maxivas 5mg/10mg tablet - Nebivolol (5mg) + Cilnidipine (10mg) medicine

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🏭 Hauz Pharma Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 31, 2026
🤰 Pregnancy Category Not established from the available information. This medicine should be used during pregnancy only if clearly needed and prescribed by a doctor. Beta-blockers and calcium channel blockers may affect the fetus. Consult your doctor for personalized advice. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for hypertension; limited for off-label uses.
Reviewed by
SaathiMed Expert Panel | Oct 31, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Very slow heartbeat or irregular heartbeat
  • Severe dizziness or fainting
  • Shortness of breath or difficulty breathing
  • Sudden swelling of face, lips, or throat
  • Chest pain or worsening angina
  • Yellowing of skin or eyes
  • Decreased urine output or swelling in legs

If experiencing severe symptoms, call emergency services immediately.

What is maxivas 5mg/10mg tablet used for?

This medicine is a combination of Nebivolol and Cilnidipine used to treat high blood pressure. It works by relaxing blood vessels and slowing the heart rate, which lowers blood pressure and reduces the risk of heart attack and stroke.

  • Generic Name: Nebivolol (5mg) + Cilnidipine (10mg)
  • Manufacturer: Hauz Pharma Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 maxivas 5mg/10mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा उच्च रक्तचाप (हाइपरटेंशन) के इलाज के लिए इस्तेमाल की जाती है। यह नेबिवोलोल और सिल्निडिपिन का संयोजन है, जो रक्त वाहिकाओं को आराम देकर और हृदय की गति को धीमा करके रक्तचाप को कम करती है। यह दिल के दौरे और स्ट्रोक के जोखिम को कम करने में मदद करती है। यह दवा एनजाइना (सीने में दर्द) और हृदय विफलता के इलाज में भी उपयोगी हो सकती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, थकान, और टखनों में सूजन शामिल हैं। कुछ लोगों को धीमी हृदय गति, मतली, या चेहरे पर लालिमा का अनुभव हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अत्यधिक चक्कर आना, बेहोशी, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे रक्तचाप खतरनाक रूप से बढ़ सकता है। शराब का सेवन न करें क्योंकि इससे चक्कर आ सकते हैं। उठते समय धीरे-धीरे उठें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 maxivas 5mg/10mg tablet Uses & Benefits

[{"condition":"Hypertension","description":"This medicine is used to lower high blood pressure in adults, reducing the risk of heart attack, stroke, and kidney problems.","evidence":"Well-established"},{"condition":"Angina pectoris","description":"The nebivolol component helps reduce the frequency of angina attacks by decreasing heart rate and oxygen demand.","evidence":"Well-established"},{"condition":"Heart failure","description":"Nebivolol is sometimes used in stable heart failure to improve heart function and reduce hospitalizations.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Migraine prophylaxis","description":"Beta blockers like nebivolol are sometimes used off-label to prevent migraines, but evidence for this combination is limited.","evidence":"Limited"},{"condition":"Anxiety with palpitations","description":"The beta-blocking effect may help reduce physical symptoms of anxiety such as rapid heartbeat, but this is not a primary approved use.","evidence":"Limited"}]

Primary treatment for: Hypertension

Also treats: Angina pectoris, Heart failure

📋 Drug Information

Generic Name(s)Nebivolol (5mg) + Cilnidipine (10mg)
Brand Namemaxivas 5mg/10mg tablet
ManufacturerHauz Pharma Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day, preferably in the morning, to maintain consistent blood levels.
2
Monitor your blood pressure regularly at home and keep a record to share with your doctor.
3
Do not stop this medicine suddenly without consulting your doctor, as it can cause rebound hypertension.
4
Avoid alcohol while taking this medicine to prevent dizziness and low blood pressure.
5
Inform your doctor if you experience persistent dizziness, fatigue, or swelling of the ankles.
6
Use caution while driving or operating machinery until you know how this medicine affects you.
7
Maintain a healthy lifestyle with a low-salt diet and regular exercise to enhance the medicine's effectiveness.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
High blood pressure
This medicine is commonly prescribed for this.
Likely Use
✅
Chest pain (angina)
This medicine may be used to reduce angina attacks.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary
❌
Headache
This medicine is not a primary headache treatment, though it may cause headache as a side effect.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNebivolol is well absorbed from the gastrointestinal tract after oral administration. Cilnidipine is also absorbed orally, but its bioavailability may be affected by food. Specific absorption data for the combination product are not established from the available information.
DistributionNebivolol is highly lipophilic and distributes widely into tissues, including the heart, lungs, and blood vessels. Cilnidipine is highly protein-bound and distributes into vascular tissues. Specific distribution data for the combination product are not established from the available information.
Protein BindingNebivolol is approximately 98% bound to plasma proteins. Cilnidipine is about 90-95% bound to plasma proteins. These values are for individual components and may not reflect the combination product exactly.
MetabolismNebivolol is extensively metabolized in the liver, primarily by CYP2D6 enzymes, and also by CYP3A4. Cilnidipine is metabolized in the liver by CYP3A4 enzymes. The combination may be affected by drugs that inhibit or induce these enzymes.
Half-LifeThe elimination half-life of nebivolol is approximately 10-12 hours in extensive metabolizers and up to 30-50 hours in poor metabolizers. The elimination half-life of cilnidipine is about 2-3 hours. These values are for individual components.
ExcretionNebivolol and its metabolites are excreted primarily in the urine and feces. Cilnidipine is excreted mainly in the urine as metabolites. Specific excretion data for the combination product are not established from the available information.
BioavailabilityThe oral bioavailability of nebivolol is about 12% in extensive metabolizers and higher in poor metabolizers. The bioavailability of cilnidipine is approximately 10-20%. These values are for individual components and may vary.
Onset of ActionThe blood pressure-lowering effect of this medicine begins within a few hours after oral administration, but the full effect may take several days to weeks to develop.
Peak Plasma TimeNebivolol reaches peak plasma concentrations in about 1-4 hours after oral administration. Cilnidipine reaches peak plasma concentrations in about 1-2 hours. These values are for individual components.
Duration of ActionThe blood pressure-lowering effect of this medicine lasts for approximately 24 hours, allowing for once-daily dosing.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Nebivolol is a cardioselective beta-1 adrenergic receptor blocker that also causes vasodilation by increasing nitric oxide release. Cilnidipine is a calcium channel blocker that inhibits L-type and N-type calcium channels, leading to relaxation of blood vessels and reduced peripheral resistance. Together, they lower blood pressure effectively while minimizing reflex tachycardia.

Mechanism Steps

1
Beta-1 receptor blockade by nebivolol: Nebivolol selectively blocks beta-1 adrenergic receptors in the heart, slowing the heart rate and reducing the force of contractions, which lowers blood pressure and cardiac workload.
2
Nitric oxide-mediated vasodilation by nebivolol: Nebivolol also stimulates beta-3 receptors, leading to increased nitric oxide release from the endothelium, which relaxes blood vessels and improves blood flow.
3
Calcium channel blockade by cilnidipine: Cilnidipine blocks L-type calcium channels in vascular smooth muscle, reducing calcium entry and causing vasodilation. It also blocks N-type calcium channels in sympathetic nerve endings, reducing norepinephrine release.
4
Combined blood pressure reduction: The dual action of nebivolol and cilnidipine leads to a more effective reduction in blood pressure with a lower risk of reflex tachycardia compared to either agent alone.

💡 How to Take maxivas 5mg/10mg tablet

Strength: Tablet containing Nebivolol 5 mg and Cilnidipine 10 mg.

1Take this medicine exactly as prescribed by your doctor.
2Swallow the tablet whole with a glass of water.
3You can take it with or without food, but taking it with food may reduce stomach upset.
4Do not crush, chew, or break the tablet.
5Take it at the same time each day to maintain consistent blood levels.

Dosage Information

Adult DosageThe usual adult dose is one tablet once daily, preferably in the morning. The dose may be adjusted by your doctor based on your blood pressure response and tolerance. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine. Start with a lower dose and monitor blood pressure and heart rate closely. Dose must be individualized by a qualified clinician.
Renal ImpairmentDose adjustment may be needed in patients with severe renal impairment. Consult your doctor for personalized dosing.
Hepatic ImpairmentDose adjustment may be needed in patients with hepatic impairment. Use with caution in severe liver disease. Consult your doctor for personalized dosing.
Maximum Daily DoseThe maximum recommended daily dose is one tablet (nebivolol 5 mg + cilnidipine 10 mg) once daily. Do not exceed this dose unless directed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and improves absorption consistency.
Grapefruit
Avoid
May increase cilnidipine levels and risk of side effects.
High-fat meals
Take with caution
May affect absorption of cilnidipine. Take at the same time each day.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of maxivas 5mg/10mg tablet

✅ Common Side Effects

Headache (Common (5-10%))
Usually resolves on its own. Consult your doctor if it persists or becomes severe.
Dizziness (Common (5-10%))
Stand up slowly and avoid driving if you feel dizzy. Consult your doctor if it continues.
Fatigue (Common (5-10%))
Get adequate rest. If fatigue interferes with daily activities, talk to your doctor.
Ankle swelling (Common (5-10%))
Elevate your legs when sitting. Consult your doctor if swelling is severe or persistent.
Slow heart rate (Common (5-10%))
This is expected. If you feel very slow heartbeat with dizziness or fainting, seek medical attention.

🚨 Serious Side Effects

Severe bradycardia (Rare (<0.1%))
Seek immediate medical attention if you experience a very slow heartbeat, dizziness, or fainting.
Worsening heart failure (Rare (<0.1%))
Contact your doctor immediately if you experience shortness of breath, swelling, or sudden weight gain.
Severe allergic reaction (Rare (<0.1%))
Seek emergency help if you notice rash, itching, swelling of the face or throat, or difficulty breathing.
Hypotension (Uncommon (0.1-1%))
If you feel very dizzy or faint, lie down and contact your doctor. Avoid sudden movements.

⚠️ Rare Side Effects

Bronchospasm
Seek medical help if you experience wheezing or difficulty breathing.
Depression
Consult your doctor if you feel persistently sad or lose interest in activities.
Gum hyperplasia
Maintain good oral hygiene and consult a dentist if your gums become swollen.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Fluoxetine Major
Ketoconazole Major
Digoxin Moderate
Salbutamol Moderate
Ibuprofen Moderate
Antacids Minor
Grapefruit juice Minor

🚨 Major Interactions

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
  • Other antihypertensives

⚡ Moderate Interactions

  • Digoxin
  • Beta-agonists (e.g., salbutamol)
  • NSAIDs

🍷 Alcohol Interaction

Alcohol may increase the blood pressure-lowering effect of this medicine and cause dizziness, drowsiness, or fainting. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Severe bradycardia","Second or third-degree heart block","Cardiogenic shock","Decompensated heart failure","Severe liver disease","Allergy to nebivolol or cilnidipine","Pregnancy and breastfeeding (unless advised by doctor)"]

⚠️ Warnings & Precautions

["Do not stop this medicine suddenly without consulting your doctor.","Avoid alcohol while taking this medicine.","Use with caution in patients with asthma or COPD.","Monitor blood pressure and heart rate regularly.","Inform your doctor if you have diabetes, as beta-blockers may mask symptoms of low blood sugar.","Use with caution in patients with kidney or liver disease.","Avoid driving or operating machinery if you feel dizzy."]

🤱 Lactation Safety

Not established from the available information. It is not known whether nebivolol and cilnidipine pass into breast milk. Consult your doctor before breastfeeding while taking this medicine.

💊 Overdose Management

Overdose of this medicine may cause severe low blood pressure, slow heart rate, heart failure, or shock. Seek immediate medical attention. Treatment is supportive and symptomatic, including monitoring of vital signs and administration of intravenous fluids, atropine, or vasopressors as needed. Contact a poison control center or emergency room immediately.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not stop taking it suddenly, as this can cause a dangerous rise in blood pressure or worsen heart conditions. Avoid alcohol while taking this medicine because it can increase dizziness and lower blood pressure further. Stand up slowly from a sitting or lying position to prevent dizziness. Inform your doctor about all other medicines you are taking, especially other blood pressure medicines, heart medicines, and certain antidepressants. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before using this medicine. Keep this medicine out of reach of children and store it in its original packaging at room temperature.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor blood pressure and heart rate closely. Falls due to dizziness are a risk; take precautions.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. Alternative treatments may be recommended to ensure the safety of both mother and baby.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthesia and affect heart rate and blood pressure during surgery. Your doctor may advise temporary discontinuation or dose adjustment.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine, as it may affect blood pressure and heart rate during dental procedures. Local anesthetics with epinephrine should be used with caution.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce strain on your heart.
🥗
Follow a low-salt diet to help control blood pressure.
😴
Engage in regular physical activity, such as brisk walking or swimming, after consulting your doctor.
💧
Avoid smoking and limit alcohol consumption.
🧘
Manage stress through relaxation techniques like deep breathing or meditation.
🌞
Get adequate sleep to support heart health.

🏋️ Exercise Considerations

Regular exercise is beneficial for blood pressure control, but avoid sudden strenuous activities. If you experience dizziness, chest pain, or shortness of breath during exercise, stop and consult your doctor. Beta-blockers may reduce your heart rate response to exercise, so monitor your exertion level.

🥗 Diet Recommendations

Reduce salt intake to less than 5 grams per day.
Include potassium-rich foods like bananas, oranges, and spinach.
Choose whole grains, lean proteins, and healthy fats.
Limit processed foods, sugary drinks, and red meat.
Stay well hydrated with water.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal work activities with dose adjustment and lifestyle modifications.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience serious side effects or your doctor decides to change your treatment, they will guide you on how to safely discontinue. Sudden withdrawal can cause rebound hypertension, angina, or heart attack.

📅 Long-Term Use Effects

Long-term use of this medicine is generally safe when monitored by a doctor. Regular check-ups of blood pressure, heart rate, kidney function, and liver function are recommended. Do not stop the medicine without medical advice, as uncontrolled hypertension can lead to heart attack, stroke, and kidney damage.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet, exercise, and stress reduction can help lower blood pressure and complement medicine.

Evidence: Well-established
Single-agent therapy

If combination therapy is not tolerated, a single antihypertensive may be used.

Evidence: Well-established
Other antihypertensive combinations

Alternative combinations like ARB + CCB or ACE inhibitor + diuretic may be considered.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established from the available information. Continue routine vaccinations as recommended by your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 55-year-old man with a 10-year history of hypertension
His blood pressure was not controlled with a single medicine. His doctor prescribed this medicine. Within 4 weeks, his blood pressure stabilized, and he noticed fewer headaches. He takes it every morning with breakfast and monitors his blood pressure weekly.
💡 Lesson: Combination therapy can be more effective than a single medicine for uncontrolled hypertension. Regular monitoring and adherence are key.
👤 A 62-year-old woman with hypertension and angina
She experienced frequent angina attacks despite taking another blood pressure medicine. After switching to this medicine, her angina episodes reduced significantly, and she could walk longer distances without chest pain. She reported mild ankle swelling, which improved with leg elevation.
💡 Lesson: This medicine can effectively reduce angina frequency. Mild side effects like ankle swelling are manageable with simple measures.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts lowering blood pressure within a few hours, but the full effect may take several days to weeks. Your doctor will monitor your blood pressure and adjust the dose if needed.

Q: Can I stop taking this medicine if my blood pressure is normal?

A: No, do not stop taking this medicine without consulting your doctor. High blood pressure often has no symptoms, and stopping suddenly can cause a dangerous rise in blood pressure.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Q: Is this medicine safe during pregnancy?

A: This medicine should be used during pregnancy only if clearly needed and prescribed by your doctor. Consult your doctor for personalized advice.

Q: Can I drink alcohol while taking this medicine?

A: It is advisable to avoid alcohol while taking this medicine, as it can increase dizziness and lower blood pressure further.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my other blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for maxivas 5mg/10mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be stopped once blood pressure is normal.
    Fact: High blood pressure often has no symptoms, and stopping this medicine suddenly can cause a dangerous rise in blood pressure. Always consult your doctor before stopping.
  • Myth: This medicine causes kidney damage.
    Fact: This medicine is used to protect the kidneys from damage caused by high blood pressure. Regular monitoring is important, but it does not inherently damage the kidneys.
  • Myth: Taking this medicine means you can eat whatever you want.
    Fact: A healthy diet low in salt and fat is still essential for controlling blood pressure and reducing the risk of heart disease.

🔄 Alternative Options

Generic Alternatives

  • Nebivolol 5 mg + Cilnidipine 10 mg tablet (generic)

Brand Alternatives

  • Lnbeta 5 Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Nebivolol + Cilnidipine","composition":"Nebivolol 5 mg + Cilnidipine 10 mg","class":"Beta-blocker + Calcium channel blocker","key_difference":"Dual mechanism with N-type calcium channel blockade; may cause less reflex tachycardia."},{"medicine":"Nebivolol + Amlodipine","composition":"Nebivolol 5 mg + Amlodipine 5 mg","class":"Beta-blocker + Calcium channel blocker","key_difference":"Amlodipine is a longer-acting L-type calcium channel blocker; may cause more ankle swelling."},{"medicine":"Cilnidipine","composition":"Cilnidipine 10 mg","class":"Calcium channel blocker","key_difference":"Single agent; may be used alone or with other antihypertensives."}]

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