Amlopres-nb 5mg/5mg Tablet: Comprehensive Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Very slow heart rate (less than 50 beats per minute)
- Difficulty breathing or wheezing
- Swelling of face, lips, tongue, or throat
- Chest pain or palpitations
- Yellowing of skin or eyes
- Decreased urine output
- Severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is amoline-nb tablet used for?
This medicine is a combination of Nebivolol and Amlodipine used to treat high blood pressure. It works by relaxing blood vessels and slowing heart rate to improve blood flow and reduce blood pressure.
- Generic Name: Nebivolol + Amlodipine
- Manufacturer: Zeelab Pharmacy Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 amoline-nb tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाइपरटेंशन) के इलाज के लिए इस्तेमाल की जाती है। यह नेबिवोलोल और एम्लोडिपिन का संयोजन है, जो रक्त वाहिकाओं को आराम देकर और हृदय गति को धीमा करके रक्तचाप को कम करती है। यह दिल के दौरे और स्ट्रोक के जोखिम को कम करने में मदद करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, थकान, मतली, और पैरों में सूजन शामिल हैं। गंभीर दुष्प्रभावों में धीमी हृदय गति, हृदय रुकावट, और सांस लेने में कठिनाई हो सकती है। यदि आपको कोई गंभीर लक्षण महसूस हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे एनजाइना या रक्तचाप बढ़ सकता है। शराब का सेवन न करें। गाड़ी चलाते समय सावधानी बरतें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। नियमित रूप से रक्तचाप की जांच कराएं।
💊 amoline-nb tablet Uses & Benefits
[{"condition":"Essential hypertension","description":"This medicine is used to lower blood pressure in adults with essential hypertension, reducing the risk of cardiovascular events such as stroke and myocardial infarction.","evidence":"Well-established"},{"condition":"Hypertension with concomitant angina","description":"The combination may be beneficial in patients with both hypertension and stable angina due to the anti-anginal effects of nebivolol and vasodilation from amlodipine.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Heart failure with reduced ejection fraction","description":"Nebivolol, a component of this medicine, has been studied as an add-on therapy in chronic heart failure, but the combination with amlodipine is not standard for this indication.","evidence":"Limited"},{"condition":"Migraine prophylaxis","description":"Beta-blockers like nebivolol are sometimes used off-label to prevent migraines, but the combination with amlodipine is not established for this purpose.","evidence":"Limited"}]
Primary treatment for: Essential hypertension
Also treats: Angina pectoris, Heart failure with reduced ejection fraction (off-label)
📋 Drug Information
| Generic Name(s) | Nebivolol + Amlodipine |
| Brand Name | Amlovas SN 5 mg/2.5 mg Tablet |
| Manufacturer | Zeelab Pharmacy Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antihypertensive combination (Beta-blocker + Calcium channel blocker) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends the use of combination therapy for hypertension when monotherapy is insufficient. This combination is in line with WHO guidelines for the management of hypertension. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines for hypertension management suggest the use of combination therapy, including beta-blockers and calcium channel blockers, for patients not controlled on monotherapy. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antihypertensive agents with complementary mechanisms. Nebivolol is a cardioselective beta-1 adrenergic receptor blocker that also causes vasodilation by increasing nitric oxide bioavailability. It reduces heart rate, myocardial contractility, and cardiac output, thereby lowering blood pressure. Amlodipine is a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle. This leads to relaxation of peripheral arterioles, reduction in systemic vascular resistance, and a decrease in blood pressure. The combination provides additive blood pressure reduction through different pathways.
Mechanism Steps
💡 How to Take amoline-nb tablet
Strength: Each immediate-release tablet contains Nebivolol 5 mg and Amlodipine 5 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily, preferably at the same time each day. The dose may be adjusted by your doctor based on your blood pressure response and tolerability. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and hypotension. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, dose adjustment may be necessary. For creatinine clearance less than 30 mL/min, the dose of nebivolol should be reduced. Amlodipine dose adjustment is not required in renal impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, the dose of nebivolol should be reduced and amlodipine should be used with caution. This medicine is contraindicated in severe hepatic impairment. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet (nebivolol 5 mg + amlodipine 5 mg) once daily. Do not exceed this dose unless directed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of amoline-nb tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Fluoxetine | Major | |
| Ketoconazole | Major | |
| Verapamil | Major | |
| Metoprolol | Major | |
| Prazosin | Moderate | |
| Ibuprofen | Moderate | |
| Prednisone | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- Beta-blockers (e.g., metoprolol, propranolol)
- Calcium channel blockers (non-dihydropyridine, e.g., verapamil, diltiazem)
⚡ Moderate Interactions
- Alpha-blockers (e.g., prazosin)
- NSAIDs
- Corticosteroids
🍷 Alcohol Interaction
Alcohol may enhance the blood pressure-lowering effects of this medicine and increase the risk of dizziness, drowsiness, and fainting. It is advisable to avoid or limit alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe bradycardia","Second- or third-degree heart block","Cardiogenic shock","Severe hepatic impairment","Known hypersensitivity to nebivolol or amlodipine","Pregnancy","Severe hypotension"]
⚠️ Warnings & Precautions
["Do not abruptly discontinue this medicine, especially in patients with coronary artery disease, as it may precipitate angina or myocardial infarction.","Use with caution in patients with bronchospastic diseases, diabetes, hyperthyroidism, and peripheral vascular disease.","May mask symptoms of hypoglycemia in diabetic patients.","May worsen heart failure; monitor for signs of worsening heart failure.","Avoid use in patients with severe aortic stenosis.","Use with caution in patients with renal impairment; dose adjustment may be needed.","May cause dizziness; avoid driving or operating machinery until you know how it affects you."]
🤱 Lactation Safety
It is not known whether nebivolol and amlodipine are excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
Overdose may cause severe hypotension, bradycardia, heart failure, and bronchospasm. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic. Gastric lavage may be considered if taken recently. Monitor vital signs and provide appropriate supportive care. Hemodialysis is not effective for removing nebivolol or amlodipine from the body.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not stop or change the dose without consulting your healthcare provider, as abrupt discontinuation of nebivolol can worsen angina or lead to rebound hypertension. Avoid alcohol while taking this medicine, as it can enhance blood pressure lowering effects and increase dizziness. Use caution when driving or operating machinery until you know how this medicine affects you. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use potassium supplements or salt substitutes containing potassium without medical advice. Keep all follow-up appointments and monitor your blood pressure regularly. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine and are at higher risk of dizziness, falls, and electrolyte imbalances. Start with a lower dose and monitor closely. Regular monitoring of renal function and electrolytes is recommended.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning to become pregnant, consult your doctor to switch to a safer alternative before conception. Both nebivolol and amlodipine may harm the fetus.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect blood pressure and heart rate during surgery. Your doctor may advise temporary discontinuation or dose adjustment before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it may cause dry mouth or gingival hyperplasia. It may also interact with local anesthetics containing epinephrine, potentially causing hypertension. Your dentist may take precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine. However, avoid sudden strenuous activities, especially in hot weather, as it may cause dizziness or fainting due to lowered blood pressure. Stay hydrated and rise slowly from sitting or lying positions.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal work activities with some adjustments. Inform your employer if your job involves operating machinery or working at heights.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your doctor decides to discontinue, the dose should be tapered gradually to avoid rebound hypertension or angina. Always follow your doctor's instructions.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when monitored appropriately. Regular check-ups should include blood pressure, heart rate, renal function, and electrolyte levels. Prolonged use may lead to tolerance, requiring dose adjustment. Beta-blockers should not be stopped abruptly. Amlodipine may cause long-term gingival hyperplasia in rare cases. Overall, the benefits of blood pressure control outweigh the risks.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and stress reduction can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedACE inhibitors or ARBs combined with calcium channel blockers or diuretics may be alternatives.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medications you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the timing of your dose. Carry enough supply for the entire trip and a few extra days in case of delays. Check customs regulations for carrying prescription medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood pressure within 1-2 hours, but the full effect may take 1-2 weeks. It may take several weeks to achieve optimal blood pressure control.
A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop taking this medicine without consulting your doctor. High blood pressure often has no symptoms, and stopping medication can cause dangerous spikes.
A: This medicine is not recommended during pregnancy as it may harm the fetus. Consult your doctor for alternative treatments.
🤔 Common Patient Concerns
🔄 Substitutes for amoline-nb tablet
View AllAlternative brands with exact same active ingredient:
-
davaindia nebivolol+amlodipine 5mg/5mg tabletDavaindia Generic Pharmacy ₹34.00 13.3% COSTLIER
-
nebiwin am 5mg/5mg tabletDocwin Healthcare ₹59.00 96.7% COSTLIER
-
nevy a 5mg/5mg tabletIntas Pharmaceuticals Ltd ₹59.63 98.8% COSTLIER
-
nebinex am 5 mg/5 mg tabletGlenmark Pharmaceuticals Ltd ₹60.94 103.1% COSTLIER
-
cardilol am 5mg/5mg tabletWelkind Pharma ₹80.00 166.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure high blood pressure permanently.
Fact: This medicine helps control blood pressure but does not cure hypertension. Lifestyle changes and long-term medication are often needed. - Myth: You can stop taking this medicine once your blood pressure is normal.
Fact: High blood pressure often has no symptoms, and stopping medication can cause dangerous spikes. Always consult your doctor before stopping. - Myth: This medicine causes kidney damage.
Fact: This medicine is not primarily nephrotoxic. It may actually protect the kidneys by controlling blood pressure.
🔄 Alternative Options
Generic Alternatives
- Nebivolol + Amlodipine (generic versions available from various manufacturers)
Brand Alternatives
- Amlopres-NB 5mg/5mg Tablet (Cipla Ltd)
- Other brands containing Nebivolol and Amlodipine