Enfiera 100mg Injection (Rituximab): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe infusion reaction with difficulty breathing or swelling of face.
- Signs of infection such as fever, chills, or persistent cough.
- Neurological symptoms like confusion, dizziness, or vision changes.
- Chest pain, shortness of breath, or irregular heartbeat.
- Yellowing of skin or eyes, or dark urine.
- Severe abdominal pain or vomiting.
If experiencing severe symptoms, call emergency services immediately.
What is mabtas t 100mg injection used for?
This medicine is a 100 mg injection containing rituximab, used to treat certain cancers and autoimmune diseases by targeting CD20 on B cells. It is given by intravenous infusion under medical supervision.
- Generic Name: Rituximab (100mg)
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 mabtas t 100mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा रिटक्सिमैब का 100 मिलीग्राम इंजेक्शन है, जिसका उपयोग कुछ प्रकार के कैंसर जैसे नॉन-हॉजकिन लिंफोमा और क्रोनिक लिम्फोसाइटिक ल्यूकेमिया के इलाज में किया जाता है। इसके अलावा यह रूमेटॉइड आर्थराइटिस और ग्रैनुलोमैटोसिस विद पोलिएंजाइटिस जैसी ऑटोइम्यून बीमारियों में भी प्रभावी है। यह दवा शरीर में बी-कोशिकाओं को नष्ट करके काम करती है, जिससे बीमारी को नियंत्रित करने में मदद मिलती है। यह दवा केवल डॉक्टर की देखरेख में अस्पताल या क्लिनिक में इंट्रावेनस इन्फ्यूजन द्वारा दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में इन्फ्यूजन प्रतिक्रियाएं जैसे बुखार, ठंड लगना, दाने और खुजली शामिल हैं। अन्य सामान्य प्रभावों में थकान, सिरदर्द और रक्त कोशिकाओं की कमी हो सकती है। गंभीर दुष्प्रभावों में गंभीर संक्रमण, प्रगतिशील मल्टीफोकल ल्यूकोएन्सेफैलोपैथी (PML), हेपेटाइटिस बी का पुनः सक्रिय होना और हृदय संबंधी समस्याएं शामिल हैं।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर की देखरेख में दी जानी चाहिए। यदि आपको कोई सक्रिय संक्रमण, हृदय की समस्या या हेपेटाइटिस बी का इतिहास है तो अपने डॉक्टर को बताएं। उपचार के दौरान नियमित रक्त परीक्षण की आवश्यकता होती है। इस दवा के दौरान लाइव टीके न लगवाएं। उपचार के दौरान और कई महीनों तक प्रभावी गर्भनिरोधक का उपयोग करें। संक्रमण, असामान्य रक्तस्राव या तंत्रिका संबंधी लक्षणों की तुरंत रिपोर्ट करें।
💊 mabtas t 100mg injection Uses & Benefits
[{"condition":"Non-Hodgkin Lymphoma","description":"Used to treat certain types of non-Hodgkin lymphoma, including follicular lymphoma and diffuse large B-cell lymphoma.","evidence":"Well-established"},{"condition":"Chronic Lymphocytic Leukemia","description":"Used in combination with other medicines for the treatment of chronic lymphocytic leukemia.","evidence":"Well-established"},{"condition":"Rheumatoid Arthritis","description":"Used to reduce signs and symptoms in adults with moderately to severely active rheumatoid arthritis who have had an inadequate response to other treatments.","evidence":"Well-established"},{"condition":"Granulomatosis with Polyangiitis","description":"Used in combination with glucocorticoids for the treatment of granulomatosis with polyangiitis and microscopic polyangiitis.","evidence":"Well-established"},{"condition":"Pemphigus Vulgaris","description":"Used for the treatment of moderate to severe pemphigus vulgaris.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Multiple Sclerosis","description":"Sometimes used off-label for certain forms of multiple sclerosis.","evidence":"Limited"},{"condition":"Systemic Lupus Erythematosus","description":"Occasionally used off-label for severe lupus.","evidence":"Limited"},{"condition":"Immune Thrombocytopenic Purpura","description":"May be used off-label for immune thrombocytopenic purpura.","evidence":"Limited"}]
Primary treatment for: Non-Hodgkin Lymphoma
Also treats: Chronic Lymphocytic Leukemia, Rheumatoid Arthritis, Granulomatosis with Polyangiitis, Pemphigus Vulgaris
📋 Drug Information
| Generic Name(s) | Rituximab (100mg) |
| Brand Name | mabtas t 100mg injection |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | CD 20 Inhibitor |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store vials refrigerated at 2°C to 8°C. Do not freeze. Keep vials in the original carton to protect from light. |
| Shelf Life | Refer to the product label for the exact shelf life. Typically 24 months from the date of manufacture when stored properly. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding specifically to the CD20 antigen on the surface of B cells. This binding leads to the destruction of B cells through various mechanisms including complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis. By depleting B cells, it helps in reducing the immune response that contributes to autoimmune diseases and targets malignant B cells in certain cancers.
Mechanism Steps
💡 How to Take mabtas t 100mg injection
Strength: 100 mg injection
Dosage Information
| Adult Dosage | The dose of this medicine varies depending on the condition being treated. For non-Hodgkin lymphoma, it is often given as 375 mg/m² body surface area weekly for 4 to 8 doses. For rheumatoid arthritis, it is given as two 1000 mg intravenous infusions separated by two weeks. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients, but they should be monitored closely for infections and cardiac events. |
| Renal Impairment | No dose adjustment is required for renal impairment. |
| Hepatic Impairment | No dose adjustment is required for hepatic impairment, but caution is advised in patients with hepatitis B. |
| Maximum Daily Dose | Not applicable as this medicine is given as a single infusion or as part of a regimen. The maximum dose is determined by the treating physician. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of mabtas t 100mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Other immunosuppressants | Major | |
| Antihypertensives | Moderate | |
| Cisplatin | Moderate |
🚨 Major Interactions
- Live vaccines
- Other immunosuppressants
⚡ Moderate Interactions
- Antihypertensives
- Cisplatin
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and should be avoided during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe allergic reaction to rituximab or any component of the product","Active severe infections"]
⚠️ Warnings & Precautions
["Infusion reactions can be severe and require immediate medical attention.","This medicine can increase the risk of infections, including serious bacterial, viral, and fungal infections.","Progressive multifocal leukoencephalopathy (PML) has been reported; monitor for neurological symptoms.","Hepatitis B reactivation can occur; screen and monitor accordingly.","Live vaccines should not be administered during treatment."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of overdose, patients should be monitored closely and given supportive care as needed.
⏰ Missed Dose
This medicine is given by a healthcare professional. If you miss an appointment for your infusion, contact your doctor as soon as possible to reschedule.
Additional Safety Advice
This medicine must be given under the supervision of a qualified healthcare professional. Inform your doctor if you have any active infections, heart problems, or a history of hepatitis B. Regular blood tests are needed to monitor your blood counts and liver function. Do not receive live vaccines while on this medicine. Use effective contraception during treatment and for several months after. Report any signs of infection, unusual bleeding, or neurological symptoms immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to infections and cardiac events. Close monitoring is recommended.
🤰 Pregnancy Planning (TTC)
Women of childbearing potential should use effective contraception during treatment and for 12 months after the last dose. If you are planning pregnancy, consult your doctor.
🏥 Post-Surgery Considerations
This medicine may increase the risk of infection after surgery. Inform your surgeon about your treatment. Timing of surgery should be discussed with your doctor.
🦷 Dental Procedures
Inform your dentist about this medicine. You may be at increased risk of infection. Prophylactic antibiotics may be recommended.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid strenuous activities if you feel fatigued or have low blood counts. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue or dizziness. Avoid driving or operating heavy machinery until you know how it affects you. You may need to take time off for infusions and recovery.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Treatment duration is determined by your condition and response. If you experience severe side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to prolonged B cell depletion, increasing the risk of infections. Regular monitoring of blood counts and immunoglobulin levels is recommended. Some patients may develop persistent low immunoglobulin levels. The risk of secondary malignancies is not well established. Patients should be monitored for signs of infection and neurological changes.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For autoimmune diseases, other medicines may be used if this medicine is not suitable.
Evidence: Well-establishedFor cancers, other chemotherapy regimens may be considered.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should not be given during treatment with this medicine. Non-live vaccines may be less effective. Consult your doctor for vaccination timing.
📦 Storage Guide
✅ DO
Store refrigerated at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not use if expired
✅ DO
Keep out of reach of children
❌ DON'T
Do not shake the vial
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. It should be stored refrigerated at 2°C to 8°C. If traveling by air, carry it in hand luggage and inform security about the medication. Check customs regulations for carrying prescription medicines. Plan your infusions around your travel schedule and consult your doctor for adjustments.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action varies. B cell depletion can begin within days, but clinical improvement may take weeks to months.
A: It is given as an intravenous infusion by a healthcare professional.
A: Avoid live vaccines, close contact with people who have infections, and alcohol.
🤔 Common Patient Concerns
🔄 Substitutes for mabtas t 100mg injection
View AllAlternative brands with exact same active ingredient:
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x mab 100mg injectionRPG Life Sciences Ltd ₹4,967.81 29.3% CHEAPER
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zestmab 100mg injectionRPG Life Sciences Ltd ₹5,175.00 26.4% CHEAPER
-
enfeira 100mg injectionZydus Cadila ₹6,914.43 1.7% CHEAPER
-
ikgdar 100mg injectionCipla Ltd ₹7,133.44 1.5% COSTLIER
-
emtux 100mg injectionEmcure Pharmaceuticals Ltd ₹7,133.80 1.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be self-administered at home.
Fact: This medicine must be given by a healthcare professional in a clinical setting. - Myth: This medicine weakens the immune system permanently.
Fact: B cell depletion is temporary and recovery occurs over months after treatment.