mefex ft 500mg/450mg tablet - Mefenamic Acid (500mg) + Paracetamol (450mg) medicine

Almefkem Forte 500mg/450mg Tablet: Complete Medicine Guide

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🏭 Medicraft Group 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. However, NSAIDs like Mefenamic Acid are generally avoided in the third trimester due to risk of premature closure of ductus arteriosus and other complications. Paracetamol is generally considered safe in all trimesters when used at recommended doses. Consult your doctor before use. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for short-term pain relief.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bleeding or bruising
  • Severe skin rash with blisters or peeling

If experiencing severe symptoms, call emergency services immediately.

What is mefex ft 500mg/450mg tablet used for?

This medicine is a combination of Mefenamic Acid 500 mg and Paracetamol 450 mg used for short-term relief of moderate to severe pain, such as musculoskeletal pain, dental pain, and menstrual cramps. It works by reducing inflammation and pain. Take it with food and do not exceed 3 tablets in 24 hours.

  • Generic Name: Mefenamic Acid (500mg) + Paracetamol (450mg)
  • Manufacturer: Medicraft Group
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 mefex ft 500mg/450mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा मेफेनामिक एसिड और पैरासिटामोल का संयोजन है, जिसका उपयोग मध्यम से गंभीर दर्द के अल्पकालिक उपचार के लिए किया जाता है, जैसे मांसपेशियों का दर्द, दांत दर्द, मासिक धर्म में ऐंठन, और सर्जरी के बाद का दर्द। यह सूजन और दर्द को कम करने में मदद करती है। इसे भोजन के साथ लें और 24 घंटे में 3 गोलियों से अधिक न लें।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सीने में जलन, दस्त, कब्ज, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, अल्सर, गुर्दे की समस्या, यकृत की क्षति, और गंभीर एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला या खूनी मल, खून की उल्टी, गंभीर पेट दर्द, आंखों या त्वचा का पीलापन, पेशाब में कमी, या चेहरे, होंठ, या गले में सूजन हो तो तुरंत चिकित्सा सहायता लें।

सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक से अधिक या निर्धारित अवधि से अधिक न लें। इसे हमेशा भोजन या दूध के साथ लें ताकि पेट में जलन कम हो। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ जाता है। पैरासिटामोल या अन्य NSAIDs युक्त दवाएं बिना डॉक्टर की सलाह के न लें। यदि आपको पेट के अल्सर, गुर्दे या यकृत की बीमारी, अस्थमा, या रक्तस्राव विकार का इतिहास है तो अपने डॉक्टर को बताएं। गर्भावस्था के तीसरे तिमाही में इस दवा का उपयोग न करें। यदि आप स्तनपान करा रही हैं, तो उपयोग से पहले अपने डॉक्टर से परामर्श लें। बच्चों की पहुंच से दूर रखें। कमरे के तापमान पर नमी और गर्मी से दूर रखें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 mefex ft 500mg/450mg tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as muscle strains, sprains, and back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from moderate to severe toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgeries.","evidence":"Well-established"},{"condition":"Menstrual cramps (dysmenorrhea)","description":"Reduces pain and inflammation associated with menstrual periods.","evidence":"Well-established"},{"condition":"Fever","description":"Paracetamol component helps reduce fever, though this combination is primarily for pain.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Osteoarthritis flare-ups","description":"May be used short-term for pain relief during flare-ups, but not for long-term management.","evidence":"Limited"}]

Primary treatment for: Acute pain

Also treats: Musculoskeletal pain, Dental pain, Post-operative pain, Menstrual cramps, Fever

📋 Drug Information

Generic Name(s)Mefenamic Acid (500mg) + Paracetamol (450mg)
Brand Namemefex ft 500mg/450mg tablet
ManufacturerMedicraft Group
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food or milk to reduce the risk of stomach upset and gastrointestinal bleeding.
2
Do not exceed the recommended dose of 3 tablets in 24 hours, as this can increase the risk of liver and kidney damage.
3
Avoid alcohol completely while taking this medicine to prevent severe gastrointestinal bleeding and liver toxicity.
4
If you have a history of stomach ulcers, kidney disease, or liver disease, inform your doctor before taking this medicine.
5
Do not use this medicine for more than 7 days without consulting your doctor, as prolonged use can lead to serious side effects.
6
If you are pregnant or planning to become pregnant, consult your doctor before taking this medicine, especially in the third trimester.
7
Report any unusual bleeding, bruising, or signs of infection such as fever and sore throat to your doctor immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Acute musculoskeletal pain
This medicine is commonly prescribed for this.
Likely Use
Dental pain
This medicine is commonly prescribed for this.
Likely Use
Menstrual cramps
This medicine is commonly prescribed for this.
Likely Use
Fever
This medicine is not a primary fever reducer, but paracetamol component may help.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMefenamic Acid is rapidly absorbed from the gastrointestinal tract after oral administration. Paracetamol is also rapidly and completely absorbed from the gastrointestinal tract. Food may slightly delay the absorption of both components but does not significantly reduce the extent of absorption.
DistributionMefenamic Acid is highly bound to plasma proteins and distributes into synovial fluid, breast milk, and across the placenta. Paracetamol distributes widely into most body tissues, with a volume of distribution of approximately 0.9 L/kg.
Protein BindingMefenamic Acid is approximately 90% bound to plasma proteins. Paracetamol is approximately 10-25% bound to plasma proteins.
MetabolismMefenamic Acid is metabolized in the liver primarily by CYP2C9 to inactive metabolites. Paracetamol is metabolized in the liver via glucuronidation and sulfation; a small fraction is metabolized by CYP2E1 to a toxic intermediate (NAPQI) that is normally detoxified by glutathione.
Half-LifeThe elimination half-life of Mefenamic Acid is approximately 2 hours. The elimination half-life of Paracetamol is approximately 2-3 hours.
ExcretionMefenamic Acid and its metabolites are excreted primarily in the urine (approximately 50-60%) and feces. Paracetamol is excreted in the urine as glucuronide and sulfate conjugates.
BioavailabilityThe oral bioavailability of Mefenamic Acid is approximately 90%. The oral bioavailability of Paracetamol is approximately 80-90%.
Onset of ActionPain relief typically begins within 30 to 60 minutes after oral administration.
Peak Plasma TimePeak plasma concentrations of Mefenamic Acid are reached in about 2 hours. Peak plasma concentrations of Paracetamol are reached in about 30 to 60 minutes.
Duration of ActionThe analgesic effect lasts approximately 4 to 6 hours.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Mefenamic Acid is a non-steroidal anti-inflammatory drug (NSAID) that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased synthesis of prostaglandins, prostacyclin, and thromboxane. This results in analgesic, anti-inflammatory, and antipyretic effects. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, producing analgesia and antipyresis. The combination provides enhanced pain relief through both peripheral and central mechanisms.

Mechanism Steps

1
Inhibition of cyclooxygenase: Mefenamic Acid binds to and reversibly inhibits COX-1 and COX-2 enzymes, blocking the conversion of arachidonic acid to prostaglandin H2.
2
Reduced prostaglandin synthesis: Decreased production of prostaglandins, prostacyclin, and thromboxane reduces inflammation, pain, and fever.
3
Central analgesic action of paracetamol: Paracetamol acts on the central nervous system, possibly by inhibiting prostaglandin synthesis in the brain and activating descending inhibitory pathways.
4
Combined analgesic effect: The peripheral anti-inflammatory action of Mefenamic Acid and the central analgesic action of paracetamol work together to provide enhanced pain relief.

💡 How to Take mefex ft 500mg/450mg tablet

Strength: Each tablet contains Mefenamic Acid 500 mg and Paracetamol 450 mg.

1Take this medicine orally with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Do not lie down immediately after taking the tablet.
5Follow the prescribed dose and duration exactly.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally every 6 to 8 hours as needed for pain, not to exceed 3 tablets in 24 hours. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not take for more than 7 days without medical advice.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function.
Renal ImpairmentUse with caution in patients with renal impairment. Dose reduction may be necessary. Consult a doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction may be necessary. Consult a doctor for individualized dosing.
Maximum Daily DoseThe maximum daily dose is 3 tablets in 24 hours. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding and liver damage.
Caffeine
Limit
May increase stomach irritation.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of mefex ft 500mg/450mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk. If persistent, consult your doctor.
Vomiting (Common (5-10%))
Stay hydrated. If severe or persistent, consult your doctor.
Stomach pain (Common (5-10%))
Take with food. Avoid alcohol. If pain is severe, seek medical advice.
Heartburn (Common (5-10%))
Take with food. Avoid lying down immediately after taking. Consult doctor if persistent.
Headache (Common (5-10%))
Usually resolves. If severe or persistent, consult your doctor.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Drowsiness (Common (5-10%))
Avoid driving or operating machinery. Consult doctor if persistent.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black or bloody stools, vomiting blood, or severe abdominal pain.
Peptic ulcer (Rare (<0.1%))
Seek immediate medical attention if you experience severe stomach pain, indigestion, or vomiting blood.
Kidney problems (Rare (<0.1%))
Seek medical attention if you notice decreased urine output, swelling, or fatigue.
Liver damage (Rare (<0.1%))
Seek immediate medical attention if you experience yellowing of skin or eyes, dark urine, or severe fatigue.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency medical help if you experience swelling of face, lips, or throat, difficulty breathing, or severe rash.
Blood disorders (e.g., agranulocytosis, aplastic anemia) (Very rare (<0.01%))
Seek medical attention if you experience unusual bleeding, bruising, fever, or sore throat.

⚠️ Rare Side Effects

Stevens-Johnson syndrome
Seek immediate medical attention if you develop a painful rash with blisters, peeling skin, or sores in mouth or eyes.
Toxic epidermal necrolysis
Seek emergency medical help if you experience severe skin peeling, blistering, or sores.
Aseptic meningitis
Seek immediate medical attention if you experience severe headache, stiff neck, fever, and sensitivity to light.
Pancreatitis
Seek immediate medical attention if you experience severe upper abdominal pain radiating to back, with nausea and vomiting.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Corticosteroids Major
Methotrexate Major
Lithium Major
ACE inhibitors Moderate
Diuretics Moderate
SSRIs Moderate
Carbamazepine Moderate
Phenytoin Moderate

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, aspirin)
  • Corticosteroids
  • Methotrexate
  • Lithium

⚡ Moderate Interactions

  • ACE inhibitors (e.g., enalapril)
  • Diuretics (e.g., furosemide)
  • SSRIs (e.g., fluoxetine)
  • Carbamazepine
  • Phenytoin

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulcers, and liver damage, especially when combined with paracetamol and NSAIDs.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to Mefenamic Acid, Paracetamol, or any component of the formulation","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs","Active peptic ulcer or history of recurrent peptic ulcer","Severe heart failure","Severe liver impairment","Severe kidney impairment","Third trimester of pregnancy","Children under 12 years of age","Concurrent use with other NSAIDs"]

⚠️ Warnings & Precautions

["Take with food to reduce gastrointestinal irritation.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose or duration of treatment.","Use with caution in elderly patients due to increased risk of side effects.","Use with caution in patients with a history of gastrointestinal bleeding or ulcers.","Use with caution in patients with kidney or liver disease.","Use with caution in patients with cardiovascular disease.","Do not use for more than 7 days without medical advice.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Keep out of reach of children."]

🤱 Lactation Safety

Mefenamic Acid is excreted in breast milk in small amounts. Paracetamol is also excreted in breast milk in small amounts. Short-term use is generally considered compatible with breastfeeding, but consult your doctor before use.

💊 Overdose Management

Overdose of this medicine can cause severe liver damage due to paracetamol and gastrointestinal bleeding, kidney failure, and central nervous system effects due to Mefenamic Acid. Seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours, N-acetylcysteine for paracetamol toxicity, and supportive care. Monitor liver and kidney function, and vital signs.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose or for longer than prescribed. Always take it with food or milk to reduce stomach irritation. Avoid alcohol while taking this medicine as it increases the risk of stomach bleeding. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, asthma, or bleeding disorders. Do not use this medicine during the third trimester of pregnancy. If you are breastfeeding, consult your doctor before use. Keep out of reach of children. Store at room temperature away from moisture and heat.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function regularly.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs like Mefenamic Acid may affect ovulation and are not recommended during pregnancy, especially in the third trimester.

🏥 Post-Surgery Considerations

This medicine may be used for post-operative pain, but consult your surgeon before taking it, as it can increase bleeding risk and interact with other medications.

🦷 Dental Procedures

This medicine can be used for dental pain, but inform your dentist if you are taking it before any dental procedure, as it may increase bleeding risk.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints and muscles.
🥗
Regular low-impact exercise like swimming or walking can help manage chronic pain.
😴
Practice good posture to prevent musculoskeletal pain.
💧
Include anti-inflammatory foods like omega-3 rich fish, fruits, and vegetables in your diet.
🧘
Get adequate sleep to help your body recover from pain and inflammation.
🌞
Stay well hydrated to support kidney function while taking this medicine.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that could cause injury while taking this medicine, as it may mask pain and lead to overexertion. Listen to your body and rest when needed.

🥗 Diet Recommendations

Include omega-3 rich foods like salmon, flaxseeds, and walnuts.
Reduce intake of processed foods and refined sugars.
Stay well hydrated by drinking plenty of water.
Eat a balanced diet rich in fruits and vegetables.
Avoid alcohol and limit caffeine intake.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your pain persists beyond 7 days, if you experience side effects, or if you develop any red-flag symptoms. Do not stop abruptly if you have been taking it for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney problems, liver damage, and cardiovascular events. It is intended for short-term use only. If you need pain relief for more than 7 days, consult your doctor for alternative treatments and monitoring.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve mobility.

Evidence: Well-established
Heat or cold therapy

Applying heat or cold packs can help reduce pain and inflammation.

Evidence: Well-established
Acupuncture

May provide pain relief for some individuals.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking it as needed for pain, but do not exceed the maximum daily dose. Check local customs regulations regarding prescription medicines before traveling internationally.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with severe menstrual cramps
She was prescribed this medicine for menstrual pain. She took one tablet with food when the pain started and experienced significant relief within an hour. She was advised not to exceed 3 tablets in 24 hours and to avoid alcohol. She found that taking it with a small snack prevented stomach upset.
💡 Lesson: Taking this medicine with food improves tolerability and ensures effective pain relief.
👤 A 50-year-old man with acute back pain after lifting heavy objects
He was prescribed this medicine for acute musculoskeletal pain. He took it as directed with meals and used a heating pad. His pain improved over 3 days, and he stopped the medicine as advised. He was cautioned about the risk of kidney problems and advised to stay hydrated.
💡 Lesson: Short-term use with proper hydration and medical supervision is key to safe and effective pain management.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.

Q: Is it safe during pregnancy?

A: It should be avoided in the third trimester. Consult your doctor before use.

Q: Can I take it with alcohol?

A: No, alcohol should be avoided as it increases the risk of gastrointestinal bleeding and liver damage.

Q: How many tablets can I take in a day?

A: Do not exceed 3 tablets in 24 hours.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for mefex ft 500mg/450mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken on an empty stomach.
    Fact: It should be taken with food to reduce stomach upset.
  • Myth: It is safe to take this medicine for long periods.
    Fact: It is intended for short-term use only. Long-term use requires medical supervision.
  • Myth: This medicine is safe during pregnancy.
    Fact: It should be avoided in the third trimester. Consult your doctor.

🔄 Alternative Options

Generic Alternatives

  • Mefenamic Acid + Paracetamol combination tablets

Brand Alternatives

  • Almefkem Forte 500mg/450mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Mefenamic Acid 500mg + Paracetamol 450mg","uses":"Acute pain, inflammation, fever","notes":"Take with food. Max 3 tablets/day."},{"medicine":"Ibuprofen + Paracetamol","composition":"Ibuprofen 400mg + Paracetamol 500mg","uses":"Acute pain, inflammation, fever","notes":"Take with food. Max 3 tablets/day."},{"medicine":"Diclofenac + Paracetamol","composition":"Diclofenac 50mg + Paracetamol 500mg","uses":"Acute pain, inflammation","notes":"Take with food. Max 3 tablets/day."}]

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