Afix SB 200mg/150mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: swelling of face, lips, throat, difficulty breathing.
- Persistent watery diarrhea, fever, or abdominal cramps (possible C. difficile infection).
- Signs of liver problems: yellowing of skin or eyes, dark urine, severe fatigue.
- Unusual bleeding or bruising.
- Decreased urine output or swelling in legs.
- Seizures or severe headache with confusion.
If experiencing severe symptoms, call emergency services immediately.
What is kyocef-sb 200mg/150mg tablet used for?
This medicine is a combination antibiotic containing cefixime and sulbactam, used to treat various bacterial infections. It works by killing bacteria and is taken orally as prescribed by a doctor.
- Generic Name: Cefixime (200mg) + Sulbactam (150mg)
- Manufacturer: Lifekyor Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kyocef-sb 200mg/150mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सेफिक्सिम और सल्बैक्टम का संयोजन है, जिसका उपयोग बैक्टीरियल संक्रमणों जैसे श्वसन तंत्र, मूत्र मार्ग और त्वचा के संक्रमण के इलाज के लिए किया जाता है। यह केवल डॉक्टर के पर्चे पर ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, पेट दर्द और सिरदर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दाने हों तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। दवा को पानी के साथ निगलें। इसे भोजन के साथ या बिना भोजन के लिया जा सकता है। गुर्दे या यकृत की समस्या होने पर डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 kyocef-sb 200mg/150mg tablet Uses & Benefits
[{"condition":"Respiratory tract infections","description":"Used to treat bacterial infections of the upper and lower respiratory tract, including pharyngitis, tonsillitis, sinusitis, and community-acquired pneumonia when caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against uncomplicated and complicated urinary tract infections caused by susceptible Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Prescribed for bacterial skin infections such as cellulitis, abscesses, and wound infections when beta-lactamase-producing bacteria are suspected.","evidence":"Well-established"},{"condition":"Gonorrhea","description":"Cefixime is used as part of combination therapy for uncomplicated gonococcal infections, though local resistance patterns should be considered.","evidence":"Established"},{"condition":"Otitis media","description":"May be used for middle ear infections in patients where other antibiotics are not suitable, based on culture and sensitivity.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prophylaxis in dental procedures","description":"Occasionally used off-label for prevention of infection in certain dental procedures for patients at risk, but not a standard recommendation.","evidence":"Limited"},{"condition":"Traveler's diarrhea","description":"Sometimes prescribed off-label for severe traveler's diarrhea caused by susceptible bacteria, but routine use is discouraged.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Skin infections
📋 Drug Information
| Generic Name(s) | Cefixime (200mg) + Sulbactam (150mg) |
| Brand Name | kyocef-sb 200mg/150mg tablet |
| Manufacturer | Lifekyor Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines cefixime, a third-generation cephalosporin antibiotic, with sulbactam, a beta-lactamase inhibitor. Cefixime works by binding to penicillin-binding proteins (PBPs) on the bacterial cell wall, inhibiting the final step of peptidoglycan synthesis, which leads to bacterial cell lysis and death. Sulbactam irreversibly inhibits certain beta-lactamase enzymes produced by bacteria, preventing them from hydrolyzing cefixime and thus extending its antibacterial spectrum against beta-lactamase-producing organisms. This combination is bactericidal.
Mechanism Steps
💡 How to Take kyocef-sb 200mg/150mg tablet
Strength: Cefixime 200 mg and Sulbactam 150 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally every 12 hours or as prescribed by your doctor. The exact dose and duration depend on the type and severity of the infection, your kidney function, and other factors. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function and may require dose adjustment. Dose must be individualized by a qualified clinician based on renal function. |
| Renal Impairment | In patients with renal impairment, dose adjustment is required. For creatinine clearance between 20 and 40 mL/min, the dose may need to be reduced. For creatinine clearance less than 20 mL/min, further reduction or alternative therapy may be necessary. Consult a clinician for individualized dosing. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution and monitor liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is 400 mg of cefixime and 300 mg of sulbactam, but this may vary based on clinical judgment. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kyocef-sb 200mg/150mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Carbamazepine | Major | |
| Oral contraceptives | Moderate | |
| Probenecid | Moderate | |
| Furosemide | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor |
🚨 Major Interactions
- Warfarin
- Carbamazepine
- Oral contraceptives
⚡ Moderate Interactions
- Probenecid
- Loop diuretics (e.g., furosemide)
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal side effects such as nausea and diarrhea. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to cefixime, sulbactam, or other cephalosporins","History of severe immediate hypersensitivity reaction to penicillins","Previous anaphylactic reaction to beta-lactam antibiotics"]
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment; dose adjustment may be needed.","Use with caution in patients with a history of gastrointestinal disease, especially colitis.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.","May cause false-positive results in urine glucose tests using copper reduction methods.","Not effective against viral infections; do not use for colds or flu.","Avoid use in patients with a history of penicillin allergy unless the benefit clearly outweighs the risk."]
🤱 Lactation Safety
Cefixime is excreted in human breast milk in small amounts. Sulbactam is also excreted in breast milk. Caution is advised when administering this medicine to a nursing mother. Consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, diarrhea, and abdominal pain. In case of overdose, seek immediate medical attention. Treatment is symptomatic and supportive. Hemodialysis may be considered in severe cases, but cefixime is not significantly removed by dialysis.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop the course early, even if you start feeling better, because incomplete treatment can lead to bacterial resistance. Swallow the tablet whole with a glass of water. It can be taken with or without food, but taking it with food may reduce stomach upset. Inform your doctor if you have kidney problems, liver problems, or a history of allergies to antibiotics. Avoid alcohol while taking this medicine, as it may worsen side effects. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Do not share this medicine with others. Keep it out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function and may require dose adjustment. They may also be more susceptible to side effects. Close monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Cefixime is generally considered safe in pregnancy, but sulbactam's safety is not well established.
🏥 Post-Surgery Considerations
This medicine may be prescribed to prevent or treat surgical site infections. Follow your surgeon's instructions carefully.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may be used prophylactically before certain dental procedures in patients at risk of infection.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild exercise is generally safe, but if you feel weak or dizzy, avoid strenuous activities. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. If affected, avoid driving or operating heavy machinery until you know how it affects you. Otherwise, it should not significantly impact your daily activities.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to relapse and antibiotic resistance. If you experience serious side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless prescribed for a specific chronic infection. Prolonged use may lead to bacterial resistance, fungal overgrowth, and rarely, blood or kidney abnormalities. Regular monitoring may be required if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection and culture results, other antibiotics may be prescribed.
Evidence: Well-establishedRest, hydration, and symptomatic treatment can complement antibiotic therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are due for a vaccine, inform your doctor, as antibiotics may be given for an active infection.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust dosing times gradually under medical guidance. Check local customs regulations regarding antibiotics before travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it is important to complete the full course as prescribed.
A: Yes, you can take it with or without food. If it upsets your stomach, take it with a meal.
A: Take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for kyocef-sb 200mg/150mg tablet
View AllAlternative brands with exact same active ingredient:
-
aelxim-sl tabletAllenge India ₹157.50 49.1% CHEAPER
-
Tabocef S 200mg/150mg TabletAlbia Biocare ₹280.31 9.4% CHEAPER
-
cefivin sb 200mg/150mg tabletAsvins Lifecare ₹285.00 7.9% CHEAPER
-
Fixlen SB 200mg/150mg TabletAlicia Healthcare ₹322.00 4.1% COSTLIER
-
bactwar 200mg/150mg tabletSolariz Healthcare Private Limited ₹325.00 5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure viral infections like the common cold.
Fact: This medicine is effective only against bacterial infections. It does not treat viral infections. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full prescribed course to prevent bacterial resistance and relapse. - Myth: Antibiotics can be shared with others.
Fact: Antibiotics are prescribed for specific infections and should never be shared.
🔄 Alternative Options
Generic Alternatives
- Cefixime 200 mg + Sulbactam 150 mg tablet
Brand Alternatives
- Afix SB 200mg/150mg Tablet