lemo p drop - Chlorpheniramine Maleate (1mg) + Paracetamol (125mg) medicine

Alersafe Cold Syrup: Complete Medicine Guide

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🏭 Yash Pharma Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 24, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for symptomatic relief of cold and allergy symptoms.
Reviewed by
SaathiMed Expert Panel | Sep 24, 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swelling of face, lips, or throat
  • Severe drowsiness or confusion
  • Yellowing of skin or eyes (jaundice)
  • Severe abdominal pain or vomiting blood
  • Blood in stool or black tarry stools
  • Decreased urine output
  • Seizures or tremors

If experiencing severe symptoms, call emergency services immediately.

What is lemo p drop used for?

This medicine is a combination of Chlorpheniramine Maleate (an antihistamine) and Paracetamol (an analgesic-antipyretic) used to relieve symptoms of common cold, allergic rhinitis, and urticaria. It reduces runny nose, sneezing, watery eyes, and mild fever. It may cause drowsiness, so avoid driving. Do not exceed the recommended dose.

  • Generic Name: Chlorpheniramine Maleate (1mg) + Paracetamol (125mg)
  • Manufacturer: Yash Pharma Laboratories Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 lemo p drop के बारे में (Hindi Summary)

उपयोग: यह दवा सर्दी-जुकाम और एलर्जी के लक्षणों जैसे नाक बहना, छींक आना, आंखों में पानी आना, गले में खुजली और हल्के बुखार या शरीर दर्द में राहत देने के लिए इस्तेमाल की जाती है। इसमें क्लोरफेनिरामाइन मेलिएट और पैरासिटामोल होते हैं। यह दवा 6 साल से बड़े बच्चों और वयस्कों के लिए है। इसे डॉक्टर की सलाह के अनुसार ही लें।

साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, धुंधली दृष्टि, जी मिचलाना और कब्ज शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, सांस लेने में कठिनाई, पीलिया या पेट में तेज दर्द हो सकता है। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसकी मात्रा या अवधि से अधिक न लें। दवा लेने के बाद गाड़ी चलाने या मशीन चलाने से बचें। शराब का सेवन न करें। अगर आपको लीवर या किडनी की बीमारी, ग्लूकोमा, मूत्र रोक या अस्थमा है तो डॉक्टर को बताएं। 6 साल से छोटे बच्चों को बिना डॉक्टर की सलाह के न दें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 lemo p drop Uses & Benefits

[{"condition":"Common cold","description":"Relieves runny nose, sneezing, watery eyes, and mild fever associated with the common cold.","evidence":"Well-established"},{"condition":"Allergic rhinitis","description":"Reduces sneezing, rhinorrhea, and itching of the nose and throat due to allergies.","evidence":"Well-established"},{"condition":"Urticaria","description":"Provides relief from itching and skin rash associated with allergic urticaria.","evidence":"Well-established"},{"condition":"Mild pain and fever","description":"Paracetamol component helps reduce mild to moderate pain and fever.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Insomnia","description":"Sometimes used off-label for its sedative effects to promote sleep, but not recommended due to side effects.","evidence":"Limited"},{"condition":"Motion sickness","description":"Chlorpheniramine may be used off-label for motion sickness, but other agents are preferred.","evidence":"Limited"}]

Primary treatment for: Common cold and allergic rhinitis

Also treats: Urticaria, Allergic conjunctivitis, Mild pain and fever

📋 Drug Information

Generic Name(s)Chlorpheniramine Maleate (1mg) + Paracetamol (125mg)
Brand Namelemo p drop
ManufacturerYash Pharma Laboratories Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Avoid driving or operating heavy machinery until you know how this medicine affects you.
3
Do not consume alcohol while taking this medicine.
4
Do not exceed the recommended dose or duration without consulting your doctor.
5
Consult your doctor if symptoms persist beyond 7 days or worsen.
6
Inform your doctor if you have liver or kidney disease, glaucoma, or asthma.
7
Keep out of reach of children and store in a cool, dry place.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Runny nose
This medicine is commonly used for this symptom.
Likely Use
✅
Sneezing
This medicine helps relieve sneezing due to allergies.
Likely Use
✅
Mild fever
Paracetamol component reduces fever.
Likely Use
❌
Severe headache
This medicine is not a primary treatment for severe headache.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionChlorpheniramine is well absorbed from the gastrointestinal tract after oral administration. Paracetamol is also rapidly and completely absorbed from the gastrointestinal tract. Food may slightly delay the absorption of paracetamol but does not significantly affect the extent of absorption.
DistributionChlorpheniramine is widely distributed throughout the body, including the central nervous system. Paracetamol distributes rapidly into most body tissues. Both drugs cross the placenta and are excreted in breast milk.
Protein BindingChlorpheniramine is approximately 70% bound to plasma proteins. Paracetamol is only minimally bound to plasma proteins (about 10-25%).
MetabolismChlorpheniramine is metabolized in the liver primarily by cytochrome P450 enzymes, including CYP2D6 and CYP3A4. Paracetamol is metabolized in the liver via glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to a toxic intermediate (NAPQI) that is normally detoxified by glutathione.
Half-LifeThe elimination half-life of chlorpheniramine is approximately 12-15 hours in adults. The elimination half-life of paracetamol is about 2-3 hours in adults with normal liver function.
ExcretionChlorpheniramine and its metabolites are excreted primarily in the urine. Paracetamol metabolites are excreted in the urine, with about 90% of the dose excreted within 24 hours.
BioavailabilityChlorpheniramine has a bioavailability of about 25-50% due to first-pass metabolism. Paracetamol has a high oral bioavailability of about 80-100%.
Onset of ActionChlorpheniramine begins to relieve allergic symptoms within 30-60 minutes after oral administration. Paracetamol starts to reduce fever and pain within 30-60 minutes.
Peak Plasma TimeChlorpheniramine reaches peak plasma concentrations in about 2-6 hours. Paracetamol reaches peak plasma concentrations in about 0.5-2 hours.
Duration of ActionChlorpheniramine's effects last for about 4-6 hours, but drowsiness may persist longer. Paracetamol's analgesic and antipyretic effects last for about 4-6 hours.

How It Works

This medicine combines two active ingredients. Chlorpheniramine Maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, reducing allergic responses such as sneezing, runny nose, and itching. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which leads to reduction of fever and pain. The combination provides symptomatic relief from cold and allergy symptoms.

Mechanism Steps

1
Histamine H1 receptor blockade: Chlorpheniramine binds to H1 receptors on effector cells, preventing histamine from triggering allergic symptoms such as vasodilation, increased vascular permeability, and sensory nerve stimulation.
2
Central prostaglandin inhibition: Paracetamol inhibits prostaglandin synthesis in the central nervous system, which reduces fever and pain perception.
3
Anticholinergic effects: Chlorpheniramine also blocks muscarinic receptors, leading to drying of secretions, which helps relieve runny nose but may cause dry mouth and blurred vision.

💡 How to Take lemo p drop

Strength: Each 5 mL of syrup contains Chlorpheniramine Maleate 1 mg and Paracetamol 125 mg.

1Shake the bottle well before use.
2Use a measuring cup or spoon to measure the dose accurately.
3Take orally with or without food.
4Follow the prescribed dose and duration.
5Do not exceed the recommended dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 10 mL (2 teaspoons) every 4 to 6 hours as needed for symptoms, not to exceed 6 doses in 24 hours. However, the dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Follow your doctor's instructions carefully.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician. This medicine is not recommended for children under 6 years of age without medical advice.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and anticholinergic effects. Use with caution and lower doses may be required. Consult a doctor for appropriate dosing.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Paracetamol dose should be reduced or avoided in severe liver disease. Consult a doctor.
Maximum Daily DoseFor adults, the maximum daily dose is 60 mL (12 teaspoons) in 24 hours. Do not exceed this dose. For children, follow pediatrician's advice.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases drowsiness and risk of liver damage.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of lemo p drop

✅ Common Side Effects

Drowsiness (Common (10-20%))
Avoid driving or operating machinery. If persistent, consult your doctor.
Dry mouth (Common (5-10%))
Sip water frequently or chew sugarless gum. Consult doctor if severe.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. Avoid sudden movements.
Nausea (Uncommon (1-5%))
Take with food or milk to reduce stomach upset.
Blurred vision (Uncommon (1-5%))
Avoid tasks requiring clear vision. Consult doctor if persistent.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience swelling of face, lips, throat, difficulty breathing, or severe rash.
Liver damage (paracetamol toxicity) (Rare (<0.1%) with normal doses)
Seek immediate medical help if you notice yellowing of skin or eyes, dark urine, or severe abdominal pain.
Blood dyscrasias (Very rare (<0.01%))
Report unusual bleeding, bruising, or sore throat with fever to your doctor immediately.

⚠️ Rare Side Effects

Paradoxical excitation
More common in children and elderly; consult doctor if restlessness or insomnia occurs.
Urinary retention
Consult doctor if you have difficulty passing urine.
Photosensitivity
Avoid prolonged sun exposure and use sunscreen.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major
Alcohol Major
Warfarin Moderate
CNS depressants Moderate
Anticholinergics Moderate
Enzyme inducers Moderate
Antihypertensives Minor
Diuretics Minor

🚨 Major Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • Alcohol
  • Warfarin

⚡ Moderate Interactions

  • CNS depressants (e.g., benzodiazepines, opioids)
  • Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
  • Enzyme inducers (e.g., carbamazepine, phenytoin, rifampin)

🍷 Alcohol Interaction

Alcohol should be strictly avoided while taking this medicine. It can increase drowsiness and dizziness caused by chlorpheniramine and increase the risk of liver toxicity from paracetamol. Concurrent use may also impair judgment and coordination.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to chlorpheniramine, paracetamol, or any component","Severe liver disease or active liver disease","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","Severe asthma or respiratory depression","Newborns and premature infants","Concurrent use with MAO inhibitors"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery.","Avoid alcohol and other CNS depressants.","Do not exceed recommended dose due to risk of liver damage.","Use with caution in elderly and children.","Consult doctor if symptoms persist beyond 7 days or worsen.","Inform doctor if you have glaucoma, urinary retention, or asthma.","Do not use for self-medication in children under 6 years without medical advice."]

🤱 Lactation Safety

Chlorpheniramine and paracetamol are excreted in breast milk. Use with caution during breastfeeding. Consult your doctor to weigh benefits and risks.

💊 Overdose Management

Overdose can cause severe drowsiness, confusion, seizures, respiratory depression, and liver damage. Seek immediate medical attention. Treatment includes gastric lavage if within 1-2 hours, activated charcoal, and supportive care. N-acetylcysteine is the antidote for paracetamol toxicity and should be administered as soon as possible. Monitor liver function and vital signs.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Avoid driving or operating heavy machinery until you know how this medicine affects you. Avoid consuming alcohol while taking this medicine as it can increase drowsiness and the risk of liver damage. Inform your doctor if you have liver or kidney disease, glaucoma, urinary retention, asthma, or if you are pregnant or breastfeeding. Do not use this medicine for children under 6 years without medical advice. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more susceptible to the side effects of this medicine, particularly drowsiness, dizziness, confusion, and anticholinergic effects such as dry mouth, constipation, and urinary retention. Use with caution and lower doses may be necessary. Consult a doctor for appropriate dosing.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant or are pregnant, consult your doctor before taking this medicine. The safety of this combination during pregnancy is not well established. Your doctor will weigh the benefits and risks.

🏥 Post-Surgery Considerations

Consult your doctor before taking this medicine after surgery, as it may interact with other medications or affect recovery. It may also increase the risk of bleeding or drowsiness.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure. It may cause dry mouth and drowsiness, and interact with anesthetics or other medications used during dental work.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to reduce dry mouth and thin mucus.
🥗
Get plenty of rest to help your body recover from cold or allergies.
😴
Use a humidifier to ease nasal congestion.
💧
Avoid known allergens such as dust, pollen, and pet dander.
🧘
Practice good hand hygiene to prevent spreading infections.

🏋️ Exercise Considerations

Avoid strenuous exercise while taking this medicine, especially if you feel drowsy or dizzy. Light activities like walking may be fine, but listen to your body and rest if needed.

🥗 Diet Recommendations

Drink warm fluids like soups and herbal teas.
Include vitamin C-rich fruits and vegetables.
Avoid alcohol and caffeine.
Eat light, easily digestible meals.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It is advisable to avoid these activities until you know how the medicine affects you. Inform your employer if your work requires alertness.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it regularly for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended without medical supervision. Prolonged use of chlorpheniramine may lead to tolerance and dependence. Paracetamol, if taken in high doses over time, can cause liver damage. Regular monitoring of liver and kidney function may be required if used for extended periods.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Saline nasal rinse

Helps clear nasal congestion and allergens.

Evidence: Well-established
Steam inhalation

Can relieve nasal congestion and soothe irritated airways.

Evidence: Limited
Allergen avoidance

Reducing exposure to allergens can prevent allergy symptoms.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying medications. Avoid driving or operating machinery after taking this medicine, especially during travel.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 30-year-old woman with allergic rhinitis
She experienced frequent sneezing, runny nose, and itchy eyes during pollen season. Her doctor prescribed this medicine. She took it as directed and noticed significant relief within an hour. She was advised to avoid driving due to drowsiness.
💡 Lesson: This medicine effectively relieves allergy symptoms but can cause drowsiness, so plan activities accordingly.
👤 A 45-year-old man with common cold and mild fever
He had a runny nose, sneezing, and body ache. He took this medicine every 6 hours as needed. His symptoms improved within a day, but he experienced dry mouth. He stayed hydrated and the dryness subsided.
💡 Lesson: Taking this medicine as prescribed helps relieve cold symptoms; staying hydrated can reduce dry mouth.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30-60 minutes after oral administration.

Q: Can I take it on an empty stomach?

A: It can be taken with or without food, but taking it with food may reduce stomach upset.

Q: Is it safe for children?

A: It is not recommended for children under 6 years without medical advice. Consult a pediatrician for appropriate dosing.

Q: Can I take it during pregnancy?

A: Consult your doctor before use during pregnancy. The safety profile is not well established.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for lemo p drop

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure the common cold.
    Fact: This medicine only relieves symptoms; it does not cure the underlying viral infection.
  • Myth: It is safe to take extra doses for faster relief.
    Fact: Taking more than the recommended dose can cause serious liver damage and increased side effects.
  • Myth: It is safe to take with alcohol.
    Fact: Alcohol increases drowsiness and the risk of liver toxicity; it should be avoided.

🔄 Alternative Options

Generic Alternatives

  • Chlorpheniramine Maleate + Paracetamol syrup

Brand Alternatives

  • Alersafe Cold Syrup

📊 Comparison with Similar Medicines

[{"medicine":"Alersafe Cold Syrup","active_ingredients":"Chlorpheniramine Maleate 1mg + Paracetamol 125mg per 5mL","onset":"30-60 minutes","duration":"4-6 hours","sedation":"High"},{"medicine":"Cetirizine + Paracetamol syrup","active_ingredients":"Cetirizine 5mg + Paracetamol 125mg per 5mL","onset":"30-60 minutes","duration":"12-24 hours","sedation":"Low"}]

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