kofout syrup - Bromhexine (4mg) + Guaifenesin (50mg) medicine

Albro Syrup: Complete Guide to Uses, Dosage, and Safety

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🏭 Neuro Pharma GmbH 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for symptomatic relief of productive cough.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in sputum or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Persistent fever for more than 3 days

If experiencing severe symptoms, call emergency services immediately.

What is kofout syrup used for?

This medicine is a combination cough syrup containing bromhexine and guaifenesin. It helps relieve productive cough by thinning mucus and making it easier to cough out. It is usually taken 10 mL three times a day for adults, but follow your doctor's advice.

  • Generic Name: Bromhexine (4mg) + Guaifenesin (50mg)
  • Manufacturer: Neuro Pharma GmbH
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 kofout syrup के बारे में (Hindi Summary)

उपयोग: यह दवा ब्रोमहेक्सिन और गुआइफेनेसिन का संयोजन है, जिसका उपयोग बलगम वाली खांसी के इलाज में किया जाता है। यह बलगम को पतला करके उसे बाहर निकालने में मदद करती है, जिससे छाती की जकड़न और खांसी में राहत मिलती है। यह दवा श्वसन संक्रमण, ब्रोंकाइटिस और अन्य स्थितियों में प्रभावी है जहां गाढ़ा बलगम परेशान करता है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, दस्त, सिरदर्द, चक्कर आना और पेट में गड़बड़ी शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। कभी-कभी गंभीर एलर्जी प्रतिक्रिया, जैसे चेहरे, होंठ या गले में सूजन, सांस लेने में कठिनाई, या त्वचा पर गंभीर दाने हो सकते हैं। ऐसी स्थिति में तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपने आप मात्रा न बढ़ाएं। दवा लेते समय खूब पानी पिएं। अगर आपको चक्कर या नींद आती है तो वाहन चलाने या मशीन चलाने से बचें। बिना डॉक्टर की सलाह के 7 दिन से ज्यादा इसका सेवन न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 kofout syrup Uses & Benefits

[{"condition":"Productive cough associated with acute bronchitis","description":"Helps thin and loosen mucus, making it easier to cough out and relieving chest congestion.","evidence":"Well-established"},{"condition":"Productive cough due to upper respiratory tract infections","description":"Provides symptomatic relief by reducing mucus viscosity and promoting expectoration.","evidence":"Well-established"},{"condition":"Chronic obstructive pulmonary disease (COPD) with thick secretions","description":"May help in clearing airway secretions, but should be used only under medical supervision.","evidence":"Limited"}]

Off-label uses: [{"condition":"Prevention of postoperative pulmonary complications","description":"Sometimes used to help clear secretions after surgery, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Productive cough

Also treats: Acute bronchitis, Upper respiratory tract infection, COPD with thick secretions

📋 Drug Information

Generic Name(s)Bromhexine (4mg) + Guaifenesin (50mg)
Brand Namekofout syrup
ManufacturerNeuro Pharma GmbH
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place, away from direct sunlight. Do not refrigerate. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Drink plenty of water throughout the day to help loosen mucus.
3
Avoid alcohol while taking this medicine as it may increase dizziness.
4
Do not take this medicine for more than 7 days without consulting your doctor.
5
If you are taking antibiotics, this medicine may enhance their effect in the lungs, but always follow your doctor's advice.
6
Report any unusual bleeding or bruising immediately, especially if you are on blood thinners.
7
Do not use this medicine for dry cough or cough due to asthma without mucus.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Productive cough with thick mucus
This medicine is commonly prescribed for this.
Likely Use
❌
Dry cough
This medicine is not effective for dry cough.
Not Primary
✅
Chest congestion
This medicine helps relieve chest congestion by thinning mucus.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionBromhexine is rapidly absorbed from the gastrointestinal tract after oral administration. Guaifenesin is also absorbed from the gastrointestinal tract. Food may delay the absorption of guaifenesin slightly but does not significantly affect the overall effect.
DistributionBromhexine is widely distributed to body tissues, including the lungs, and crosses the blood-brain barrier to a small extent. Guaifenesin is distributed throughout body fluids and tissues. Protein binding information for both agents is not well established.
Protein BindingNot established from the available information.
MetabolismBromhexine undergoes extensive first-pass metabolism in the liver, primarily by cytochrome P450 enzymes, to active and inactive metabolites. Guaifenesin is metabolized in the liver by oxidation and conjugation.
Half-LifeThe elimination half-life of bromhexine is approximately 1-2 hours. The half-life of guaifenesin is approximately 1 hour.
ExcretionBromhexine and its metabolites are mainly excreted in the urine. Guaifenesin and its metabolites are also excreted primarily in the urine.
BioavailabilityThe oral bioavailability of bromhexine is low due to first-pass metabolism, approximately 20-30%. The bioavailability of guaifenesin is not well established but is considered to be around 50%.
Onset of ActionThe onset of action for bromhexine is typically within 30 minutes to 1 hour after oral administration. Guaifenesin may start working within 15-30 minutes.
Peak Plasma TimePeak plasma concentrations of bromhexine are reached approximately 1 hour after oral administration. For guaifenesin, peak levels occur within 15-30 minutes.
Duration of ActionThe effects of bromhexine last for about 6-8 hours. Guaifenesin effects last for about 4-6 hours. Therefore, dosing every 6-8 hours is common.

How It Works

This medicine combines two active ingredients with complementary actions. Bromhexine is a mucolytic that reduces the viscosity of mucus by breaking down acidic mucopolysaccharide fibers, making secretions thinner and easier to expel. Guaifenesin is an expectorant that increases the volume and reduces the viscosity of bronchial secretions by increasing hydration, thereby facilitating their removal by ciliary action and coughing. Together, they improve the clearance of thick, sticky mucus from the airways.

Mechanism Steps

1
Bromhexine breaks down mucus structure: Bromhexine disrupts the network of acidic mucopolysaccharide fibers in mucus, reducing its thickness and stickiness.
2
Guaifenesin increases mucus hydration: Guaifenesin draws water into the mucus, making it less viscous and easier to cough up.
3
Enhanced mucociliary clearance: The combined effect allows the cilia in the airways to move the loosened mucus more effectively toward the throat for expulsion.
4
Relief of productive cough: As mucus is cleared, cough frequency and chest congestion are reduced, providing symptomatic relief.

💡 How to Take kofout syrup

Strength: Each 5 mL of syrup contains bromhexine 4 mg and guaifenesin 50 mg.

1Shake the bottle well before each use.
2Use a measuring cup or spoon to measure the exact dose.
3Take the medicine orally with or without food.
4Drink a glass of water after taking the medicine.
5Wash the measuring cup after each use.
6Close the bottle tightly after use.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 10 mL (2 teaspoons) three times a day, or as directed by your doctor. The dose may be adjusted based on your condition and response. Do not exceed 30 mL in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially dizziness and stomach upset. Use with caution and follow your doctor's advice. Dose adjustment may be needed based on kidney and liver function.
Renal ImpairmentUse with caution in patients with kidney impairment. Dose adjustment may be necessary. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with liver impairment. Dose adjustment may be necessary. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose for adults is 30 mL (6 teaspoons) in 24 hours. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Water
Drink plenty
Helps loosen mucus.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of kofout syrup

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk to reduce stomach upset. If it persists, consult your doctor.
Vomiting (Common (5-10%))
Take with a small snack and stay hydrated. If vomiting is severe or persistent, seek medical advice.
Diarrhea (Common (5-10%))
Drink plenty of fluids to prevent dehydration. If diarrhea is severe or contains blood, contact your doctor.
Headache (Common (5-10%))
Rest and stay hydrated. If headache is severe or persistent, consult your doctor.
Dizziness (Uncommon (1-5%))
Avoid driving or operating machinery until you feel normal. If dizziness persists, consult your doctor.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience swelling of the face, lips, tongue, or throat, difficulty breathing, or a severe rash.
Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black, tarry stools, vomiting blood, or severe abdominal pain.
Severe skin reactions (Stevens-Johnson syndrome) (Very rare (<0.01%))
Stop the medicine and seek immediate medical help if you develop a painful rash, blistering, or peeling skin.

⚠️ Rare Side Effects

Bronchospasm
Seek immediate medical attention if you experience wheezing or difficulty breathing.
Liver enzyme elevation
Report to your doctor if you notice yellowing of eyes or skin, dark urine, or persistent nausea.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Codeine Major
Warfarin Major
Amoxicillin Moderate
Doxycycline Moderate
Erythromycin Moderate
Theophylline Moderate
Atropine Minor

🚨 Major Interactions

  • Codeine and other cough suppressants
  • Warfarin

⚡ Moderate Interactions

  • Antibiotics (amoxicillin, doxycycline, erythromycin)
  • Theophylline

🍷 Alcohol Interaction

Alcohol may increase the risk of dizziness, drowsiness, and stomach upset while taking this medicine. It is advisable to avoid alcohol during treatment.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity or allergy to bromhexine, guaifenesin, or any component of the formulation.","Severe liver disease.","Severe kidney disease.","Children under 2 years of age.","Use in patients with dry cough or cough due to asthma without mucus.","Use in patients with active peptic ulcer disease."]

⚠️ Warnings & Precautions

["Do not exceed the recommended dose.","Do not use for more than 7 days without consulting a doctor.","Drink plenty of water while taking this medicine.","Avoid driving or operating machinery if you feel dizzy or drowsy.","Consult a doctor before use if you are pregnant, planning pregnancy, or breastfeeding.","Use with caution in patients with liver or kidney disease.","Use with caution in patients with stomach ulcers or bleeding disorders.","Keep out of reach of children."]

🤱 Lactation Safety

It is not known whether bromhexine and guaifenesin pass into breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose of this medicine may cause nausea, vomiting, diarrhea, and abdominal pain. In severe cases, it may lead to drowsiness, dizziness, and electrolyte imbalance. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not increase the dose or take it more frequently than recommended. Drink plenty of water while taking this medicine to help loosen mucus. Avoid driving or operating heavy machinery if you feel dizzy or drowsy. Do not take this medicine for a dry cough or for more than 7 days without medical advice. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Inform your doctor about all other medicines you are taking, especially antibiotics, blood thinners, and medicines for asthma or allergies. Keep this medicine out of reach of children. Store in a cool, dry place away from direct sunlight. Do not use after the expiry date.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness, drowsiness, and stomach upset. They may also have reduced kidney and liver function, which can affect drug clearance. Use with caution and follow your doctor's advice.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established. Your doctor will weigh the benefits and risks.

🏥 Post-Surgery Considerations

After surgery, this medicine may be used to help clear secretions if you have a productive cough. However, consult your surgeon or doctor before use, as some surgeries may require avoiding cough medicines.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure. It is generally safe, but they may need to know for your overall health assessment.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated by drinking plenty of water.
🥗
Use a humidifier to add moisture to the air, which can help loosen mucus.
😴
Avoid smoking and exposure to secondhand smoke.
💧
Get plenty of rest to help your body recover.
🧘
Practice good hand hygiene to prevent infections.
🌞
Avoid alcohol as it can worsen dehydration and dizziness.

🏋️ Exercise Considerations

Avoid strenuous exercise if you have a fever or feel weak. Light activity like walking may be fine, but listen to your body and rest when needed. If you experience shortness of breath or chest pain during exercise, stop and consult your doctor.

🥗 Diet Recommendations

Drink warm fluids like herbal tea or soup to soothe your throat and loosen mucus.
Include foods rich in vitamin C, such as oranges and bell peppers, to support your immune system.
Avoid dairy products if they seem to thicken your mucus.
Eat a balanced diet with plenty of fruits and vegetables.
Avoid spicy and oily foods that may irritate your stomach.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. If you experience these effects, avoid driving or operating heavy machinery. It is generally safe to continue desk work, but take breaks and stay hydrated. If your cough is severe, consider taking rest days to recover.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your cough persists for more than 7 days, if it worsens, or if you develop new symptoms such as fever, rash, or difficulty breathing. Do not stop abruptly if you are taking it for a chronic condition without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended without medical supervision. Prolonged use may lead to electrolyte imbalance, gastrointestinal disturbances, and rarely, liver enzyme elevation. It may also mask underlying conditions such as chronic bronchitis or asthma. Regular monitoring of liver and kidney function may be advised if used for extended periods.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Inhaling steam can help loosen mucus and relieve chest congestion.

Evidence: Well-established
Saline nasal irrigation

Rinsing nasal passages with saline can help clear mucus and reduce postnasal drip.

Evidence: Well-established
Honey and warm fluids

Honey can soothe the throat and warm fluids can help thin mucus.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are due for a vaccination, inform your doctor that you are taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case you need to show it at customs. Store it in a cool, dry place, away from direct sunlight. If you are crossing time zones, continue taking the medicine at the same intervals as prescribed, but adjust the timing gradually to the new local time. Do not leave it in a hot car or checked luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute bronchitis
He had a severe productive cough with thick yellow mucus. His doctor prescribed this medicine three times a day. After two days, he noticed that the mucus became thinner and easier to cough out. He also drank plenty of water as advised. By day five, his cough had significantly improved.
💡 Lesson: Taking this medicine as prescribed and staying hydrated can effectively relieve productive cough.
👤 A 60-year-old woman with COPD
She experienced frequent episodes of thick mucus that was hard to clear. Her doctor added this medicine to her regimen. She found that it helped her clear her airways more easily, especially in the morning. She was advised to monitor for any stomach upset and to report if it occurred.
💡 Lesson: This medicine can be beneficial for COPD patients with thick secretions, but it should be used under medical supervision.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 minutes to 1 hour after taking it. You may notice that mucus becomes thinner and easier to cough out.

Q: Can I take this medicine with antibiotics?

A: Yes, this medicine is often prescribed with antibiotics for respiratory infections. Bromhexine may increase the concentration of antibiotics in the lungs, which can be beneficial. However, always follow your doctor's advice.

Q: Is this medicine safe for children?

A: This medicine is not recommended for children under 2 years of age. For older children, consult a pediatrician for appropriate dosing.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for kofout syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any type of cough.
    Fact: This medicine is only for productive cough with thick mucus. It is not effective for dry cough or cough due to asthma.
  • Myth: More medicine means faster relief.
    Fact: Taking more than the recommended dose can increase side effects without providing extra benefit. Always follow the prescribed dose.
  • Myth: It is safe to take this medicine for weeks.
    Fact: This medicine should not be used for more than 7 days without medical advice. Prolonged use may mask underlying conditions.

🔄 Alternative Options

Generic Alternatives

  • Bromhexine + Guaifenesin syrup (various manufacturers)

Brand Alternatives

  • Albro Syrup

📊 Comparison with Similar Medicines

[{"medicine":"This medicine (Bromhexine + Guaifenesin)","composition":"Bromhexine 4 mg + Guaifenesin 50 mg per 5 mL","primary_use":"Productive cough","notes":"Combines mucolytic and expectorant."},{"medicine":"Ambroxol + Guaifenesin","composition":"Ambroxol 15 mg + Guaifenesin 50 mg per 5 mL","primary_use":"Productive cough","notes":"Ambroxol is a metabolite of bromhexine with similar action."},{"medicine":"Guaifenesin alone","composition":"Guaifenesin 50 mg per 5 mL","primary_use":"Productive cough","notes":"Only expectorant, no mucolytic."}]

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