koftis syrup - Phenylpropanolamine (NA) + Chlorpheniramine Maleate (NA) medicine

Betaphil D Syrup: Complete Medicine Guide

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🏭 Scortis Lab Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for symptomatic relief of allergic rhinitis and common cold.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swelling of face, lips, or throat
  • Fast, irregular, or pounding heartbeat
  • Seizures or convulsions
  • Severe dizziness or fainting
  • Confusion or hallucinations
  • Yellowing of skin or eyes
  • Blood in vomit or stool

If experiencing severe symptoms, call emergency services immediately.

What is koftis syrup used for?

This medicine is a combination syrup used to relieve nasal congestion, sneezing, and runny nose due to allergies or common cold. It contains a decongestant and an antihistamine.

  • Generic Name: Phenylpropanolamine (NA) + Chlorpheniramine Maleate (NA)
  • Manufacturer: Scortis Lab Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 koftis syrup के बारे में (Hindi Summary)

उपयोग: यह दवा एलर्जी और सर्दी-जुकाम से होने वाली नाक बंद, छींक, बहती नाक और आंखों में पानी जैसी समस्याओं में राहत देती है। इसमें फेनिलप्रोपेनॉलामाइन और क्लोरफेनिरामाइन मेलिएट होते हैं। यह नाक की भीड़ को कम करती है और एलर्जी के लक्षणों को शांत करती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, धुंधली दृष्टि और जी मिचलाना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, तेज़ धड़कन, दौरे या भ्रम हो सकते हैं। ऐसा होने पर तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को लेने के बाद नींद आ सकती है, इसलिए वाहन चलाने या मशीन चलाने से बचें। शराब न पिएं। यदि आपको उच्च रक्तचाप, हृदय रोग, मधुमेह, ग्लूकोमा या प्रोस्टेट की समस्या है तो डॉक्टर को बताएं। 7 दिनों से अधिक उपयोग न करें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 koftis syrup Uses & Benefits

[{"condition":"Allergic rhinitis","description":"Relieves nasal congestion, sneezing, runny nose, and itching associated with seasonal or perennial allergies.","evidence":"Well-established"},{"condition":"Common cold","description":"Provides temporary relief of nasal congestion and sneezing due to the common cold.","evidence":"Well-established"},{"condition":"Upper respiratory tract allergies","description":"Helps reduce symptoms such as watery eyes, itchy throat, and postnasal drip.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Sinusitis","description":"Sometimes used off-label to relieve congestion associated with sinusitis, but evidence is limited.","evidence":"Limited"},{"condition":"Eustachian tube dysfunction","description":"Occasionally used to reduce congestion and improve ear pressure, but not a standard treatment.","evidence":"Limited"}]

Primary treatment for: Allergic rhinitis

Also treats: Common cold, Upper respiratory allergies

📋 Drug Information

Generic Name(s)Phenylpropanolamine (NA) + Chlorpheniramine Maleate (NA)
Brand Namekoftis syrup
ManufacturerScortis Lab Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place. Protect from light and moisture. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine exactly as prescribed by your doctor.
2
Avoid driving or operating machinery after taking this medicine as it may cause drowsiness.
3
Do not consume alcohol while taking this medicine.
4
Use a measuring cup to ensure accurate dosing.
5
Do not use for more than 7 days without consulting a doctor.
6
Inform your doctor if you have high blood pressure, heart disease, or diabetes.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Nasal congestion
This medicine is commonly prescribed for this.
Likely Use
✅
Sneezing
This medicine helps relieve sneezing due to allergies.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionPhenylpropanolamine is absorbed from the gastrointestinal tract. Chlorpheniramine maleate is also absorbed from the gastrointestinal tract. The exact bioavailability and absorption rates are not established from the available information.
DistributionBoth ingredients are distributed widely throughout the body. Phenylpropanolamine may cross the blood-brain barrier. Chlorpheniramine is known to cross the blood-brain barrier and may cause drowsiness. Protein binding information is not established from the available information.
Protein BindingNot established from the available information.
MetabolismPhenylpropanolamine is primarily metabolized in the liver. Chlorpheniramine is metabolized in the liver by cytochrome P450 enzymes, primarily CYP2D6. The exact metabolic pathways are not fully established from the available information.
Half-LifeThe elimination half-life of phenylpropanolamine is approximately 3-6 hours. The elimination half-life of chlorpheniramine is approximately 12-43 hours. These values may vary.
ExcretionBoth ingredients and their metabolites are primarily excreted in the urine. The exact excretion patterns are not established from the available information.
BioavailabilityNot established from the available information.
Onset of ActionThe onset of action for phenylpropanolamine is typically within 15-30 minutes. Chlorpheniramine onset is also within 30-60 minutes. The exact onset for this combination is not established from the available information.
Peak Plasma TimePeak plasma concentrations for phenylpropanolamine are reached in about 1-2 hours. For chlorpheniramine, peak levels occur in about 2-6 hours. These values may vary.
Duration of ActionThe duration of action for phenylpropanolamine is about 4-6 hours. Chlorpheniramine duration is about 4-6 hours. The combination may provide relief for up to 6 hours.

How It Works

This medicine combines two active ingredients. Phenylpropanolamine is a sympathomimetic amine that acts primarily on alpha-adrenergic receptors, causing vasoconstriction in the nasal mucosa, which reduces swelling and congestion. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, thereby reducing allergic symptoms such as sneezing, runny nose, and itching. The combination provides both decongestant and antihistaminic effects.

Mechanism Steps

1
Alpha-adrenergic stimulation: Phenylpropanolamine stimulates alpha-adrenergic receptors on nasal blood vessels, causing vasoconstriction and reduced swelling.
2
Histamine H1 receptor blockade: Chlorpheniramine competitively blocks histamine at H1 receptors, preventing histamine-mediated allergic symptoms.
3
Combined symptomatic relief: The dual action reduces nasal congestion and allergic symptoms such as sneezing and runny nose.

💡 How to Take koftis syrup

Strength: Syrup containing phenylpropanolamine and chlorpheniramine maleate. Exact strengths not specified.

1Shake the bottle well before use.
2Use a measuring cup or spoon to measure the dose accurately.
3Take orally with or without food.
4Follow the dosage instructions on the label or as prescribed by your doctor.
5Do not exceed the recommended dose.

Dosage Information

Adult DosageThe usual adult dose is 5-10 mL (1-2 teaspoons) every 4-6 hours as needed, not to exceed 4 doses in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially drowsiness and dizziness. Use with caution and lower doses may be appropriate. Consult a doctor.
Renal ImpairmentDose adjustment may be needed in renal impairment. Consult a doctor.
Hepatic ImpairmentDose adjustment may be needed in hepatic impairment. Consult a doctor.
Maximum Daily DoseNot established from the available information. Do not exceed the recommended dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of koftis syrup

✅ Common Side Effects

Drowsiness (Common (10-20%))
Avoid driving or operating machinery. If persistent, consult your doctor.
Dry mouth (Common (5-15%))
Sip water or chew sugarless gum. Consult if severe.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. Avoid alcohol.
Nausea (Common (5-10%))
Take with food or milk. Consult if persistent.
Blurred vision (Uncommon (1-5%))
Avoid tasks requiring clear vision. Consult if persistent.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, swelling, or difficulty breathing.
Fast or irregular heartbeat (Rare (<0.1%))
Contact your doctor immediately if you notice palpitations.
Seizures (Rare (<0.1%))
Seek emergency medical help if seizures occur.
Hallucinations or confusion (Rare (<0.1%))
Stop the medicine and consult a doctor immediately.

⚠️ Rare Side Effects

Blood dyscrasias
Report unusual bleeding or bruising to your doctor.
Liver enzyme elevation
Report yellowing of skin or eyes to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major
Alcohol Moderate
CNS depressants Moderate
Antihypertensives Moderate

🚨 Major Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • Other sympathomimetics

⚡ Moderate Interactions

  • Alcohol
  • CNS depressants
  • Antihypertensives

🍷 Alcohol Interaction

Alcohol increases drowsiness and dizziness caused by this medicine. Avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to phenylpropanolamine or chlorpheniramine","Severe hypertension","Coronary artery disease","Use with MAOIs","Children under 12 years (unless prescribed)"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving.","Avoid alcohol.","Use with caution in patients with glaucoma, prostate enlargement, or urinary retention.","Do not use for more than 7 days without medical advice.","Consult doctor if pregnant or breastfeeding."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before use while breastfeeding.

💊 Overdose Management

Overdose may cause severe drowsiness, confusion, seizures, irregular heartbeat, or difficulty breathing. Seek immediate medical attention. Treatment is supportive and symptomatic.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

This medicine can cause drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. Do not drink alcohol while taking this medicine, as it can increase drowsiness and dizziness. Inform your doctor if you have high blood pressure, heart disease, diabetes, thyroid disorder, glaucoma, or prostate enlargement. Do not use this medicine for longer than 7 days without consulting a doctor. Keep out of reach of children. If you are pregnant or breastfeeding, consult your doctor before use. Do not take more than the recommended dose.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to drowsiness, dizziness, and anticholinergic effects. Use with caution and lower doses may be needed.

🤰 Pregnancy Planning (TTC)

Consult your doctor before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery, as it may interact with other medications or affect recovery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may cause dry mouth and interact with other medications.

💚 Lifestyle Tips for Better Results

🏃
Stay hydrated to help thin mucus.
🥗
Use a humidifier to ease nasal congestion.
😴
Avoid allergens such as dust and pollen.
💧
Get plenty of rest to support recovery.
🧘
Wash hands frequently to prevent infections.

🏋️ Exercise Considerations

Avoid strenuous exercise if you feel drowsy or dizzy. Listen to your body and rest if needed.

🥗 Diet Recommendations

Drink warm fluids like soup and tea.
Avoid cold drinks and ice cream.
Include vitamin C rich foods.
Avoid alcohol.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness, affecting your ability to drive or operate machinery. Avoid these activities until you know how it affects you. It may also reduce alertness at work.

🛑 When to Stop This Medicine

Stop taking this medicine if symptoms persist beyond 7 days or if you experience serious side effects. Consult your doctor before stopping if you have been taking it regularly.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended. Prolonged use may lead to rebound congestion, increased drowsiness, and other side effects. Use only for short-term relief and consult a doctor if symptoms persist beyond 7 days.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Saline nasal spray

Helps relieve nasal congestion without medication.

Evidence: Well-established
Steam inhalation

Can temporarily relieve nasal congestion.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions with vaccines. Consult your doctor if you have any concerns.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of the prescription. Store at room temperature and protect from light. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying medications.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with seasonal allergies
She experienced sneezing, runny nose, and itchy eyes every spring. Her doctor prescribed this medicine. She took it as directed and found significant relief within 30 minutes. She noted that it made her slightly drowsy, so she took it at bedtime.
💡 Lesson: Taking this medicine at bedtime can help manage drowsiness while providing relief from allergy symptoms.
👤 A 50-year-old man with common cold
He had severe nasal congestion and sneezing. He took this medicine every 6 hours for 3 days. His symptoms improved, but he stopped after 3 days as advised by his doctor. He avoided driving due to drowsiness.
💡 Lesson: Short-term use as directed is effective, and avoiding driving prevents accidents due to drowsiness.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30-60 minutes after taking a dose.

Q: Can I take this medicine with food?

A: Yes, you can take it with or without food. Taking with food may reduce stomach upset.

Q: Is it safe for children?

A: It is not recommended for children under 12 years unless prescribed by a doctor.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my blood pressure?
  • Can I drive after taking this medicine?
  • Does it interact with my other medicines?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for koftis syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure the common cold.
    Fact: It only relieves symptoms; it does not cure the underlying infection.
  • Myth: It is safe to take with alcohol.
    Fact: Alcohol increases drowsiness and should be avoided.

📊 Comparison with Similar Medicines

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