Aztreonam 500mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe rash with blistering or peeling skin
- Severe diarrhea with blood or mucus
- Seizures or confusion
- Decreased urine output or swelling in the legs
- Yellowing of the skin or eyes
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is namap 500mg injection used for?
Aztreonam is a monobactam antibiotic used to treat serious infections caused by gram-negative bacteria. It is given by injection and is often used in patients allergic to penicillin.
- Generic Name: Aztreonam (500mg)
- Manufacturer: Apkavit Lifesciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 namap 500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एज़्ट्रेओनम 500 मिलीग्राम इंजेक्शन के रूप में एक एंटीबायोटिक है, जिसका उपयोग गंभीर जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह मुख्य रूप से ग्राम-निगेटिव बैक्टीरिया के कारण होने वाले संक्रमणों जैसे कि मूत्र पथ के संक्रमण, निमोनिया, त्वचा संक्रमण, पेट के अंदर के संक्रमण, और सेप्टिसीमिया के लिए दिया जाता है। यह उन रोगियों के लिए विशेष रूप से उपयोगी है जिन्हें पेनिसिलिन से एलर्जी है। यह दवा केवल डॉक्टर या नर्स द्वारा इंजेक्शन के माध्यम से दी जाती है, इसे घर पर स्वयं नहीं लगाया जाना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, लालिमा या सूजन, दस्त, मतली, उल्टी, दाने और सिरदर्द शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तीव्र एलर्जी प्रतिक्रिया, गंभीर दस्त, दौरे और रक्त विकार शामिल हो सकते हैं। यदि आपको कोई गंभीर या असामान्य लक्षण महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा ही दी जानी चाहिए। स्वयं इंजेक्शन न लगाएं। अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों और दवाओं के बारे में बताएं। यदि आपको पेनिसिलिन या अन्य बीटा-लैक्टम एंटीबायोटिक्स से एलर्जी है, तो डॉक्टर को सूचित करें। उपचार के दौरान गुर्दे की कार्यप्रणाली की निगरानी की जा सकती है। यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दाने जैसे एलर्जी के लक्षण दिखाई दें, तो तुरंत आपातकालीन चिकित्सा सहायता लें।
💊 namap 500mg injection Uses & Benefits
[{"condition":"Complicated urinary tract infections","description":"Used to treat serious kidney and bladder infections caused by susceptible gram-negative bacteria.","evidence":"Well-established"},{"condition":"Lower respiratory tract infections","description":"Effective against hospital-acquired pneumonia and other serious lung infections caused by gram-negative pathogens.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats severe skin infections, including those caused by Pseudomonas aeruginosa.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for complicated intra-abdominal infections.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Treats pelvic inflammatory disease and other serious gynecological infections caused by gram-negative bacteria.","evidence":"Well-established"},{"condition":"Septicemia","description":"Used to treat bloodstream infections caused by susceptible gram-negative organisms.","evidence":"Well-established"},{"condition":"Meningitis","description":"May be used for meningitis caused by gram-negative bacteria, often in combination with other antibiotics.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Cystic fibrosis exacerbations","description":"Sometimes used off-label for treating pulmonary exacerbations in cystic fibrosis patients with Pseudomonas aeruginosa, either alone or in combination.","evidence":"Limited"},{"condition":"Febrile neutropenia","description":"May be used off-label as part of empirical therapy in febrile neutropenic patients, especially those with penicillin allergy.","evidence":"Limited"}]
Primary treatment for: Bacterial infections caused by susceptible gram-negative organisms
Also treats: Complicated urinary tract infections, Lower respiratory tract infections, Skin and soft tissue infections, Intra-abdominal infections, Gynecological infections, Septicemia, Meningitis
📋 Drug Information
| Generic Name(s) | Aztreonam (500mg) |
| Brand Name | namap 500mg injection |
| Manufacturer | Apkavit Lifesciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Monobactams |
| Route of Administration | Parenteral (intramuscular or intravenous) |
| Storage | Store the unreconstituted vial at room temperature (20-25°C). After reconstitution, the solution should be used within 24 hours if stored at room temperature or within 72 hours if refrigerated (2-8°C). Protect from light. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Aztreonam is a monobactam antibiotic that inhibits bacterial cell wall synthesis by binding with high affinity to penicillin-binding protein 3 (PBP3) in susceptible gram-negative bacteria. This binding prevents the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death. Unlike other beta-lactams, aztreonam has minimal affinity for PBP2 and does not induce beta-lactamase production. It is stable against many beta-lactamases produced by gram-negative bacteria, but it can be hydrolyzed by extended-spectrum beta-lactamases (ESBLs) and carbapenemases.
Mechanism Steps
💡 How to Take namap 500mg injection
Strength: 500 mg lyophilized powder for injection
Dosage Information
| Adult Dosage | The usual adult dose of aztreonam ranges from 500 mg to 2 grams every 6 to 12 hours, depending on the type and severity of infection. For complicated urinary tract infections, 500 mg to 1 gram every 8 to 12 hours is typical. For severe systemic infections, 2 grams every 6 to 8 hours may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function, which can increase aztreonam levels. Dose adjustment based on renal function is recommended. Monitor renal function closely. |
| Renal Impairment | In patients with renal impairment, the dose of aztreonam must be reduced. For creatinine clearance 10-30 mL/min, the usual dose is 500 mg to 1 gram every 8 to 12 hours. For creatinine clearance less than 10 mL/min, the dose is 500 mg every 12 hours. For patients on hemodialysis, a loading dose of 500 mg is given, followed by 500 mg after each dialysis session. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No dose adjustment is necessary for hepatic impairment alone, as aztreonam is minimally metabolized. However, if both hepatic and renal impairment are present, dose adjustment based on renal function is required. |
| Maximum Daily Dose | The maximum recommended daily dose is 8 grams per day in adults with normal renal function. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of namap 500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | |
| Gentamicin | Major | |
| Furosemide | Moderate | |
| Probenecid | Moderate | |
| Amphotericin B | Moderate | |
| Vancomycin | Moderate | |
| Other beta-lactams | Major |
🚨 Major Interactions
- Other beta-lactam antibiotics (e.g., penicillins, cephalosporins)
- Aminoglycosides (e.g., gentamicin, tobramycin)
- Loop diuretics (e.g., furosemide)
⚡ Moderate Interactions
- Warfarin
- Probenecid
- Nephrotoxic drugs (e.g., amphotericin B, vancomycin)
🍷 Alcohol Interaction
Alcohol does not directly interact with aztreonam, but consuming alcohol while fighting an infection may worsen dehydration and impair recovery. It is advisable to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to aztreonam or any component of the formulation.","Previous anaphylactic reaction to aztreonam."]
⚠️ Warnings & Precautions
["Serious hypersensitivity reactions, including anaphylaxis, have been reported. Discontinue immediately if allergic reaction occurs.","Clostridioides difficile-associated diarrhea may occur. Monitor for severe diarrhea.","Use with caution in patients with renal impairment; dose adjustment is required.","Prolonged use may lead to superinfection with non-susceptible organisms.","May cause seizures in patients with renal impairment if dose is not adjusted.","Not effective against gram-positive bacteria and anaerobes; consider combination therapy for mixed infections."]
🤱 Lactation Safety
Aztreonam is excreted in human breast milk in low concentrations. It is generally considered safe during breastfeeding, but consult your doctor to weigh the benefits and risks.
💊 Overdose Management
There is no specific antidote for aztreonam overdose. Treatment should be symptomatic and supportive. Aztreonam can be removed by hemodialysis or peritoneal dialysis. Monitor vital signs and renal function closely.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse as soon as possible. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must be administered only by a qualified healthcare professional. Do not attempt to self-administer. Inform your doctor if you are allergic to penicillin, cephalosporins, or other beta-lactam antibiotics, as cross-reactivity is possible though rare. Tell your doctor about all your medical conditions, especially kidney or liver disease, and all medications you are taking. Your kidney function may be monitored during treatment. If you develop severe diarrhea, abdominal pain, or signs of an allergic reaction such as difficulty breathing, swelling of the face or throat, or a severe skin rash, seek emergency medical help immediately. Do not skip doses or stop treatment early, as this can lead to antibiotic resistance and treatment failure.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced renal function, which can increase the levels of this medicine and the risk of side effects. Dose adjustment based on renal function is essential. Monitor renal function closely during treatment.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. It is classified as Pregnancy Category B, meaning animal studies show no risk but human studies are lacking. Use only if clearly needed.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent surgical site infections. If you are scheduled for surgery, inform your surgeon about any allergies and medications you are taking. Follow your surgeon's instructions regarding antibiotic prophylaxis.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It is not typically used for dental infections, but if you have a dental procedure while on this medicine, your dentist may need to coordinate with your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While on this medicine, you may feel fatigued or dizzy. Avoid strenuous exercise until you feel fully recovered. Light activities like walking are generally safe, but listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic setting, so you may need to take time off work for treatment. You may experience fatigue or dizziness, so avoid driving or operating heavy machinery until you feel better. Discuss your work schedule with your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can lead to incomplete treatment and antibiotic resistance. Your doctor will determine the appropriate duration of therapy based on your infection and response to treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance and superinfection with non-susceptible organisms. Prolonged use may also increase the risk of Clostridioides difficile-associated diarrhea and renal impairment. Regular monitoring of renal and liver function is recommended for patients on prolonged therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another beta-lactam antibiotic with similar gram-negative coverage, but may have cross-reactivity in penicillin-allergic patients.
Evidence: Well-establishedA fluoroquinolone antibiotic that can be used for gram-negative infections, but has different side effect profile.
Evidence: Well-establishedOften used in combination with beta-lactams for serious gram-negative infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, ensure you are up to date with recommended vaccinations, especially if you have a chronic condition.
📦 Storage Guide
✅ DO
Store the unreconstituted vial at room temperature (20-25°C).
❌ DON'T
Do not freeze the vial.
✅ DO
After reconstitution, use within 24 hours if stored at room temperature or within 72 hours if refrigerated.
❌ DON'T
Do not use if the solution is cloudy or contains particles.
✅ DO
Protect from light.
❌ DON'T
Do not store in direct sunlight.
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Since it is an injectable antibiotic, you may need to declare it at customs. Store it at room temperature and protect it from light. If you need to administer it while traveling, ensure you have access to a healthcare professional. Plan ahead for time zone changes if you are on a scheduled dosing regimen.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within a few hours after administration. You may start feeling better within 1-2 days, but it is important to complete the full course as prescribed.
A: No, this medicine must be administered by a healthcare professional in a hospital or clinic setting.
A: This medicine is often a safe alternative for patients with penicillin allergy because the risk of cross-reactivity is very low. However, inform your doctor about your allergy.
A: It is best to avoid alcohol during treatment as it may worsen dehydration and delay recovery.
🤔 Common Patient Concerns
🔄 Substitutes for namap 500mg injection
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Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Aztreonam can be taken orally.
Fact: Aztreonam is not absorbed orally and must be given by injection. - Myth: Aztreonam is effective against all bacteria.
Fact: Aztreonam is only effective against aerobic gram-negative bacteria; it does not cover gram-positive bacteria or anaerobes. - Myth: Aztreonam is unsafe for people with penicillin allergy.
Fact: Aztreonam has a very low risk of cross-reactivity with penicillins and is often used safely in patients with penicillin allergy.
🔄 Alternative Options
Generic Alternatives
- Aztreonam injection
Brand Alternatives
- Azactam
- Cayston