levodiva device - Levonorgestrel (intrauterine delivery system) (52mg) medicine

Eloira Hormonal Intrauterine System: Complete Guide

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🏭 Bharat Serums & Vaccines Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
🤰 Pregnancy Category This medicine is not indicated for use during pregnancy. If pregnancy occurs with the device in place, it should be removed because leaving it in increases the risk of miscarriage and preterm labor. Consult a healthcare provider immediately. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: High
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe abdominal pain or cramping
  • Fever with chills
  • Foul-smelling vaginal discharge
  • Sudden heavy vaginal bleeding
  • Missed period with abdominal pain (possible ectopic pregnancy)
  • Inability to feel the strings of the device
  • Pain during intercourse

If experiencing severe symptoms, call emergency services immediately.

What is levodiva device used for?

This medicine is a hormonal intrauterine system containing 52 mg levonorgestrel. It is a long-acting reversible contraceptive that also treats heavy menstrual bleeding. It works by releasing levonorgestrel locally to prevent pregnancy and reduce bleeding.

  • Generic Name: Levonorgestrel (intrauterine delivery system) (52mg)
  • Manufacturer: Bharat Serums & Vaccines Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 levodiva device के बारे में (Hindi Summary)

उपयोग: यह दवा एक हार्मोनल इंट्रायूटेराइन सिस्टम है जिसमें लेवोनोर्जेस्ट्रेल 52 मिलीग्राम होता है। इसका उपयोग गर्भनिरोधक के रूप में और अत्यधिक मासिक धर्म रक्तस्राव के इलाज के लिए किया जाता है। यह गर्भाशय में डाली जाती है और 5 साल तक प्रभावी रहती है। यह गर्भाशय की परत को पतला करके और गर्भाशय ग्रीवा के बलगम को गाढ़ा करके गर्भधारण को रोकती है।

साइड इफेक्ट्स: सामान्य दुष्प्रभावों में अनियमित रक्तस्राव, सिरदर्द, स्तन में कोमलता, मूड में बदलाव और मुँहासे शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेल्विक सूजन, गर्भाशय में छेद, एक्टोपिक गर्भावस्था और डिवाइस का बाहर निकलना शामिल हो सकता है। यदि आपको तेज पेट दर्द, बुखार या असामान्य रक्तस्राव हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: यह दवा केवल प्रशिक्षित डॉक्टर द्वारा ही डाली और निकाली जानी चाहिए। डालने के बाद 7 दिनों तक अतिरिक्त गर्भनिरोधक का उपयोग करें। 48 घंटे तक टैम्पोन या संभोग से बचें। हर महीने डिवाइस के धागों की जांच करें। यदि आपको गंभीर दर्द, बुखार या बदबूदार स्राव हो तो तुरंत डॉक्टर से संपर्क करें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 levodiva device Uses & Benefits

[{"condition":"Contraception","description":"Provides long-term, reversible contraception with a failure rate of less than 1% per year.","evidence":"Well-established"},{"condition":"Heavy menstrual bleeding (menorrhagia)","description":"Significantly reduces menstrual blood loss and is approved for this indication.","evidence":"Well-established"},{"condition":"Endometrial protection during hormone replacement therapy","description":"Used to protect the endometrium in women receiving estrogen therapy.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Dysmenorrhea","description":"May reduce painful menstrual cramps, though not a primary approved indication.","evidence":"Limited"},{"condition":"Endometriosis-related pain","description":"Sometimes used to manage pain associated with endometriosis.","evidence":"Limited"}]

Primary treatment for: Contraception

Also treats: Heavy menstrual bleeding, Endometrial protection during hormone replacement therapy

📋 Drug Information

Generic Name(s)Levonorgestrel (intrauterine delivery system) (52mg)
Brand Namelevodiva device
ManufacturerBharat Serums & Vaccines Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGYNAECOLOGICAL
Action ClassProgestins (Second generation)
Route of AdministrationIntrauterine
StorageStore at room temperature (15-30°C) in the original packaging. Protect from direct sunlight and moisture. Do not freeze.
Shelf Life5 years from the date of manufacture.
WHO GuidelineThe World Health Organization recognizes the levonorgestrel-releasing intrauterine system as a highly effective, long-acting reversible contraceptive method. It is included in the WHO Model List of Essential Medicines.
ICMR GuidelineThe Indian Council of Medical Research supports the use of intrauterine devices, including the levonorgestrel intrauterine system, as effective contraception and for management of heavy menstrual bleeding.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Ensure the device is inserted by a trained healthcare professional to minimize risks.
2
Advise the patient to use backup contraception for the first 7 days after insertion.
3
Instruct the patient to check for the strings monthly and report if they cannot feel them.
4
Schedule a follow-up visit 4-6 weeks after insertion to confirm correct placement.
5
Warn the patient about the risk of pelvic inflammatory disease and advise prompt reporting of symptoms.
6
Discuss the possibility of irregular bleeding, which usually improves after 3-6 months.
7
Remind the patient that this device does not protect against sexually transmitted infections.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Heavy menstrual bleeding
This medicine is commonly prescribed for this condition.
Likely Use
✅
Need for contraception
This medicine is a long-acting reversible contraceptive.
Likely Use
❌
Pelvic pain
Pelvic pain may indicate a complication and requires medical evaluation.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionLevonorgestrel is absorbed directly from the uterine cavity into the systemic circulation, but plasma concentrations are low due to the local delivery. The absorption is slow and sustained, with a steady-state plasma concentration reached after several weeks.
DistributionLevonorgestrel is highly bound to plasma proteins, primarily sex hormone-binding globulin (SHBG) and albumin. It distributes into various tissues, including the endometrium and myometrium, where it exerts its local effects.
Protein BindingApproximately 97-99% of levonorgestrel is bound to plasma proteins, mainly SHBG and albumin.
MetabolismLevonorgestrel is metabolized in the liver primarily by reduction and conjugation, forming various metabolites that are excreted in urine and feces.
Half-LifeThe elimination half-life of levonorgestrel from the intrauterine system is approximately 12-20 hours, but the local release prolongs its action for years.
ExcretionMetabolites of levonorgestrel are excreted mainly in urine, with a smaller fraction in feces.
BioavailabilityThe bioavailability of levonorgestrel from the intrauterine system is high locally, but systemic bioavailability is low due to the local delivery and first-pass metabolism.
Onset of ActionContraceptive effect begins within 7 days after insertion; for heavy menstrual bleeding, reduction in blood loss may take 3-6 months.
Peak Plasma TimePlasma concentrations of levonorgestrel peak within a few hours after insertion and then decline to a steady state over several weeks.
Duration of ActionThe contraceptive effect lasts up to 5 years for this 52 mg device, after which it should be removed or replaced.

How It Works

This medicine releases levonorgestrel, a progestin, directly into the uterine cavity. Levonorgestrel binds to progesterone receptors in the endometrium, causing decidualization and atrophy of the endometrial lining. It also thickens cervical mucus, making it impenetrable to sperm, and alters sperm motility and function, preventing fertilization. The hormonal effect is primarily local, with minimal systemic absorption.

Mechanism Steps

1
Local release of levonorgestrel: The intrauterine system releases levonorgestrel at a controlled rate directly into the uterine cavity.
2
Binding to progesterone receptors: Levonorgestrel binds to progesterone receptors in the endometrium, leading to changes in gene expression.
3
Endometrial atrophy: The endometrium becomes thin and inactive, which reduces menstrual bleeding and creates an environment unfavorable for implantation.
4
Cervical mucus thickening: Levonorgestrel causes the cervical mucus to become thick and sticky, forming a barrier that prevents sperm from entering the uterus.
5
Inhibition of sperm function: Sperm motility and viability are reduced within the uterine cavity, further preventing fertilization.

💡 How to Take levodiva device

Strength: Intrauterine system containing 52 mg levonorgestrel.

1This medicine is inserted into the uterus by a healthcare professional during a brief office procedure.
2You may feel some cramping during insertion; take an over-the-counter pain reliever if needed.
3After insertion, rest for a short period and avoid strenuous activity for 24 hours.
4Check for the strings monthly to ensure the device is in place.
5Use backup contraception for the first 7 days after insertion.
6Attend follow-up appointments as scheduled.

Dosage Information

Adult DosageThis medicine is inserted into the uterine cavity by a healthcare professional. The usual dose is one intrauterine system containing 52 mg of levonorgestrel, which releases approximately 20 mcg per day initially and gradually decreases over 5 years. The device is effective for up to 5 years for contraception and 3 years for heavy menstrual bleeding. Dose must be individualized by a qualified clinician based on indication, age, and medical history.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageThis medicine is not typically used in postmenopausal women unless for endometrial protection during hormone replacement therapy. Consult a healthcare provider for individualized advice.
Renal ImpairmentNo dosage adjustment is required for renal impairment, but use with caution in severe renal disease.
Hepatic ImpairmentUse with caution in women with severe liver disease. Contraindicated in severe hepatic impairment or liver tumors.
Maximum Daily DoseNot applicable as this is a long-acting intrauterine device. The device releases a controlled amount of levonorgestrel daily.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

⏰ What to Do If You Miss a Dose

📌 You miss a follow-up appointment
→ Reschedule as soon as possible.
💡 Regular check-ups are important to ensure the device is in place.
📌 You suspect the device has been expelled
→ Use backup contraception and contact your healthcare provider immediately.
💡 Do not attempt to reinsert the device yourself.

⚠️ Side Effects of levodiva device

✅ Common Side Effects

Irregular bleeding or spotting (Very common (>10%))
Usually improves after 3-6 months. Use sanitary pads if needed. Consult if bleeding is heavy or persistent.
Headache (Common (5-10%))
Rest and stay hydrated. Over-the-counter pain relief may help. Consult if severe or persistent.
Breast tenderness (Common (5-10%))
Wear a supportive bra. Usually resolves within a few months. Consult if severe.
Mood changes (Common (5-10%))
Practice stress-reduction techniques. Consult if mood changes are significant or persistent.
Acne (Common (5-10%))
Maintain good skin hygiene. Consult a dermatologist if severe.

🚨 Serious Side Effects

Pelvic inflammatory disease (PID) (Rare (<0.1%))
Seek immediate medical attention if you experience fever, pelvic pain, or foul-smelling discharge.
Uterine perforation (Rare (<0.1%))
Requires immediate medical evaluation if severe abdominal pain occurs after insertion.
Ectopic pregnancy (Rare (<0.1%))
Seek emergency care if you have severe abdominal pain, missed period, or abnormal bleeding.
Expulsion of the device (Uncommon (1-5%))
Check for the strings monthly. If you cannot feel them or suspect expulsion, use backup contraception and see your doctor.

⚠️ Rare Side Effects

Ovarian cysts
Usually resolve spontaneously. Consult if persistent pain or bloating.
Allergic reaction
Seek immediate medical help if you experience rash, itching, swelling, or difficulty breathing.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Rifampicin Major
Carbamazepine Major
Phenytoin Major
Tranexamic acid Moderate
NSAIDs Minor

🚨 Major Interactions

  • Enzyme-inducing drugs (e.g., rifampicin, carbamazepine, phenytoin)

⚡ Moderate Interactions

  • Antifibrinolytic drugs (e.g., tranexamic acid)

🍷 Alcohol Interaction

Alcohol does not directly interact with this medicine, but excessive alcohol consumption may affect liver function and overall health. Moderate alcohol intake is generally acceptable.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known or suspected pregnancy","Current pelvic inflammatory disease or lower genital tract infection","Unexplained vaginal bleeding","Congenital or acquired uterine anomaly that distorts the uterine cavity","Known hypersensitivity to levonorgestrel or any component of the device","Current or history of breast cancer","Severe liver disease or liver tumor","Acute or history of thromboembolic disease"]

⚠️ Warnings & Precautions

["Insertion and removal should be performed by a trained healthcare professional.","Use additional barrier contraception for the first 7 days after insertion.","Avoid intercourse or tampon use for 48 hours after insertion to reduce infection risk.","Check for the strings regularly; if you cannot feel them, use backup contraception and consult your doctor.","Seek immediate medical attention if you experience severe abdominal pain, fever, or foul-smelling discharge.","This device does not protect against sexually transmitted infections (STIs).","Inform your healthcare provider about this device before any medical procedure or surgery."]

🤱 Lactation Safety

This medicine is considered safe during breastfeeding. Levonorgestrel is excreted in breast milk in small amounts, but it is not known to cause adverse effects in breastfed infants. Consult a healthcare provider for guidance.

💊 Overdose Management

Overdose with this intrauterine system is unlikely due to its local delivery. If accidental ingestion of the device occurs, seek medical attention. Symptoms of levonorgestrel overdose may include nausea, vomiting, and withdrawal bleeding. Treatment is supportive.

⏰ Missed Dose

This medicine is a long-acting intrauterine device and does not require daily dosing. If you miss a follow-up appointment, reschedule as soon as possible. If you suspect the device has been expelled, use backup contraception and contact your healthcare provider immediately.

Additional Safety Advice

General Safety

This medicine must be inserted and removed by a trained healthcare provider. Regular follow-up visits are recommended to check the position of the device. Use additional barrier contraception for the first seven days after insertion to ensure full contraceptive effect. Avoid using tampons or having intercourse for at least 48 hours after insertion to reduce infection risk. If you suspect pregnancy, have the device checked immediately. Do not attempt to remove the device yourself. Inform any healthcare provider that you have this device before undergoing any medical procedure.

👴 Special Considerations for Elderly

💡 For Patients Above 65

This medicine is not typically used in elderly women unless for endometrial protection during hormone replacement therapy. Consult a healthcare provider for individualized advice.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, have the device removed by a healthcare professional. Fertility usually returns to normal soon after removal. Preconception counseling and folic acid supplementation are recommended.

🏥 Post-Surgery Considerations

Inform your surgeon that you have this device before any surgery. It may need to be removed if surgery involves the pelvic area. Consult your healthcare provider for guidance.

🦷 Dental Procedures

No specific precautions for dental procedures. Inform your dentist about this device as part of your medical history.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy diet rich in iron to prevent anemia from heavy periods.
🥗
Stay hydrated and eat fiber-rich foods to prevent constipation.
😴
Engage in regular physical activity, but avoid strenuous exercise for 24 hours after insertion.
💧
Practice good genital hygiene to reduce infection risk.
🧘
Attend all follow-up appointments and check the strings regularly.
🌞
Use condoms to protect against sexually transmitted infections.

🏋️ Exercise Considerations

Avoid strenuous exercise or heavy lifting for 24-48 hours after insertion. After that, you can resume normal activities. If you experience pain or discomfort during exercise, consult your doctor.

🥗 Diet Recommendations

Include iron-rich foods like leafy greens, beans, and lean meats to prevent anemia.
Eat a balanced diet with plenty of fruits and vegetables.
Stay well hydrated.
Limit caffeine and alcohol as they may affect menstrual symptoms.

💼 Impact on Daily Work & Life

This medicine has minimal impact on daily activities. You can return to work and drive after insertion, but avoid heavy lifting for 24 hours. Some women may experience cramping or spotting initially, which can be managed with over-the-counter pain relief.

🛑 When to Stop This Medicine

This medicine should be removed after 5 years or earlier if you wish to become pregnant, experience complications, or no longer need contraception. Removal should be done by a healthcare professional. Do not attempt to remove it yourself.

📅 Long-Term Use Effects

Long-term use of this medicine is generally safe. The device is effective for up to 5 years. Regular check-ups are recommended to monitor for any complications. Some women may experience continued irregular bleeding or amenorrhea. Bone mineral density may be slightly affected, but this is usually reversible after removal. There is no evidence of increased risk of cancer with long-term use.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Copper intrauterine device

Non-hormonal option for contraception, effective for up to 10 years.

Evidence: Well-established
Oral contraceptive pills

Daily pill that provides contraception and regulates periods.

Evidence: Well-established
Contraceptive implant

Hormonal implant placed in the arm, effective for up to 3 years.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines. Continue routine vaccinations as recommended.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C) before insertion.

❌ DON'T

Do not freeze.

✅ DO

Keep in original sterile packaging until insertion.

❌ DON'T

Do not open packaging until ready for use.

✅ DO

Protect from direct sunlight and moisture.

❌ DON'T

Do not store in bathroom.

✈️ Traveling with This Medicine

When traveling with this medicine, it is already inserted in your body, so no special storage is needed. Carry a copy of your prescription or a note from your doctor stating that you have an intrauterine device, especially if you are traveling internationally. If you have a follow-up appointment scheduled during travel, plan accordingly. Be aware that if you experience any unusual symptoms while traveling, seek medical attention promptly.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 32-year-old woman with heavy menstrual bleeding
She had been suffering from heavy periods for years, leading to anemia and fatigue. After discussing options with her doctor, she chose this medicine. Within 3 months, her bleeding significantly reduced, and her energy levels improved. She appreciated the convenience of not having to remember a daily pill.
💡 Lesson: This medicine can dramatically improve quality of life for women with heavy menstrual bleeding.
👤 A 28-year-old woman seeking long-term contraception
She wanted a reliable contraceptive method that didn't require daily attention. She opted for this medicine and experienced some irregular spotting initially, which resolved after 4 months. She valued the 5-year duration and the fact that it is reversible.
💡 Lesson: This medicine offers effective, long-term contraception with the convenience of a single procedure.

💬 Questions Patients Often Ask

Q: How long does it take for this medicine to work?

A: The contraceptive effect begins within 7 days after insertion. For heavy menstrual bleeding, improvement may take 3-6 months.

Q: Is the insertion painful?

A: Insertion may cause some cramping, similar to menstrual cramps. Your doctor may recommend a pain reliever before the procedure.

Q: Can I get pregnant after removal?

A: Yes, fertility typically returns to normal soon after removal. Many women conceive within a year.

Q: Does this medicine protect against STIs?

A: No, this medicine does not protect against sexually transmitted infections. Use condoms for protection.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I use this medicine if I have not had children?
  • Will this medicine affect my future fertility?
  • Can I use tampons with this medicine?
  • What happens if I get pregnant with this medicine?
  • How is this medicine removed?
  • Does this medicine cause weight gain?

🔄 Substitutes for levodiva device

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine causes infertility.
    Fact: This medicine does not cause infertility. Fertility returns to normal after removal.
  • Myth: This medicine is only for contraception.
    Fact: It is also used to treat heavy menstrual bleeding and protect the endometrium during hormone replacement therapy.
  • Myth: This medicine causes weight gain.
    Fact: Clinical studies have not consistently shown significant weight gain with this medicine.

📊 Comparison with Similar Medicines

[{"feature":"Active ingredient","this_medicine":"Levonorgestrel 52 mg","copper_iud":"Copper","levonorgestrel_13_5":"Levonorgestrel 13.5 mg"},{"feature":"Duration","this_medicine":"Up to 5 years","copper_iud":"Up to 10 years","levonorgestrel_13_5":"Up to 3 years"},{"feature":"Effect on bleeding","this_medicine":"Reduces bleeding","copper_iud":"May increase bleeding","levonorgestrel_13_5":"Reduces bleeding"}]

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