Meftal-Forte Tablet: Comprehensive Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Severe skin rash or blisters
If experiencing severe symptoms, call emergency services immediately.
What is mefbrake p forte 500mg/325mg tablet used for?
This medicine is a combination of mefenamic acid and paracetamol used for short-term relief of mild to moderate pain, including menstrual cramps, dental pain, and musculoskeletal pain. It works by reducing inflammation and blocking pain signals. Take it with food to avoid stomach upset and do not exceed 3 tablets in 24 hours.
- Generic Name: Mefenamic Acid (500mg) + Paracetamol (325mg)
- Manufacturer: Mankind Pharma Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 mefbrake p forte 500mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेफेनामिक एसिड और पैरासिटामोल का संयोजन है, जिसका उपयोग हल्के से मध्यम दर्द और बुखार के इलाज के लिए किया जाता है। यह मासिक धर्म के दर्द, दांत दर्द, मांसपेशियों और जोड़ों के दर्द, और सर्जरी के बाद के दर्द में राहत देती है। यह दर्द और सूजन पैदा करने वाले प्रोस्टाग्लैंडिन को कम करके काम करती है। इसे भोजन के साथ लें ताकि पेट में जलन न हो। इस दवा को बिना डॉक्टर की सलाह के 3 दिन से ज्यादा न लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, कब्ज, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट या आंतों में रक्तस्राव, गुर्दे की समस्या, यकृत की क्षति, और त्वचा पर गंभीर प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला मल, खून की उल्टी, गंभीर पेट दर्द, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या त्वचा या आंखों का पीला पड़ना दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। एक दिन में 3 गोलियों से ज्यादा न लें। इसे भोजन या दूध के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब न पिएं क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ सकता है। यदि आपको पेट के अल्सर, गुर्दे या यकृत की बीमारी, दमा, या रक्तस्राव विकार है तो डॉक्टर को बताएं। इस दवा से चक्कर आ सकते हैं, इसलिए वाहन चलाने या मशीन चलाने से बचें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 mefbrake p forte 500mg/325mg tablet Uses & Benefits
[{"condition":"Menstrual cramps (dysmenorrhea)","description":"Relieves moderate to severe menstrual pain by reducing prostaglandin production.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Musculoskeletal pain","description":"Reduces pain and inflammation in conditions such as sprains, strains, and arthritis.","evidence":"Well-established"},{"condition":"Postoperative pain","description":"Used for short-term management of mild to moderate pain after minor surgery.","evidence":"Well-established"},{"condition":"Fever","description":"Helps lower fever when other measures are inadequate.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation
Also treats: Dysmenorrhea, Dental pain, Musculoskeletal pain, Postoperative pain, Fever
📋 Drug Information
| Generic Name(s) | Mefenamic Acid (500mg) + Paracetamol (325mg) |
| Brand Name | mefbrake p forte 500mg/325mg tablet |
| Manufacturer | Mankind Pharma Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Mefenamic acid is a non-steroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, reducing the synthesis of prostaglandins, prostacyclin, and thromboxane. This leads to decreased inflammation, pain, and fever. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, producing analgesia and antipyresis with minimal anti-inflammatory effects. Together, they provide enhanced pain relief through both peripheral and central mechanisms.
Mechanism Steps
💡 How to Take mefbrake p forte 500mg/325mg tablet
Strength: Tablet containing mefenamic acid 500 mg and paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally every 6 to 8 hours as needed for pain or fever. Do not exceed 3 tablets in 24 hours. The dose must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. Take with food or milk to reduce stomach upset. Use the lowest effective dose for the shortest duration possible. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are at increased risk of adverse effects, especially gastrointestinal bleeding and renal impairment. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Avoid in severe renal impairment (eGFR <30 mL/min). Consult a nephrologist or clinician for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Avoid in severe hepatic impairment. Consult a hepatologist or clinician for individualized dosing. |
| Maximum Daily Dose | Maximum daily dose: 3 tablets in 24 hours (mefenamic acid 1500 mg and paracetamol 975 mg). Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of mefbrake p forte 500mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| SSRIs | Moderate | |
| Anticoagulants | Moderate | |
| Phenytoin | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., aspirin, ibuprofen)
- Corticosteroids
- Methotrexate
- Lithium
⚡ Moderate Interactions
- ACE inhibitors and ARBs
- Diuretics (e.g., furosemide, hydrochlorothiazide)
- SSRIs
- Anticoagulants (e.g., apixaban, rivaroxaban)
- Phenytoin
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and may enhance the liver toxicity of paracetamol, especially with chronic use or high doses.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to mefenamic acid, paracetamol, or any component of the formulation","Active peptic ulcer disease or history of recurrent ulcers","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Cardiovascular risk: NSAIDs may increase the risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke. Use with caution in patients with cardiovascular risk factors.","Gastrointestinal risk: NSAIDs can cause gastrointestinal bleeding, ulceration, and perforation, which can be fatal. Use with caution in the elderly and those with a history of peptic ulcer disease.","Renal risk: NSAIDs can cause acute kidney injury, especially in patients with dehydration, heart failure, or chronic kidney disease.","Hepatic risk: Paracetamol can cause hepatotoxicity in overdose. Do not exceed the recommended dose.","Skin reactions: Serious skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported with NSAIDs. Discontinue at the first sign of rash.","Haematological effects: Mefenamic acid may cause blood dyscrasias such as agranulocytosis and aplastic anemia. Monitor blood counts if symptoms occur.","Use in the elderly: Elderly patients are at increased risk of NSAID-related adverse effects, especially gastrointestinal bleeding and renal impairment. Use the lowest effective dose for the shortest duration.","Use in pregnancy: Avoid use in the third trimester. Use only if clearly needed in the first and second trimesters under medical supervision."]
🤱 Lactation Safety
Mefenamic acid and paracetamol are excreted in breast milk in small amounts. Consult your doctor before use during breastfeeding. Short-term use is generally considered acceptable, but monitor the infant for any adverse effects.
💊 Overdose Management
Overdose of this medicine can cause severe nausea, vomiting, abdominal pain, drowsiness, and potentially life-threatening liver damage from paracetamol and kidney failure from mefenamic acid. Seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours of ingestion, N-acetylcysteine for paracetamol toxicity, and supportive care. Monitor liver and kidney function, and manage symptoms accordingly.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose or for longer than advised. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding. Do not take other pain relievers or fever reducers containing paracetamol or NSAIDs without consulting your doctor, as this may lead to overdose or increased side effects. If you have a history of stomach ulcers, kidney or liver disease, asthma, or bleeding disorders, inform your doctor before taking this medicine. This medicine may cause dizziness or drowsiness; avoid driving or operating heavy machinery until you know how it affects you. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children and store it in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal function and blood pressure regularly. Avoid concurrent use with other NSAIDs or anticoagulants.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs may affect ovulation and are generally avoided in the third trimester. Use only if clearly needed and prescribed by a doctor.
🏥 Post-Surgery Considerations
This medicine may be used for postoperative pain, but consult your surgeon before taking it, especially after procedures like coronary artery bypass graft (CABG) surgery, where NSAIDs are contraindicated. It may increase bleeding risk during recovery.
🦷 Dental Procedures
This medicine can be taken for dental pain, but inform your dentist if you are taking it before any dental procedure, as it may increase bleeding risk. Do not take it immediately before oral surgery without medical advice.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or drowsiness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you have pain, gentle stretching and low-impact exercises may be beneficial, but consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your pain or fever persists beyond 3 days, if you experience severe side effects, or if you develop signs of an allergic reaction. Do not stop abruptly if you have been taking it regularly for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney impairment, and cardiovascular events. It may also cause liver damage due to paracetamol. Regular monitoring of kidney and liver function is advised if prolonged use is necessary. Use the lowest effective dose for the shortest duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help manage chronic pain and improve mobility.
Evidence: Well-establishedApplying heat or cold packs can relieve localized pain.
Evidence: Well-establishedMind-body practices like yoga and meditation can help reduce pain perception.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination. There is no need to postpone vaccination unless advised by a healthcare professional.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If crossing time zones, continue taking it as needed for pain or fever, but do not exceed the maximum daily dose. Check local customs regulations regarding prescription medicines before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30-60 minutes after taking it orally.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.
A: Do not take other NSAIDs or paracetamol-containing products without consulting your doctor, as this can increase the risk of side effects.
A: Do not exceed 3 tablets in 24 hours unless directed by your doctor.
A: Consult your doctor before use. It is generally avoided in the third trimester.
🤔 Common Patient Concerns
🔄 Substitutes for mefbrake p forte 500mg/325mg tablet
View AllAlternative brands with exact same active ingredient:
-
mef-plus tabletZeelab Pharmacy Pvt Ltd ₹22.50 50% CHEAPER
-
mefrite p 500mg/325mg tabletMHS Pharmaceuticals Pvt Ltd ₹25.00 44.4% CHEAPER
-
stayhappi mefenamic acid+paracetamol 500mg/325mg tabletSarvagunaushdhi Pvt Ltd ₹25.31 43.8% CHEAPER
-
mflocid forte 500mg/325mg tabletFloreat Medica Pvt Ltd ₹29.44 34.6% CHEAPER
-
mefwal forte 500mg/325mg tabletWallace Pharmaceuticals Pvt Ltd ₹30.00 33.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of pain.
Fact: This medicine is effective for mild to moderate pain but is not suitable for all types of pain. It should be used only as prescribed. - Myth: It is safe to take this medicine for a long time.
Fact: Long-term use of this medicine can increase the risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use only for short-term relief unless advised by a doctor. - Myth: Taking this medicine with alcohol is safe.
Fact: Alcohol increases the risk of stomach bleeding and liver damage when taken with this medicine. Avoid alcohol. - Myth: This medicine is safe during pregnancy.
Fact: This medicine should be avoided in the third trimester of pregnancy. Consult your doctor before use.
🔄 Alternative Options
Generic Alternatives
- Mefenamic acid + Paracetamol
Brand Alternatives
- Meftal-Forte