Actizo 20 mg/120 mg Tablet: Complete Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe skin rash with blisters or peeling
- Irregular or very fast heartbeat, fainting, or chest pain
- Yellowing of the eyes or skin, dark urine, or severe abdominal pain
- Unusual bleeding or bruising
- Persistent vomiting or inability to keep the medicine down
- Confusion, seizures, or loss of consciousness
If experiencing severe symptoms, call emergency services immediately.
What is lonart 20mg/120mg tablet dt used for?
This medicine is a combination antimalarial tablet containing artemether 20 mg and lumefantrine 120 mg. It is used to treat uncomplicated Plasmodium falciparum malaria. It works by killing the malaria parasites in the blood. It must be taken with fatty food or milk for best absorption, and the full 3-day course must be completed.
- Generic Name: Artemether (20mg) + Lumefantrine (120mg)
- Manufacturer: Bliss Gvs Pharma Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 lonart 20mg/120mg tablet dt के बारे में (Hindi Summary)
उपयोग: यह दवा आर्टेमेथर और लुमेफैंट्रिन का संयोजन है, जिसका उपयोग मलेरिया (प्लास्मोडियम फाल्सीपेरम) के इलाज के लिए किया जाता है। यह मलेरिया परजीवी को खून में मारती है और बुखार, ठंड लगना, पसीना आना और शरीर दर्द जैसे लक्षणों को कम करती है। इसे खाने के साथ या दूध के साथ लेना चाहिए ताकि यह अच्छी तरह से अवशोषित हो सके। डॉक्टर के बताए अनुसार पूरा कोर्स पूरा करना बहुत जरूरी है, भले ही आपको पहले दिन ही आराम महसूस होने लगे।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में सिरदर्द, चक्कर आना, भूख न लगना, जी मिचलाना, उल्टी, पेट दर्द, धड़कन तेज होना और नींद में गड़बड़ी शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको सांस लेने में तकलीफ, चेहरे या गले में सूजन, त्वचा पर गंभीर दाने, बेहोशी, या दिल की धड़कन अनियमित महसूस हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे खाने के साथ या दूध के साथ लें, क्योंकि इससे दवा का असर बढ़ता है। पूरा कोर्स पूरा करें, बीच में न छोड़ें। शराब न पिएं क्योंकि इससे चक्कर और पेट की समस्या बढ़ सकती है। अगर आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। अपनी अन्य दवाओं के बारे में भी डॉक्टर को जानकारी दें। दवा को ठंडी और सूखी जगह पर, धूप से दूर, बच्चों की पहुंच से दूर रखें।
💊 lonart 20mg/120mg tablet dt Uses & Benefits
- [{"condition":"Uncomplicated Plasmodium falciparum malaria","description":"This medicine is used to treat acute, uncomplicated malaria caused by Plasmodium falciparum in adults and children.
- It rapidly reduces parasite load and resolves fever and other symptoms.","evidence":"Well-established"},{"condition":"Mixed malaria infections","description":"It may be used when a mixed infection is suspected, but a separate medicine is needed to clear liver-stage parasites of Plasmodium vivax.","evidence":"Established"}]
Off-label uses: [{"condition":"Malaria in pregnancy (second and third trimester)","description":"In some settings, this medicine may be used in the second and third trimesters under strict medical supervision when the benefits outweigh the risks.","evidence":"Limited"},{"condition":"Malaria chemoprophylaxis","description":"This medicine is not recommended for malaria prevention, but in rare situations it may be considered off-label by specialists.","evidence":"Insufficient"}]
Primary treatment for: Uncomplicated Plasmodium falciparum malaria
Also treats: Mixed malaria infections (with additional therapy for vivax)
📋 Drug Information
| Generic Name(s) | Artemether (20mg) + Lumefantrine (120mg) |
| Brand Name | lonart 20mg/120mg tablet dt |
| Manufacturer | Bliss Gvs Pharma Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI MALARIALS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store below 30°C in a dry place, protected from light and moisture. Keep in the original packaging. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated Plasmodium falciparum malaria. Artemether-lumefantrine is one of the recommended ACTs. |
| ICMR Guideline | The Indian Council of Medical Research recommends artemether-lumefantrine as a first-line treatment for uncomplicated Plasmodium falciparum malaria in India, in accordance with national malaria treatment guidelines. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimalarial agents with complementary mechanisms. Artemether is converted in the body to dihydroartemisinin, which generates free radicals and alkylates parasite proteins, leading to rapid destruction of the malaria parasite's cellular structures. Lumefantrine interferes with the parasite's ability to detoxify heme, causing toxic heme accumulation that kills the parasite. Together, they provide a rapid initial kill and a longer-lasting effect that prevents recrudescence.
Mechanism Steps
💡 How to Take lonart 20mg/120mg tablet dt
Strength: Tablet containing artemether 20 mg and lumefantrine 120 mg.
Dosage Information
| Adult Dosage | The standard adult dose is 4 tablets (each containing artemether 20 mg and lumefantrine 120 mg) taken orally at 0, 8, 24, 36, 48, and 60 hours. This provides a total of 24 tablets over 3 days. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always take with fatty food or milk to improve absorption. |
| Pediatric Dosage | Pediatric dosing is weight-based and must be determined by a pediatrician. The number of tablets per dose varies with body weight. Do not attempt to calculate the dose yourself. Consult a pediatrician for accurate dosing. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness and heart rhythm changes. Use with caution and monitor closely. Dose adjustment may be needed based on renal and hepatic function. |
| Renal Impairment | No specific dose adjustment is established for mild to moderate renal impairment. Use with caution in severe renal impairment; consult your doctor. |
| Hepatic Impairment | No specific dose adjustment is established for mild to moderate hepatic impairment. Use with caution in severe hepatic impairment; consult your doctor. |
| Maximum Daily Dose | The maximum daily dose is 4 tablets per dose, with a maximum of 16 tablets on day 1 (0 and 8 hours) and 8 tablets on days 2 and 3. Do not exceed the prescribed course. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of lonart 20mg/120mg tablet dt
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Amiodarone | Major | |
| Warfarin | Major | |
| Hormonal contraceptives | Moderate | |
| Antacids | Moderate | |
| Grapefruit juice | Moderate | |
| Paracetamol | Minor | |
| Ibuprofen | Minor | |
| Omeprazole | Minor |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin)
- CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin)
- QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
- Warfarin
⚡ Moderate Interactions
- Hormonal contraceptives
- Antacids
- Grapefruit juice
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can worsen dizziness, drowsiness, and stomach upset, and may increase the risk of liver problems.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to artemether, lumefantrine, or any component of the tablet","Severe malaria (including cerebral malaria)","First trimester of pregnancy (unless no other option and under strict medical supervision)","Known congenital QT prolongation or family history of sudden cardiac death","Severe liver impairment","Severe kidney impairment","Concurrent use with strong CYP3A4 inducers or QT-prolonging drugs"]
⚠️ Warnings & Precautions
["Take with fatty food or milk to ensure adequate absorption.","Do not use for malaria prevention.","Avoid in patients with heart rhythm problems or electrolyte imbalances.","Use with caution in elderly patients and those with liver or kidney disease.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Do not share this medicine with others.","Complete the full course as prescribed.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Report any signs of allergic reaction, irregular heartbeat, or liver problems immediately."]
🤱 Lactation Safety
It is not known whether artemether and lumefantrine pass into breast milk in significant amounts. Consult your doctor before breastfeeding while taking this medicine. In many cases, breastfeeding can continue, but monitoring the infant for side effects is advised.
💊 Overdose Management
Overdose may cause severe nausea, vomiting, dizziness, and heart rhythm disturbances. Seek emergency medical attention immediately. Treatment is supportive and symptomatic, including monitoring of vital signs and ECG. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one. If you vomit within 1 hour of taking a dose, consult your doctor; you may need to repeat that dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with water, milk, or a fatty drink such as coconut milk, and always take it with food to help your body absorb the medicine properly. Do not skip meals while on this medicine. Complete the full course even if you feel better after the first dose, because stopping early can allow the malaria parasites to return and may lead to treatment failure. Avoid alcohol during treatment as it can worsen dizziness and stomach upset. Do not take this medicine if you are pregnant unless specifically advised by your doctor, and inform your doctor if you are breastfeeding. Tell your doctor about all other medicines you are taking, especially heart rhythm medicines, antibiotics, and HIV medicines, because some can interact dangerously. Do not share this medicine with anyone else, even if they have similar symptoms. Store the tablets in their original packaging, away from moisture and direct sunlight, and keep them out of reach of children. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Never double the dose to make up for a missed one.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness and heart rhythm changes. Use with caution and monitor closely. Dose adjustment may be needed based on renal and hepatic function.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor. This medicine is generally avoided in the first trimester. Use effective contraception during treatment and for one week after, as it may reduce the effectiveness of hormonal contraceptives.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may affect heart rhythm and interact with other medicines used during surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with certain medicines used in dentistry, and you may need to take precautions if you have heart rhythm concerns.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while you are recovering from malaria. Take it easy and gradually return to your normal routine as you feel better. Dizziness is a common side effect, so avoid activities that require alertness until you know how the medicine affects you.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness and sleep disturbance. Avoid driving or operating heavy machinery until you know how it affects you. You may need to take rest from work during the first few days of treatment.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Complete the full 3-day course as prescribed. If you experience severe side effects, contact your doctor immediately; they will advise whether to stop or adjust the treatment.
📅 Long-Term Use Effects
This medicine is usually taken for a short 3-day course, so long-term effects are not a concern. However, if used repeatedly or for prolonged periods, monitoring of liver function, kidney function, and heart rhythm may be advised. There is no evidence of long-term harm from a standard course.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Alternatives such as artesunate + sulfadoxine + pyrimethamine or dihydroartemisinin + piperaquine may be used if this medicine is not suitable.
Evidence: Well-establishedRest, hydration, and fever control with paracetamol can complement antimalarial treatment.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are acutely ill with malaria, it is best to postpone non-urgent vaccinations until you have recovered.
📦 Storage Guide
✅ DO
Store at room temperature (below 30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue your dosing schedule based on the time you took the first dose. Check customs regulations for carrying prescription medicines. Always carry enough for the full course and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts killing malaria parasites within hours. Fever usually subsides within 24 to 48 hours, but you must complete the full 3-day course.
A: Yes, taking it with milk or a fatty meal improves absorption of the medicine and is recommended.
A: If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: The safety in the first trimester is not well established. In the second and third trimesters, it may be used if the benefits outweigh the risks, under medical supervision.
A: It is best to avoid alcohol as it can worsen dizziness and stomach upset.
🤔 Common Patient Concerns
🔄 Substitutes for lonart 20mg/120mg tablet dt
View AllAlternative brands with exact same active ingredient:
-
Sviz LF 20 mg/120 mg TabletManeesh Pharmaceuticals Ltd ₹48.80 29.2% CHEAPER
-
artisafe l 20 mg/120 mg tablet dtAlkem Laboratories Ltd ₹62.86 8.8% CHEAPER
-
ecother xl tabletLeo Pharmaceuticals ₹71.57 3.9% COSTLIER
-
lumether 20mg/120mg tabletThemis Medicare Ltd ₹71.57 3.9% COSTLIER
-
Rmether LF 20 mg/120 mg TabletWiscon Pharmaceuticals Pvt Ltd ₹75.00 8.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used to prevent malaria.
Fact: This medicine is for treatment, not prevention. It should not be used as a prophylactic. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full 3-day course to ensure all parasites are killed and prevent recurrence. - Myth: This medicine works for all types of malaria.
Fact: It is effective against Plasmodium falciparum but not against the liver stages of Plasmodium vivax, which require additional treatment.
🔄 Alternative Options
Generic Alternatives
- Artemether + Lumefantrine 20 mg + 120 mg tablet
Brand Alternatives
- Actizo 20 mg/120 mg tablet