Nac Tablet: Complete Guide to Uses, Dosage, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Yellowing of skin or eyes
- Decreased urine output
- Swelling of face, lips, or throat
- Difficulty breathing
- Severe headache with visual changes
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is nac tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain, inflammation, and fever in adults. It should be taken with food and not exceeding 3 tablets in 24 hours.
- Generic Name: Nimesulide (100mg) + Paracetamol (330mg)
- Manufacturer: Nac International
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nac tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग वयस्कों में तीव्र दर्द, सूजन और बुखार के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, पोस्ट-ऑपरेटिव दर्द और मासिक धर्म के दर्द में राहत देती है। इसे भोजन के साथ लेना चाहिए और 24 घंटे में 3 गोलियों से अधिक नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, यकृत की क्षति, गुर्दे की समस्या और गंभीर त्वचा प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला मल, खून की उल्टी, पेट में तेज दर्द, आंखों या त्वचा का पीलापन, या पेशाब में कमी हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक या अवधि से अधिक न लें। इसे भोजन या दूध के साथ लें ताकि पेट की जलन कम हो। इस दवा के साथ शराब न लें क्योंकि इससे यकृत और पेट की समस्याओं का खतरा बढ़ता है। पैरासिटामोल या अन्य दर्द निवारक दवाओं के साथ इसका सेवन करने से पहले डॉक्टर से सलाह लें। यदि आपको पेट अल्सर, यकृत या गुर्दे की बीमारी, अस्थमा या रक्तस्राव विकार है तो डॉक्टर को बताएं। 7 दिनों से अधिक इसका उपयोग न करें।
💊 nac tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and soft tissues due to sprains, strains, or injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and post-dental procedure pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgeries.","evidence":"Moderate"},{"condition":"Fever","description":"Reduces fever due to its paracetamol component.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Osteoarthritis flare","description":"May be used short-term for osteoarthritis pain flares, but not for long-term management.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Fever, Dental pain, Musculoskeletal pain, Post-operative pain, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Nimesulide (100mg) + Paracetamol (330mg) |
| Brand Name | nac tablet |
| Manufacturer | Nac International |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide is a selective cyclooxygenase-2 (COX-2) inhibitor that reduces the production of prostaglandins, which are mediators of inflammation and pain. Paracetamol acts primarily in the central nervous system to reduce pain and fever, with weak peripheral anti-inflammatory effects. Together, they provide analgesic, antipyretic, and anti-inflammatory effects.
Mechanism Steps
💡 How to Take nac tablet
Strength: Tablet containing nimesulide 100 mg and paracetamol 330 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally every 6 to 8 hours as needed for pain and fever, not exceeding 3 tablets in 24 hours. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not take for more than 7 days without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects, especially gastrointestinal bleeding and kidney impairment. Use with caution and lower doses may be appropriate. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Avoid in patients with severe liver impairment. In mild to moderate impairment, dose reduction and monitoring of liver function are advised. Consult a doctor. |
| Maximum Daily Dose | Maximum daily dose is 3 tablets (300 mg nimesulide and 990 mg paracetamol) in 24 hours. Do not exceed this limit. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nac tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Lithium | Moderate | |
| Phenytoin | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, aspirin)
- Methotrexate
- ACE inhibitors / ARBs
- Diuretics
⚡ Moderate Interactions
- Corticosteroids
- SSRIs
- Lithium
- Phenytoin
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially due to paracetamol, and increases the risk of gastrointestinal bleeding due to nimesulide.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nimesulide, paracetamol, or any component of the formulation.","Active peptic ulcer or history of recurrent ulcers.","Severe liver impairment.","Severe kidney impairment.","History of NSAID-induced asthma, urticaria, or allergic reactions.","Children below 12 years of age.","Pregnancy, especially third trimester.","Breastfeeding."]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose or duration of treatment.","Take with food to minimize stomach upset.","Avoid alcohol consumption.","Do not use concurrently with other paracetamol-containing products.","Use with caution in elderly patients and those with kidney or liver disease.","Discontinue if signs of liver damage or severe skin reaction occur.","Not for long-term use; if pain persists beyond 7 days, consult a doctor."]
🤱 Lactation Safety
Not recommended during breastfeeding as nimesulide may pass into breast milk and harm the infant. Consult your doctor for alternative pain relief.
💊 Overdose Management
Overdose can cause severe liver damage, especially due to paracetamol. Symptoms may include nausea, vomiting, abdominal pain, and confusion. Seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless advised by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it increases the risk of liver damage and gastrointestinal bleeding. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, liver or kidney disease, asthma, or bleeding disorders. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use with caution, at the lowest effective dose, and for the shortest duration. Monitor kidney and liver function regularly.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for use during pregnancy or when planning pregnancy. Consult your doctor for safe alternatives for pain relief.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain management, but it can increase the risk of bleeding. Consult your surgeon before taking it after surgery.
🦷 Dental Procedures
This medicine can be used for dental pain, but inform your dentist if you are taking it before any dental procedure, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you have musculoskeletal pain. Gentle stretching and low-impact activities are generally safe. Consult your doctor before starting any exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.
🛑 When to Stop This Medicine
Stop taking this medicine if your pain or fever resolves, or after the prescribed duration (usually not more than 7 days). If you experience any serious side effects, stop immediately and seek medical attention. Do not stop abruptly if you have been on long-term therapy without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of liver damage, kidney impairment, gastrointestinal bleeding, and cardiovascular events. If long-term use is unavoidable, regular monitoring of liver and kidney function is essential. Consult your doctor if you need pain relief for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay help relieve localized pain and inflammation.
Evidence: ModerateSome evidence for pain relief in certain conditions.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, continue taking it as prescribed, but do not exceed the maximum daily dose. Check local customs regulations regarding prescription medicines before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30-60 minutes after taking it.
A: It is best taken with food or milk to reduce the risk of stomach upset.
A: No, do not take with other NSAIDs or paracetamol-containing products without consulting your doctor.
A: It is not recommended during pregnancy. Consult your doctor for safer alternatives.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is not recommended for long-term use due to risks of liver, kidney, and gastrointestinal side effects. - Myth: It can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach upset. - Myth: It is safe to take with other painkillers.
Fact: Combining with other NSAIDs or paracetamol can increase the risk of toxicity.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol combination tablets from other manufacturers