amoline-nb tablet - Uses, Price, Side Effects & Substitutes
What is amoline-nb tablet used for?
Amlovas SN 5 mg/2.5 mg Tablet (Nebivolol + Amlodipine) is used to treat CARDIAC. It contains Nebivolol (5mg) + Amlodipine (5mg), which Nebivolol: Selective beta-1 adrenergic receptor blocker with nitric oxide-mediat. Always consult your doctor before use. Take as prescribed.
- Generic Name: Nebivolol + Amlodipine
- Manufacturer: Zeelab Pharmacy Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ amoline-nb tablet Uses & Benefits
Hypertension (first-line or add-on therapy).
Off-label uses: Chronic stable angina, heart failure (nebivolol only).
๐ Drug Information
| Generic Name(s) | Nebivolol + Amlodipine |
| Brand Name | Amlovas SN 5 mg/2.5 mg Tablet |
| Manufacturer | Zeelab Pharmacy Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antihypertensive combination (Beta-blocker + Calcium channel blocker) |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Nebivolol: Selective beta-1 adrenergic receptor blocker with nitric oxide-mediated vasodilation; Amlodipine: Dihydropyridine calcium channel blocker inhibiting calcium influx into vascular smooth muscle and cardiac muscle.
Mechanism Steps
๐ก How to Take amoline-nb tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of amoline-nb tablet
โ Common Side Effects
- Headache
- Dizziness
- Fatigue
- Edema
- Nausea
- Bradycardia
๐จ Serious Side Effects
- Heart block
- Severe hypotension
- Bronchospasm
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Thrombocytopenia
- Stevens-Johnson syndrome
- Gingival hyperplasia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | Increased INR (nebivolol may potentiate) |
| Insulin | Moderate | Masking of hypoglycemia symptoms (tachycardia) |
| Clonidine | Major | Rebound hypertension on withdrawal |
๐จ Major Interactions
- CYP2D6 inhibitors (e.g., paroxetine, fluoxetine)
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- Other antihypertensives (additive hypotension)
- Beta-blockers (additive bradycardia)
โก Moderate Interactions
- NSAIDs (reduced antihypertensive effect)
- Digoxin (increased bradycardia)
- Cimetidine (increased nebivolol levels)
โน๏ธ Minor Interactions
- Grapefruit juice (increased amlodipine levels)
- Alcohol (enhanced hypotensive effect)
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase amlodipine levels; avoid excessive intake.
๐ท Alcohol Interaction
May enhance hypotensive effect; avoid excessive alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, severe bradycardia, heart block, cardiogenic shock, sick sinus syndrome, severe hypotension, decompensated heart failure.
๐ Monitoring Parameters
Blood pressure, heart rate, ECG, renal function, hepatic function.
๐คฑ Lactation Safety
Not recommended; both drugs excreted in breast milk.
๐ Overdose Management
Supportive care; atropine for bradycardia, vasopressors for hypotension, calcium gluconate for calcium channel blocker overdose.
โฐ Missed Dose
Take as soon as remembered; skip if almost time for next dose; do not double dose.