Nebivolol + Hydrochlorothiazide 5mg/12.5mg Tablet: Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Irregular or very slow heartbeat
- Difficulty breathing or wheezing
- Swelling of face, lips, tongue, or throat
- Decreased urine output or swelling in legs
- Severe abdominal pain or vomiting
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is nebistar-h tablet used for?
This medicine is a combination of Nebivolol and Hydrochlorothiazide used to treat high blood pressure. It works by slowing the heart rate and removing excess fluid from the body.
- Generic Name: Nebivolol (5mg) + Hydrochlorothiazide (12.5mg)
- Manufacturer: Lupin Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nebistar-h tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाइपरटेंशन) के इलाज के लिए इस्तेमाल की जाती है। इसमें नेबिवोलोल और हाइड्रोक्लोरोथियाजाइड दो सक्रिय तत्व हैं। नेबिवोलोल दिल की धड़कन को धीमा करता है और रक्त वाहिकाओं को फैलाता है, जिससे रक्तचाप कम होता है। हाइड्रोक्लोरोथियाजाइड शरीर से अतिरिक्त नमक और पानी को बाहर निकालता है, जिससे रक्तचाप और कम होता है। यह दवा उन वयस्कों के लिए है जिनका रक्तचाप एक दवा से नियंत्रित नहीं होता। इसे डॉक्टर की सलाह के बिना बंद या शुरू न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, थकान, जी मिचलाना और बार-बार पेशाब आना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें तेज एलर्जी, गुर्दे की समस्या, बहुत कम रक्तचाप और इलेक्ट्रोलाइट असंतुलन हो सकते हैं। यदि आपको लगातार चक्कर आना, असामान्य थकान, मांसपेशियों में ऐंठन या संक्रमण के लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। बिना सलाह के दवा बंद या उसकी मात्रा न बदलें। शराब से बचें क्योंकि इससे चक्कर और कम रक्तचाप बढ़ सकता है। पर्याप्त पानी पिएं जब तक डॉक्टर कुछ और न कहें। अचानक उठने से बचें, धीरे-धीरे उठें। अगर आपको मधुमेह, गुर्दे की बीमारी, लीवर की बीमारी या अस्थमा है तो डॉक्टर को बताएं। नियमित रूप से रक्तचाप, गुर्दे की कार्यप्रणाली और इलेक्ट्रोलाइट्स की जांच कराएं। डॉक्टर की सलाह के बिना पोटैशियम सप्लीमेंट न लें।
💊 nebistar-h tablet Uses & Benefits
- [{"condition":"Essential Hypertension","description":"This medicine is used to lower high blood pressure in adults when a single medicine is not effective.
- It helps reduce the risk of strokes, heart attacks, and kidney problems.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Heart failure with reduced ejection fraction","description":"Nebivolol, a component of this medicine, is sometimes used off-label in heart failure, but the combination with hydrochlorothiazide is not standard for this use.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Heart failure, Angina, Post-myocardial infarction
📋 Drug Information
| Generic Name(s) | Nebivolol (5mg) + Hydrochlorothiazide (12.5mg) |
| Brand Name | nebistar-h tablet |
| Manufacturer | Lupin Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Nebivolol is a selective beta-1 adrenergic receptor blocker that also causes vasodilation by increasing nitric oxide. It reduces heart rate, contractility, and cardiac output, thereby lowering blood pressure. Hydrochlorothiazide inhibits the sodium-chloride symporter in the distal convoluted tubule of the kidney, increasing excretion of sodium, chloride, and water. This reduces blood volume and peripheral resistance, contributing to blood pressure reduction.
Mechanism Steps
💡 How to Take nebistar-h tablet
Strength: Tablet containing Nebivolol 5 mg and Hydrochlorothiazide 12.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (Nebivolol 5 mg + Hydrochlorothiazide 12.5 mg) once daily, preferably in the morning. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Start with a lower dose and monitor closely for dizziness, falls, and electrolyte imbalances. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Hydrochlorothiazide is ineffective in severe renal impairment (CrCl <30 mL/min). Dose adjustment may be required. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Nebivolol is metabolized in the liver; dose reduction may be necessary. Consult your doctor. |
| Maximum Daily Dose | One tablet (Nebivolol 5 mg + Hydrochlorothiazide 12.5 mg) once daily. Do not exceed the recommended dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nebistar-h tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Fluoxetine | Major | |
| Verapamil | Major | |
| Digoxin | Major | |
| Lithium | Major | |
| Ibuprofen | Moderate | |
| Prednisone | Moderate | |
| Metformin | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor | |
| Warfarin | Moderate |
🚨 Major Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
- Calcium channel blockers (e.g., verapamil, diltiazem)
- Digoxin
- Lithium
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
- Antidiabetic drugs
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can enhance the blood pressure-lowering effect and increase the risk of dizziness, fainting, and falls.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe bradycardia","Heart block greater than first degree","Cardiogenic shock","Decompensated heart failure","Severe renal impairment (CrCl
⚠️ Warnings & Precautions
["Do not stop this medicine abruptly, as it may worsen angina or cause heart attack.","Use with caution in patients with asthma or COPD; may cause bronchospasm.","May mask symptoms of hypoglycemia in diabetic patients.","Can cause dizziness; avoid driving or operating machinery until you know how it affects you.","Monitor for signs of electrolyte imbalance such as muscle cramps, weakness, or irregular heartbeat.","May increase sensitivity to sunlight; use sunscreen.","Inform your doctor if you have a history of gout or kidney stones."]
🤱 Lactation Safety
Not recommended during breastfeeding. Both drugs are excreted in breast milk and may affect the infant. Consult your doctor for alternatives.
💊 Overdose Management
Overdose may cause severe bradycardia, hypotension, electrolyte imbalance, and dehydration. Seek immediate medical attention. Treatment is supportive and symptomatic, including gastric lavage, activated charcoal, and monitoring of vital signs and electrolytes.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not stop or change the dose without consulting your doctor. Avoid alcohol as it can increase dizziness and low blood pressure. Drink plenty of fluids unless your doctor advises otherwise. Stand up slowly to avoid dizziness. Inform your doctor if you have diabetes, kidney disease, liver disease, or asthma. Regular monitoring of blood pressure, kidney function, and electrolytes is important. Do not take potassium supplements without your doctor's advice.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine, especially dizziness and electrolyte imbalances. Start with a lower dose and monitor closely. Regular check-ups are essential.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning pregnancy, consult your doctor to switch to a safer alternative before conception.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthesia and affect blood pressure and heart rate during surgery. Your doctor may advise temporary discontinuation.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth and increase the risk of orthostatic hypotension during dental procedures. Take precautions when getting up from the dental chair.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is encouraged but avoid strenuous activities in hot weather to prevent dehydration. Stay hydrated and monitor for dizziness. If you feel faint or short of breath, stop and rest.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, especially when standing up quickly. Avoid driving or operating heavy machinery until you know how it affects you. It should not affect your ability to work if you take precautions.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects, contact your doctor immediately. Your doctor may adjust the dose or switch to another medicine.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular monitoring of blood pressure, kidney function, and electrolytes. It may increase blood sugar and lipid levels. Periodic eye exams are recommended as hydrochlorothiazide can cause fluid buildup in the eye. Do not stop abruptly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and weight loss can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedACE inhibitors, ARBs, calcium channel blockers, or other combinations may be used if this medicine is not suitable.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, inform your doctor about this medicine before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, consult your doctor about adjusting the timing. Keep enough supply for the entire trip and carry it in your hand luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood pressure within 1-2 hours, but full effect may take 1-2 weeks of regular use.
A: No, do not stop without consulting your doctor. High blood pressure often has no symptoms, and stopping can cause a dangerous rise.
A: If you remember within 12 hours, take it. If more than 12 hours have passed, skip it and continue with your regular schedule. Do not double dose.
A: This medicine is not recommended during pregnancy as it may harm the fetus. Consult your doctor for alternative treatments.
🤔 Common Patient Concerns
🔄 Substitutes for nebistar-h tablet
View AllAlternative brands with exact same active ingredient:
-
davaindia nebivolol+hydrochlorothiazide 5mg/12.5mg tabletDavaindia Generic Pharmacy ₹34.00 89.9% CHEAPER
-
nebinorm 5h 5 mg/12.5 mg tabletIpca Laboratories Ltd ₹49.22 85.4% CHEAPER
-
nebimac h 5 mg/12.5 mg tabletMacleods Pharmaceuticals Pvt Ltd ₹51.34 84.7% CHEAPER
-
nevol h 5mg/12.5mg tabletMedley Pharmaceuticals ₹58.13 82.7% CHEAPER
-
nebilol h 5mg/12.5mg tabletJ B Chemicals and Pharmaceuticals Ltd ₹59.00 82.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure high blood pressure permanently.
Fact: This medicine controls blood pressure but does not cure it. Lifestyle changes and long-term medication are often needed. - Myth: You can stop taking this medicine once your blood pressure is normal.
Fact: High blood pressure often has no symptoms. Stopping medication can cause a dangerous rise in blood pressure. Always consult your doctor before stopping. - Myth: This medicine causes kidney damage.
Fact: When used as prescribed and monitored, this medicine is safe. Regular check-ups help prevent kidney problems.
🔄 Alternative Options
Generic Alternatives
- Nebivolol + Hydrochlorothiazide generic tablets
Brand Alternatives
- Nebilet H
- Nebicard H
- Nebilong H