duovir-e kit - Uses, Price, Side Effects & Substitutes
What is duovir-e kit used for?
Combivir (Lamivudine + Zidovudine) is used to treat ANTI INFECTIVES. It contains Lamivudine (150mg) + Zidovudine (300mg), which Lamivudine and Zidovudine are nucleoside analogs that inhibit HIV reverse transc. Always consult your doctor before use. Take as prescribed.
- Generic Name: Lamivudine + Zidovudine
- Manufacturer: Cipla Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ duovir-e kit Uses & Benefits
Treatment of HIV-1 infection in combination with other antiretroviral agents.
Off-label uses: Post-exposure prophylaxis (PEP) for HIV; prevention of mother-to-child transmission (PMTCT).
๐ Drug Information
| Generic Name(s) | Lamivudine + Zidovudine |
| Brand Name | Combivir |
| Manufacturer | Cipla Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Nucleoside Reverse Transcriptase Inhibitors (NRTIs) |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Lamivudine and Zidovudine are nucleoside analogs that inhibit HIV reverse transcriptase, causing chain termination of viral DNA synthesis.
Mechanism Steps
๐ก How to Take duovir-e kit
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of duovir-e kit
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Headache
- Fatigue
- Anemia
- Neutropenia
๐จ Serious Side Effects
- Lactic acidosis
- Severe hepatomegaly with steatosis
- Bone marrow suppression
- Pancreatitis
- Peripheral neuropathy
โ ๏ธ Rare Side Effects
- Lipodystrophy
- Myopathy
- Cardiomyopathy
- Seizures
- Anaphylaxis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Stavudine | Major | Antagonistic effect; decreased antiviral activity |
| Doxorubicin | Major | Increased risk of bone marrow suppression |
| Ribavirin | Major | Antagonistic effect; decreased phosphorylation of zidovudine |
| Ganciclovir | Major | Increased risk of hematologic toxicity |
| Interferon alfa | Major | Increased risk of hepatotoxicity |
| Methadone | Moderate | Increased zidovudine levels; monitor for toxicity |
| Probenecid | Moderate | Decreased renal clearance of zidovudine; increased levels |
| Valproic acid | Moderate | Increased zidovudine levels; monitor for toxicity |
| Fluconazole | Moderate | Increased zidovudine levels; monitor for toxicity |
| Atovaquone | Moderate | Increased zidovudine levels; monitor for toxicity |
| Acetaminophen | Minor | Possible increased risk of hepatotoxicity |
| Cimetidine | Minor | Decreased renal clearance of zidovudine |
| Ranitidine | Minor | Decreased renal clearance of zidovudine |
| Trimethoprim/sulfamethoxazole | Minor | Increased lamivudine levels |
๐จ Major Interactions
- Stavudine
- Doxorubicin
- Ribavirin
- Ganciclovir
- Interferon alfa
โก Moderate Interactions
- Methadone
- Probenecid
- Valproic acid
- Fluconazole
- Atovaquone
โน๏ธ Minor Interactions
- Acetaminophen
- Cimetidine
- Ranitidine
- Trimethoprim/sulfamethoxazole
๐ฝ๏ธ Food Interactions
No significant food interactions; may be taken with or without food.
๐ท Alcohol Interaction
Alcohol may increase the risk of hepatotoxicity; avoid excessive alcohol consumption.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to lamivudine or zidovudine; severe bone marrow suppression; concomitant use with stavudine or ribavirin.
๐ Monitoring Parameters
HIV viral load, CD4 count, complete blood count, liver function tests, renal function tests.
๐คฑ Lactation Safety
Not recommended; HIV-infected mothers should not breastfeed to avoid transmission.
๐ Overdose Management
Supportive care; monitor for hematologic toxicity; hemodialysis may remove lamivudine and zidovudine.
โฐ Missed Dose
Take as soon as remembered unless it is almost time for the next dose; do not double dose.