Grewia Oz 200mg/500mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Tendon pain or swelling
- Seizures or confusion
If experiencing severe symptoms, call emergency services immediately.
What is makxime-oz tablet used for?
This medicine is a combination antibiotic containing Cefixime 200 mg and Ofloxacin 500 mg. It is used to treat bacterial infections such as typhoid, urinary tract infections, and respiratory infections. It works by killing bacteria through two different mechanisms. It should be taken as prescribed by a doctor, usually with food, and the full course must be completed.
- Generic Name: Cefixime (200mg) + Ofloxacin (500mg)
- Manufacturer: Maksal Pharmaceuticals (P) Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 makxime-oz tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सेफिक्साइम और ऑफ्लोक्सासिन का संयोजन है, जिसका उपयोग बैक्टीरियल संक्रमणों जैसे टाइफाइड, मूत्र मार्ग संक्रमण, श्वसन तंत्र संक्रमण और त्वचा संक्रमण के इलाज के लिए किया जाता है। यह दवा बैक्टीरिया को मारती है और संक्रमण को फैलने से रोकती है। इसे डॉक्टर के निर्देशानुसार ही लें और कोर्स पूरा करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, टेंडन टूटना, दौरे और त्वचा पर गंभीर प्रतिक्रियाएं हो सकती हैं। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खाने के साथ लें ताकि पेट खराब न हो। पर्याप्त पानी पिएं। एंटासिड, आयरन या डेयरी उत्पादों के साथ 2 घंटे का अंतर रखें। शराब न पिएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। कोर्स पूरा करें।
💊 makxime-oz tablet Uses & Benefits
[{"condition":"Typhoid fever","description":"Used to treat enteric fever caused by Salmonella typhi.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against complicated and uncomplicated UTIs caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Respiratory tract infections","description":"Used for community-acquired pneumonia, bronchitis, and pharyngitis.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats cellulitis, abscesses, and wound infections.","evidence":"Well-established"},{"condition":"Gonorrhea","description":"May be used as an alternative treatment for uncomplicated gonorrhea.","evidence":"Limited"}]
Off-label uses: [{"condition":"Prostatitis","description":"Sometimes used for chronic bacterial prostatitis, but not FDA-approved for this indication.","evidence":"Limited"},{"condition":"Traveler's diarrhea","description":"May be prescribed off-label for severe traveler's diarrhea caused by susceptible bacteria.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Typhoid fever, Urinary tract infections, Respiratory tract infections, Skin infections
📋 Drug Information
| Generic Name(s) | Cefixime (200mg) + Ofloxacin (500mg) |
| Brand Name | makxime-oz tablet |
| Manufacturer | Maksal Pharmaceuticals (P) Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antibiotics with different mechanisms. Cefixime, a third-generation cephalosporin, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to cell lysis and death. Ofloxacin, a fluoroquinolone, inhibits DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. The combination provides broad-spectrum coverage and may be synergistic against certain bacteria.
Mechanism Steps
💡 How to Take makxime-oz tablet
Strength: Tablet containing Cefixime 200 mg and Ofloxacin 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily, depending on the severity of the infection and the prescribing doctor's judgment. The duration of treatment varies by indication, typically 5 to 14 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate or adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require dose adjustment based on renal function. Use with caution due to increased risk of tendon rupture, CNS effects, and QT prolongation. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance less than 50 mL/min, the dose may need to be reduced or the dosing interval extended. Consult a nephrologist or clinical pharmacist for guidance. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution and monitor liver function. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 400 mg of cefixime and 800 mg of ofloxacin, but this may vary based on the indication and patient factors. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of makxime-oz tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Antacids | Major | |
| Theophylline | Major | |
| NSAIDs | Major | |
| Caffeine | Moderate | |
| Cyclosporine | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Minor | |
| Multivitamins | Minor | |
| Sucralfate | Major |
🚨 Major Interactions
- Antacids, sucralfate, iron, zinc
- Warfarin
- Theophylline
- NSAIDs
⚡ Moderate Interactions
- Caffeine
- Cyclosporine
- Probenecid
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the risk of central nervous system side effects such as dizziness, drowsiness, and seizures. It may also worsen gastrointestinal irritation and increase the risk of liver toxicity.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to cefixime, ofloxacin, or any component of the formulation","History of allergic reaction to penicillins or cephalosporins","History of tendon disorders with fluoroquinolones","Myasthenia gravis","Pregnancy and breastfeeding","Children under 18 years (unless specifically indicated)","Severe renal impairment (dose adjustment required)"]
⚠️ Warnings & Precautions
["Serious allergic reactions can occur. Discontinue and seek immediate medical help if rash, swelling, or difficulty breathing occurs.","Tendon rupture, including Achilles tendon, can occur. Stop the medicine and rest if tendon pain occurs.","Peripheral neuropathy may occur. Report numbness or tingling.","Central nervous system effects including seizures, dizziness, and confusion may occur. Avoid driving if affected.","Clostridium difficile-associated diarrhea may occur. Report severe or bloody diarrhea.","May cause photosensitivity. Avoid prolonged sun exposure.","May worsen muscle weakness in patients with myasthenia gravis.","Use with caution in elderly patients and those with renal impairment."]
🤱 Lactation Safety
This medicine is excreted in breast milk and is not recommended during breastfeeding. Consult your doctor for alternative antibiotics.
💊 Overdose Management
Overdose may cause nausea, vomiting, dizziness, and seizures. There is no specific antidote. Treatment is supportive and symptomatic. Maintain adequate hydration. Hemodialysis may be considered for ofloxacin overdose. Contact a poison control center or emergency room immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop the course early, even if you feel better. Take it with food to reduce stomach upset. Drink plenty of water throughout the day. Avoid taking antacids, iron supplements, or dairy products within 2 hours of this medicine, as they can reduce its absorption. Do not consume alcohol while taking this medicine, as it may increase the risk of central nervous system side effects. Inform your doctor if you have kidney or liver disease, diabetes, or a history of seizures. Avoid prolonged sun exposure and use sunscreen, as this medicine may make your skin more sensitive to sunlight. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, CNS effects, and renal impairment. Dose adjustment may be required based on renal function. Use with caution and monitor closely.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for women planning pregnancy. Consult your doctor for alternative antibiotics if you are trying to conceive.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery to prevent or treat bacterial infections. Follow your surgeon's instructions carefully. Inform your surgeon if you have any allergies or kidney problems.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with other medications used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while taking this medicine, especially if you experience dizziness or fatigue. Fluoroquinolones can increase the risk of tendon injury, so stop exercising and consult your doctor if you feel tendon pain.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or confusion. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take rest and avoid strenuous activities during the course of treatment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full prescribed course even if you feel better. If you experience serious side effects such as severe allergic reaction, tendon pain, or seizures, stop the medicine and seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to bacterial resistance, fungal overgrowth, and rare blood or liver abnormalities. It is not intended for prolonged use. Regular monitoring of renal and hepatic function may be required if used for extended periods. Always consult your doctor before using for more than the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help prevent antibiotic-associated diarrhea.
Evidence: Well-establishedHelps flush out bacteria and supports recovery.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics may reduce the efficacy of live bacterial vaccines such as the typhoid vaccine. Consult your doctor regarding vaccination timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust dosing times gradually under medical guidance. Check customs regulations for carrying prescription medicines. Always carry enough supply for the entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it is important to complete the full course as prescribed.
A: Yes, take it with food to reduce stomach upset.
A: Take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule.
A: This medicine is not recommended during pregnancy. Consult your doctor for safer alternatives.
A: No, alcohol should be avoided as it can increase side effects.
🤔 Common Patient Concerns
🔄 Substitutes for makxime-oz tablet
View AllAlternative brands with exact same active ingredient:
-
cefirex ox 200mg/500mg tabletMedrex Pharma ₹140.00 25.5% COSTLIER
-
melfix oz 200mg/500mg tabletElwiss Biotech Private Limited ₹153.75 37.8% COSTLIER
-
grewia oz 200mg/500mg tabletAdvance Revive ₹160.31 43.7% COSTLIER
-
cefleo-lb tabletLeo Star Healthcare Pvt Ltd ₹210.94 89.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and only works against bacterial infections. It is ineffective against viruses. - Myth: You can stop taking it once you feel better.
Fact: You must complete the full course to prevent bacterial resistance and relapse. - Myth: It is safe to take with alcohol.
Fact: Alcohol can increase side effects and should be avoided. - Myth: It can be taken without a prescription.
Fact: This is a prescription medicine and should only be taken under a doctor's supervision.
🔄 Alternative Options
Generic Alternatives
- Cefixime 200 mg + Ofloxacin 500 mg tablet (various manufacturers)