Aldigram 100 Mg/150 Mg Suspension: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Numbness or tingling in hands or feet
- Sudden joint pain or swelling
If experiencing severe symptoms, call emergency services immediately.
What is nalidys suspension used for?
This medicine is a combination antibiotic suspension containing nalidixic acid and metronidazole, used to treat mixed bacterial and protozoal infections. It works by inhibiting bacterial DNA replication and damaging anaerobic organisms. It should be taken exactly as prescribed, with food, and alcohol must be avoided.
- Generic Name: Nalidixic Acid (100mg) + Metronidazole (150mg)
- Manufacturer: Biological E Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nalidys suspension के बारे में (Hindi Summary)
उपयोग: यह दवा नालिडिक्सिक एसिड और मेट्रोनिडाजोल का संयोजन है, जिसका उपयोग मिश्रित जीवाणु और प्रोटोजोआ संक्रमणों के इलाज के लिए किया जाता है। यह मूत्र मार्ग संक्रमण, पेल्विक सूजन रोग, गियार्डिया और अमीबियासिस में प्रभावी है। यह दवा बैक्टीरिया के डीएनए को नष्ट करके उन्हें मारती है। इसे डॉक्टर के निर्देशानुसार ही लें और शराब का सेवन बिल्कुल न करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द, चक्कर आना और मुँह में धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभावों में टेंडन टूटना, तंत्रिका क्षति, दौरे और एलर्जी प्रतिक्रियाएँ शामिल हैं। शराब के साथ लेने पर गंभीर प्रतिक्रिया हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। हर बार उपयोग से पहले बोतल को अच्छी तरह हिलाएँ। दवा को भोजन के साथ लें ताकि पेट खराब न हो। उपचार के दौरान और अंतिम खुराक के 48 घंटे बाद तक शराब न पिएँ। धूप में बाहर निकलते समय सनस्क्रीन और सुरक्षात्मक कपड़े पहनें। दवा का कोर्स पूरा करें, बीच में न छोड़ें। बच्चों की पहुँच से दूर रखें।
💊 nalidys suspension Uses & Benefits
[{"condition":"Complicated urinary tract infections","description":"Used when mixed aerobic and anaerobic bacteria are suspected, especially after catheterization or in patients with structural abnormalities.","evidence":"Moderate"},{"condition":"Pelvic inflammatory disease","description":"Combination covers both gonococcal and anaerobic organisms in polymicrobial pelvic infections.","evidence":"Moderate"},{"condition":"Bacterial vaginosis","description":"Metronidazole component targets Gardnerella vaginalis and anaerobes; nalidixic acid adds gram-negative coverage.","evidence":"Limited"},{"condition":"Giardiasis","description":"Metronidazole is effective against Giardia lamblia; nalidixic acid may cover concurrent bacterial overgrowth.","evidence":"Limited"},{"condition":"Amebiasis","description":"Metronidazole treats Entamoeba histolytica; combination may be used in mixed intestinal infections.","evidence":"Limited"}]
Off-label uses: [{"condition":"Prophylaxis in colorectal surgery","description":"Sometimes used to cover aerobic and anaerobic bowel flora, though other regimens are preferred.","evidence":"Limited"},{"condition":"Diverticulitis","description":"Combination may be used in mild cases, but standard regimens usually include other agents.","evidence":"Limited"}]
Primary treatment for: Mixed bacterial infections
Also treats: Urinary tract infections, Pelvic inflammatory disease, Giardiasis, Amebiasis, Bacterial vaginosis
📋 Drug Information
| Generic Name(s) | Nalidixic Acid (100mg) + Metronidazole (150mg) |
| Brand Name | nalidys suspension |
| Manufacturer | Biological E Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the bottle tightly closed. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antibiotics with distinct mechanisms. Nalidixic acid inhibits bacterial DNA gyrase (topoisomerase II), blocking DNA replication and causing bacterial cell death, primarily in gram-negative organisms. Metronidazole enters anaerobic bacteria and protozoa, where its nitro group is reduced to reactive radicals that damage DNA and inhibit nucleic acid synthesis, leading to cell death. Together, they provide broad coverage against aerobic gram-negative and anaerobic organisms.
Mechanism Steps
💡 How to Take nalidys suspension
Strength: Each 5 mL of suspension contains nalidixic acid 100 mg and metronidazole 150 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this suspension is individualized by a qualified clinician based on the type and severity of infection, patient weight, and renal/hepatic function. A typical regimen may involve taking one to two teaspoonfuls (5-10 mL) every 6 to 8 hours, but this must be confirmed by your doctor. Do not self-medicate. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Nalidixic acid is generally not recommended for children under 12 years due to risk of cartilage and tendon damage. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects such as tendon rupture, peripheral neuropathy, and renal impairment. Dose adjustment may be necessary based on renal function. Close monitoring is advised. |
| Renal Impairment | In patients with renal impairment, nalidixic acid may accumulate. Dose reduction or alternative therapy should be considered. Metronidazole generally does not require dose adjustment in renal impairment, but monitoring is advised. Consult a clinician for individualized dosing. |
| Hepatic Impairment | Metronidazole is metabolized in the liver; dose reduction may be required in severe hepatic impairment. Nalidixic acid should be used with caution. Regular liver function monitoring is recommended. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on the patient's condition and response to treatment. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nalidys suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Theophylline | Major | |
| Lithium | Major | |
| Antacids | Moderate | |
| Cimetidine | Moderate | |
| Phenytoin | Moderate | |
| Cyclosporine | Moderate | |
| Oral contraceptives | Moderate | |
| Sucralfate | Minor |
🚨 Major Interactions
- Warfarin
- Alcohol
- Antacids containing aluminum or magnesium
- Theophylline
- Lithium
⚡ Moderate Interactions
- Cimetidine
- Phenytoin
- Cyclosporine
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Metronidazole can cause a disulfiram-like reaction characterized by severe nausea, vomiting, flushing, headache, and rapid heartbeat. This reaction can be dangerous and requires immediate medical attention if it occurs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["History of tendon disorders related to quinolone use","Severe hepatic impairment","First trimester of pregnancy (nalidixic acid)","Known hypersensitivity to nalidixic acid, metronidazole, or other nitroimidazoles","Children under 12 years (nalidixic acid)","Concurrent use of disulfiram","Alcohol consumption during treatment"]
⚠️ Warnings & Precautions
["May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Photosensitivity reactions can occur; use sunscreen and protective clothing.","Avoid alcohol completely during and for 48 hours after treatment.","May cause peripheral neuropathy; report numbness or tingling.","Tendon rupture risk, especially in elderly and those on corticosteroids.","May increase risk of seizures in patients with CNS disorders.","Prolonged use may lead to superinfections.","Use with caution in patients with renal or hepatic impairment."]
🤱 Lactation Safety
Both nalidixic acid and metronidazole are excreted in breast milk. Metronidazole may cause diarrhea or thrush in the nursing infant. Breastfeeding is generally not recommended while taking this medicine, especially with high doses or prolonged use. Consult your doctor for guidance; you may need to pump and discard milk during treatment.
💊 Overdose Management
Overdose may cause nausea, vomiting, dizziness, and in severe cases, seizures or peripheral neuropathy. There is no specific antidote. Treatment is supportive and symptomatic. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide anticonvulsant therapy if seizures occur. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Shake the bottle well before each dose to ensure uniform mixing. Measure the dose using the provided measuring cup or spoon, not a household spoon. Take it with food to reduce stomach upset. Avoid alcohol completely during treatment and for at least 48 hours after the last dose, as it can cause a severe reaction. Use sunscreen and protective clothing when outdoors because this medicine can make your skin more sensitive to sunlight. Do not stop taking this medicine early, even if you feel better, as this can lead to resistance. Inform your doctor if you have kidney or liver problems, or if you are taking blood thinners, antacids, or other antibiotics. Do not share this medicine with others. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, peripheral neuropathy, and renal impairment. Dose adjustment may be necessary based on kidney function. Close monitoring is recommended.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy, especially in the first trimester. If you are planning pregnancy, consult your doctor to discuss alternative treatments. Use effective contraception while taking this medicine.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your surgeon about this medicine. It may interact with other medications and affect wound healing. Follow your doctor's instructions regarding dosing and monitoring.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with anesthetics or other medications used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, as it may increase the risk of tendon rupture. If you experience joint pain or swelling, stop exercising and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take it with food and rest if needed. Most people can continue their daily activities with caution.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance. If you experience severe side effects, contact your doctor immediately for guidance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to bacterial resistance, superinfections, and rare but serious effects such as peripheral neuropathy, tendon rupture, and liver toxicity. Regular monitoring of renal and hepatic function is advised for prolonged therapy. Use only for the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Other combinations like ciprofloxacin and metronidazole may be used for broader coverage.
Evidence: Well-establishedBased on culture and sensitivity results, a more specific antibiotic may be chosen.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your doctor about your current medications.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust dosing times gradually as advised by your doctor. Do not pack it in checked luggage; keep it in your carry-on. Check customs regulations for restricted medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it is important to complete the full course as prescribed.
A: Yes, taking it with food helps reduce stomach upset.
A: Take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, alcohol must be strictly avoided during treatment and for 48 hours after the last dose due to the risk of a severe reaction.
🤔 Common Patient Concerns
🔄 Substitutes for nalidys suspension
View AllAlternative brands with exact same active ingredient:
-
qugyl n syrupRPG Life Sciences Ltd ₹22.36 6.8% COSTLIER
-
aldiagram 100 mg/150 mg suspensionAlkem Laboratories Ltd ₹28.03 33.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: It is only effective against specific susceptible bacteria and protozoa; inappropriate use can lead to resistance. - Myth: You can stop taking it once you feel better.
Fact: You must complete the full prescribed course to prevent recurrence and resistance. - Myth: It is safe to drink alcohol while on this medicine.
Fact: Alcohol can cause a severe disulfiram-like reaction with metronidazole; avoid completely.
🔄 Alternative Options
Generic Alternatives
- Nalidixic acid + Metronidazole suspension (generic)
Brand Alternatives
- Aldigram 100 mg/150 mg suspension