Duovir Ep 150 Mg/300 Mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe upper abdominal pain spreading to the back, with nausea or vomiting
- Rapid breathing, extreme tiredness, or muscle pain with stomach pain
- Yellowing of the eyes or skin, dark urine, or pale stools
- Unusual bleeding, bruising, or tiny red spots on the skin
- Fever with rash, swelling of the face or lips, or difficulty breathing
- Persistent vomiting or inability to keep fluids down
- Sudden weakness, confusion, or fainting
- Decreased urine output or swelling of the legs
If experiencing severe symptoms, call emergency services immediately.
What is lazid-e kit used for?
This medicine is a combination of lamivudine 150 mg and zidovudine 300 mg used as part of HIV treatment. It blocks the virus from copying itself, helping to lower viral load and support the immune system. It must be taken exactly as prescribed with regular blood tests and specialist follow-up.
- Generic Name: Lamivudine (150mg) + Zidovudine (300mg)
- Manufacturer: Emcure Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 lazid-e kit के बारे में (Hindi Summary)
उपयोग: यह दवा लैमिव्यूडीन 150 मिलीग्राम और ज़िडोव्यूडीन 300 मिलीग्राम का संयोजन है, जिसका उपयोग एचआईवी (HIV) संक्रमण के इलाज के हिस्से के रूप में किया जाता है। यह वायरस को शरीर में फैलने से रोकने में मदद करती है और रोग प्रतिरोधक क्षमता को सुधारने में सहायक होती है। इसे एचआईवी विशेषज्ञ की सलाह के अनुसार ही लेना चाहिए और बीच में बंद नहीं करना चाहिए। यह दवा एचआईवी का इलाज पूरी तरह से नहीं करती, लेकिन नियमित रूप से लेने पर वायरस को नियंत्रण में रखती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, जी मिचलाना, उल्टी, पेट में असहजता, थकान, चक्कर आना और नींद न आना शामिल हैं। कुछ लोगों में खून की कमी, सफेद रक्त कोशिकाओं की कमी, लिवर की समस्या, पैन्क्रियाज की सूजन या लैक्टिक एसिडोसिस जैसी गंभीर समस्याएं भी हो सकती हैं। अगर आपको बहुत अधिक कमजोरी, सांस लेने में तकलीफ, पेट में तेज दर्द, आंखों या त्वचा का पीला पड़ना, या बार-बार संक्रमण हो रहा है, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें और अपनी मर्जी से बंद या डोज़ कम-ज्यादा न करें। इसे पानी के साथ निगलें; खाने के साथ लेने से पेट की तकलीफ कम हो सकती है। नियमित रूप से खून की जांच, लिवर और किडनी की जांच कराते रहें। शराब न लें, क्योंकि इससे लिवर और पेट की समस्याएं बढ़ सकती हैं। अपने डॉक्टर को अन्य सभी दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में बताएं। गर्भावस्था की योजना बनाने से पहले विशेषज्ञ से सलाह लें। यह दवा किसी और के साथ साझा न करें।
💊 lazid-e kit Uses & Benefits
[{"condition":"Human immunodeficiency virus (HIV) infection","description":"Used as part of combination antiretroviral therapy to suppress HIV viral load and improve immune function in adults and adolescents.","evidence":"Well-established"},{"condition":"Prevention of mother-to-child transmission of HIV","description":"May be used in specific regimens under specialist guidance to reduce the risk of HIV transmission from mother to child.","evidence":"Well-established in specialist settings"},{"condition":"Post-exposure prophylaxis (PEP) for HIV","description":"May be included in some PEP regimens after occupational or non-occupational exposure, as decided by a specialist.","evidence":"Established in guideline-based regimens"}]
Off-label uses: [{"condition":"Hepatitis B virus (HBV) infection","description":"Lamivudine, one component of this medicine, has activity against hepatitis B virus and has been used in some patients with HBV, but this combination is not a standard first-line treatment for HBV alone.","evidence":"Limited"}]
Primary treatment for: Human immunodeficiency virus (HIV) infection
Also treats: Hepatitis B virus infection (due to lamivudine component, under specialist care), HIV-related opportunistic infections (as part of combination therapy)
📋 Drug Information
| Generic Name(s) | Lamivudine (150mg) + Zidovudine (300mg) |
| Brand Name | lazid-e kit |
| Manufacturer | Emcure Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature, between 15°C and 30°C, in a dry place. Keep it in the original container with the lid tightly closed. Protect it from direct sunlight and moisture. Do not store it in the bathroom. Keep all medicines out of the reach of children and pets. |
| Shelf Life | Not established from the available information. Always check the expiry date printed on the pack and do not use the medicine after that date. |
| WHO Guideline | Not established from the available information. HIV treatment guidelines are updated regularly, and this combination should be used according to current national or international HIV treatment guidelines under specialist care. |
| ICMR Guideline | Not established from the available information. In India, HIV treatment is guided by national program guidelines and specialist advice. Patients should follow the regimen prescribed by their treating HIV specialist. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two nucleoside reverse transcriptase inhibitors. Lamivudine and zidovudine are taken up by cells and converted into active triphosphate forms. These active forms compete with natural building blocks of viral DNA and are incorporated into the growing viral DNA chain, where they block further chain elongation. This stops HIV from copying its genetic material and prevents the virus from multiplying. Because the two ingredients act at the same viral enzyme through slightly different chemical forms, they work together to provide stronger viral suppression than either alone.
Mechanism Steps
💡 How to Take lazid-e kit
Strength: Immediate-release tablet containing lamivudine 150 mg and zidovudine 300 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this fixed-dose combination is one tablet taken orally once or twice daily, depending on the full antiretroviral regimen prescribed by the HIV specialist. The exact schedule depends on kidney function, liver function, blood counts, other medicines, and the overall treatment plan. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Never change the dose or stop the medicine without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this exact fixed-dose combination. Children and adolescents living with HIV should be treated by a pediatric HIV specialist using weight-based and age-appropriate formulations. Consult a pediatrician. |
| Elderly Dosage | Older adults may be more sensitive to the blood count and liver effects of this medicine. Kidney function often declines with age, and lamivudine removal depends on the kidneys, so kidney function should be checked and the dose adjusted by a clinician if needed. Regular monitoring of blood counts and liver tests is especially important in this age group. |
| Renal Impairment | Lamivudine is removed mainly by the kidneys, so kidney impairment can increase its levels. The dose and dosing interval may need to be adjusted by a clinician based on creatinine clearance or estimated glomerular filtration rate. Zidovudine removal is less dependent on the kidneys, but blood counts should still be monitored. Do not adjust the dose on your own. |
| Hepatic Impairment | Zidovudine is metabolized in the liver, so liver impairment can increase its levels and the risk of side effects. This medicine should be used with caution in people with liver disease, and liver function tests should be checked regularly. In severe liver impairment, the medicine may not be suitable. Dose adjustments must be decided by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information for this fixed-dose combination. The prescribed dose depends on the full antiretroviral regimen and the patient's kidney and liver function. Do not exceed the dose prescribed by your HIV specialist. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of lazid-e kit
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Stavudine | Major | |
| Doxorubicin | Major | |
| Ribavirin | Major | |
| Probenecid | Moderate | |
| Fluconazole | Moderate | |
| Valproic acid | Moderate | |
| Clarithromycin | Moderate | |
| Paracetamol | Minor | |
| Cimetidine | Minor | |
| Indomethacin | Minor |
🚨 Major Interactions
- Stavudine
- Doxorubicin
- Ribavirin
- Bone marrow suppressants
⚡ Moderate Interactions
- Probenecid
- Fluconazole
- Valproic acid
- Clarithromycin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Both zidovudine and alcohol can stress the liver, and alcohol may worsen nausea, vomiting, and fatigue. People with HIV should also avoid excessive alcohol because it can reduce adherence to treatment and increase risky behaviors.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to lamivudine, zidovudine, or any ingredient of this medicine","Severe low blood counts, such as very low hemoglobin or very low neutrophil count, unless specialist decides otherwise","Severe liver impairment or unexplained persistent liver test abnormalities","Use with stavudine because of antagonism and toxicity","Not for use as a single medicine for HIV; it must be part of a complete antiretroviral regimen"]
⚠️ Warnings & Precautions
["This medicine is not a cure for HIV and must be used with other antiretroviral medicines.","Do not stop or change the dose without talking to your HIV specialist, as the virus can become resistant.","Blood counts can drop, so regular blood tests are needed.","Lactic acidosis and severe liver problems can occur and may be life-threatening.","Pancreatitis has been reported and requires urgent medical care.","Tell your doctor if you have kidney or liver disease, as dose adjustments may be needed.","Avoid alcohol and discuss all other medicines, supplements, and herbal products with your doctor.","Use effective contraception and discuss pregnancy plans with your specialist."]
🤱 Lactation Safety
Breastfeeding is generally not recommended for mothers living with HIV in settings where safe infant feeding alternatives are available, because HIV can pass to the baby through breast milk. This medicine may also pass into breast milk. Infant feeding decisions must be made with an HIV specialist and pediatrician.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. If a large overdose is taken, seek emergency medical care immediately. Treatment is supportive and may include monitoring of blood counts, liver function, kidney function, and vital signs. Hemodialysis may help remove lamivudine but has limited effect on zidovudine. Do not try to vomit unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is less than half the usual dosing interval away. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure, contact your HIV clinic or pharmacist for advice.
Additional Safety Advice
Take this medicine exactly as prescribed by your HIV specialist and do not change the dose or stop it on your own. Swallow the tablet whole with water, with or without food, but taking it with food may reduce stomach upset. Keep all scheduled blood tests, including complete blood counts and liver function tests, because this medicine can affect blood cells and the liver. Tell your doctor about all other medicines, supplements, and herbal products you use, as many can interact with this medicine. Avoid alcohol because it can worsen liver and stomach side effects. Do not share this medicine with anyone else. If you miss a dose, follow your doctor's instructions and do not double the next dose. Use effective contraception and discuss pregnancy plans with your doctor, as this medicine may affect the baby and requires specialist care during pregnancy.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may have reduced kidney function and other health conditions that affect how this medicine is handled. Blood counts and liver tests should be monitored closely. The risk of anemia and other side effects may be higher. Doses may need adjustment based on kidney function. Discuss all other medicines with your doctor to avoid interactions.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, talk to your HIV specialist before conceiving. This medicine may be continued or changed depending on your health, viral load, and the safety of the regimen for the baby. Good viral control before pregnancy reduces the risk of passing HIV to the baby. Use effective contraception until your doctor says it is safe to conceive.
🏥 Post-Surgery Considerations
Tell your surgeon and anesthesiologist that you are taking this medicine. It should generally be continued during surgery and recovery, but the timing of doses may need to be adjusted if you cannot take anything by mouth. Blood counts and liver function may be checked more often after surgery. Do not stop the medicine without your HIV specialist's advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. There is no need to stop it for routine dental work, but your dentist should know about your HIV status and medicines to plan safe care. Good oral hygiene is important because HIV and some medicines can affect the mouth and gums. If you have low blood counts, your dentist may take extra precautions to prevent bleeding or infection.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally encouraged, but if you feel very tired, dizzy, or breathless, stop and rest. People with anemia or muscle weakness should avoid strenuous activity until their doctor says it is safe. Always warm up and stay hydrated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
Most people can continue their usual work and daily activities while taking this medicine. If you feel dizzy, very tired, or unwell, avoid driving or operating heavy machinery until you feel better. Keep your medicine with you if you work long hours, and inform your employer only if you are comfortable and it is necessary for accommodations.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Stopping suddenly can cause the virus to rebound and become resistant. Your HIV specialist may change or stop the medicine if you develop serious side effects, your kidney or liver function changes, or your treatment plan needs to be updated. Always consult your doctor before stopping.
📅 Long-Term Use Effects
Long-term use of this medicine can cause blood count problems, muscle weakness, fat redistribution, and liver or pancreatic issues. Regular monitoring of blood counts, liver function, kidney function, and viral load is needed. Some people develop resistance if doses are missed. Long-term adherence to effective HIV treatment helps prevent AIDS-related complications and improves quality of life.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Your HIV specialist may choose different combinations of antiretroviral medicines based on resistance testing, side effects, and other health conditions.
Evidence: Well-establishedCounseling, reminders, and support groups can help you take your medicine consistently.
Evidence: Well-establishedA balanced diet supports immune function and overall health during HIV treatment.
Evidence: Supportive💉 Vaccination Considerations
💉 If You're Getting Vaccinated
People living with HIV should discuss vaccinations with their doctor. Inactivated vaccines are generally safe, but live vaccines may not be suitable if the immune system is very weak. Vaccines for influenza, hepatitis B, pneumococcal disease, and others may be recommended based on your CD4 count and overall health. Timing of vaccinations should be planned with your HIV specialist.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not store in excessive heat or direct sunlight
✅ DO
Keep in the original container with the lid tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from moisture and out of reach of children
❌ DON'T
Do not store in the bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription and a doctor's letter stating your diagnosis and medicines. Carry enough supply for your entire trip plus extra in case of delays. Keep it in your hand luggage, away from heat and direct sunlight. If you cross time zones, ask your HIV specialist how to adjust the timing of doses so you do not miss any. Check local customs rules for carrying prescription medicines and keep all documents handy. Do not stop treatment while traveling.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts reducing HIV viral load within days to weeks, but the full benefit on immune function takes weeks to months. Your doctor will check your viral load regularly to see how well it is working.
A: No. This medicine controls HIV but does not cure it. It must be taken consistently as part of lifelong treatment to keep the virus suppressed.
A: Avoid driving or operating machinery until you know how this medicine affects you. Tell your doctor if dizziness is persistent or severe.
A: Occasional paracetamol is usually acceptable, but tell your doctor if you use it regularly because it may rarely affect blood counts when combined with zidovudine.
A: Even with effective HIV treatment, using condoms helps prevent transmission of HIV and other sexually transmitted infections. Discuss safe sex practices with your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for lazid-e kit
View AllAlternative brands with exact same active ingredient:
-
cytocom e 150 mg/300 mg/600 mg tabletAlkem Laboratories Ltd ₹108.00 0.5% COSTLIER
-
virocomb e 150mg/300mg/600mg kitSun Pharmaceutical Industries Ltd ₹110.81 3.1% COSTLIER
-
duovir-e kitCipla Ltd ₹129.47 20.4% COSTLIER
-
cytocom 150 mg/300 mg tabletAlkem Laboratories Ltd ₹190.38 77.1% COSTLIER
-
Nexvir Z TabletNexus India ₹210.94 96.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure HIV.
Fact: This medicine controls HIV but does not cure it. It must be taken consistently as part of lifelong treatment. - Myth: I can stop this medicine once my viral load is undetectable.
Fact: Stopping treatment can cause the virus to rebound and become resistant. Only a specialist should decide about changes. - Myth: This medicine can be shared with a partner who also has HIV.
Fact: HIV treatment must be individualized. Never share prescription medicines with anyone else. - Myth: Side effects mean the medicine is not working.
Fact: Many side effects are manageable and do not mean treatment failure. Report them to your doctor.
🔄 Alternative Options
Generic Alternatives
- Lamivudine 150 mg + Zidovudine 300 mg tablet (generic versions may be available)
Brand Alternatives
- Duovir EP 150 mg/300 mg tablet