some beta blockers are used off-label to prevent migraines, but there is insufficient evidence for this specific combination.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Angina, Heart failure
📋 Drug Information
| Generic Name(s) | Nebivolol (5mg) + S-Amlodipine (2.5mg) |
| Brand Name | nebrol plus tablet |
| Manufacturer | Brilliant Lifesciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Keep in the original container, away from moisture and direct sunlight. Do not refrigerate. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antihypertensive agents with complementary actions. Nebivolol is a cardioselective beta-1 adrenergic receptor blocker that also causes vasodilation by increasing nitric oxide release. S-Amlodipine is the active S-enantiomer of amlodipine, a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle cells. The result is a reduction in heart rate, cardiac output, and peripheral vascular resistance, leading to lower blood pressure.
Mechanism Steps
💡 How to Take nebrol plus tablet
Strength: Tablet containing Nebivolol 5 mg and S-Amlodipine 2.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet of Nebivolol 5 mg and S-Amlodipine 2.5 mg taken orally once daily, with or without food. The dose may be adjusted by your doctor based on your blood pressure response and tolerability. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a low dose and monitor closely for dizziness and falls. Dose adjustment may be necessary based on kidney and liver function. |
| Renal Impairment | In patients with mild to moderate renal impairment, no dose adjustment is usually needed. In severe renal impairment, use with caution and monitor closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, start with a low dose and titrate slowly. This medicine is contraindicated in severe hepatic impairment. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet of Nebivolol 5 mg and S-Amlodipine 2.5 mg. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nebrol plus tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Fluoxetine | Major | |
| Ketoconazole | Major | |
| Verapamil | Major | |
| Clonidine | Major | |
| Ibuprofen | Moderate | |
| Prazosin | Moderate | |
| Insulin | Moderate | |
| Digoxin | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- Verapamil or diltiazem
- Clonidine
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen, naproxen)
- Alpha-blockers (e.g., prazosin)
- Insulin and oral hypoglycemics
- Digoxin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can intensify the blood pressure-lowering effect, leading to dizziness, fainting, and falls. It may also increase the risk of liver-related side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe bradycardia","Second- or third-degree heart block","Cardiogenic shock","Severe hypotension","Severe liver impairment","Known allergy to nebivolol or amlodipine","Untreated pheochromocytoma","Severe peripheral arterial disease"]
⚠️ Warnings & Precautions
["Do not stop this medicine abruptly, as it can worsen angina or cause a heart attack.","Use with caution in patients with asthma or COPD due to beta-blocking effects.","May mask symptoms of hypoglycemia in diabetic patients.","Avoid alcohol while taking this medicine.","Use with caution in patients with liver or kidney disease.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]
🤱 Lactation Safety
Nebivolol and amlodipine are excreted in breast milk. The effects on a nursing infant are not well established. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose can cause severe hypotension, bradycardia, heart failure, and bronchospasm. Seek immediate medical attention. Treatment is supportive and may include intravenous fluids, atropine, glucagon, and vasopressors. Hemodialysis is not effective for removing nebivolol or amlodipine.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed, usually once daily, with or without food. Do not crush or chew the tablet unless your doctor approves. Do not stop this medicine suddenly, especially if you have heart disease, because abrupt withdrawal can worsen angina or cause a heart attack. Avoid alcohol because it can amplify dizziness and low blood pressure. Stand up slowly from sitting or lying positions to reduce the risk of fainting. Inform all healthcare providers, including dentists and surgeons, that you take this medicine. Keep regular appointments for blood pressure, heart rate, and blood test monitoring. Store the tablets in their original container at room temperature, away from moisture and direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to dizziness, falls, and low blood pressure. Start with a low dose and monitor closely. Regular kidney and liver function tests are advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before conception. This medicine may need to be switched to a safer alternative. Use effective contraception while taking this medicine unless advised otherwise.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery to avoid interactions with anesthesia. Do not stop without medical advice.
🦷 Dental Procedures
Inform your dentist that you take this medicine, as it can interact with certain local anesthetics and affect blood pressure. Monitor blood pressure during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid sudden strenuous activity if you are not used to it. Beta-blockers can reduce your maximum heart rate, so monitor your exertion level. Stay hydrated and avoid exercising in extreme heat. Consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal work activities with dose adjustment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects such as fainting, very slow heartbeat, or allergic reactions, seek immediate medical attention. Your doctor may adjust the dose or switch to another medicine.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when monitored by a doctor. Regular check-ups for blood pressure, heart rate, kidney function, and liver function are recommended. Do not stop the medicine without medical advice, as uncontrolled hypertension can lead to heart attack, stroke, and kidney damage.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, weight loss, and stress reduction can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedACE inhibitors, ARBs, diuretics, or other calcium channel blockers may be alternatives based on individual patient profile.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, inform your doctor about this medicine before receiving any vaccine, especially if you have allergies.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If traveling across time zones, take your dose at the usual time or adjust gradually as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood pressure within 1-2 hours, but full effect may take 1-2 weeks. Continue taking it regularly as prescribed.
A: No, do not stop without consulting your doctor. High blood pressure often has no symptoms, and stopping suddenly can cause dangerous rebound hypertension.
A: If you remember within 12 hours, take the missed dose. If more than 12 hours have passed, skip it and continue with your regular schedule. Do not double dose.
A: Consult your doctor. This medicine is generally not recommended during pregnancy unless clearly needed.
A: Avoid alcohol as it can increase dizziness and low blood pressure.
🤔 Common Patient Concerns
🔄 Substitutes for nebrol plus tablet
View AllAlternative brands with exact same active ingredient:
-
asivol a 5mg/2.5mg tabletAS Pharmaceutical (India) Pvt Ltd ₹64.69 40.5% CHEAPER
-
nebicure sa 5mg/2.5mg tabletAccilex Diacardo ₹92.81 14.7% CHEAPER
-
nebivas sa 5mg/2.5mg tabletIntra Labs India Pvt Ltd ₹95.00 12.6% CHEAPER
-
esamlovin n 5mg/2.5mg tabletEast West Pharma ₹110.02 1.2% COSTLIER
-
cardiolol s 5mg/2.5mg tabletCubit Healthcare ₹118.59 9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once blood pressure is normal.
Fact: High blood pressure often has no symptoms and requires long-term treatment. Stopping suddenly can cause dangerous rebound hypertension or heart problems. - Myth: This medicine damages the kidneys.
Fact: This medicine is used to protect the kidneys from damage caused by high blood pressure. Regular monitoring is important. - Myth: You can take extra doses if you feel your blood pressure is high.
Fact: Taking extra doses can cause dangerously low blood pressure. Always follow your doctor's prescription.
🔄 Alternative Options
Generic Alternatives
- Nebivolol 5 mg + S-Amlodipine 2.5 mg tablet (generic)
Brand Alternatives
- Esamlovin N 5mg/2.5mg Tablet