Dacihep 60mg Tablet (daclatasvir): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain, especially in the upper right quadrant
- Persistent nausea and vomiting
- Signs of allergic reaction: rash, itching, swelling of face or throat, difficulty breathing
- Unusual tiredness or weakness
- Bleeding or bruising easily
If experiencing severe symptoms, call emergency services immediately.
What is natdac 60 tablet used for?
Daclatasvir is an antiviral medicine used in combination with other drugs to treat chronic hepatitis C virus (HCV) infection. It works by blocking a viral protein called NS5A, which the virus needs to multiply. It is taken orally once daily for 12 to 24 weeks, depending on the genotype and other factors. It is not used alone and must be prescribed by a liver specialist.
- Generic Name: Daclatasvir (60mg)
- Manufacturer: Natco Pharma Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 natdac 60 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डैक्लाटासवीर नामक एंटीवायरल दवा है, जिसका उपयोग वयस्कों में क्रोनिक हेपेटाइटिस सी वायरस (HCV) संक्रमण के इलाज के लिए अन्य एंटीवायरल दवाओं के संयोजन में किया जाता है। यह वायरस के NS5A प्रोटीन को रोककर वायरस को बढ़ने से रोकती है। यह दवा अकेले नहीं ली जाती, बल्कि सोफोसबुवीर या रिबाविरिन जैसी अन्य दवाओं के साथ ली जाती है। यह आमतौर पर 12 से 24 सप्ताह तक रोजाना एक बार ली जाती है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, थकान, जी मिचलाना, दस्त और नींद न आना शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यकृत की समस्या या एलर्जी हो सकती है। अगर आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक न छोड़ें और इलाज बीच में न रोकें। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं, क्योंकि यह कई दवाओं के साथ प्रतिक्रिया कर सकती है। इलाज के दौरान शराब न पिएं। अगर आप गर्भवती हो सकती हैं तो गर्भनिरोधक का इस्तेमाल करें। नियमित रूप से खून की जांच कराएं। इस दवा को कमरे के तापमान पर सूखी जगह पर रखें।
💊 natdac 60 tablet Uses & Benefits
[{"condition":"Chronic hepatitis C virus (HCV) infection","description":"Used in combination with other antiviral agents for the treatment of chronic HCV genotypes 1, 2, 3, and 4 in adults.","evidence":"Well-established"},{"condition":"HCV with compensated cirrhosis","description":"Effective in patients with compensated liver disease, including those with cirrhosis.","evidence":"Well-established"},{"condition":"HCV in patients with HIV co-infection","description":"Can be used in combination with other DAAs in patients co-infected with HIV, with careful attention to drug interactions.","evidence":"Well-established"}]
Off-label uses: [{"condition":"HCV genotypes 5 and 6","description":"May be used off-label for other genotypes based on resistance testing and specialist opinion.","evidence":"Limited"},{"condition":"Acute HCV infection","description":"Sometimes used in acute settings, but evidence is limited and specialist guidance is required.","evidence":"Limited"}]
Primary treatment for: Chronic hepatitis C virus (HCV) infection
Also treats: Compensated cirrhosis due to HCV, HIV/HCV co-infection
📋 Drug Information
| Generic Name(s) | Daclatasvir (60mg) |
| Brand Name | natdac 60 tablet |
| Manufacturer | Natco Pharma Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Direct acting hepatitis C agent |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep in the original container, tightly closed, away from moisture and heat. Do not refrigerate. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization (WHO) recommends daclatasvir-containing regimens as an option for the treatment of chronic hepatitis C in adults, including those with compensated cirrhosis. It is included in the WHO Model List of Essential Medicines. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines for hepatitis C management include daclatasvir as a component of direct-acting antiviral regimens for the treatment of chronic HCV infection in India. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Daclatasvir is a direct-acting antiviral that inhibits the NS5A protein of the hepatitis C virus. The NS5A protein is essential for viral RNA replication and assembly of new virions. By binding to the NS5A protein, daclatasvir disrupts these processes, leading to a rapid decline in viral load. It is active against multiple HCV genotypes, though potency varies. This medicine is used in combination with other antivirals to prevent resistance and achieve sustained virologic response.
Mechanism Steps
💡 How to Take natdac 60 tablet
Strength: Daclatasvir 60 mg immediate-release tablet
Dosage Information
| Adult Dosage | The recommended adult dose of this medicine is 60 mg taken orally once daily, with or without food. It must be used in combination with other antiviral medicines, such as sofosbuvir, with or without ribavirin. The duration of treatment depends on the HCV genotype, presence of cirrhosis, and prior treatment history, and is typically 12 to 24 weeks. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and potential drug interactions. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No dose adjustment is required for elderly patients based on age alone. However, elderly patients may have reduced hepatic or renal function and should be monitored accordingly. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is required for patients with renal impairment, including those on hemodialysis. However, daclatasvir is highly protein-bound and not significantly removed by dialysis. |
| Hepatic Impairment | No dose adjustment is required for patients with mild to moderate hepatic impairment (Child-Pugh A or B). Daclatasvir is contraindicated in patients with severe hepatic impairment (Child-Pugh C). |
| Maximum Daily Dose | The maximum recommended daily dose is 60 mg once daily. Higher doses have not been shown to provide additional benefit and may increase the risk of side effects. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of natdac 60 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Rifampin | Major | |
| Carbamazepine | Major | |
| Phenytoin | Major | |
| St. John's wort | Major | |
| Ketoconazole | Major | |
| Clarithromycin | Major | |
| Omeprazole | Moderate | |
| Atorvastatin | Moderate | |
| Antacids | Moderate | |
| Famotidine | Moderate |
🚨 Major Interactions
- Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin, St. John's wort)
- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir-boosted protease inhibitors)
- Proton pump inhibitors (e.g., omeprazole)
⚡ Moderate Interactions
- HMG-CoA reductase inhibitors (statins)
- Antacids
- H2 receptor antagonists (e.g., famotidine)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase the risk of liver damage and may worsen the underlying liver disease. Alcohol can also affect the metabolism of this medicine and increase the risk of side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to daclatasvir or any component of the formulation","Severe hepatic impairment (Child-Pugh C)","Concomitant use with strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin, St. John's wort)"]
⚠️ Warnings & Precautions
["This medicine should be used in combination with other antivirals; do not use as monotherapy.","Serious liver problems have been reported; monitor liver function closely.","Drug interactions are common; review all concomitant medications before starting therapy.","Use effective contraception during treatment for women of childbearing potential.","Avoid alcohol to reduce liver stress.","Do not share this medicine with others, even if they have similar symptoms."]
🤱 Lactation Safety
It is not known whether daclatasvir is excreted in human breast milk. Because of the potential for adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
There is no specific antidote for daclatasvir overdose. In case of overdose, discontinue the medicine and provide supportive care. Monitor vital signs and liver function. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is within 12 hours of the scheduled time. If more than 12 hours have passed, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop treatment early, as this can lead to treatment failure and viral resistance. Inform your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements, as this medicine can interact with many drugs. Avoid alcohol while on this medicine to reduce liver stress. Use effective contraception during treatment if you are of childbearing potential. Regular blood tests are needed to monitor your liver function and viral load. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) can take this medicine without dose adjustment based on age alone. However, they may have reduced liver or kidney function and should be monitored closely for side effects and drug interactions. Regular follow-up is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. Effective contraception is recommended during treatment for women of childbearing potential. It is not known if this medicine affects fertility. For men, no specific precautions are required, but consult your doctor for personalized advice.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anesthesiologist that you are taking this medicine. There are no specific restrictions, but they need to be aware of all your medications to avoid interactions with anesthetic agents. Continue taking this medicine as prescribed unless your doctor advises otherwise.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. There are no specific contraindications, but your dentist should be aware of your medical history and medications. Maintain good oral hygiene to prevent infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine. However, if you experience fatigue or weakness, adjust your activity level. Avoid strenuous exercise if you have advanced liver disease or feel unwell. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue or headache, which can affect your ability to drive or operate machinery. If you experience these side effects, avoid driving or operating heavy machinery until you feel better. Most people can continue their normal daily activities while on treatment. Inform your employer if you need flexible hours for medical appointments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping early can lead to treatment failure and viral resistance. If you experience severe side effects, contact your doctor immediately; they will decide whether to adjust or stop treatment. Complete the full prescribed course even if you feel better.
📅 Long-Term Use Effects
Long-term use of this medicine is generally limited to the treatment duration of 12 to 24 weeks. After completing therapy, most patients achieve a sustained virologic response, which is considered a cure. There are no known long-term side effects beyond the treatment period. However, patients with cirrhosis should continue regular liver monitoring even after cure, as the risk of liver cancer remains. Monitoring includes liver function tests and imaging as recommended by the doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A fixed-dose combination of two direct-acting antivirals that is highly effective for all HCV genotypes.
Evidence: Well-establishedAnother pan-genotypic DAA combination used for hepatitis C treatment.
Evidence: Well-establishedAvoiding alcohol, maintaining a healthy weight, and getting vaccinated can support liver health but do not replace antiviral therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Patients with chronic hepatitis C should be vaccinated against hepatitis A and hepatitis B if they are not already immune. These vaccines are safe and can be administered during treatment with this medicine. There are no known interactions between this medicine and vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate
✅ DO
Keep in the original container, tightly closed
❌ DON'T
Do not transfer to another container
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from moisture. If crossing time zones, continue taking your dose at the same local time as before, or adjust gradually as advised by your doctor. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts reducing the hepatitis C virus in your body within days, but the full treatment course lasts 12 to 24 weeks. You will need blood tests to monitor your response.
A: Yes, you can take this medicine with or without food. Taking it with food may help reduce nausea.
A: If you miss a dose and it is within 12 hours of the scheduled time, take it as soon as you remember. If more than 12 hours have passed, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, you should avoid alcohol while taking this medicine because it can increase the risk of liver damage and may worsen your condition.
A: There is limited data on the use of this medicine in pregnancy. It should be used only if clearly needed, and effective contraception is recommended during treatment for women who can become pregnant.
🤔 Common Patient Concerns
🔄 Substitutes for natdac 60 tablet
View AllAlternative brands with exact same active ingredient:
-
hepcdac 60mg tabletCipla Ltd ₹5,243.19 59.8% COSTLIER
-
dacihep 60mg tabletZydus Cadila ₹5,255.00 60.2% COSTLIER
-
mydekla 60 tabletMylan Pharmaceuticals Pvt Ltd ₹5,255.00 60.2% COSTLIER
-
daclitof 60mg tabletWockhardt Ltd ₹5,399.26 64.5% COSTLIER
-
dalsiclear 60 tabletAbbott ₹5,625.00 71.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Daclatasvir alone can cure hepatitis C.
Fact: Daclatasvir must be used in combination with other antiviral medicines to effectively cure hepatitis C and prevent resistance. - Myth: Daclatasvir has severe side effects.
Fact: Most people tolerate daclatasvir well. Common side effects are mild and temporary, such as headache and fatigue. - Myth: You can stop taking daclatasvir once you feel better.
Fact: You must complete the full course as prescribed, even if you feel better, to ensure the virus is completely cleared and to prevent resistance. - Myth: Daclatasvir is safe to take with any other medicine.
Fact: Daclatasvir can interact with many drugs, including certain antibiotics, anticonvulsants, and herbal supplements. Always consult your doctor before taking any other medicine.
🔄 Alternative Options
Generic Alternatives
- Daclatasvir 60 mg tablet (generic)
Brand Alternatives
- Dacihep 60mg Tablet
- Daklinza 60mg Tablet