Bdsure 3.75mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Sudden severe headache, vision changes, or confusion
- Back pain with weakness or numbness in the legs
- Chest pain, palpitations, or fainting
- Severe allergic rash or hives
- Signs of infection at the injection site (increasing pain, redness, swelling, fever)
If experiencing severe symptoms, call emergency services immediately.
What is bdsure 3.75mg injection used for?
This medicine contains leuprolide 3.75 mg, a GnRH agonist given as an intramuscular injection every 28 days. It is used to treat advanced prostate cancer, endometriosis, uterine fibroids, and central precocious puberty by suppressing hormone production.
- Generic Name: Leuprolide
- Manufacturer: BDR Pharmaceuticals Internationals Pvt
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 bdsure 3.75mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा ल्यूप्रोलाइड 3.75 मिलीग्राम इंजेक्शन के रूप में उपलब्ध है और इसे हर 28 दिन में एक बार मांसपेशी में इंजेक्शन द्वारा दिया जाता है। यह मुख्य रूप से पुरुषों में प्रोस्टेट कैंसर के इलाज, महिलाओं में एंडोमेट्रियोसिस और गर्भाशय फाइब्रॉएड के लक्षणों को कम करने, और बच्चों में समय से पहले यौवन को रोकने के लिए उपयोग की जाती है। यह दवा शरीर में हार्मोन के स्तर को नियंत्रित करके काम करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में गर्म लहरें (हॉट फ्लैश), मूड में बदलाव, थकान, और इंजेक्शन की जगह पर दर्द या सूजन शामिल हैं। पुरुषों में स्तन में कोमलता और यौन इच्छा में कमी हो सकती है। महिलाओं में योनि में सूखापन या अनियमित रक्तस्राव हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, हड्डियों की घनत्व में कमी, या अचानक तेज सिरदर्द हो सकता है। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा इंजेक्शन के रूप में दी जानी चाहिए। इसे स्वयं न लगाएं। इलाज के दौरान नियमित जांच कराते रहें। गर्भवती महिलाओं को यह दवा नहीं लेनी चाहिए। यह गर्भनिरोधक नहीं है, इसलिए इलाज के दौरान अन्य गर्भनिरोधक तरीके अपनाएं। शराब का सेवन कम करें। दवा को कमरे के तापमान पर, धूप से दूर, मूल पैकेजिंग में रखें।
💊 bdsure 3.75mg injection Uses & Benefits
[{"condition":"Advanced prostate cancer","description":"Used as palliative therapy to reduce testosterone levels, which slows tumour growth and relieves symptoms in hormone-sensitive prostate cancer.","evidence":"Well-established"},{"condition":"Endometriosis","description":"Helps shrink endometrial tissue and reduce pain associated with endometriosis by suppressing estrogen production.","evidence":"Well-established"},{"condition":"Uterine fibroids","description":"Reduces the size of fibroids and associated symptoms such as heavy bleeding and pelvic pressure before surgery.","evidence":"Well-established"},{"condition":"Central precocious puberty","description":"Delays premature puberty in children by suppressing gonadotropin release until an appropriate age.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Hormone receptor-positive breast cancer in premenopausal women","description":"Sometimes used to induce ovarian suppression as part of endocrine therapy, but this is not a standard approved indication for all patients.","evidence":"Limited"},{"condition":"Gender-affirming hormone therapy","description":"May be used off-label to suppress endogenous hormone production in certain protocols, always under specialist supervision.","evidence":"Limited"}]
Primary treatment for: Advanced prostate cancer
Also treats: Endometriosis, Uterine fibroids, Central precocious puberty
📋 Drug Information
| Generic Name(s) | Leuprolide |
| Brand Name | Agopride Injection |
| Manufacturer | BDR Pharmaceuticals Internationals Pvt |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | GNRH agonists/analogue |
| Route of Administration | Intramuscular injection |
| Storage | Store in the original carton at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Do not freeze. |
| Shelf Life | Refer to the expiry date printed on the packaging. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a synthetic nonapeptide analogue of naturally occurring gonadotropin-releasing hormone (GnRH). It binds to GnRH receptors in the anterior pituitary gland and, when given continuously, causes downregulation and desensitization of these receptors. This leads to suppressed secretion of luteinizing hormone and follicle-stimulating hormone, which in turn reduces gonadal steroid production. The initial stimulation can cause a transient rise in testosterone or estrogen, but continuous therapy results in profound suppression.
Mechanism Steps
💡 How to Take bdsure 3.75mg injection
Strength: 3.75 mg immediate-release intramuscular injection
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 3.75 mg administered as a single intramuscular injection once every 28 days. For prostate cancer, endometriosis, and uterine fibroids, the same dose is typically used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and clinical response. Do not self-administer; injections must be given by a healthcare professional. |
| Pediatric Dosage | Pediatric dosing for central precocious puberty is not established from available information for this specific 3.75 mg immediate-release formulation. Consult a pediatric endocrinologist for appropriate dosing and monitoring. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients based on age alone. However, elderly patients may be more susceptible to bone loss and cardiac effects. Monitor renal and hepatic function and adjust therapy as clinically indicated. |
| Renal Impairment | Dose adjustment is not well established for renal impairment. Use with caution in patients with severe renal impairment and monitor for adverse effects. |
| Hepatic Impairment | Dose adjustment is not well established for hepatic impairment. Use with caution and monitor liver function periodically. |
| Maximum Daily Dose | The maximum recommended dose is 3.75 mg per 28-day cycle for this formulation. Higher doses or different formulations may be used for other indications under specialist supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of bdsure 3.75mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Degarelix | Major | |
| QT-prolonging drugs | Major | |
| Corticosteroids | Moderate | |
| Warfarin | Moderate |
🚨 Major Interactions
- GnRH antagonists (e.g., degarelix)
- Drugs that prolong QT interval (e.g., certain antiarrhythmics, antipsychotics)
⚡ Moderate Interactions
- Corticosteroids
- Anticoagulants (e.g., warfarin)
🍷 Alcohol Interaction
Alcohol may exacerbate side effects such as hot flashes, mood changes, and fatigue. It is advisable to limit or avoid alcohol while receiving this medicine, especially if you have liver disease or are taking other medications.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to leuprolide or any component of the formulation","Pregnancy","Breastfeeding","Undiagnosed abnormal vaginal bleeding","Use in children under 2 years of age for central precocious puberty (safety not established)"]
⚠️ Warnings & Precautions
["May cause initial flare of symptoms in prostate cancer patients, which can worsen bone pain or urinary obstruction. Close monitoring is required during the first few weeks.","Long-term use may lead to decreased bone mineral density and increased risk of osteoporosis.","May cause QT prolongation; use with caution in patients with cardiac disease.","Not a contraceptive; women of childbearing potential must use effective non-hormonal contraception.","Injection must be given by a healthcare professional; do not self-administer.","May affect blood glucose levels; monitor if diabetic.","Rare cases of pituitary apoplexy have been reported; seek immediate care for sudden severe headache or vision changes."]
🤱 Lactation Safety
It is not known whether leuprolide is excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding is not recommended during treatment.
💊 Overdose Management
Overdose with leuprolide is unlikely due to its injectable route and medical supervision. If accidental overdose occurs, seek immediate medical attention. Treatment is supportive and symptomatic. Monitor vital signs and hormone levels.
⏰ Missed Dose
If you miss a scheduled injection, contact your healthcare provider as soon as possible to reschedule. Do not attempt to double the dose. The dosing interval may need to be adjusted to maintain therapeutic effect.
Additional Safety Advice
This medicine must only be given by a healthcare professional as an intramuscular injection. Do not attempt to self-administer. Keep all scheduled appointments for monitoring of hormone levels, prostate-specific antigen (PSA) in men, and bone density if treatment is long-term. Use a reliable non-hormonal method of contraception during treatment, as this medicine is not a contraceptive and can harm a developing fetus. Avoid alcohol and inform your doctor about all other medicines, especially those affecting heart rhythm or hormone levels. Do not stop treatment abruptly without consulting your specialist, as symptoms may return. Store the injection in its original packaging at room temperature, away from direct sunlight and moisture.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to bone loss and cardiac effects. Regular monitoring of bone density, renal function, and cardiac status is advised.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated in pregnancy. Women planning pregnancy should discuss alternative treatments with their doctor. Use effective non-hormonal contraception during treatment and for at least 3 months after the last dose.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anaesthesiologist about this medicine. It may affect hormone levels and could interact with anaesthetic agents. Follow your doctor's advice regarding when to resume treatment after surgery.
🦷 Dental Procedures
Inform your dentist about this medicine before any dental procedure. No specific precautions are established, but it is important for your dental team to be aware of your medication.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular exercise is encouraged, but avoid high-impact activities if you have bone metastases or osteoporosis. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or mood changes that could affect your ability to drive or operate machinery. Avoid driving if you feel unwell. Most patients can continue their normal work activities, but listen to your body and rest when needed.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your specialist. Treatment duration depends on the condition and your response. Your doctor will determine when to stop based on clinical assessment and monitoring.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to decreased bone mineral density and increased risk of osteoporosis. Regular monitoring of bone health, hormone levels, and cardiac function is recommended. Some patients may experience persistent hot flashes or mood changes. Discuss any long-term concerns with your specialist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Similar hormonal suppression with different administration routes or frequencies.
Evidence: Well-establishedFor certain conditions like uterine fibroids or endometriosis, surgery may be an option.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, consult your doctor before receiving any live vaccines while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label intact. Keep a copy of your prescription and a letter from your doctor explaining the medical need. Store at room temperature and protect from light. If travelling across time zones, maintain the 28-day schedule as closely as possible; consult your doctor for adjustments. Check customs regulations for injectable medicines before travelling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Hormone suppression typically occurs within 2 to 4 weeks of continuous therapy, but initial flare of symptoms may occur in the first weeks.
A: No, this medicine is not a contraceptive. Use effective non-hormonal contraception during treatment.
A: No, this medicine must be given by a healthcare professional as an intramuscular injection.
A: Contact your healthcare provider as soon as possible to reschedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for bdsure 3.75mg injection
View AllAlternative brands with exact same active ingredient:
-
luprocare depot 3.75mg injectionGufic Bioscience Ltd ₹1,845.70 29.4% CHEAPER
-
eurolide 3.75mg depot injectionSamarth Life Sciences Pvt Ltd ₹2,075.00 20.7% CHEAPER
-
prolimax 3.75mg injectionGLS Pharma Ltd. ₹2,202.19 15.8% CHEAPER
-
endorelin 3.75mg injectionSerum Institute Of India Ltd ₹2,604.58 0.4% CHEAPER
-
luprodex depot 3.75mg injectionBharat Serums & Vaccines Ltd ₹3,144.00 20.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a contraceptive.
Fact: This medicine is not a contraceptive. It suppresses hormones but does not prevent pregnancy. Use effective non-hormonal contraception during treatment. - Myth: This medicine can be self-administered at home.
Fact: This medicine must be given by a healthcare professional as an intramuscular injection. Do not attempt to self-administer. - Myth: This medicine works immediately.
Fact: It may take 2 to 4 weeks for full hormone suppression. Initial flare of symptoms can occur in the first weeks.
🔄 Alternative Options
Generic Alternatives
- Leuprolide acetate 3.75 mg injection
Brand Alternatives
- Lupride 3.75 mg injection
- Leuprolide 3.75 mg injection (various manufacturers)