asivol a 5mg/2.5mg tablet - Uses, Price, Side Effects & Substitutes
What is asivol a 5mg/2.5mg tablet used for?
Asivol A 5mg/2.5mg Tablet (Nebivolol + S-Amlodipine) is used to treat CARDIAC. It contains Nebivolol (5mg) + S-Amlodipine (2.5mg), which Nebivolol: Selective beta1-blocker with vasodilatory effects via NO; S-Amlodipin. Always consult your doctor before use. Take as prescribed.
- Generic Name: Nebivolol + S-Amlodipine
- Manufacturer: AS Pharmaceutical (India) Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ asivol a 5mg/2.5mg tablet Uses & Benefits
Off-label uses: Angina, heart failure (Nebivolol), arrhythmias
๐ Drug Information
| Generic Name(s) | Nebivolol + S-Amlodipine |
| Brand Name | Asivol A 5mg/2.5mg Tablet |
| Manufacturer | AS Pharmaceutical (India) Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antihypertensive combination (Beta-blocker + Calcium channel blocker) |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Nebivolol: Selective beta1-blocker with vasodilatory effects via NO; S-Amlodipine: Dihydropyridine calcium channel blocker inhibiting calcium influx
Mechanism Steps
๐ก How to Take asivol a 5mg/2.5mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of asivol a 5mg/2.5mg tablet
โ Common Side Effects
- Headache
- Dizziness
- Fatigue
- Edema (ankle swelling)
- Nausea
- Bradycardia
๐จ Serious Side Effects
- Heart block
- Severe hypotension
- Bronchospasm
- Hepatotoxicity
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Thrombocytopenia
- Leukopenia
- Angioedema
- Gynecomastia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | Increased INR (rare) |
| Insulin | Moderate | Masking of hypoglycemia symptoms |
| Clonidine | Major | Rebound hypertension if clonidine withdrawn |
๐จ Major Interactions
- CYP2D6 inhibitors (e.g., paroxetine, quinidine)
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- Other antihypertensives (additive hypotension)
- Beta-blockers (additive bradycardia)
โก Moderate Interactions
- NSAIDs (reduced antihypertensive effect)
- Digoxin (increased bradycardia risk)
- Calcium channel blockers (additive effects)
โน๏ธ Minor Interactions
- Cimetidine (increased nebivolol levels)
- Grapefruit juice (increased amlodipine levels)
๐ฝ๏ธ Food Interactions
Avoid grapefruit juice (increases amlodipine levels); take with or without food
๐ท Alcohol Interaction
May enhance hypotensive effect; avoid excessive alcohol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Sinus bradycardia, heart block, cardiogenic shock, severe hypotension, sick sinus syndrome, hypersensitivity
๐ Monitoring Parameters
Blood pressure, heart rate, ECG, renal function, hepatic function, blood glucose (in diabetics)
๐คฑ Lactation Safety
Excreted in breast milk; avoid or use with caution
๐ Overdose Management
Symptomatic and supportive; atropine for bradycardia, vasopressors for hypotension, calcium gluconate for calcium channel blocker overdose
โฐ Missed Dose
Take as soon as remembered; skip if almost time for next dose; do not double dose