Alkem Plus Syrup: Complete Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe abdominal pain or yellowing of the eyes or skin
- Blood in vomit or black, tarry stools
- Unusual bruising or bleeding
- Severe drowsiness or confusion
- Decreased urine output
- Persistent fever for more than 3 days
If experiencing severe symptoms, call emergency services immediately.
What is koldcet p tablet used for?
This medicine is a combination syrup of cetirizine and paracetamol used to treat symptoms of allergies and cold, such as sneezing, runny nose, itching, fever, and mild pain. It works by blocking histamine and reducing fever and pain.
- Generic Name: Cetirizine (NA) + Paracetamol (NA)
- Manufacturer: Alchemist Life Science Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 koldcet p tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एलर्जी और सर्दी-जुकाम के लक्षणों जैसे छींक आना, नाक बहना, खुजली, बुखार और हल्के दर्द से राहत दिलाने के लिए इस्तेमाल की जाती है। इसमें सेटिरिज़िन और पैरासिटामोल दो सक्रिय तत्व होते हैं। सेटिरिज़िन एलर्जी को कम करता है और पैरासिटामोल दर्द और बुखार को कम करता है। यह सिरप बच्चों और बड़ों दोनों के लिए उपलब्ध है, लेकिन इसका उपयोग डॉक्टर की सलाह के अनुसार ही करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुँह सूखना, थकान और हल्का पेट दर्द शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभावों में एलर्जी की प्रतिक्रिया, सांस लेने में कठिनाई, चकत्ते, या लीवर की क्षति (पैरासिटामोल की अधिक मात्रा से) शामिल हो सकते हैं। यदि कोई भी दुष्प्रभाव गंभीर हो या बना रहे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर की सलाह के बिना न लें। निर्धारित मात्रा से अधिक न लें। इस दवा को लेने के बाद नींद आ सकती है, इसलिए वाहन चलाने या मशीनरी चलाने से बचें। शराब का सेवन न करें क्योंकि इससे नींद और लीवर की समस्या बढ़ सकती है। यदि आपको लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। बच्चों को डॉक्टर की सलाह के बिना न दें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से परामर्श करें।
💊 koldcet p tablet Uses & Benefits
[{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, itchy and watery eyes, and nasal congestion associated with seasonal or perennial allergies.","evidence":"Well-established"},{"condition":"Urticaria","description":"Reduces itching and hives associated with acute or chronic urticaria.","evidence":"Well-established"},{"condition":"Common cold","description":"Provides symptomatic relief from fever, body ache, and allergic symptoms like sneezing and runny nose.","evidence":"Commonly used, though evidence for combination is limited"},{"condition":"Allergic conjunctivitis","description":"Helps reduce itching and redness in the eyes due to allergies.","evidence":"Supportive"}]
Off-label uses: [{"condition":"Mild anxiety","description":"Sometimes used off-label for its sedative effects, but not recommended due to lack of evidence and potential side effects.","evidence":"Limited"},{"condition":"Insomnia","description":"Occasionally used off-label for short-term sleep aid, but not a standard treatment.","evidence":"Limited"}]
Primary treatment for: Allergic rhinitis
Also treats: Urticaria, Common cold, Allergic conjunctivitis
📋 Drug Information
| Generic Name(s) | Cetirizine (NA) + Paracetamol (NA) |
| Brand Name | koldcet p tablet |
| Manufacturer | Alchemist Life Science Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Do not freeze. Keep the bottle tightly closed. |
| Shelf Life | 24 months from the date of manufacture, or as indicated on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Cetirizine is a selective antagonist of the histamine H1 receptor. It competes with histamine for binding sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract, thereby reducing allergic symptoms such as sneezing, itching, and vasodilation. Paracetamol's mechanism is not fully understood, but it is believed to act primarily in the central nervous system by inhibiting prostaglandin synthesis, possibly through interaction with the COX-3 enzyme variant, and by modulating descending serotonergic pathways. This results in analgesic and antipyretic effects without significant anti-inflammatory action.
Mechanism Steps
💡 How to Take koldcet p tablet
Strength: Syrup containing cetirizine and paracetamol. Exact strengths not specified in the available information.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 mL to 10 mL (one to two teaspoons) taken orally every 4 to 6 hours as needed for symptoms, not to exceed 4 doses in 24 hours. However, the exact dose depends on the indication, severity of symptoms, and individual patient factors. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the sedative effects of cetirizine and may have reduced liver or kidney function, requiring lower doses. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, dose reduction may be necessary, especially for cetirizine. Consult a doctor for appropriate dosing. |
| Hepatic Impairment | In patients with hepatic impairment, paracetamol dose should be reduced or avoided due to risk of liver toxicity. Consult a doctor for appropriate dosing. |
| Maximum Daily Dose | The maximum daily dose should not exceed 4 doses of the recommended strength in 24 hours. For paracetamol, the maximum daily dose is generally 4 grams for adults, but this may be lower with this combination. Follow your doctor's instructions. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of koldcet p tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Ketoconazole | Moderate | |
| Isoniazid | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Alcohol
- Other antihistamines, sedatives, or hypnotics
⚡ Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
- CYP2E1 inducers (e.g., isoniazid)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol increases the sedative effects of cetirizine and enhances the risk of liver toxicity from paracetamol, even at therapeutic doses. Chronic alcohol use can also induce liver enzymes, increasing the production of toxic paracetamol metabolites.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to cetirizine, paracetamol, or any component of the formulation","Severe liver disease or active liver disease","Severe kidney impairment (creatinine clearance
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not exceed the recommended dose of paracetamol; overdose can cause severe liver damage.","Avoid alcohol while taking this medicine.","Use with caution in patients with liver or kidney disease.","Consult a doctor before use in pregnancy or breastfeeding.","Do not use for more than 5 days for pain or 3 days for fever without medical advice.","Keep out of reach of children."]
🤱 Lactation Safety
Cetirizine is excreted in breast milk in small amounts and may cause drowsiness in the infant. Paracetamol is also excreted in breast milk but is generally considered safe. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can lead to severe liver damage from paracetamol and increased sedation from cetirizine. Symptoms of paracetamol overdose may not appear immediately and can include nausea, vomiting, abdominal pain, and yellowing of skin or eyes. If overdose is suspected, seek immediate medical attention even if you feel well. Treatment may include administration of N-acetylcysteine as an antidote for paracetamol toxicity, and supportive care for cetirizine effects. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Do not exceed the recommended dose of this medicine. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness. Do not consume alcohol while taking this medicine because it can increase drowsiness and the risk of liver damage from paracetamol. Inform your doctor if you have liver or kidney disease, or if you are taking other medications, especially blood thinners, other antihistamines, or drugs that affect the liver. Do not use this medicine for more than a few days without consulting a doctor. Keep out of reach of children. If you are pregnant or breastfeeding, consult your doctor before use. Do not use this medicine to treat a fever for more than three days or pain for more than five days without medical advice.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the sedative effects of cetirizine and may have reduced liver or kidney function. Lower doses may be needed. Consult a doctor for appropriate dosing.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both cetirizine and paracetamol are generally considered safe during pregnancy when used as directed, but medical advice is essential.
🏥 Post-Surgery Considerations
After surgery, consult your doctor before taking this medicine, as it may interact with other medications or affect recovery. Paracetamol may be used for pain relief, but cetirizine's sedative effects could interfere with post-operative care.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may cause dry mouth, which can affect dental work, and drowsiness may interact with sedatives used during procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness, which can affect your coordination and reaction time. Avoid strenuous exercise or activities that require alertness until you know how it affects you. If you feel dizzy or sleepy, do not exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your job involves operating heavy machinery.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 5 days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it regularly for a long time without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine should be avoided unless prescribed by a doctor. Prolonged use of paracetamol can increase the risk of liver damage, especially with alcohol. Cetirizine may cause tolerance or rebound effects. Regular monitoring of liver and kidney function may be needed if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps clear nasal passages and reduce allergy symptoms.
Evidence: Well-establishedReducing exposure to allergens can decrease the need for medication.
Evidence: Well-establishedAllergy shots can provide long-term relief for certain allergies.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination. It is safe to take this medicine before or after vaccination if needed for symptom relief.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label. Bring a copy of your prescription in case of customs checks. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue with your regular dosing schedule as advised by your doctor. Do not leave it in a hot car. If you need to take it while flying, keep it in your carry-on luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Cetirizine starts working within 1 hour, and paracetamol within 30-60 minutes. You may feel relief from symptoms within an hour.
A: It can be taken with or without food, but taking it with food may reduce stomach upset.
A: It may be used in children above 2 years, but only under a doctor's supervision and with the correct dose.
A: Consult your doctor before use. Both ingredients are generally considered safe when used as directed, but medical advice is essential.
🤔 Common Patient Concerns
🔄 Substitutes for koldcet p tablet
View AllAlternative brands with exact same active ingredient:
-
crel tabletPerk Pharmaceuticals Ltd ₹18.10 24.6% CHEAPER
-
toco tabletAdroit Lifescience Pvt Ltd ₹19.67 18% CHEAPER
-
radone tabletRoyal Labs ₹19.69 18% CHEAPER
-
cold-p plus tabletCure Quick Pharmaceuticals ₹23.71 1.2% CHEAPER
-
alkem plus syrupAlkem Laboratories Ltd ₹28.47 18.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: It only relieves symptoms; it does not cure the underlying viral infection. - Myth: It is safe to take with alcohol.
Fact: Alcohol increases the risk of drowsiness and liver damage. - Myth: More is better.
Fact: Taking more than the recommended dose can cause serious harm, especially liver damage.
🔄 Alternative Options
Generic Alternatives
- Cetirizine + Paracetamol syrup (generic)