natiz 60mg tablet - Nateglinide (60mg) medicine

Glinate 60 Tablet: Complete Medicine Guide

No reviews yet
🏭 Intas Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 28, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for type 2 diabetes mellitus.
Reviewed by
SaathiMed Expert Panel | Oct 28, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe hypoglycemia with confusion, seizures, or loss of consciousness
  • Signs of a severe allergic reaction such as swelling of the face, lips, or throat, or difficulty breathing
  • Persistent vomiting or diarrhea leading to dehydration
  • Unusual bleeding or bruising
  • Yellowing of the skin or eyes
  • Severe abdominal pain
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is natiz 60mg tablet used for?

This medicine is an oral antidiabetic drug used to lower post-meal blood sugar in adults with type 2 diabetes. It is taken before meals and works by stimulating insulin release from the pancreas.

  • Generic Name: Nateglinide (60mg)
  • Manufacturer: Intas Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 natiz 60mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा टाइप 2 डायबिटीज वाले वयस्कों में खाने के बाद बढ़ने वाले ब्लड शुगर को कंट्रोल करने के लिए इस्तेमाल की जाती है। यह अग्न्याशय से इंसुलिन निकलने में मदद करती है, खासकर खाने के बाद जब शुगर बढ़ती है। इसे आमतौर पर खाने से पहले लिया जाता है। यह दवा डायबिटीज को पूरी तरह ठीक नहीं करती, बल्कि डाइट और एक्सरसाइज के साथ मिलकर शुगर को नियंत्रित रखने में मदद करती है।

साइड इफेक्ट्स: इस दवा के आम साइड इफेक्ट्स में लो ब्लड शुगर (हाइपोग्लाइसीमिया), चक्कर आना, कमजोरी, पसीना आना, भूख लगना, जोड़ों में दर्द, दस्त और सर्दी-जुकाम जैसे लक्षण शामिल हो सकते हैं। अगर शुगर बहुत कम हो जाए तो बेहोशी या दौरे भी पड़ सकते हैं। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार खाने से पहले लें। खाना न छोड़ें, वरना शुगर कम हो सकती है। हमेशा अपने पास ग्लूकोज या मिठाई रखें। शराब न पिएं क्योंकि इससे शुगर कम होने का खतरा बढ़ जाता है। ब्लड शुगर की नियमित जांच करें। अगर आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर को बताएं।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 natiz 60mg tablet Uses & Benefits

[{"condition":"Type 2 diabetes mellitus (post-meal glucose control)","description":"This medicine is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes by reducing postprandial blood glucose excursions.","evidence":"Well-established"},{"condition":"Type 2 diabetes mellitus (combination therapy)","description":"It may be used in combination with metformin or other oral antidiabetic agents when monotherapy does not achieve target blood glucose levels.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Impaired glucose tolerance","description":"Sometimes studied or used off-label to delay progression to type 2 diabetes in people with impaired glucose tolerance, but this is not a standard approved indication.","evidence":"Limited"}]

Primary treatment for: Type 2 diabetes mellitus

Also treats: Impaired glucose tolerance, Metabolic syndrome

📋 Drug Information

Generic Name(s)Nateglinide (60mg)
Brand Namenatiz 60mg tablet
ManufacturerIntas Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI DIABETIC
Action ClassMeglitinides (Insulin Secretogogues)
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep in the original container.
Shelf LifeRefer to the packaging for the expiry date. Do not use after the expiry date.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine within 30 minutes before each main meal to match the post-meal glucose rise.
2
If you skip a meal, skip the dose for that meal to avoid hypoglycemia.
3
Carry fast-acting glucose at all times and teach family members how to recognize and treat low blood sugar.
4
Monitor your blood glucose regularly, especially when starting or changing the dose.
5
Avoid alcohol because it can increase the risk of hypoglycemia and mask its symptoms.
6
Inform your doctor about all other medicines, especially other diabetes drugs, beta-blockers, and antifungal agents.
7
Report any unusual bruising, bleeding, or signs of infection promptly.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
High post-meal blood sugar
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is rapidly absorbed after oral administration. Food can affect the rate and extent of absorption, so it is usually taken shortly before meals.
DistributionNot established from the available information.
Protein BindingThis medicine is highly bound to plasma proteins, primarily albumin.
MetabolismThis medicine is extensively metabolized in the liver, mainly by cytochrome P450 enzymes including CYP2C9 and CYP3A4.
Half-LifeThe elimination half-life is approximately 1.5 hours.
ExcretionMetabolites are excreted primarily in urine and to a lesser extent in feces.
BioavailabilityThe absolute bioavailability is approximately 73%.
Onset of ActionThis medicine begins to lower blood glucose within 15 to 30 minutes after oral intake.
Peak Plasma TimePeak plasma concentration is reached in about 1 hour.
Duration of ActionThe glucose-lowering effect lasts approximately 4 hours, covering the post-meal period.

How It Works

This medicine is a meglitinide analog that stimulates insulin secretion from pancreatic beta cells by closing ATP-sensitive potassium channels. This closure causes membrane depolarization, calcium influx, and release of insulin. The effect is glucose-dependent, so insulin secretion is enhanced mainly when blood glucose is elevated, such as after a meal.

Mechanism Steps

1
Binding to beta-cell potassium channels: This medicine binds to the sulfonylurea receptor subunit of ATP-sensitive potassium channels on pancreatic beta cells.
2
Channel closure and depolarization: Binding closes the potassium channels, reducing potassium efflux and causing the beta-cell membrane to depolarize.
3
Calcium influx: Depolarization opens voltage-gated calcium channels, allowing calcium to enter the beta cell.
4
Insulin secretion: Increased intracellular calcium triggers exocytosis of insulin-containing granules, releasing insulin into the bloodstream.
5
Glucose-dependent effect: Because the effect depends on glucose metabolism within the beta cell, insulin release is greater when blood glucose is high, such as after a meal.

💡 How to Take natiz 60mg tablet

Strength: Immediate-release tablet, 60 mg

1Take this medicine by mouth with a glass of water.
2Take it within 30 minutes before a meal.
3If you skip a meal, skip the dose for that meal.
4Do not crush, chew, or break the tablet unless advised by your doctor.
5Follow your prescribed dosing schedule exactly.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 60 mg or 120 mg taken orally within 30 minutes before each meal, up to three times daily. The dose depends on your blood glucose levels, kidney and liver function, and other medicines you take. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the glucose-lowering effects and are at higher risk of hypoglycemia. Start with a lower dose and monitor blood glucose closely. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be needed based on kidney function. Consult your doctor for personalized dosing.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be needed. Consult your doctor for personalized dosing.
Maximum Daily DoseThe maximum recommended daily dose is 360 mg (120 mg three times daily before meals).

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

Meals
Take within 30 minutes before a meal
Ensures the medicine's effect matches the post-meal glucose rise.
Alcohol
Avoid
Increases risk of hypoglycemia and may mask symptoms.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of natiz 60mg tablet

✅ Common Side Effects

Hypoglycemia (Common (5-10%))
Treat with fast-acting sugar if symptoms occur. If frequent, consult your doctor to adjust dose or meal timing.
Upper respiratory tract infection (Common (5-10%))
Usually self-limiting. Consult a doctor if symptoms persist or worsen.
Back pain (Common (5-10%))
Use gentle stretching and over-the-counter pain relief if suitable. Consult a doctor if severe or persistent.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how this medicine affects you. Report persistent dizziness to your doctor.
Joint pain (Common (5-10%))
Rest and gentle movement may help. Consult a doctor if pain interferes with daily activities.
Diarrhea (Common (5-10%))
Stay hydrated. Consult a doctor if diarrhea is severe or lasts more than a few days.

🚨 Serious Side Effects

Severe hypoglycemia (Uncommon (0.1-1%))
Seek immediate medical help if you experience confusion, seizures, or loss of consciousness. Treat with glucose if able.
Severe allergic reaction (Rare (<0.1%))
Stop the medicine and seek emergency care if you develop rash, swelling of face or throat, or difficulty breathing.
Blood dyscrasias (e.g., thrombocytopenia, leukopenia) (Rare (<0.1%))
Report unusual bruising, bleeding, or signs of infection to your doctor promptly.

⚠️ Rare Side Effects

Hepatic enzyme elevation
Your doctor may monitor liver enzymes. Report yellowing of skin or eyes.
Severe skin reactions
Seek immediate medical attention if you develop a severe rash with blisters or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Insulin Major
Sulfonylureas Major
Metformin Major
Beta-blockers Major
MAOIs Major
Fluconazole Moderate
Ketoconazole Moderate
NSAIDs Moderate
Thiazide diuretics Minor
Corticosteroids Minor

🚨 Major Interactions

  • Other antidiabetic agents (e.g., insulin, sulfonylureas, metformin)
  • Beta-blockers
  • Monoamine oxidase inhibitors (MAOIs)

⚡ Moderate Interactions

  • CYP2C9 inhibitors (e.g., fluconazole)
  • CYP3A4 inhibitors (e.g., ketoconazole)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)

🍷 Alcohol Interaction

Alcohol can increase the risk of hypoglycemia and may make its symptoms harder to recognize. It is best to avoid alcohol while taking this medicine, or to limit intake and monitor blood glucose closely if you do drink.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to nateglinide or any component of the formulation","Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe hepatic impairment"]

⚠️ Warnings & Precautions

["May cause hypoglycemia; monitor blood glucose regularly.","Take before meals; skipping meals increases hypoglycemia risk.","Use with caution in elderly patients and those with renal or hepatic impairment.","Avoid alcohol as it can increase hypoglycemia risk.","Not for use in type 1 diabetes or diabetic ketoacidosis.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]

🤱 Lactation Safety

It is not known whether this medicine passes into breast milk. Breastfeeding is not recommended while taking this medicine unless advised by a doctor.

💊 Overdose Management

Overdose can cause severe hypoglycemia. If overdose is suspected, seek emergency medical attention immediately. Treatment may include intravenous glucose and close monitoring of blood glucose and vital signs.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember if there is still time before your next meal. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Always take this medicine exactly as prescribed by your doctor, usually within 30 minutes before a meal. Do not skip meals after taking this medicine, because doing so increases the risk of low blood sugar. Carry a fast-acting source of sugar such as glucose tablets or candy with you at all times in case of hypoglycemia. Check your blood glucose regularly, especially during illness, stress, or changes in diet or activity. Avoid drinking alcohol because it can make low blood sugar more likely and harder to recognize. Tell your doctor about all other medicines, supplements, and herbal products you take, because some can interact with this medicine. Do not drive or operate heavy machinery if you feel dizzy or have symptoms of low blood sugar. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Keep this medicine out of reach of children and store it as directed on the label.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of hypoglycemia and may need lower doses. Regular monitoring of blood glucose, kidney function, and overall health is important.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before conception. This medicine is not recommended during pregnancy unless clearly needed. Your doctor may switch you to a safer alternative.

🏥 Post-Surgery Considerations

After surgery, blood sugar control is important. Inform your surgical team about this medicine. Your doctor will decide whether to continue, adjust, or temporarily stop it.

🦷 Dental Procedures

Inform your dentist about this medicine. If you are having a procedure that requires fasting, discuss dose adjustments with your doctor to avoid hypoglycemia.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to improve blood sugar control.
🥗
Eat regular, balanced meals and do not skip meals.
😴
Engage in regular physical activity as advised by your doctor.
💧
Monitor your blood sugar as recommended.
🧘
Get adequate sleep and manage stress.
🌞
Avoid smoking and limit alcohol intake.

🏋️ Exercise Considerations

Exercise can lower blood sugar. Check your blood glucose before and after exercise, and carry a fast-acting sugar source. Adjust your medicine dose only under medical advice.

🥗 Diet Recommendations

Choose high-fiber foods like whole grains, vegetables, and legumes.
Limit sugary drinks and refined carbohydrates.
Include lean protein in meals.
Stay well hydrated with water.
Eat meals at consistent times each day.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or low blood sugar, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Inform your employer if your job involves safety-sensitive tasks.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects or your blood sugar is well controlled on other treatments, your doctor may adjust or stop it.

📅 Long-Term Use Effects

Long-term use of this medicine may help maintain blood sugar control, but it requires regular monitoring of blood glucose, HbA1c, and kidney and liver function. Prolonged uncontrolled diabetes can lead to complications, so lifestyle measures and regular follow-up are essential.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Medical nutrition therapy

A personalized diet plan can help control blood sugar and complement medicine.

Evidence: Well-established
Regular physical activity

Exercise improves insulin sensitivity and helps lower blood sugar.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

People with diabetes should stay up to date with recommended vaccines, including influenza and COVID-19 vaccines. Discuss timing with your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid temperature extremes. If crossing time zones, adjust meal times and doses in consultation with your doctor. Store away from direct sunlight and moisture. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 52-year-old man with type 2 diabetes not controlled on metformin alone
His doctor added this medicine before meals. He noticed better post-meal sugar readings within a few weeks. He learned to take it consistently before meals and to carry glucose tablets. He experienced one mild low-sugar episode when he skipped lunch, which resolved after eating.
💡 Lesson: Taking this medicine before meals and not skipping meals are key to avoiding hypoglycemia.
👤 A 65-year-old woman with type 2 diabetes and mild kidney impairment
She was started on a lower dose of this medicine and monitored closely. Her blood sugar improved without significant side effects. She was advised to check her blood glucose more often and to report any dizziness or sweating.
💡 Lesson: Elderly patients and those with kidney problems may need lower doses and closer monitoring.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts lowering blood sugar within 15 to 30 minutes after taking it, with peak effect in about 1 hour.

Q: Can I take this medicine if I have kidney problems?

A: It should be used with caution in kidney impairment. Your doctor may adjust the dose and monitor you closely.

Q: What should I do if I feel shaky or sweaty after taking this medicine?

A: These are signs of low blood sugar. Eat or drink something sugary immediately, such as glucose tablets or fruit juice, and inform your doctor.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for natiz 60mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure diabetes.
    Fact: This medicine helps control blood sugar but does not cure diabetes. It must be used along with diet, exercise, and regular monitoring.
  • Myth: This medicine can be taken without meals.
    Fact: This medicine should be taken before meals to work properly and reduce the risk of low blood sugar.
  • Myth: This medicine is safe for everyone with diabetes.
    Fact: It is not for people with type 1 diabetes or diabetic ketoacidosis, and it requires medical supervision.

🔄 Alternative Options

Generic Alternatives

  • Nateglinide 60 mg tablet

Brand Alternatives

  • Glinate 60 Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Nateglinide","class":"Meglitinide","onset":"Rapid (15-30 min)","duration":"Short (about 4 hours)","hypoglycemia_risk":"Moderate"},{"medicine":"Repaglinide","class":"Meglitinide","onset":"Rapid (15-30 min)","duration":"Short (about 4-6 hours)","hypoglycemia_risk":"Moderate"},{"medicine":"Glimepiride","class":"Sulfonylurea","onset":"Slower (1-2 hours)","duration":"Long (up to 24 hours)","hypoglycemia_risk":"Higher"}]

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory