Agopride 3.75mg Depot Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Sudden severe headache with vision changes
- Chest pain or shortness of breath
- Severe back pain with weakness or numbness in legs
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is luprocare depot 3.75mg injection used for?
This medicine is a depot injection containing leuprolide 3.75 mg, used to treat hormone-sensitive conditions like prostate cancer, endometriosis, and uterine fibroids by suppressing testosterone and estrogen production.
- Generic Name: Leuprolide (3.75mg)
- Manufacturer: Gufic Bioscience Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 luprocare depot 3.75mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा ल्यूप्रोलाइड 3.75 मिलीग्राम डिपो इंजेक्शन है, जिसका उपयोग प्रोस्टेट कैंसर, एंडोमेट्रियोसिस, गर्भाशय फाइब्रॉएड और बच्चों में समय से पहले यौवन को रोकने के लिए किया जाता है। यह हार्मोन के स्तर को कम करके काम करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में गर्म चमक, मूड स्विंग, कामेच्छा में कमी, इंजेक्शन स्थल पर दर्द, सूजन या लालिमा शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, रीढ़ की हड्डी में दबाव, और दृष्टि में बदलाव हो सकते हैं। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर द्वारा दी जानी चाहिए। गर्भवती या स्तनपान कराने वाली महिलाओं को यह दवा नहीं लेनी चाहिए। उपचार के दौरान गर्भनिरोधक उपाय करें। शराब से बचें। नियमित जांच कराएं।
💊 luprocare depot 3.75mg injection Uses & Benefits
[{"condition":"Advanced prostate cancer","description":"Used as palliative treatment to reduce testosterone levels and slow cancer growth.","evidence":"Well-established"},{"condition":"Endometriosis","description":"Helps relieve pain and reduce endometrial lesions by lowering estrogen levels.","evidence":"Well-established"},{"condition":"Uterine fibroids","description":"Shrinks fibroids and reduces associated symptoms like heavy bleeding and pain.","evidence":"Well-established"},{"condition":"Central precocious puberty","description":"Delays premature puberty in children by suppressing gonadotropin release.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Breast cancer (hormone receptor-positive)","description":"Sometimes used in premenopausal women to suppress ovarian function.","evidence":"Limited"},{"condition":"Ovarian suppression for fertility preservation","description":"May be used during chemotherapy to protect ovaries.","evidence":"Investigational"}]
Primary treatment for: Prostate cancer
Also treats: Endometriosis, Uterine fibroids, Central precocious puberty
📋 Drug Information
| Generic Name(s) | Leuprolide (3.75mg) |
| Brand Name | luprocare depot 3.75mg injection |
| Manufacturer | Gufic Bioscience Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | GNRH agonists/analogue |
| Route of Administration | Parenteral (subcutaneous or intramuscular injection) |
| Storage | Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Keep in original carton until use. |
| Shelf Life | 24 months from the date of manufacture when stored under recommended conditions. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a synthetic analog of gonadotropin-releasing hormone (GnRH). It binds to GnRH receptors in the pituitary gland, initially causing a surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release, but with continuous administration, it downregulates the receptors, leading to suppressed LH and FSH secretion. This results in decreased production of testosterone in men and estrogen in women, thereby reducing the growth of hormone-sensitive tissues.
Mechanism Steps
💡 How to Take luprocare depot 3.75mg injection
Strength: Depot injection, 3.75 mg per vial or prefilled syringe.
Dosage Information
| Adult Dosage | The usual adult dose is 3.75 mg administered as a single subcutaneous or intramuscular injection once every 28 days. For prostate cancer, the dose may be 7.5 mg monthly or 22.5 mg every 3 months, depending on the formulation. For endometriosis, 3.75 mg monthly for up to 6 months is common. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | For central precocious puberty, dosing is weight-based and must be determined by a pediatric endocrinologist. Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients, but caution is advised due to increased risk of bone loss and cardiovascular events. Monitor renal and hepatic function. |
| Renal Impairment | No dose adjustment is recommended for mild to moderate renal impairment. Use with caution in severe renal impairment; monitor closely. |
| Hepatic Impairment | No dose adjustment is recommended for mild to moderate hepatic impairment. Use with caution in severe hepatic impairment; monitor liver function. |
| Maximum Daily Dose | Not applicable as it is administered monthly. The maximum recommended dose is 3.75 mg per 28 days for the 3.75 mg depot formulation. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of luprocare depot 3.75mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Degarelix | Major | |
| Warfarin | Moderate | |
| Corticosteroids | Moderate | |
| Antidiabetic drugs | Moderate |
🚨 Major Interactions
- GnRH antagonists (e.g., degarelix)
- Anticoagulants (e.g., warfarin)
⚡ Moderate Interactions
- Corticosteroids
- Antidiabetic drugs
🍷 Alcohol Interaction
Alcohol may worsen side effects such as hot flashes, mood swings, and dizziness. It is advisable to limit or avoid alcohol while on this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to leuprolide or any component of the formulation","Pregnancy","Breastfeeding","Undiagnosed abnormal vaginal bleeding","Use in children under 2 years for precocious puberty (safety not established)"]
⚠️ Warnings & Precautions
["May cause initial flare of symptoms in prostate cancer; monitor for spinal cord compression.","May increase risk of osteoporosis with prolonged use.","May cause mood changes and depression; monitor mental health.","Injection site reactions may occur; rotate sites.","Use with caution in patients with cardiovascular disease.","May affect blood glucose; monitor in diabetics."]
🤱 Lactation Safety
Not recommended during breastfeeding. It is not known if leuprolide is excreted in human milk. Consult your doctor for alternative options.
💊 Overdose Management
Overdose is unlikely due to the depot formulation and administration by healthcare professionals. In case of accidental overdose, monitor for signs of hormonal imbalance and provide supportive care. Contact a poison control center or emergency department if needed.
⏰ Missed Dose
If you miss a scheduled dose, contact your healthcare provider immediately to reschedule. Do not attempt to self-administer an extra dose. The dosing schedule is critical for therapeutic effect.
Additional Safety Advice
This medicine must be administered by a healthcare professional only. Do not attempt to self-inject. Inform your doctor if you have a history of allergies, heart disease, diabetes, or bone problems. Women of childbearing potential should use effective non-hormonal contraception during treatment and for at least 12 weeks after the last dose. Avoid alcohol as it may worsen side effects. Regular follow-up visits are necessary to monitor hormone levels and manage side effects. Report any unusual symptoms such as severe headache, vision changes, or difficulty breathing immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be at higher risk of bone loss and cardiovascular events. Regular monitoring of bone density and heart health is advised.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy. Women planning pregnancy should discuss alternative treatments with their doctor. Use effective contraception during treatment and for at least 12 weeks after the last dose.
🏥 Post-Surgery Considerations
If you have surgery planned, inform your surgeon about this medicine. It may affect hormone levels and healing. Follow your doctor's instructions regarding continuation.
🦷 Dental Procedures
No specific precautions for dental procedures, but inform your dentist about this medicine. Maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Weight-bearing exercises are beneficial for bone health, but avoid high-impact activities if you have bone pain or osteoporosis. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue; avoid driving or operating heavy machinery if affected. Hot flashes and mood swings may impact daily activities. Discuss with your employer if you need accommodations.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Treatment duration depends on the condition and response. Your doctor will determine when to discontinue based on clinical evaluation.
📅 Long-Term Use Effects
Long-term use may lead to decreased bone mineral density and increased risk of osteoporosis. Regular monitoring of bone health is recommended. Other effects include continued hormonal suppression and potential cardiovascular risks. Periodic evaluation by your doctor is essential.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Alternative class of medicines that suppress hormones without initial flare.
Evidence: Well-establishedFor prostate cancer or fibroids, surgical options may be considered.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions reported. However, consult your doctor before receiving any live vaccines while on this medicine.
📦 Storage Guide
✅ DO
Store refrigerated at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not transfer to another container
✅ DO
Keep out of reach of children
❌ DON'T
Do not use if expired
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a prescription copy. Store in a cool, refrigerated environment during travel. Use an insulated bag with ice packs if needed. Inform security about the injection and carry a doctor's letter. Plan doses around travel schedule to avoid missed injections.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Therapeutic effects typically begin within 2-4 weeks after the first injection.
A: No, it is contraindicated during pregnancy as it may harm the fetus.
A: No, it must be given by a healthcare professional.
🤔 Common Patient Concerns
🔄 Substitutes for luprocare depot 3.75mg injection
View AllAlternative brands with exact same active ingredient:
-
eurolide 3.75mg depot injectionSamarth Life Sciences Pvt Ltd ₹2,075.00 12.4% COSTLIER
-
prolimax 3.75mg injectionGLS Pharma Ltd. ₹2,202.19 19.3% COSTLIER
-
endorelin 3.75mg injectionSerum Institute Of India Ltd ₹2,604.58 41.1% COSTLIER
-
bdsure 3.75mg injectionBDR Pharmaceuticals Internationals Pvt ₹2,615.63 41.7% COSTLIER
-
luprodex depot 3.75mg injectionBharat Serums & Vaccines Ltd ₹3,144.00 70.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a cure for prostate cancer.
Fact: It is a palliative treatment that slows cancer growth but does not cure it. - Myth: This injection can be self-administered.
Fact: It must be given by a healthcare professional.
🔄 Alternative Options
Generic Alternatives
- Leuprolide acetate 3.75 mg depot injection
Brand Alternatives
- Agopride 3.75mg Depot Injection