Appime 250mg Injection (Cefepime): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe or bloody diarrhea
- Seizures or confusion
- Decreased urine output
- Severe skin rash with blisters or peeling
- Persistent high fever despite treatment
If experiencing severe symptoms, call emergency services immediately.
What is appime 250mg injection used for?
This medicine is a fourth-generation cephalosporin antibiotic given intravenously to treat serious bacterial infections. It works by killing bacteria and is used in hospitals for conditions like pneumonia and urinary tract infections.
- Generic Name: Cefepime
- Manufacturer: Apkavit Lifesciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 appime 250mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक चौथी पीढ़ी का सेफलोस्पोरिन एंटीबायोटिक है, जिसे सेफेपाइम 250 मिलीग्राम के रूप में दिया जाता है। यह नस के माध्यम से दी जाती है और गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए उपयोग की जाती है, जैसे निमोनिया, मूत्र मार्ग संक्रमण, त्वचा संक्रमण और बुखार के साथ न्यूट्रोपेनिया। यह दवा बैक्टीरिया की कोशिका भित्ति को नष्ट करके उन्हें मार देती है। यह वायरल संक्रमणों जैसे सर्दी-जुकाम या फ्लू के लिए प्रभावी नहीं है। इसका उपयोग केवल डॉक्टर की देखरेख में ही किया जाना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, दस्त, मतली, दाने और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, गंभीर दस्त, दौरे और गुर्दे की समस्याएं हो सकती हैं। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल स्वास्थ्य पेशेवर द्वारा ही दी जानी चाहिए। अपने डॉक्टर को पेनिसिलिन या सेफलोस्पोरिन से एलर्जी के बारे में बताएं। गुर्दे की बीमारी, दौरे या पेट की समस्याओं की जानकारी दें। खुद से इंजेक्शन न लगाएं। एलर्जी के लक्षण, गंभीर दस्त या असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
💊 appime 250mg injection Uses & Benefits
[{"condition":"Pneumonia","description":"Used to treat community-acquired and hospital-acquired pneumonia caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against complicated urinary tract infections, including pyelonephritis.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for complicated skin infections, including cellulitis and abscesses.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Empiric therapy for febrile neutropenia in cancer patients.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for complicated intra-abdominal infections.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Meningitis","description":"Sometimes used off-label for bacterial meningitis when other options are not suitable.","evidence":"Limited"},{"condition":"Endocarditis","description":"May be used off-label for endocarditis caused by susceptible organisms.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Pneumonia, Urinary tract infections, Skin infections, Febrile neutropenia, Intra-abdominal infections
📋 Drug Information
| Generic Name(s) | Cefepime |
| Brand Name | Appime 250mg Injection |
| Manufacturer | Apkavit Lifesciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporins: 4th generation |
| Route of Administration | Intravenous (IV) injection or infusion |
| Storage | Store vials at 20°C to 25°C (68°F to 77°F). Protect from light. Reconstituted solutions should be used within recommended time frames as per manufacturer instructions. |
| Shelf Life | Typically 24 months from the date of manufacture. Check the expiry date on the vial. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Cefepime is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This binding interferes with the cross-linking of peptidoglycan chains, leading to weakening of the cell wall and ultimately bacterial cell lysis and death. Cefepime has enhanced stability against beta-lactamases and good activity against both gram-positive and gram-negative bacteria.
Mechanism Steps
💡 How to Take appime 250mg injection
Strength: 250 mg per vial, powder for injection.
Dosage Information
| Adult Dosage | The usual adult dose ranges from 1 g to 2 g intravenously every 8 to 12 hours, depending on the type and severity of infection. For severe infections, up to 2 g every 8 hours may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose should be adjusted based on creatinine clearance. Use with caution and monitor renal function. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance 30-60 mL/min, the usual dose is given every 12 hours; for 11-29 mL/min, every 24 hours; for <10 mL/min, every 48 hours. Consult a clinician for precise dosing. |
| Hepatic Impairment | No specific dosage adjustment is established for hepatic impairment. Use with caution. |
| Maximum Daily Dose | The maximum recommended daily dose is 6 g (e.g., 2 g every 8 hours) for severe infections in adults with normal renal function. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of appime 250mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Furosemide | Major | |
| Warfarin | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin)
- Loop diuretics (e.g., furosemide)
- Warfarin
⚡ Moderate Interactions
- Probenecid
- Other beta-lactams
🍷 Alcohol Interaction
No specific interaction with alcohol is established, but alcohol may worsen dehydration or gastrointestinal side effects. It is advisable to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to cefepime or other cephalosporins","Severe allergy to penicillins (cross-reactivity possible)"]
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment; dose adjustment required.","May cause seizures, especially in patients with renal impairment.","May cause Clostridioides difficile-associated diarrhea.","Serious hypersensitivity reactions, including anaphylaxis, can occur.","Prolonged use may lead to superinfection with resistant organisms."]
🤱 Lactation Safety
Cefepime is excreted in human milk in low concentrations. Caution should be exercised when administered to a nursing woman. Consult a doctor.
💊 Overdose Management
Overdose may cause seizures, encephalopathy, and neuromuscular excitability. Treatment is symptomatic and supportive. Cefepime can be removed by hemodialysis. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If a dose is missed, contact your healthcare provider for instructions. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be administered by a healthcare professional. Inform your doctor about any allergies to antibiotics, especially penicillins or cephalosporins. Tell your doctor if you have kidney disease, seizures, or gastrointestinal problems. Do not self-administer. Report any signs of allergic reaction, severe diarrhea, or unusual symptoms immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney impairment and neurotoxicity. Dose adjustment based on renal function is essential. Monitor closely for confusion or seizures.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. It is generally used only if clearly needed during pregnancy.
🏥 Post-Surgery Considerations
This medicine may be used to prevent or treat surgical site infections. Follow your surgeon's instructions for use.
🦷 Dental Procedures
Inform your dentist if you are on this medicine. It may be used for prophylaxis in certain dental procedures in patients at risk of endocarditis.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Rest is recommended during acute infection. Gradually resume light activities as you recover. Avoid strenuous exercise until you feel fully well.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may need to take time off work during treatment, especially if hospitalized. Driving is not recommended if you feel weak or dizzy. Avoid operating machinery until you are fully alert.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. Stopping early can lead to recurrence of infection and resistance.
📅 Long-Term Use Effects
Long-term use may lead to antibiotic resistance and superinfections. Prolonged therapy requires monitoring of kidney function, liver function, and blood counts. Use only as long as necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection and susceptibility, other antibiotics like ceftriaxone or meropenem may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interaction with vaccines is established. However, antibiotics may reduce the efficacy of live bacterial vaccines like typhoid vaccine. Consult your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not use if solution is discolored or contains particles
✈️ Traveling with This Medicine
This medicine is usually administered in a healthcare setting. If you need to travel while on therapy, ensure you carry a copy of your prescription and medical records. Store vials in their original packaging at room temperature, protected from light. Check with airlines about carrying injectable medications. Plan for timely administration with a healthcare provider at your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it is important to complete the full course as prescribed.
A: This medicine is usually given in a hospital or clinic setting by a healthcare professional.
A: Inform your doctor. There is a risk of cross-reactivity, and your doctor will decide if this medicine is safe for you.
🤔 Common Patient Concerns
🔄 Substitutes for appime 250mg injection
View AllAlternative brands with exact same active ingredient:
-
cachepime 250mg injectionCachet Pharmaceuticals Pvt Ltd ₹33.75 20% CHEAPER
-
cefetune 250mg injectionFortune Labs ₹45.00 6.7% COSTLIER
-
biopime 250mg injectionBiochem Pharmaceutical Industries ₹46.83 11% COSTLIER
-
curepime 250mg injectionMancure Drugs Pvt Ltd ₹46.88 11.1% COSTLIER
-
enpime 250mg injectionShrinivas Gujarat Laboratories Pvt Ltd ₹46.88 11.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure viral infections like the flu.
Fact: This medicine is only effective against bacterial infections, not viruses. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full course as prescribed to prevent resistance.
🔄 Alternative Options
Generic Alternatives
- Cefepime injection (generic)
Brand Alternatives
- Maxipime
- Cefepime injection (various brands)