Naprosyn P 300mg/500mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is naprosyn p 300mg/500mg tablet used for?
This medicine is a combination of Naproxen 300 mg and Paracetamol 500 mg used for short-term relief of moderate to severe pain and inflammation. It is taken orally with food, usually 2-3 times daily, and should not be used for more than 7 days without medical advice.
- Generic Name: Naproxen (300mg) + Paracetamol (500mg)
- Manufacturer: RPG Life Sciences Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 naprosyn p 300mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नेप्रोक्सन 300 मिलीग्राम और पैरासिटामोल 500 मिलीग्राम का संयोजन है। इसका उपयोग मध्यम से गंभीर दर्द और सूजन के अल्पकालिक उपचार के लिए किया जाता है, जैसे कि जोड़ों का दर्द, मांसपेशियों का दर्द, दांत का दर्द, मासिक धर्म में ऐंठन, और ऑस्टियोआर्थराइटिस। यह दर्द और सूजन को कम करने में मदद करता है। इसे भोजन के साथ लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में जलन, दस्त, कब्ज, सिरदर्द, चक्कर आना और त्वचा पर दाने शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, एलर्जी की प्रतिक्रिया, दिल का दौरा, स्ट्रोक, और लीवर या किडनी की समस्या शामिल हैं। यदि आपको काला मल, खून की उल्टी, सीने में दर्द, सांस लेने में कठिनाई, या त्वचा या आंखों का पीलापन दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा भोजन या दूध के साथ लें ताकि पेट में जलन न हो। खाली पेट न लें। इस दवा के साथ शराब न पिएं। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आपको पेट के अल्सर, हृदय रोग, उच्च रक्तचाप, गुर्दे या यकृत की बीमारी, अस्थमा है, या आप गर्भवती या स्तनपान करा रही हैं, तो अपने डॉक्टर को बताएं। चक्कर आने पर वाहन न चलाएं। कम से कम प्रभावी खुराक सबसे कम समय के लिए लें। 7 दिनों से अधिक उपयोग न करें।
💊 naprosyn p 300mg/500mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from moderate to severe dental pain, including post-extraction pain.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Reduces menstrual cramps and associated pain.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Symptomatic relief of pain and stiffness in osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces pain and inflammation in rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Management of mild to moderate post-operative pain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not a first-line treatment.","evidence":"Limited"},{"condition":"Gout","description":"May be used for acute gout attacks, but other NSAIDs are preferred.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation
Also treats: Osteoarthritis, Rheumatoid arthritis, Dysmenorrhea, Dental pain, Musculoskeletal pain
📋 Drug Information
| Generic Name(s) | Naproxen (300mg) + Paracetamol (500mg) |
| Brand Name | naprosyn p 300mg/500mg tablet |
| Manufacturer | RPG Life Sciences Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Naproxen is a non-selective non-steroidal anti-inflammatory drug (NSAID) that reversibly inhibits the cyclooxygenase (COX) enzymes, COX-1 and COX-2. This inhibition reduces the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. Paracetamol (acetaminophen) has analgesic and antipyretic properties, but its mechanism of action is not fully understood. It is believed to act primarily in the central nervous system by inhibiting prostaglandin synthesis, possibly through interaction with the COX-3 variant or by activating descending serotonergic pathways. The combination provides enhanced pain relief through different pathways.
Mechanism Steps
💡 How to Take naprosyn p 300mg/500mg tablet
Strength: Tablet containing Naproxen 300 mg and Paracetamol 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (Naproxen 300 mg + Paracetamol 500 mg) taken orally two to three times daily, preferably with food or milk. The maximum daily dose should not exceed 3 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Use the lowest effective dose for the shortest duration. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are at increased risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly. |
| Renal Impairment | Use with caution in patients with mild to moderate kidney impairment. Avoid in severe kidney impairment (eGFR <30 mL/min). Dose adjustment may be required. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with mild to moderate liver impairment. Avoid in severe liver impairment. Dose adjustment may be required. Consult your doctor. |
| Maximum Daily Dose | Maximum daily dose: Naproxen 900 mg and Paracetamol 1500 mg (3 tablets) in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of naprosyn p 300mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Ibuprofen | Major | |
| ACE inhibitors | Major | |
| Lithium | Major | |
| Methotrexate | Major | |
| SSRIs | Moderate | |
| Corticosteroids | Moderate | |
| Diuretics | Moderate | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., aspirin, ibuprofen)
- Corticosteroids
- ACE inhibitors and ARBs
- Diuretics
- Lithium
- Methotrexate
⚡ Moderate Interactions
- SSRIs
- Antacids
- Cholestyramine
- Probenecid
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulcers, and liver damage, especially when combined with paracetamol and NSAIDs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to naproxen, paracetamol, or any component of the formulation.","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.","Active peptic ulcer disease or history of recurrent ulcers.","Severe heart failure.","Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["Cardiovascular risk: NSAIDs may increase the risk of serious cardiovascular thrombotic events. Use with caution in patients with cardiovascular risk factors.","Gastrointestinal risk: NSAIDs can cause gastrointestinal bleeding, ulceration, and perforation, which can be fatal. Use with caution in the elderly and those with a history of ulcers.","Kidney risk: NSAIDs can cause kidney injury, especially in patients with dehydration or pre-existing kidney disease.","Liver risk: Paracetamol can cause hepatotoxicity if taken in excess or with alcohol.","Skin reactions: Serious skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported with NSAIDs and paracetamol.","Use in the elderly: Increased risk of adverse effects; use lowest effective dose for shortest duration.","Use in pregnancy: Avoid in the third trimester; consult doctor before use.","Do not exceed the recommended dose of paracetamol from all sources."]
🤱 Lactation Safety
Naproxen is excreted in breast milk in small amounts. Paracetamol is also excreted in breast milk in small amounts. The combination is generally considered compatible with breastfeeding, but consult your doctor before use.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to paracetamol and gastrointestinal bleeding, kidney failure, and central nervous system effects due to naproxen. Seek immediate medical attention. Treatment includes gastric lavage if within 1-2 hours, administration of activated charcoal, and acetylcysteine for paracetamol toxicity. Monitor liver and kidney function, and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.
Additional Safety Advice
Always take this medicine with food or milk to reduce the risk of stomach upset. Do not take it on an empty stomach. Avoid alcohol while taking this medicine as it can increase the risk of gastrointestinal bleeding and liver damage. Do not take other medications containing paracetamol or other NSAIDs without consulting your doctor, as this can lead to overdose or increased side effects. Inform your doctor if you have a history of stomach ulcers, heart disease, high blood pressure, kidney or liver disease, asthma, or if you are pregnant or breastfeeding. Do not drive or operate heavy machinery if you experience dizziness or drowsiness. Take the lowest effective dose for the shortest possible duration. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at increased risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration and monitor kidney and liver function regularly.
🤰 Pregnancy Planning (TTC)
Consult your doctor before taking this medicine if you are planning pregnancy. NSAIDs may affect ovulation and are generally avoided in the third trimester.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain, but it can increase the risk of bleeding. Consult your surgeon before taking it after surgery.
🦷 Dental Procedures
This medicine can be used for dental pain, but it may increase the risk of bleeding during dental procedures. Inform your dentist if you are taking this medicine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase pain while taking this medicine. Gentle stretching and low-impact exercises are recommended. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take it with food to avoid stomach upset during work hours.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as gastrointestinal bleeding, allergic reactions, or if your pain persists beyond 7 days. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, kidney impairment, liver damage, and cardiovascular events. Regular monitoring of kidney and liver function is recommended. Use the lowest effective dose for the shortest duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help reduce pain and inflammation.
Evidence: LimitedMay provide pain relief for some individuals.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before vaccination if you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing times gradually. Check customs regulations for carrying prescription medicines. Do not expose to extreme temperatures.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 1 hour after taking it with food.
A: No, it should be taken with food or milk to reduce the risk of stomach upset.
A: No, do not take other painkillers containing paracetamol or NSAIDs without consulting your doctor.
A: It is intended for short-term use only. Do not use for more than 7 days without medical advice.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of pain.
Fact: This medicine is intended for specific types of pain and should only be used as prescribed. - Myth: It is safe to take this medicine with other painkillers.
Fact: Taking multiple painkillers can increase the risk of side effects, especially liver and kidney damage. - Myth: This medicine is not addictive.
Fact: This medicine is not habit-forming, but it should be used only for the prescribed duration.
🔄 Alternative Options
Generic Alternatives
- Naproxen 300 mg + Paracetamol 500 mg tablet (various manufacturers)
Brand Alternatives
- Naprosyn P 300mg/500mg tablet